InhibitionPhosphorylationLuteolinApoptosisAntitumorFlavonoidsSignaling pathwayImmuneActivatesFindingsCellularRestorationFoundEffectsExpressionWild typeTreatmentCellsPresenceModelResultsInhibitionFlavonoidKinaseQuercetinChamomileDrug-inducedAlzheimer'sSignificantlyLipopolysaccharideAnti-inflammatoryProliferationToxicityTherapeuticInflammationMolecular MechanismsConstituentTranscriptionMechanismsFruits and vegetablesPrimarilyHumanResultsActivityIncludeStudyCandidateNaturalBreast cancerSourcesRoleTimeStrategiesReduce
Inhibition4
- Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression. (alstuttu.org)
- These results indicate that FoxO3a is repressed in imatinib resistant T315I cells, and that proteasome inhibition restores FoxO3a and induces apoptosis. (mi-rna.com)
- Here, we found that Axl inhibition by tyrosine kinase inhibitors induces antitumor efficacy critically depending on immune effector mechanisms in two highly clinical relevant murine tumor models. (oncotarget.com)
- More importantly, we show that Axl inhibition induces an adaptive immune resistance evidenced by unregulated PD-L1 expression on tumor cells and combined Axl inhibition with PD-1 blockade mounts a potent synergistic antitumor efficacy leading to tumor eradication. (oncotarget.com)
Phosphorylation3
- We found that apigenin could inhibit PMA-induced phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK), which was involved in the down-regulation of the expression of matrix metalloproteinase-9 (MMP-9) at mRNA levels. (spandidos-publications.com)
- In addition, apigenin and luteolin markedly inhibited IFN-γ-induced phosphorylation of STAT1 with little impact on cell survival. (alstuttu.org)
- In addition, apigenin and luteolin markedly inhibited IFN-gamma-induced phosphorylation of STAT1 with little impact on cell survival. (alstuttu.org)
Luteolin5
- Apigenin and luteolin concentration-dependently suppressed IFN-γ-induced CD40 expression. (alstuttu.org)
- Apigenin and luteolin also suppressed microglial TNF-α and IL-6 production stimulated by IFN-gamma challenge in the presence of CD40 ligation. (alstuttu.org)
- Luteolin concentration-dependently abolished LPS/IFN-γ-induced NO, tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) production as well as inducible nitric oxide synthase (iNOS) protein and mRNA expression. (alstuttu.org)
- In particular, flavonoids, apigenin and luteolin have been found to be effective CD40 immunomodulators. (alstuttu.org)
- RESULTS: Apigenin and luteolin concentration-dependently suppressed IFN-gamma-induced CD40 expression. (alstuttu.org)
Apoptosis2
- The main mechanism was confirmed as inducing apoptosis. (bvsalud.org)
- Bortezomib treatment of imatinib resistant BCRABL T315I cells signifcantly reduced cell survival and induced apoptosis, as measured by the MTT assay and Annexin V PE/7 AAD staining, respectively. (mi-rna.com)
Antitumor1
- Apigenin has special interest for the development of chemopreventive agents against cancer because it is a widely distributed plant flavonoid that has antitumor properties. (spandidos-publications.com)
Flavonoids2
- Additionally, the three flavonoids inhibited A23187-induced histamine release. (alstuttu.org)
- CONCLUSION: Our findings provide further support for apigenin and luteolin's anti-inflammatory effects and suggest that these flavonoids may have neuroprotective/disease-modifying properties in various neurodegenerative disorders, including Alzheimer's disease (AD). (alstuttu.org)
Signaling pathway3
- These results showed apigenin might inhibit the invasion and migration abilities of Caski cells by reducing the MMP-9 expression through suppressing the p38 MAPK signaling pathway. (spandidos-publications.com)
- For example, it is well known that the activation of the signal transducer and activator of transcription (STAT) signaling pathway plays a central role in interferon-gamma (IFN-gamma)-induced microglial CD40 expression. (alstuttu.org)
- 5 , 6 NF-κB-inducing kinase (NIK) is a central and specific signal component in the noncanonical NF-κB signaling pathway, 6 , 7 while inducible p100 processing is a central step in noncanonical NF-κB signaling transduction. (xiahepublishing.com)
Immune1
- Acne is one of the most common multifactorial chronic inflammatory diseases of the pilosebaceous follicles involving androgen induced sebaceous hyperplasia, altered follicular keratinisation, hormonal imbalance, immune hypersensitivity, and bacterial ( Propionibacterium acnes ) colonisation [ 2 , 3 ]. (hindawi.com)
Activates1
- A central adaptor protein of the noncanonical NF-κB pathway is NF-κB-inducing kinase (NIK), which activates the downstream kinase IKKα to process p100 to p52, thereby forming the RelB/p52 heterodimer to initiate the expression of target genes. (xiahepublishing.com)
