• Apigenin has special interest for the development of chemopreventive agents against cancer because it is a widely distributed plant flavonoid that has antitumor properties. (spandidos-publications.com)
  • Apigenin (API), a flavonoid with a potent Akt-inhibitory effect, shows oncostatic activities in various cancers. (figshare.com)
  • Apigenin is a natural flavonoid that is abundantly present in a range of plants such as chamomile. (scienceresearchwellness.com)
  • Apigenin is a flavonoid found in celery, parsley and chamomile that appears to have some significant health benefits for helping prevent heart disease and bone loss, along with supporting mood. (buesingnaturopathic.com)
  • Apigenin er et naturlig forekommende flavonoid, som hemmer CD38, og igjen øker NAD+ nivåene. (sweetmood.no)
  • The Apigenin flavonoid refers to compounds produced by certain plants for defending themselves against infection and UV light. (eternumlabs.com.au)
  • Apigenin is a naturally occurring flavonoid, which exists in a variety of plants in the form of plant yellow pigment, mainly from the umbelliferaceae plant, and other plants such as chamomile, bee flower, Perilla, verbena, yarrow also found its presence. (meetsupplement.com)
  • Apigenin is a kind of flavonoid substance. (meetsupplement.com)
  • Apigenin is a naturally occurring flavonoid compound that exists in a selection of plants in the form of plant yellow pigments. (zspharmac.com)
  • Apigenin is a flavonoid compound found in certain foods and has been studied for its potential health benefits, including antioxidant and anti-inflammatory properties. (longevitybox.co.uk)
  • Apigenin, a dietary flavonoid, is reported to have several therapeutic effects in different diseases including cancer. (johnshopkins.edu)
  • A flavonoid called apigenin is one of the key chemical constituents in chamomile . (trishdeseine.com)
  • The characterization results showed that isolate F1 was a flavonoid group, Apigenin compound, while isolate F2 was a steroid group, Squalene compound. (phcogj.com)
  • Apigenin is particularly abundant in the flowers of chamomile plants, constituting 68% of total flavonoids. (wikipedia.org)
  • The experimental spectra of apigenin and luteolin upon addition of increasing [ Al 3+ ] show a general red-shift of the lowest absorption bands of both flavonoids spectra , associated with the presence of two and three isosbestic points for apigenin and luteolin , respectively. (rsc.org)
  • Apigenin is part of a family of compounds found in plants called flavonoids, which have exhibited anti-inflammatory, antiviral, and antimutagenic effects in studies. (livemomentous.com)
  • Apigenin is one of the most-studied flavonoids, and an overview of the research published in the International Journal of Molecular Sciences in 2019 suggests that it may improve cognitive function and reduce inflammation, anxiety, and depression. (livemomentous.com)
  • Plants that contain flavonoids like Apigenin have been used for battling diseases for a long time. (eternumlabs.com.au)
  • Apigenin has gained particular interest in recent years as a beneficial and health promoting agent because of its low intrinsic toxicity and because of its striking effects on normal versus cancer cells, compared with other structurally-related flavonoids. (riottobotanicals.com)
  • Key findings: Among five flavonoids isolated from GFF, only apigenin potently inhibited the differentiation of 3T3-L1 cells. (kist.re.kr)
  • Apigenin is a plant-derived compound belonging to the flavonoids category and bears protective effects on different cells. (ijfs.ir)
  • Apigenin is a plant-derived compound belonging to the flavonoids category presented in various fruits and vegetables, such as parsley, onion, celery, chamomile and orange ( 3 ). (ijfs.ir)
  • The flavonoids diversity showed a significant content of luteolin and its derivatives, except for Landoltia punctata that had significant apigenin content. (rsc.org)
  • Mechanism is due to essential oil containing bisabolol constituents and the flavonoids apigenin and luteolin. (msdmanuals.com)
  • A DFT-TDDFT investigation on the aluminium complexation of apigenin and luteolin has been carried out. (rsc.org)
