Apical membrane of renal proximal tubules kidney tubules proximal. Medical search. Frequent questions

Therefore, in this study, we generated a SUMOylation profile of the aldosterone-sensitive kidney distal convoluted tubule (DCT) as a basis for understanding SUMOylation events in this cell type. (nih.gov)
Thiazide diuretics:- Late thick ascending limb & early distal convoluted tubule- Aquatensen®, metolazone. (documents.pub)
Renal tubules consist of four main segments with different anatomies and functions: proximal convoluted tubule (PCT), thick ascending limb of Henle's loop (TAL), distal convoluted tubule (DCT), and collecting duct (CD). (chikd.org)
TRPM6 is localized along the apical membrane of the loop of Henle and the distal convoluted tubule, as well as the brush border of the small intestine. (nephronpower.com)
[00:00:00] Thiazide diuretics act at the distal convoluted tubule. (medmastery.com)

SLC16A7, also known as MCT2, is a unidirectional proton-linked transporter of monocarboxylates across the plasma membrane encoded by SLC16A7 , located on chromosome 12q13. (medscape.com)
Moesin is a member of the ERM family and is involved in plasma membrane-actin cytoskeleton cross-linking, resulting cell adhesion, shape, and motility. (embl-heidelberg.de)
By immunocytochemistry, it was shown that podocalyxin and the actin binding protein ezrin are co-expressed in podocytes and co-localize along the apical plasma membrane, where they form a co-immunoprecipitable complex. (embl-heidelberg.de)
It can also translocate to plasma membrane ruffles upon stimulation with growth-factors. (medscape.com)
Megalin is internalized by endocytosis and delivered to vacuolar endosomes, which then sort megalin into recycling tubules and deliver it back to the plasma membrane, thus keeping an abundant number of megalin receptors at the apical surface of PTC for further endocytosis and recycling. (medscape.com)
In the collecting duct, the apical plasma membrane abundance of ENaC subunits (α, β, and γ) and AQP2 can be regulated by changes in intracellular trafficking to the apical plasma membrane providing a mechanism to control the rate of sodium and water reabsorption in this region of the nephron. (ucc.ie)
In the thyroid gland, iodide is concentrated or "trapped" by the sodium-iodide symporter (NIS), which utilizes the sodium gradient developed by the Na + ,K + -ATPase to move iodide through the basolateral plasma membrane of the thyroid follicular cell. (veteriankey.com)

The multidrug transporter MATE1 sequesters OCs within an intracellular compartment that has no influence on OC secretion in renal proximal tubules. (nih.gov)
Unlike MAO -A and MAO -B, which are anchored through the carboxyl terminus to the outer mitochondrial membrane and confined to intracellular compartments, renalase is secreted into the blood, where it is detectable by Western blotting. (diff.org)
Immunohistochemistry shows that Slc26a9 is present at apical and intracellular membranes of lung and stomach epithelia. (xenbase.org)

RT-PCR of renal proximal tubule and collecting duct cells obtained by laser capture micro-dissection of mouse kidney sections, confirmed these findings. (gwu.edu)
These include the major components of the glomerulus, proximal and distal tubules, loop of Henle, and collecting duct [ 1 ]. (j-organoid.org)
These renal vesicles connect the collecting duct and ureter, developing into metanephric nephron progenitors ( Fig. 1 ) [ 8 , 9 ]. (j-organoid.org)
Impairments in renal potassium excretion can be the result of reduced sodium delivery to the distal nephron, decreased mineralocorticoid level or activity, or abnormalities in the cortical collecting duct. (ccjm.org)
The epithelial sodium channel (ENaC) and aquaporin 2 (AQP2) have been demonstrated to play central roles in renal sodium and water reabsorption in the collecting duct. (ucc.ie)

