High-density lipoprotein choApoECholesterolSingle nucleotide pLipaseGenotypeTriglyceride rich lipoproteinsTriglyceridesGeneLipidsSerumProteinGenesApoBSNPsCoronaryPrognosisEndothelial cellsHaplotypesGeneticPlasmaLevelsPeripheralParametersHumansRiskSignificantlyElderlyStudyMajorStudiesRoleResultsPopulation
High-density lipoprotein cho4
- 2001). The Ser(447)-Stop polymorphism of lipoprotein lipase is associated with variation in longitudinal serum high-density lipoprotein-cholesterol profiles: the Bogalusa Heart Study. (geneticsmr.com)
- Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies. (sdu.dk)
- Serum Total Cholesterol (TC), Triglyceride (TG), High Density Lipoprotein Cholesterol (HDL-C) of the study subjects were measured using commercial kits and Low Density Lipoprotein Cholesterol (LDL-C) was calculated. (ijcrr.com)
- Using data from the second phase (1991-1994) of the Third National Health and Nutrition Examination Survey (NHANES III), we examined associations between 22 polymorphisms in 13 candidate genes and four serum lipids: high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG). (cdc.gov)
ApoE6
- [ 5 ] Only 10% of amyloidosis deposits consist of components such as glycosaminoglycans (GAGs), apolipoprotein-E (apoE), and serum amyloid P-component (SAP), while nearly 90% of the deposits consist of amyloid fibrils that are formed by the aggregation of misfolded proteins. (medscape.com)
- Genetic and biochemical studies support the apolipoprotein E ( APOE ) ε4 allele as a major risk factor for late-onset Alzheimer's disease (AD), though ~50% of AD patients do not carry the allele. (biomedcentral.com)
- Since polymorphisms of LH beta-subunit ( LHB ) and its receptor ( LHCGR ) have not been tested for their association with AD, we scored AD and age-matched control samples for APOE genotype and 14 polymorphisms of LHB and LHCGR . (biomedcentral.com)
- To date, only four genes have been unambiguously associated with AD, of which only one, Apolipoprotein E ( APOE ), is associated with the common, late-onset form of AD [ 1 ]. (biomedcentral.com)
- And the immunohistochemical staining of APOE was used to verify the predicted results. (jcancer.org)
- ApoE produces a protein named Apolipoprotein E , which combines with lipids in the body to form lipoproteins that carry cholesterol and other fats through the bloodstream. (darkdaily.com)
Cholesterol8
- 2012). Comparison of Apolipoprotein (apoB/apoA-I) and Lipoprotein (Total Cholesterol/HDL) Ratio Determinants. (gianlucatognon.com)
- Carriers of the minor allele of rs290481 exhibited an altered lipid profile, with increased plasma levels of apolipoprotein B, non-esterified fatty acids, cholesterol and apolipoprotein B in triglyceride rich lipoproteins, and LDL cholesterol. (reading.ac.uk)
- 2001). Influence of lipoprotein lipase serine 447 stop polymorphism on tracking of triglycerides and HDL cholesterol from childhood to adulthood and familial risk of coronary artery disease: the Bogalusa Heart Study. (geneticsmr.com)
- For early onset heart attacks, a high polygenic score is ten times more predictive than the best predictor now in use, which is elevated cholesterol of the bad kind (low-density lipoprotein). (4recruitmentservices.com)
- There is also evidence of racial differences in lipid and lipoprotein levels, as black subjects have been found to have lower levels of triglycerides and higher levels of highdensity lipoprotein (HDL) cholesterol (11-21). (ijcrr.com)
- A meta-analysis of randomized, controlled trials of T4-triiodothyronine (T3) combination therapy versus T4 monotherapy for treatment of clinical hypothyroidism found no difference in effectiveness between combination therapy and monotherapy with respect to side effects such as bodily pain, depression, fatigue, body weight, anxiety, quality of life, and total low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol and triglyceride levels. (medscape.com)
- Results from our study contribute to a growing body of literature identifying key determinants of plasma lipoprotein concentrations and could provide insight into the biological mechanisms underlying serum lipid and cholesterol concentrations. (cdc.gov)
