Apigenin significantly. Medical search. Frequent questions

To address this hypothesis, we used an in vitro model of mouse macrophage cells to assess whether the flavonoids chrysin, apigenin and/or baicalein suppress expression of the inflammatory genes IL-6, IL-1β and/or TNFα. (emerging-researchers.org)
Apigenin is a plant-derived compound belonging to the flavonoids category and bears protective effects on different cells. (ijfs.ir)
Apigenin is a plant-derived compound belonging to the flavonoids category presented in various fruits and vegetables, such as parsley, onion, celery, chamomile and orange ( 3 ). (ijfs.ir)
In particular, flavonoids, apigenin and luteolin have been found to be effective CD40 immunomodulators. (alstuttu.org)
CONCLUSION: Our findings provide further support for apigenin and luteolin's anti-inflammatory effects and suggest that these flavonoids may have neuroprotective/disease-modifying properties in various neurodegenerative disorders, including Alzheimer's disease (AD). (alstuttu.org)
Hawthorn pills may also lower buildup thanks in part to their significantly high levels of bioactive compounds like pectin and flavonoids. (shopnaturescraft.com)
The other flavonoids (chrysin, 2-carboxy ethyl dihydroxy flavone, apigenin, cirsimaritin, α-naphto flavone and flavanone) failed to protect erythrocytes against the observed oxidative damages. (scirp.org)
Several amino acids (ornithine, alanine, isoleucine, GABA, asparagine and tryptophan) and classes of secondary metabolites, including anthocyanidins (peonidin-3-O-galactoside), flavonoids (apigenin, isorhamnetin, chrysin and trilobatin) and lignin-related compounds (sinapyl and coniferyl alcohols) were altered across developmental stages. (fmach.it)

Apigenin and luteolin concentration-dependently suppressed IFN-γ-induced CD40 expression. (alstuttu.org)
Apigenin and luteolin also suppressed microglial TNF-α and IL-6 production stimulated by IFN-gamma challenge in the presence of CD40 ligation. (alstuttu.org)
In addition, apigenin and luteolin markedly inhibited IFN-γ-induced phosphorylation of STAT1 with little impact on cell survival. (alstuttu.org)
Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression. (alstuttu.org)
RESULTS: Apigenin and luteolin concentration-dependently suppressed IFN-gamma-induced CD40 expression. (alstuttu.org)
In addition, apigenin and luteolin markedly inhibited IFN-gamma-induced phosphorylation of STAT1 with little impact on cell survival. (alstuttu.org)
Chamomile contains bioactive compounds, such as apigenin and luteolin, which bind to GABA-A receptors in the brain. (naturalherbalism.com)
Beyond apigenin and luteolin, celery contains other plant compounds that have powerful antioxidant properties. (medicalnewstoday.com)

Apigenin is another flavonoid found in cannabis. (zativo.com)
Based on HPLC analysis, the main flavonoid components of the extract were included rutin and apigenin. (jmbfs.org)
It is proposed that the psychiatric effect of chamomile is due to the flavonoid, apigenin (and perhaps others), which works by reducing GABA activity. (drdavidbrady.com)
Apigenin, a citrus extract flavonoid has a vasodilatory effect (dilates the capillaries for increased oxygen flow) Oleanic acid extracted from olive tree leaves inhibits the production of DHT (dihydroxytestosterone). (brightonbeautysupply.com)
Kim M, Jung J. The natural plant flavonoid apigenin is a strong antioxidant that effectively delays peripheral neurodegenerative processes. (usp-pl.com)

Moreover, apigenin prevents cell apoptosis by suppressing ROS compounds ( 6 ) and decreasing the expression of caspase-3, caspase-9 and TNF-α ( 7 ). (ijfs.ir)
To evaluate the anti-oxidant and anti-apoptotic effects of apigenin, we used H 2 O 2 and actinomycin D in the culture medium to create ROS and apoptosis. (ijfs.ir)
There were no significant differences in the outcomes related to necrosis and early and late apoptosis of PBMCs derived from MS patients when the cells were treated with methyl-prednisolone-acetate, apigenin-3-acetate, and apigenin when compared with dimethyl sulfoxide (DMSO). (mdnewsline.com)
Objective To study the effect of Apigenin on the proliferation,migration and apoptosis of HBBDSF in vitro ,and to observe the effect of Apigenin on TGF-β 1 ,α-SMA,Collagen I and Collagen Ⅲ protein expression levels. (yydbzz.com)
The apoptosis induced by Apigenin was detected by flow cytometry. (yydbzz.com)
Conclusion Apigenin can inhibit proliferation and migration of HBBDSF and induce apoptosis by inhibiting TGF-β 1 . (yydbzz.com)
Cell proliferation and apoptosis experiments showed that LPHyNPs could significantly inhibit cell proliferation and promote cell apoptosis. (usp-pl.com)
Targeted hyaluronic acid-based lipid nanoparticle for apigenin delivery to induce Nrf2-dependent apoptosis in lung cancer cells. (usp-pl.com)
According to the authors of a 2016 review , lab tests have shown that apigenin may contribute to apoptosis, a kind of programmed cell death, which could make it useful as a cancer treatment. (medicalnewstoday.com)