Findings1
- These findings indicate that apigenin might be a useful strategy for controlling metastasis and the invasiveness of tumors. (spandidos-publications.com)
Cellular2
- While growing body of evidence suggests a critical function of p53 in thiamine homeostasis, the part of p53 inside a coordination of cellular events induced by changes in thiamine rate of metabolism are not completely elucidated. (nibbp2p.org)
- However at the relatively small doses ingested by humans that consume the plants, the phytochemicals are not toxic and instead induce mild cellular stress responses. (psychosocialsomatic.com)
Restoration1
- Restoration of p38 expression partly increased PMA-induced MMP-9 secretion blocked by apigenin treatment in Caski cells. (spandidos-publications.com)
Found1
- We found that apigenin markedly inhibits the phorbol-12-myristate-13-acetate (PMA)-induced increase in MMP-9 expression and activity in several cancer cell lines. (spandidos-publications.com)
Effects3
- In this study, we investigated the apigenin effects on the protease-mediated invasiveness in human metastatic cancer cell lines Caski, SK-Hep1, and MDA-231. (spandidos-publications.com)
- These effects of apigenin are dose-dependent and correlate with the suppression of MMP-9 mRNA expression levels. (spandidos-publications.com)
- Therefore, we speculate that purinergic receptors might play dualistic roles in response to EA effects treating inflammatory injury induced by ischemia. (biomedcentral.com)
Expression4
- Results: Phenotypes, Nod factors and gene expression of nodD1 and nodD2 mutants of CIAT 899 were compared with those of the wild type strain, both in the presence and in the absence of the nod-gene-inducing molecules apigenin and salt (NaCl). (us.es)
- differences in nodD1 and nodD2 expression were observed between the wild type and the mutants, with variation according to the inducing molecule, and with a major role of apigenin with nodD1 and of salt with nodD2. (us.es)
- We and others have previously reported that microglial CD40 expression is significantly induced by IFN-gamma and amyloid-beta (A beta) peptide. (alstuttu.org)
- Hormetic pathways activated by phytochemicals may involve kinases and transcription factors that induce the expression of genes that encode antioxidant enzymes, protein chaperones, phase-2 enzymes, neurotrophic factors and other cytoprotective proteins. (psychosocialsomatic.com)
Wild type1
- Moreover, pretreatment of the cells having a decoy oligonucleotide transporting wild-type p53-response element markedly attenuated OT-induced THTR1, PDHB and OGDH gene manifestation suggesting an important part of p53 in transactivation of these genes. (nibbp2p.org)
Treatment2
- PMA caused about a 5-fold induction in MMP-9 promoter activity, which was also suppressed by apigenin treatment in Caski cells. (spandidos-publications.com)
- Ischemia-reperfusion injured rat model was induced by middle cerebral artery occlusion and reperfusion (MCAO/R). EA treatment at the DU 20 and DU 24 acupoints treatment were conducted to rats from the 12 h after MCAO/R injury for consecutive 7 days. (biomedcentral.com)
Cells1
- 2.4 Induction of Neuronal Cell Excitotoxicity and Their Assessment Earle's balanced salt solution (EBSS) was used to rinse Cilengitide trifluoroacetate the cultured neuronal cells before the excitotoxic injuries were induced by exposure to 350? (morainetownshipdems.org)
Presence1
Model1
- wogonin decreased the death rate of hippocampal neurons the induction of iNOS and TNF-in hippocampus whereas in the kainate injection model this flavonoid markedly protected from excitotoxic brain injury. (morainetownshipdems.org)
Results1
- From our results, we conclude that propolis is a potent antioxidant and, when given in combination with paclitaxel, offers maximum protection against DMBA induced mammary carcinogenesis. (propoleo.cl)
Inhibition6
- The reviewed research data implies that these co-therapies exhibited a synergistic effect on various cancer cells, where apigenin sensitized the chemo drug through different pathways including a significant reduction in overexpressed genes, AKT phosphorylation, NFκB, inhibition of Nrf2, overexpression of caspases, up-regulation of p53 and MAPK, compared to the monotherapies. (biomedcentral.com)
- [36] [37] Apigenin may also play direct roles in the removal of free radicals, inhibition of tumor growth enzymes, and induction of detoxification enzymes such as glutathione. (examine.com)
- 4. Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism. (nih.gov)