  • The molecular geometries of all the Al-apigenin and -luteolin complexes have been optimized, followed by calculation of the formation Gibbs free energies and UV-vis absorption spectra . (rsc.org)
  • We have thus been able to associate specific Al-apigenin ( -luteolin ) complexes with the experimental absorption spectra as a function of the [ Al 3+ ] concentration, thus providing insights into the aluminium complexation of these hydroxyflavonoids and most importantly into the weld lake composition. (rsc.org)
  • Methods In this study we evaluated and compare antioxidant, anti-glycative and anti-degenerative actions of two flavones apigenin and luteolin and a flavonol quercetin, in function of their hydroxyl groups arrangement. (unict.it)
  • Sixteen compounds were identified and quantified, in which three were chlorogenic acid derivatives and eleven apigenin and luteolin derivatives. (rsc.org)
  • Role of apigenin in chronic inflammatory diseases. (encyclopedia.pub)
  • The role of apigenin has been far greater than our common celery, its nutrients can meet the needs of the human body, can be said to be more helpful to health. (meetsupplement.com)
  • The aim of this study was to evaluate the effect of apigenin on the number of viable and apoptotic blastomeres, the zona pellucida (ZP) thickness and hatching rate of pre-implantation mouse embryos exposed to H2O2 and actinomycin D. (ijfs.ir)
  • Although the beneficial effects of apigenin on different cells and tissues have been investigated ( 10 , 11 ), there is no report yet concerning the effect of apigenin on growth and quality of embryos. (ijfs.ir)
  • The flavone apigenin can exert both its antioxidant potential via the usual enzymatic reactive oxygen species scavenging system and the mitochondrial biogenesis via the peroxisome Proliferator-activated receptor Gamma Coactivator 1-alpha (PGC-1α) mitochondrial Transcription Factor A (TFAM) Nuclear Respiratory factor 1 (NRF-1) pathway. (ac.ir)
  • reported that the flavone apigenin (4',5,7-trihydroxyflavone) improves spatial working memory in adult male Wistar rats (Nikbakht et al. (ac.ir)
  • At the dose used by the authors, 50 mg/ kg by oral gavage every day, the flavone apigenin can induce the early expression of procaspase-3, which is crucial for the activation of mitochondrial biogenesis initiators, such as TFAM and NRF-1 (Kim, Ha, Yang, & Son, 2018). (ac.ir)
  • Riotto is a leading wholesale chamomile extract apigenin bulk powder manufacturer from China, our Apigenin features of instantly dissolved and easy to use. (riottobotanicals.com)
  • Buy Celery Seed Extract, Celery Juice Powder, Apigenin Product on Hunan Huakang Biotech Inc. (huakangsw.com)
  • This product is prepared in a non-greasy gel base, as well as biotin are other ingredients such apigenin, biotinoyl tripeptide-1 and ginkgo extract which help strengthen the hair follicle and produces a synergistic action on it. (nih.gov)
  • Quality sleep is a core pillar of overall health, and apigenin is a natural compound that can help you make sure you're getting the rest that you need. (livemomentous.com)
  • A study published in The Journal of Steroid Biochemistry and Molecular Biology also showed a reduction of cortisol production in human adrenal cells by 47.5% when exposed to apigenin, suggesting that the compound can be helpful in reducing stress as well. (livemomentous.com)
  • Apigenin as an anti-inflammatory compound acts as a protective agent in several disorders via inhibition of key inflammatory mediators, signaling pathways, and molecules. (encyclopedia.pub)
  • Apigenin is also a very potent anticancer compound. (herb-extract-supplier.com)
  • Apigenin, a bioflavonoid compound, is commonly found in many herbs and plants, specifically in chamomile tea. (eternumlabs.com.au)
  • Apigenin is also known to be a potent anti-cancer compound. (eternumlabs.com.au)
  • Apigenin, also known as apigenin, is a polyphenol substance and a bioflavonoid compound that we can find in a variety of plants. (meetsupplement.com)
  • Apigenin powder is a bioflavonoid and a very effective anticancer compound. (riottobotanicals.com)
  • Apigenin is a compound found in a wide variety of herbs (particularly in chamomile) as well as some fruits and vegetables. (gowinglife.com)