- Previous reports from the Framingham Heart Study suggested a strong positive relationship between coronary heart disease and elevated levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels, in addition to an inverse relationship between the disease and high-density lipoprotein cholesterol (HDL-C) levels [ 5 - 8 ]. (cdc.gov)
Single nucleotide p2
- Two well-known CSK (CSK rs34933034 and CSK rs1378942) and two functional PTPN22 (PTPN22 rs2476601 (R620W) and PTPN22 rs33996649 (R263Q)) polymorphisms, previously associated with autoimmunity, were genotyped with TaqMan single nucleotide polymorphism (SNP) genotyping assays. (unican.es)
- single nucleotide polymorphism-DNA sequence variations with a single nucleotide (adenine, thymine, cytosine, or guanine) in the genome sequence altered. (biomedcentral.com)
Lipase11
- " Association of lipase lipoprotein polymorphisms with high-density lipoprotein and triglycerides in elderly men " , vol. 9, pp. 89-96, 2010. (geneticsmr.com)
- 1993). Two DNA polymorphisms in the lipoprotein lipase gene and their associations with factors related to cardiovascular disease. (geneticsmr.com)
- 2003). Metabolism of chylomicron-like emulsions in carriers of the S447X lipoprotein lipase polymorphism. (geneticsmr.com)
- The S447X polymorphism of lipoprotein lipase: effect on the incidence of premature coronary disease and on plasma lipids. (geneticsmr.com)
- Functional significance of lipoprotein lipase HindIII polymorphism associated with the risk of coronary artery disease. (geneticsmr.com)
- 2007). Association of lipase lipoprotein polymorphisms with myocardial infarction and lipid levels. (geneticsmr.com)
- Direct detection and automated sequencing of individual alleles after electrophoretic strand separation: identification of a common nonsense mutation in exon 9 of the human lipoprotein lipase gene. (geneticsmr.com)
- 1998). Lipoprotein lipase gene variation is associated with a paternal history of premature coronary artery disease and fasting and postprandial plasma triglycerides: the European Atherosclerosis Research Study (EARS). (geneticsmr.com)
- 1992). A heterozygous mutation (the codon for Ser447 - a stop codon) in lipoprotein lipase contributes to a defect in lipid interface recognition in a case with type I hyperlipidemia. (geneticsmr.com)
- Lipoprotein lipase increases low density lipoprotein retention by subendothelial cell matrix. (jci.org)
- Lipoprotein lipase (LPL), the rate-limiting enzyme for hydrolysis of plasma lipoprotein triglycerides, is a normal constituent of the arterial wall. (jci.org)
Genotype4
- Effect of HLA genotype or CTLA-4 polymorphism on cytokine response in healthy children. (cdc.gov)
- Results: No significant differences in the genotype and allele frequencies between HSP patients and controls were observed when the CSK rs34933034, CSK rs1378942, PTPN22 rs2476601 (R620W) and PTPN22 rs33996649 (R263Q) polymorphisms were analyzed independently. (unican.es)
- We utilized polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method to genotype these four single nucleotide polymorphisms (SNPs). (biomedcentral.com)
- Specifically, patients with LMCAD and B1B1 genotype of TaqIB polymorphism were more frequent present compared to Controls (33.8% vs 22.9%, respectively). (biomedcentral.com)
Triglyceride rich lipoproteins2
- Large triglyceride-rich lipoproteins in hypertriglyceridemia are associated with the severity of acute pancreatitis in experimental mice. (omicsdi.org)
- Plasma triglyceride-rich lipoproteins (TRLs), including chylomicrons and very low-density lipoprotein (VLDL), were collected via ultracentrifugation to evaluate their cytotoxic effects on primary pancreatic acinar cells (PACs). (omicsdi.org)
Triglycerides2
- 1997). Fasting triglycerides, high-density lipoprotein, and risk of myocardial infarction. (geneticsmr.com)
- The LDL:HDL ratio in humans is set mainly by CETP activity, which exchanges cholesteryl esters for triglycerides across lipoprotein fractions to raise LDL and lower HDL as CETP activity increases. (biomedcentral.com)
Gene8
- Apo lipoprotein A1 gene polymorphisms predict cardio-metabolic risk in South Asian immigrants. (cdc.gov)
- Aims/hypothesis: Variants of the TCF7L2 gene predict the development of type 2 diabetes mellitus (T2DM). (reading.ac.uk)
