Myeloproliferative DisordersMyelodysplastic SyndromesJanus Kinase 2Primary MyelofibrosisMyelodysplastic-Myeloproliferative DiseasesPolycythemia VeraThrombocythemia, EssentialAnemia, RefractoryLeukemia, Myelomonocytic, ChronicReceptors, ThrombopoietinBone Marrow NeoplasmsAnemia, Refractory, with Excess of BlastsLeukemia, Myeloid, AcuteThrombocytosisSyndromeLeukemia, Myeloid, Chronic, Atypical, BCR-ABL NegativeLeukemia, MyeloidBone MarrowLeukemia, Myelomonocytic, JuvenileAnemia, SideroblasticMutationChromosomes, Human, Pair 5Proto-Oncogene Proteins c-cblHematologic NeoplasmsSplenomegalyHematopoietic Stem CellsAzacitidineLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLeukemiaPhiladelphia ChromosomeBlast CrisisKaryotypingPrognosisChromosome AberrationsBone Marrow DiseasesHematologyMonosomyPreleukemiaMyeloid Progenitor CellsJanus KinasesDNA Mutational AnalysisThalidomideTreatment OutcomeMegakaryocyte Progenitor CellsBone Marrow CellsSTAT5 Transcription FactorMegakaryocytesChromosomes, Human, Pair 7Megakaryocyte-Erythroid Progenitor CellsCell Transformation, NeoplasticDisease ProgressionPancytopeniaAnemia, AplasticMutation, MissenseClonal EvolutionCytogenetic AnalysisNeoplasms, Second PrimaryChromosome DeletionAcute DiseaseMyelopoiesisFusion Proteins, bcr-ablAmino Acid SubstitutionPoint MutationGene Knock-In TechniquesProtein Kinase InhibitorsDown SyndromeGranulocyte Precursor CellsHematopoietic Stem Cell TransplantationAntineoplastic Agents