  • A C-glycosyl compound that consists of apigenin substituted by a 1,5-anhydro-D-glucitol moiety at position 6. (chemspider.com)
  • By assessing the levels of interleukin-6 (IL-6), interleukin-18 (IL-18), resistin (R), and CD45 in blood and high mobility group box 1 protein (HMGB1) in intestinal tissue using a rat experimental model, the study's goal was to determine the impact of apigenin (AP) on acute pancreatitis (ACP). (digiwire.co.in)
  • Impact of apigenin and seashell nano-additives on the antifungal and roughness behavior of a soft denture liner. (bvsalud.org)
  • So, in this study, we evaluated for the first time the impact of apigenin on some morphological indicators of pre-implantation mouse embryos including ZP thickness, viable and apoptotic blastomere quantity and hatching rate. (ijfs.ir)
  • have reportedly shown that apigenin improves obesity and obesity induced inflammation [ 8 ] . (encyclopedia.pub)
  • But, studies have shown that apigenin has significant antioxidant effects, boosting skin health and healthy aging. (eternumlabs.com.au)
  • earns more insightful clues about the activity of apigenin in the prevention of the rat hippocampus neuronal loss caused by the Aβ25-35 injection. (ac.ir)
  • Significance: These findings suggest that apigenin can prevent 3T3-L1 preadipocyte differentiation by the inhibition of the mitotic clonal expansion and the adipogenesis related factors and upregulation of the expression of multiple C/EBPβ inhibitors. (kist.re.kr)
  • The results suggest that apigenin may protect mouse embryos against H2O2 and actinomycin D. So that it increases the number of viable blastomeres and decreases the number of apoptotic blastomeres, which may cause expanding the blastocysts, thinning of the ZP thickness and increasing the rate of hatching in mouse embryos. (ijfs.ir)
  • Apigenin is one of the known bioflavonoid compounds with high selectivity in inducing selective apoptosis of cancer cells in vivo. (herb-extract-supplier.com)
  • Apigenin is among the widely known bioflavonoid compounds that has high selectivity in causing careful apoptosis of cancer cells in vivo. (zspharmac.com)
  • We found that apigenin could inhibit PMA-induced phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK), which was involved in the down-regulation of the expression of matrix metalloproteinase-9 (MMP-9) at mRNA levels. (spandidos-publications.com)
  • These results showed apigenin might inhibit the invasion and migration abilities of Caski cells by reducing the MMP-9 expression through suppressing the p38 MAPK signaling pathway. (spandidos-publications.com)
  • Apigenin has been shown to inhibit an important inflammatory biomarker, CD38, in a metabolic syndrome model, as well as decrease adipose tissue mass and the levels of proinflammatory cytokines [ 7 ] . (encyclopedia.pub)
  • Apigenin can inhibit lipid peroxidation. (herb-extract-supplier.com)
  • Apigenin can inhibit the proliferation of vascular smooth muscle cells, thereby preventing hypertension, arteriosclerosis and cardiovascular and cerebrovascular diseases. (meetsupplement.com)
  • Apigenin has antioxidant effect, can reduce the generation of oxygen free radicals, inhibit the reaction of lipid peroxide, and delay the aging of human body. (meetsupplement.com)
  • Apigenin can inhibit the growth of tumor cells, inhibit the metastasis of tumor, has a certain anti-tumor effect. (meetsupplement.com)
  • Apigenin exerts its anti-inflammatory effect through the influence of lipopolysaccharide by inhibiting NO synthase and COX2 enzymes in macrophages. (herb-extract-supplier.com)
  • Apigenin exerts its anti-inflammatory effect with the impact of lipopolysaccharide by avoiding NO synthase and COX2 enzyme in macrophages. (zspharmac.com)
  • Apigenin exerts its inflammatory properties by mediating the inhibition of the proliferation of interferon gamma-secreting Th1 cells. (mdnewsline.com)
  • Apigenin exerts its antioxidant role also by inducing the activation of PGC-1α, which in turn can attenuate hydrogen peroxide-induced apoptotic cell death by upregulating Nrf-2 via GSK3β inactivation mediated by activated p38 (Choi et al. (ac.ir)