- Previous studies suggested that Apolipoprotein AI (ApoAI) and apolipoprotein B (ApoB) gene polymorphisms may result in lipid metabolism disorders. (biomedcentral.com)
- The authors found C7623T polymorphism of ApoB gene was associated with osteonecrosis. (biomedcentral.com)
- The DNA of 471 subjects [133 subjects with angiographically documented left main coronary artery disease (LMCAD), 241 subjects with more peripheral coronary artery disease (MPCAD) and 97 subjects self reported healthy (Controls)] was analyzed for the frequency of TaqIB and I405V polymorphisms in the gene coding CETP. (biomedcentral.com)
- The relationship between TaqIB gene polymorphism and the LMCAD was independent of lipid profile, with the exception of apolipoprotein A. (biomedcentral.com)
- Thus the studies evaluating the influence of CETP gene polymorphisms in humans are essential. (biomedcentral.com)
- Recent candidate gene studies [ 13 - 16 ], as well as genome-wide association studies [ 17 - 25 ], have identified polymorphisms that account for a portion of the variation in blood lipid levels. (cdc.gov)
Lipids1
- Since the discovery of cholesteryl ester transfer protein (CETP) and its identification as a modulator of HDL-C levels (mediates the exchange of lipids between lipoproteins), there has been much speculation about its role in CAD [ 17 ]. (biomedcentral.com)
Serum4
- Background: Racial differences in serum lipid and lipoprotein levels exist and assumed to be important determinants of cardiovascular disease. (ijcrr.com)
- The purpose of this study is to investigate if there are any differences in serum lipid and lipoprotein level in the population of two different races of Bangladesh. (ijcrr.com)
- No significant difference was found for LDL-C. Conclusion: This study clearly showed that racial variations exist in serum lipid and lipoproteins levels between the Bangalee and Chakma population of Bangladesh. (ijcrr.com)
- Increased serum lipid and lipoprotein concentrations are recognized risk factors for coronary heart disease and atherosclerosis (2-4). (ijcrr.com)
Protein5
- Polymorphisms that slightly vary native peptides or inflammatory processes set the stage for abnormal protein folding and amyloid fibril deposition. (medscape.com)
- Intravenous injection of apolipoprotein A-V reconstituted high-density lipoprotein decreases hypertriglyceridemia in apoav-/- mice and requires glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1. (omicsdi.org)
- Apolipoprotein A-V (apoA-V), a minor protein associated with lipoproteins, has a major effect on triacylglycerol (TG) metabolism. (omicsdi.org)
- To investigate whether hypertriglyceridemia subtypes affect acute pancreatitis progression, we analyzed two genetically modified hypertriglyceridemia mouse models-namely, glycosylphosphatidylinositol high-density lipoprotein binding protein 1 knockout (Gpihbp1-/-) and apolipoprotein C3 transgenic (ApoC3-tg) mice. (omicsdi.org)
- This narrative review focuses on the role of cholesteryl ester transfer protein (CETP) and peripheral lipoproteins in the vascular contributions to cognitive impairment and dementia (VCID). (biomedcentral.com)
Genes2
- Genetic polymorphisms in these genes may be associated with the occurrence of osteonecrosis. (biomedcentral.com)
- We furthermore examine genes and polymorphisms relevant to each technique. (biomedcentral.com)
ApoB1
- To further clarify the association of ApoAI and ApoB genetic polymorphism and osteonecrosis, we designed a larger sample-size case-control study. (biomedcentral.com)
SNPs1
- Self-reported i nsomnia symptoms were instrumented by a genetic risk score (GRS) created from 129 single-nucleotide polymorphisms (SNPs). (biomedcentral.com)
Coronary1
- Plasma lipoprotein levels are predictors of risk for coronary artery disease. (omicsdi.org)
Prognosis2
- Thus, it is essential to identify a new biomarker that can be used to assist in screening diagnosis and predict the prognosis of PTC. (jcancer.org)
- Background A precise description of renal histological lesions and an appropriate classification of lupus nephritis are both essential for nephrologists to guide treatment and predict prognosis among patients. (kidneypmk.com)
Endothelial cells1