Hawthorn berries are packed with nourishing antioxidants proanthocyanidins and bioactive compounds including Quercetin Apigenin Myricetin Rutin Naringenin and Kaempferol. (shopnaturescraft.com)
In fact, hawthorn berry is one of the most antioxidant rich berries that is also loaded with Proanthocyanidins and bioactive compounds including Quercetin Apigenin Myricetin Rutin Naringenin and Kaempferol. (shopnaturescraft.com)
quercetin, 3,5,7-trihydroxy-4'-methoxy flavone-7-rutinoside and 3-hydroxy flavone significantly protected erythrocytes against protein degradation. (scirp.org)
Quercetin and 3,5,7-trihydroxy-4'-methoxy flavone-7-rutinoside significantly protected erythrocytes against loss of deformability and increased osmotic fragility, indicating that the loss of erythrocyte deformability and the increase in osmotic fragility of erythrocytes exposed to H 2 O 2 are related to protein degradation rather than to lipid peroxidation. (scirp.org)

Another study found that chamomile tea consumption was associated with a significantly higher sleep efficiency and reduced awakenings during the night. (naturalherbalism.com)
In a randomized, double-blind, placebo-controlled trial , 57 outpatients with mild to moderate Generalized Anxiety Disorder (GAD) were given 220 to 1100mg of German chamomile extract, standardized to 1.2 percent of its key constituent apigenin, or placebo. (drdavidbrady.com)
apigenin (found in Matricaria recutita (Chamomile), parsley and celery. (risingms.com)
Apigenin is a bioflavonoid found in a number of plants, including chamomile, onions, grapefruits, and celery, that has the unique ability to inhibit both aromatase and 17β-hydroxysteroid dehydrogenase (17β-HSD). (highdefinitionsupplements.ca)
- Chamomile flower extract (containing a minimum of 1.2% apigenin) - when scientists studied chamomile's properties in treating insomnia, they came to an exciting conclusion. (crossthelimits.co.uk)

Celery contains a plant compound called apigenin, which plays a role in traditional Chinese medicine as an anti-inflammatory, antibacterial, antiviral, and antioxidant agent. (medicalnewstoday.com)

We evaluated the effects of catechin, theaflavin, malvidin, cyanidin and apigenin on the activity of antioxidant enzymes in human intestinal-407 (Int-407) cells and rat primary gastric cells treated with ketoprofen. (ntnu.edu.tw)
Apigenin (AGN) is an effective phytochemical with strong antioxidant and anticancer potential. (usp-pl.com)

Role of apigenin in chronic inflammatory diseases. (encyclopedia.pub)
Apigenin as an anti-inflammatory compound acts as a protective agent in several disorders via inhibition of key inflammatory mediators, signaling pathways, and molecules. (encyclopedia.pub)
Apigenin has been shown to inhibit an important inflammatory biomarker, CD38, in a metabolic syndrome model, as well as decrease adipose tissue mass and the levels of proinflammatory cytokines [ 7 ] . (encyclopedia.pub)
In diabetic rats, apigenin reduces metabolic inflammation by successfully polarizing infiltrating macrophages to an anti-inflammatory M2 phenotype by binding and activating PPAR-γ and the subsequent suppression of the NF-κB pathway [ 8 ] . (encyclopedia.pub)
Apigenin served as a potent therapy against UC in C57BL/6 mice through the inhibition of inflammatory cytokines,and COX-2, and through the reduction in immune cell infiltration in colon tissues [ 11 ] . (encyclopedia.pub)
Apigenin has different biological activities such as anti-oxidative, anti-inflammatory, anti-cancer and anti-tumorigenic properties ( 4 , 5 ). (ijfs.ir)
Apigenin exerts its inflammatory properties by mediating the inhibition of the proliferation of interferon gamma-secreting Th1 cells. (mdnewsline.com)
Of note, Sambucus significantly increases inflammatory cytokines, including IL-B1, so should be discontinued with symptoms of infection (or positive test). (risingms.com)
In 2015, researchers behind a study in mice concluded that apigenin and apigenin-rich diets reduced the expression of certain inflammatory proteins. (medicalnewstoday.com)

Parsley contains a chemical substance called "apigenin. (raw-food-diet-magazine.com)

By the LC-MS analysis, shikimic acid and apigenin were identified as the major secondary compounds found in tomato plants and 1:1 companionship with basil seemed to have a positive influence on their content in tomato shoots. (scirp.org)