- 9. PI3K/mTOR inhibition markedly potentiates HDAC inhibitor activity in NHL cells through BIM- and MCL-1-dependent mechanisms in vitro and in vivo. (nih.gov)
- In this study, we investigated inhibition of angiogenesis using Genipin-mediated hypoxia-induced hypoxia inducible factor (HIF-1) and VEGF expression in human cervical cancer cells. (kosinmedj.org)
- 5. Final results Apigenin inhibits CK2 kinase find out this here exercise and induces development inhibition and cell cycle arrest in MM cells At first, we investigated the results of apigenin on CK2 kinase activity and expression level and compared these results with that of TBB, that's a acknowledged selective CK2 inhibitor. (atpase-signal.com)
Flavonoid3
- Abstract: The purpose of this administrative supplement, through the NIH Office of Dietary Supplements, is to investigate the efficacy of the food-derived flavonoid apigenin initiated prior to the onset of experimentally (DOXO) or aging induced increases in cellular senescence for preventing the development of arterial stiffening and endothelial dysfunction in sedentary mice fed a normal chow diet. (nih.gov)
- Apigenin is brought to the attention of the CSWG because of a recent scientific article citing this flavonoid as a substance that can be metabolically activated to produce toxic prooxidant phenoxyl radicals. (nih.gov)
- I was recently informed by a reader who responds well to Ponstan (250mg once a day) that he gets exactly the same relief from sound sensitivity from taking the flavonoid Apigenin (500mg a day). (epiphanyasd.com)
Kinase2
- Pure apigenin is used primarily in research as a protein kinase inhibitor that may suppress tumor promotion and that has anti-proliferating effects on human breast cancer cells and inhibitory actions on MAP kinase. (nih.gov)
- The results showed that in accordance with TBB, apigenin suppresses CK2 kinase Droxinostat action, and decreases CK2a protein amounts in both U266 and RPMI 8226 cells within a dose dependent method. (atpase-signal.com)
Quercetin1
- The findings also add to mounting evidence that chronic inflammation underlies the development of numerous diseases, and that the use of anti-inflammatories-including natural anti-inflammatories such as Nexrutine®, curcumin, quercetin, apigenin, and resveratrol, among others-may prevent or reverse a variety of diseases. (lifeextension.com)
Chamomile4
- Apigenin is also one of several active ingredients in the popular herbal remedy, chamomile. (nih.gov)
- Apigenin is a major constituent of chamomile, which is recognized for its antiphlogistic, antispasmodic, and antibacterial effects. (nih.gov)
- In particular, the focus is on apigenin, found in things like chamomile, parsley, oregano and in medicinal herbs like Bacopa monnieri. (epiphanyasd.com)
- For adults with sound sensitivity drinking chamomile tea might be a good source of 50 mg of Apigenin (you would need about 20g of chamomile flowers). (epiphanyasd.com)
Drug-induced1
- Discovery of potent and safe UGT1A1 inducers will provide an alternative therapy for ameliorating hyperbilirubinaemia and drug-induced hepatoxicity. (frontiersin.org)
Alzheimer's2
- 2014. Anthocyanins restore behavioral and biochemical changes caused by streptozotocin-induced sporadic dementia of Alzheimer's type. (raysahelian.com)
- Nobody has studied apigenin in human Alzheimer's, but in animal studies, apigenin has been shown to improve cognitive function, reduce amyloid plaques, and protect neurons from damage. (epiphanyasd.com)
Significantly3
- We and others have previously reported that microglial CD40 expression is significantly induced by IFN-γ and amyloid-β (Aβ) peptide. (medscape.com)
- Genipin treatment also significantly reduced hypoxia-induced secretion of VEGF. (kosinmedj.org)
- The enrichment of sunflower oil with 0.1, 0.25 and 0.5% OLE (w/v) significantly inhibited thermal-induced peroxidation in a dose-dependent fashion. (csic.es)
Lipopolysaccharide2
- In this study, to investigate the protective mechanism of catalpol on lipopolysaccharide (LPS)-induced bovine endometrial epithelial cells (bEECs) and mouse endometritis , in vitro and in vivo inflammation models were established. (zju.edu.cn)
- Objective: To explore the effect of ethyl acetate gum resin extract of Boswellia serrata on lipopolysaccharide (LPS) induced inflammation and oxidative damage in hepatic and renal tissues of rats. (bvsalud.org)
Anti-inflammatory1
- The results of this study suggest that catalpol can exert an anti-inflammatory impact on LPS-induced bEECs and mouse endometritis by inhibiting inflammation and activation of the TLR4/NF-κB signaling pathway. (zju.edu.cn)
Proliferation1