- We explored whether LPL affects (a) lipoprotein transport across bovine aortic endothelial cells or (b) lipoprotein binding to subendothelial cell matrix (retention). (jci.org)
Haplotypes1
- In keeping with this observation, no significant differences were found when we assessed these polymorphisms combined conforming haplotypes. (unican.es)
Genetic2
- It seems every day that diagnostic test developers are announcing new genetic tests for everything from researching bloodlines to predicting vulnerability to specific chronic diseases. (darkdaily.com)
- The genetic basis for elevation in lipid levels is not well understood, but substantial heritability has been demonstrated in twin [ 9 ] and family-based [ 10 - 12 ] studies, which have estimated that approximately 43% to 83% of the variance in blood lipid and lipoprotein levels is attributable to genetic factors. (cdc.gov)
Plasma1
- We also validate our protocol for analyzing the major plasma lipoprotein classes HDL, LDL, IDL, and VLDL, as well as homogeneously prepared apoA-I-containing rHDL. (omicsdi.org)
Levels2
- No significant study has been conducted to examine if there are any differences in lipid and lipoprotein levels of these different races. (ijcrr.com)
- The aim of this investigation was to determine whether there is any variation in the lipid and lipoprotein levels in the population of two different races namely Bangalee (Proto-Austriod or Veddas in origin and the mainstream population) and Chakma (Tibeto-Mongoloids in origin and tribal population) of Bangladesh. (ijcrr.com)
Peripheral2
- Humans have a peripheral lipoprotein profile where low-density lipoproteins (LDL) represent the dominant lipoprotein fraction and high-density lipoproteins (HDL) represent a minor lipoprotein fraction. (biomedcentral.com)
- Although most peripheral lipoproteins cannot enter the brain parenchyma due to the BBB, it is increasingly appreciated that direct access to the vascular endothelium may enable peripheral lipoproteins to have indirect effects on brain health. (biomedcentral.com)
Parameters1
- The presence of dyslipidemia is associated with both changes in basic lipid parameters and modified lipoproteins, which are not routinely measured in clinical practice. (encyclopedia.pub)
Humans1
- Unlike humans, wild-type mice do not express catalytically active CETP and have HDL as their major lipoprotein fraction. (biomedcentral.com)
Risk1
- These findings indicate that the TaqIB polymorphism may have potential importance in screening individuals at high risk for developing CAD. (biomedcentral.com)
Significantly1
- Polygenic scores have become able to significantly predict common dis-orders from DNA alone. (4recruitmentservices.com)
Elderly1
- Does the Mediterranean diet predict longevity in the elderly? (gianlucatognon.com)
Study1
- In a previous study of apolipoprotein (apo)E4-containing reconstituted HDL (rHDL) particles, we optimized the NS method in a way that eliminated rouleaux. (omicsdi.org)
Major1
- The compositional and conformational heterogeneity of lipoproteins are major barriers to the identification of their structures, as discovered using traditional approaches. (omicsdi.org)
Studies2
- Results of published studies of the association between the methylenetetrahydrofolate reductase C677T polymorphism and ischemic stroke. (jamanetwork.com)
- We investigated whether apoA-V complexed with phospholipid in the form of a reconstituted high-density lipoprotein (rHDL) has potential utility as a therapeutic agent for treatment of hypertriglyceridemia (HTG) when delivered intravenously.Intravenous injection studies were performed in genetically engineered mouse models of severe HTG, including apoav-/- and gpihbp1-/- mice. (omicsdi.org)
Role1
- Lipoprotein structure-function relationships provide important clues that help identify the role of lipoproteins in cardiovascular disease. (omicsdi.org)
Results1
- Results: Several single nucleotide polymorphisms (SNP) showed phenotypic associations independent of SFA or IR. (reading.ac.uk)
Population2
- A polymorphism may be associated with susceptibility to osteonecrosis in Chinese population. (biomedcentral.com)
- A polymorphism was associated with osteonecrosis in Chinese population. (biomedcentral.com)