Apigenin" Encyclopedia , https://encyclopedia.pub/entry/14229 (accessed December 06, 2023). (encyclopedia.pub)

These properties are comparable to the therapeutic potential of apigenin-3-acetate and the standard treatment with methyl-prednisolone-acetate. (mdnewsline.com)
Salehi B, Venditti A. The Therapeutic Potential of Apigenin. (usp-pl.com)

Apigenin also ameliorated renal dysfunction in diabetic rats by suppressing inflammation through reduced secretion of TNF-α and IL-6 via MAPK inhibition. (encyclopedia.pub)
Flow cytometric analysis demonstrated that apigenin 3-acetate, apigenin, and methyl-prednisolone-acetate reduced Th1 cell proliferation to approximately 41%, 26%, and 33%, respectively, when compared to the inhibition of Th1 cell proliferation by dimethyl sulphoxide (DMSO). (mdnewsline.com)

69]. a number of phytochemicals such as curcumin, ginsetin, lycopene, and apigenin have been directly this is why body builders use aromatase inhibitors: more testosterone, less estrogen! (foxcharter.com)

Apigenin has also been reported to attenuate inflammation and the resultant pathological alterations in rats fed with a high fat, fructose diet [ 9 ] . (encyclopedia.pub)
This substance seems to significantly slow down the spread of cancer cells in laboratory rats. (raw-food-diet-magazine.com)
In studies on aging in rats, thymol was shown to protect and significantly increase the proportion of healthy fats found in cell membranes. (nourishdoc.com)
In a 2009 study , researchers gave rats apigenin and found that it stimulated nerve cell generation and improved the ability to learn and remember. (medicalnewstoday.com)

Detection of TGF-β 1 ,α-SMA,Collagen I and Collagen Ⅲ protein expression levels in cells after Apigenin incubation was carried out by cell immunofluorescence and Western Boltting. (yydbzz.com)

As the health effects of polyphenols depend on intake and bioavailability, the biological activities of apigenin (4',5,7-trihydroxyflavone), an abundantly occurring flavone have, been extensively studied [ 1 ] [ 2 ] . (encyclopedia.pub)

and to significantly decrease sleep latency in mice. (drdavidbrady.com)
Purslane extract fed mice showed higher activity upon induction by new environmental stimuli, lower anxiety and higher novelty-seeking behavior in the open field tasks, and significantly improved learning and memory ability in step-through compared with d-gal-treated mice. (raysahelian.com)

have reportedly shown that apigenin improves obesity and obesity induced inflammation [ 8 ] . (encyclopedia.pub)
In patients with mucopolysaccharidosis type I, laronidase significantly improves respiratory function and physical capacity, reduces GAG storage, and has a favorable safety profile. (medscape.com)

The results of viable and apoptotic blastomeres quantity, the ZP thickness, and the percentage of blastocysts and hatched blastocysts were significantly more favorable in the apigenin group, rather than the control group (P (ijfs.ir)

Besides, EA extract significantly inhibited cell migration and colony formation at 250 to 1000 Âµg/ml concentration. (jmbfs.org)
The effect of Apigenin on cell migration was detected by cell scratch test. (yydbzz.com)

Our results showed that M. aeruginosa and TAN significantly induced lipid deposition and tissue damage in the liver of zebrafish. (bvsalud.org)

Studies have shown that a daily dose of L-theanine improved the sleep of children with ADHD significantly over the placebo group. (supermindhacker.com)

This significantly reduces hair loss. (brightonbeautysupply.com)

3. The half-maximal inhibitory concentration (IC 50 ) of methyl-prednisolone-acetate and apigenin 3-acetate was found to be 2.5 µM and 80 µM, respectively. (mdnewsline.com)
Total phosphorus content in leaves was significantly higher than phosphorus found in stems and roots. (raysahelian.com)

Although the beneficial effects of apigenin on different cells and tissues have been investigated ( 10 , 11 ), there is no report yet concerning the effect of apigenin on growth and quality of embryos. (ijfs.ir)

The rapid rise in the prevalence of obesity and diabetes has significantly contributed to the increasing global burden of noncommunicable diseases. (intechopen.com)

Thus, it's significantly beneficial for those that suffer from pain and swelling. (zativo.com)

Preparation of apigenin nanostructured lipid carrier and its antitumor activity in vivo. (usp-pl.com)

Animal studies also indicate that apigenin may significantly increase muscle protein synthesis (and therefore hypertrophy) via increased phosphorylation of several key players in the mTOR pathway, including Akt, S6K1, and 4E-BP1. (highdefinitionsupplements.ca)

Purslane extract significantly increased superoxide dismutase (SOD) activity and decreased the malondialdehyde (MDA) level. (raysahelian.com)