  • Like other bioflavonoids, apigenin reduces oxidative stress, induces cell cycle inhibition, increases the efficacy of liver detoxification enzymes, and to some extent acts as an anti-inflammatory. (herb-extract-supplier.com)
  • An animal study showed that apigenin protects against heart attack by decreasing oxidative stress, cell death, and edema. (eternumlabs.com.au)
  • In conclusion, these results suggested the oxidative stress induced liver damage which may be due to the regulation of multiple genes by Apigenin at higher doses in Swiss mice. (johnshopkins.edu)
  • Apigenin protects DNA from oxidative stress by binding to nucleic acids. (ijfs.ir)
  • We found that apigenin markedly inhibits the phorbol-12-myristate-13-acetate (PMA)-induced increase in MMP-9 expression and activity in several cancer cell lines. (spandidos-publications.com)
  • Apigenin inhibits the proliferation of vascular smooth muscle cells, a key cause of aortic atherosclerosis and other vascular disorders. (herb-extract-supplier.com)
  • Apigenin similarly inhibits TNFα altitude by impeding NF-kb transcription and potentially TNFα-induced upregulation of add-on particle 1. (zspharmac.com)
  • 2019). According to the authors, apigenin induces a protective effect against neurotoxicity caused by the amyloid fragment β-25-35 in a rodent Alzheimer disease model (Nikbakht et al. (ac.ir)
  • Apigenin is also a metal ion chelating agent, which can reduce its participation in the reaction of free radicals by chelating with metal ions, thereby reducing the generation of oxygen free radicals and inhibiting lipid peroxidation. (meetsupplement.com)
  • Apigenin is found in many fruits and vegetables, but parsley, celery, celeriac, and chamomile tea are the most common sources. (wikipedia.org)
  • The apigenin content of fresh parsley is reportedly 215.5 mg/100 grams, which is much higher than the next highest food source, green celery hearts providing 19.1 mg/100 grams. (wikipedia.org)
  • The naturally occurring glycosides formed by the combination of apigenin with sugars include: Apiin (apigenin 7-O-apioglucoside), isolated from parsley and celery Apigetrin (apigenin 7-glucoside), found in dandelion coffee Vitexin (apigenin 8-C-glucoside) Isovitexin (apigenin 6-C-glucoside) Rhoifolin (apigenin 7-O-neohesperidoside) Schaftoside (apigenin 6-C-glucoside 8-C-arabinoside) Some foods contain relatively high amounts of apigenin: Amentoflavone Merck Index, 11th Edition, 763. (wikipedia.org)
  • Apigenin Apigenin can be said to be the stem of wild celery, which contains the protein content of the leaves is far more than we usually eat celery. (meetsupplement.com)
  • Apigenin, as the name suggests, can be extracted from celery. (meetsupplement.com)
  • Studies have shown that celery leaves contain twice as much apigenin as celery root, so try not to discard celery leaves when eating celery. (meetsupplement.com)
  • A common natural flavanoid, Apigenin is found in numerous commonplace plants including Chamomile, Parsley and Celery. (stromsportsireland.ie)
  • Apigenin calms, improves memory, improves sleep and improves learning. (meetsupplement.com)
  • Apigenin improves spatial working memory in Wistar rats. (ac.ir)
  • Apigenin" Encyclopedia , https://encyclopedia.pub/entry/14229 (accessed December 06, 2023). (encyclopedia.pub)
  • These findings indicate that apigenin might be a useful strategy for controlling metastasis and the invasiveness of tumors. (spandidos-publications.com)
  • In diabetic rats, apigenin reduces metabolic inflammation by successfully polarizing infiltrating macrophages to an anti-inflammatory M2 phenotype by binding and activating PPAR-γ and the subsequent suppression of the NF-κB pathway [ 8 ] . (encyclopedia.pub)
  • If you are looking to buy apigenin powder, please don't hesitate to contact us. (riottobotanicals.com)
  • One of the highly talked about benefits of Apigenin is how beneficial it is to treating insomnia. (eternumlabs.com.au)
  • Why Might Apigenin Be Beneficial? (gowinglife.com)
  • Supplementation with apigenin is therefore unlikely to be detrimental, and has a reasonable chance of being beneficial. (gowinglife.com)