- D3 markedly increased uterine weight and proliferation of the uterine epithelium in ovariectomized mice, whereas D1 and D2 were inactive. (nih.gov)
Toxicity2
- Briefly, our analysis proposed that the combination therapies with apigenin could suppress the unwanted toxicity of chemotherapeutic agents. (biomedcentral.com)
- [8] No toxicity has been reported as a result of standard dietary apigenin intake. (examine.com)
Therapeutic1
- The therapeutic effects of apigenin are pleiotropic. (epiphanyasd.com)
Inflammation1
- Catalpol ameliorates LPS-induced endometritis by inhibiting inflammation and TLR4/NF-κB signaling[J]. Journal of Zhejiang University Science B, 2019, 20(10): 816-827. (zju.edu.cn)
Molecular Mechanisms1
- Luciferase reporter assays were used to investigate the molecular mechanisms underlying the hypoxia-induced survivin activation. (kosinmedj.org)
Constituent1
- Resveratrol, a red wine constituent polyphenol, prevents superoxide-dependent inflammatory responses induced byischemia/reperfusion, platelet-activating factor, or oxidants. (lifeextension.com)
Transcription3
- For example, it is well known that the activation of the signal transducer and activator of transcription (STAT) signaling pathway plays a central role in interferon-gamma (IFN-γ)-induced microglial CD40 expression. (medscape.com)
- In HepG2 cells transfected with estrogen receptor (ER) β or different ERα functional receptor mutants and the Vit-ERE-TATA-Luc reporter gene, all diarylheptanoids induced transcription through a ligand-dependent human ERα-ERE-driven pathway, which was abolished with ICI 182,780 (ER antagonist), whereas only D2 was active with ERβ. (nih.gov)
- Our results revealed that transcription factor Nrf2 could induce CBR1 transcription in liver of mice during I/R. Pre-treatment with sulforaphane, an activator of Nrf2, increased CBR1 expression, decreased liver enzymes such as aspartate aminotransferase and alanine transaminase, and reduced I/R-related pathological changes. (molcells.org)
Mechanisms1
- AIM OF THE STUDY: The objective of this study was to explore and validate the nephroprotective potential of sugar-free SBM (SF-SBM) and its mechanisms of action against sodium fluoride (NaF)-induced nephrotoxicity in HEK-293 cells. (bvsalud.org)
Fruits and vegetables2
- Apigenin is found naturally in many fruits and vegetables, including apples and celery. (nih.gov)
- For general health needs, multiple daily servings of fruits and vegetables can provide adequate amounts of apigenin, which is estimated to be less than 5 mg/day. (examine.com)
Primarily1
- Apigenin is a flavone (a subclass of bioflavonoids) primarily found in plants. (examine.com)
Human1
- Nevertheless, human clinical trials are a prerequisite to consider the potential use of apigenin in the prevention and treatment of various cancers. (biomedcentral.com)
Results2
- Collectively, our results demonstrated that NBIF is a natural inducer of UGT1A1, while this agent induced UGT1A1 mainly via activating and up-regulating PPARα and PPARγ. (frontiersin.org)
- From our results, we conclude that propolis is a potent antioxidant and, when given in combination with paclitaxel, offers maximum protection against DMBA induced mammary carcinogenesis. (propoleo.cl)
Activity1
- Apigenin is recognized in traditional or alternative medicine for its pharmacological activity. (nih.gov)
Include1
Study1
Candidate1
- The combination therapy with apigenin is potential candidate in cancer therapeutics. (biomedcentral.com)
Natural2
- Recently, apigenin has been introduced as an effective anti-neoplastic natural product. (biomedcentral.com)
- Our experimental evidence demonstrated that the natural drug under investigation is able to protect genomic DNA by damage induced by benzo[a]pyrene, hydrogen peroxide (H(2)O(2)) and hydrogen peroxide in combination with adenosine 5'-diphosphate (ADP) and ferrous sulfate (FeSO(4)), determining a significant reduction of the intracellular oxidants. (propoleo.cl)
Breast cancer1
- The effect of propolis along with paclitaxel on 7,12 dimethyl benz(a)anthracene (DMBA) induced experimental breast cancer was investigated in female Sprague Dawley rats. (propoleo.cl)
Sources2
- Eleven US producers or distributors of apigenin are listed by Chem-Sources USA (Chemical Sources International, 2000). (nih.gov)
- [1] [2] Apigenin is sufficiently bioavailable through such dietary sources. (examine.com)
Role1
- Conclusively, the clinical trials to comprehend the role of apigenin as a chemoprotective agent are still in infancy. (biomedcentral.com)
Time1
Strategies1
- This review explicates the combinatorial strategies involving apigenin to overcome drug resistance and boost the anti-cancer properties. (biomedcentral.com)