Here, we show that BD is not toxic and its oral application significantly suppresses time-dependent increase in tumor sizes and inhibits breast-to-lung cancer metastasis. (spandidos-publications.com)

Further, LPS-induced IL-1β upregulation was inhibited by 50% when cells were pre-treated with apigenin. (emerging-researchers.org)
Apigenin 3-acetate, apigenin, and methyl-prednisolone-acetate significantly downregulated T-box transcription factor ( T-bet) and IFN-γ gene expressions in the Th1 cells. (mdnewsline.com)
Comparative Analysis of Apigenin-3 Acetate versus Apigenin and Methyl-Prednisolone in Inhibiting Proliferation and Gene Expression of Th1 Cells in Multiple Sclerosis. (mdnewsline.com)
Apigenin may also stimulate neurogenesis, the growth and development of nerve cells. (medicalnewstoday.com)

In the second year, there was no difference in yield between early or late harvesting but all the parameters considered in the study were significantly higher in first harvest than in the second harvest. (auburn.edu)
The aim of this study was to evaluate the effect of apigenin on the number of viable and apoptotic blastomeres, the zona pellucida (ZP) thickness and hatching rate of pre-implantation mouse embryos exposed to H2O2 and actinomycin D. (ijfs.ir)
So, in this study, we evaluated for the first time the impact of apigenin on some morphological indicators of pre-implantation mouse embryos including ZP thickness, viable and apoptotic blastomere quantity and hatching rate. (ijfs.ir)
In this study, oil samples from 80 cultivars selected for their impact on worldwide oil production were analyzed to compare their phenolic composition by using a method based on LC-MS/MS. Secoiridoid derivatives were the most concentrated phenols in virgin olive oil, showing high variability that was significantly due to the cultivar. (unboundmedicine.com)
Therefore, apigenin lipid polymer hybrid nanoparticles (LPHyNPs) were prepared and characterized according to various parameters in this study. (usp-pl.com)

Results showed that OPD' (1 μmol·L-1) significantly induced the expression of ferroptosis-related proteins, the contents of Fe2+, ROS, and GSH-Px were increased, and the content of GSH were decreased. (bvsalud.org)

The results suggest that apigenin may protect mouse embryos against H2O2 and actinomycin D. So that it increases the number of viable blastomeres and decreases the number of apoptotic blastomeres, which may cause expanding the blastocysts, thinning of the ZP thickness and increasing the rate of hatching in mouse embryos. (ijfs.ir)

The reduction in the expression of IFN-γ was more pronounced for apigenin-3-acetate. (mdnewsline.com)

The data demonstrate that apigenin significantly suppressed LPS-induced expression of IL-1β. (emerging-researchers.org)
We and others have previously reported that microglial CD40 expression is significantly induced by IFN-gamma and amyloid-beta (A beta) peptide. (alstuttu.org)

As is well known, anxiety and restlessness are feelings that significantly interfere with sleep. (crossthelimits.co.uk)

As a result, apigenin has gained a lot of interest in the past few years as a potential therapeutic agent to treat various diseases such as cancer, diabetes, cardiovascular, and neurological disorders [ 6 ] ( Figure 1 ). (encyclopedia.pub)

Nevertheless, the form of the extract makes it possible to increase their effectiveness significantly. (crossthelimits.co.uk)

However, they can significantly benefit from vaping at a high enough temperature capable of releasing CBD. (zativo.com)

Genotypes significantly differed in growth stages and life cycle length (from 172 to 204 days after sowing), plant height (from 36.1 to 97.2 cm), seed yield (from 1.02 to 3.50 Mg ha −1 ), and yield components. (mdpi.com)
Iron (Fe) content varied significantly among growth stages, and roots and leaves had the highest Fe content. (raysahelian.com)

Compared to the control group, the mouse in the group treated with purslane extracts by 1 g/d had significantly higher activities of phosphofructokinase, lactate dehydroenase and higher levels of ATP in the cortices, especially under the hypoxic environment for 24 hours. (raysahelian.com)

Anatomy20

Organisms24

Diseases13

Chemicals and Drugs105

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes38

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science1

Health Care2

Flavonoids8

Luteolin8

Flavonoid5

Apoptosis9

Quercetin4

Chamomile5

Celery1

Antioxidant2

Inflammatory9

Parsley1

Compounds1

20231

Therapeutic potential2

Inhibition2

Curcumin1

Rats4

Incubation1

Biological activities1

Mice2

Improves2

Favorable1

Cell migration2

Deposition1

Placebo1

Reduces1

Found2

Tissues1

Obesity1

Beneficial1

Preparation1

Phosphorylation1

Extract significantly1

Inhibits1

Cells4

Study5

Proteins1

Results1

Reduction1

Expression2

Feelings1

Potential1

Increase1

High1

Growth2

Activities1