  • Apigenin is beneficial as a powerful antioxidant. (trishdeseine.com)
  • Apigenin also ameliorated renal dysfunction in diabetic rats by suppressing inflammation through reduced secretion of TNF-α and IL-6 via MAPK inhibition. (encyclopedia.pub)
  • Apigenin also protects our heart and controls our blood pressure. (meetsupplement.com)
  • Apigenin in addition protects against the production of interleukin-4. (zspharmac.com)
  • Apigenin puts in neuroprotective results versus excitotoxicity and prevents calcium build-up in neural mitochondria. (zspharmac.com)
  • Apigenin can reduce anxiety in sufficient doses, and thus may have neuroprotective and cognition-enhancing benefits. (gowinglife.com)
  • By taking the Apigenin 50mg supplement tablets, you can also benefit from the antioxidant effects of the nutrient. (eternumlabs.com.au)
  • Apigenin contains a lot of minerals and vitamins, so apigenin has a wide range of antioxidant effects. (meetsupplement.com)
  • Apigenin served as a potent therapy against UC in C57BL/6 mice through the inhibition of inflammatory cytokines,and COX-2, and through the reduction in immune cell infiltration in colon tissues [ 11 ] . (encyclopedia.pub)
  • Apigenin has anti-inflammatory effects, but it can decrease pain and discomfort caused by inflammatory issues. (eternumlabs.com.au)
  • Like other bioflavonoids, apigenin can minimize oxidative tension, cause cell cycle inhibition, rise liver detoxing enzymes, and act as an anti-inflammatory somewhat. (zspharmac.com)
  • Apigenin can also reduce inflammation via a number of other mechanisms, including reducing the production of inflammatory mediators and preventing the migration of inflammatory cells into tissues. (gowinglife.com)
  • Apigenin has different biological activities such as anti-oxidative, anti-inflammatory, anti-cancer and anti-tumorigenic properties ( 4 , 5 ). (ijfs.ir)
  • Moreover, apigenin prevents cell apoptosis by suppressing ROS compounds ( 6 ) and decreasing the expression of caspase-3, caspase-9 and TNF-α ( 7 ). (ijfs.ir)
  • Finally, a flavanone synthase (FNS) enzyme oxidizes naringenin to apigenin. (wikipedia.org)
  • Our hero ingredients Apigenin, Fisetin and Oleuropein work together to support your body's natural defences against 3 of the 9 Hallmarks of Aging. (scienceresearchwellness.com)
  • At lower doses, apigenin can suppress inflammation, which is a major hallmark of ageing. (gowinglife.com)
  • In the present study, Apigenin was administered intraperitoneally to Swiss mice at doses of 25, 50, 100 and 200 mg/kg. (johnshopkins.edu)
  • Apigenin has a modest sedative effect in the brain by binding to receptors involved in generating tiredness and lowering anxiety. (trishdeseine.com)
  • A study published by the International Journal of Molecular Sciences laid down the wide range of benefits of Apigenin. (eternumlabs.com.au)
  • As a result, apigenin has gained a lot of interest in the past few years as a potential therapeutic agent to treat various diseases such as cancer, diabetes, cardiovascular, and neurological disorders [ 6 ] ( Figure 1 ). (encyclopedia.pub)
  • Apigenin is a substance with relatively high nutritional content, and it also has a certain effect of curing diseases. (herb-extract-supplier.com)
  • Experimental animal investigates have actually revealed that apigenin is antimutagenic against exogenous toxic substances and microbial responses, and plays a straight duty in steel chelation, free extreme scavenging, and induction of phase II cleansing enzymes such as glutathione, It is likewise an avoidance of ornithine decarboxylase and may advertise the development of particular lumps. (zspharmac.com)
  • As the health effects of polyphenols depend on intake and bioavailability, the biological activities of apigenin (4',5,7-trihydroxyflavone), an abundantly occurring flavone have, been extensively studied [ 1 ] [ 2 ] . (encyclopedia.pub)
  • However, due to the poor water solubility and intestinal absorption of apigenin, its oral bioavailability is low, and its activity in vivo is low, which limits its application to some extent. (meetsupplement.com)
  • Apigenin acts to suppress CD38 activity within cells, thereby fostering a rise in NAD+ levels. (longevitybox.co.uk)
  • Apigenin reduces inflammation and blood pressure, supporting cardiovascular health. (eternumlabs.com.au)
  • Apigenin (4′,5,7-trihydroxyflavone), found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally occurring glycosides. (wikipedia.org)
  • Apigenin is naturally found in chamomile, which is one of the world's oldest herbal medicines, used since ancient times for many purposes including as a sleep aid. (livemomentous.com)
  • 2019). The Therapeutic Potential of Apigenin. (gowinglife.com)
  • 2019). According to the authors, besides the antioxidant and anti-apoptotic properties of apigenin that may prevent neurodegenerative damages in the hippocampal area, further mechanisms can be addressed. (ac.ir)
  • We employed 126 male Wistar rats and put them into three groups: Apigenin (A), Control (C), and Sham (S) (Ap). (digiwire.co.in)
  • There were no significant differences in the outcomes related to necrosis and early and late apoptosis of PBMCs derived from MS patients when the cells were treated with methyl-prednisolone-acetate, apigenin-3-acetate, and apigenin when compared with dimethyl sulfoxide (DMSO). (mdnewsline.com)
  • To evaluate the anti-oxidant and anti-apoptotic effects of apigenin, we used H 2 O 2 and actinomycin D in the culture medium to create ROS and apoptosis. (ijfs.ir)
  • Apigenin and the two glucopyranosides of apigenin can put in antidiabetic impacts in the body. (zspharmac.com)
  • More recently, researchers have studied chamomile and found that its sleep-enhancing properties can be attributed to its bounty of apigenin. (livemomentous.com)
  • In experiments using human cells, apigenin has been found to have a variety of anti-cancer effects. (gowinglife.com)
  • One study also found apigenin lowered blood glucose in diabetic rats. (gowinglife.com)
  • 3. The half-maximal inhibitory concentration (IC 50 ) of methyl-prednisolone-acetate and apigenin 3-acetate was found to be 2.5 µM and 80 µM, respectively. (mdnewsline.com)
  • Increase in ALT, AST, ALP, ROS, ratio of oxidized to reduced glutathione (GSSG/GSH) and LPO, altered enzyme activities along with damaged histoarchitecture in the liver of 100 or 200 mg/kg Apigenin treated animals were found. (johnshopkins.edu)
  • Apigenin is recommended for supplementation of the population. (meetsupplement.com)
  • What Is The Evidence Behind Apigenin Supplementation? (gowinglife.com)
  • Even though there is a relatively large and convincing amount of evidence to support the health benefits of apigenin, there is unfortunately a scarcity of human trials to support supplementation. (gowinglife.com)
  • These properties are comparable to the therapeutic potential of apigenin-3-acetate and the standard treatment with methyl-prednisolone-acetate. (mdnewsline.com)
  • The study aims to assess apigenin and seashell nano-additives for their antifungal efficacy and their impact on the surface roughness of a soft denture liner . (bvsalud.org)
  • Apigenin prevents neurodegeneration in rat hippocampus. (ac.ir)
  • Apigenin prevents neurodegeneration by inducing PGC-1α. (ac.ir)
  • Taking an Apigenin supplement for sleep can also help you function better the next day. (eternumlabs.com.au)
  • Because of its significant antioxidant properties, the Apigenin supplement also works as an anti-aging product. (eternumlabs.com.au)
  • 2017). This phenomenon would mean that apigenin can exert both its antioxidant potential via the usual enzymatic reactive oxygen species scavenging system and the mitochondrial biogenesis via the PGC-1α/TFAM/NRF-1 pathway. (ac.ir)
  • In this study, we investigated the apigenin effects on the protease-mediated invasiveness in human metastatic cancer cell lines Caski, SK-Hep1, and MDA-231. (spandidos-publications.com)
  • These effects of apigenin are dose-dependent and correlate with the suppression of MMP-9 mRNA expression levels. (spandidos-publications.com)
  • What are the effects of apigenin? (meetsupplement.com)
  • On top of that, in the application process of existing apigenin, as a result of the low pureness of existing apigenin, the treatment and healthcare effects of the pills or other healthcare items generated are not excellent. (zspharmac.com)