Kidney tubuloids derived from adult stem cells offer the advantage of long-term culture and expansion, but they include only tubular structures and lack glomerular components. (j-organoid.org)
During development, renal glomerular epithelial cells (podocytes) undergo extensive morphologic changes necessary for creation of the glomerular filtration apparatus. (embl-heidelberg.de)
Membrane trafficking defects caused by mutation in OCRL may explain renal tubular defects observed in Lowe syndrome, including the inability of proximal tubular cells (PTC) to reabsorb low-molecular weight (LMW) proteins and other solutes such as phosphorus and bicarbonate from the glomerular filtrate. (medscape.com)
The podocytes revealed united foot processes and increase in the thickness of the glomerular basement membrane. (ijpsonline.com)
Diabetic nephropathy (DN) is one of the main causes of end-stage renal disease, and features include proteinuria, glomerular sclerosis, and gradual loss of renal function. (medicilon.com)
Glomerular ultrafiltration and reduced reabsorption of proximal tubules are the two major determinants of proteinuria. (medicilon.com)
Glomerular injury can lead to an overload of the proximal tubules with proteins. (simons-lab.de)
Based on these findings, we propose that the targeting of cubilin could be a safe strategy in conditions with glomerular proteinuria, such as diabetic kidney disease. (simons-lab.de)

As a result of FGF8 and Wnt4 secretion, Lhx1 activation initiates the mesenchymal-to-epithelial transition, causing the pretubular aggregates to form renal vesicles. (j-organoid.org)
Secretion of organic cations (OCs) across renal proximal tubules (RPTs) involves basolateral OC transporter (OCT)2-mediated uptake from the blood followed by apical multidrug and toxin extruder (MATE)1/2-mediated efflux into the tubule filtrate. (nih.gov)
The tubules modulate reabsorption and secretion of fluid and solutes by passive or active mechanisms [ 1 - 3 ]. (chikd.org)
Decreased distal delivery of sodium, reduced mineralocorticoid levels or activity, and a distal tubular defect are causes of impaired renal potassium secretion. (ccjm.org)
Shifting of potassium from the cells to the extracellular space is a cause of transient hyperkalemia, while chronic hyperkalemia indicates an impairment in renal potassium secretion. (ccjm.org)
The basic process of moving these substances (secretion and reabsorption) requires that solutes and water cross 2 cell layers: (1) the epithelium that makes up the walls of the tubules and (2) the endothelium that makes up the vascular walls. (mhmedical.com)
[00:00:30] bound and cannot be filtered at the glomerulus and so they enter the tubular fluid by secretion in the proximal tubule. (medmastery.com)
Measurements with this technique revealed secretion of salicylate across the main and distal segments of the Malpighian tubule as well as the midgut, ileum and rectum. (silverchair.com)
The second method used a salicylate-selective microelectrode to measure the concentration of salicylate in fluid droplets secreted by isolated Drosophila Malpighian tubules set up in a Ramsay secretion assay. (silverchair.com)
The rate of salicylate secretion by Malpighian tubules in vitro was sufficient to account for the measured rate of decline of salicylate concentration in the haemolymph in vivo . (silverchair.com)

Renal excretion of excess dietary phosphate intake ensures maintenance of phosphate homeostasis, maintaining serum phosphate at a level of approximately 3-4 mg/dL in the serum. (medscape.com)
MRP2 is also expressed in the apical membrane of proximal renal tubule endothelial cells where they are involved in the excretion of small organic anions. (wikipedia.org)
The ablation of the transporters in the kidney is accompanied by a marked increase in urinary excretion of lactate as well as a decrease in blood levels of lactate in c/ebpΔ -/- mice. (elsevierpure.com)
In addition, we show that urinary excretion of urate is significantly elevated in c/ebpδ -/- mice even though the expression of URAT1, the transporter responsible for the apical membrane uptake of urate in renal proximal tubule, is not altered. (elsevierpure.com)
Hyperkalemia results either from the shift of potassium out of cells or from abnormal renal potassium excretion. (ccjm.org)
Cell shift leads to transient increases in the plasma potassium concentration, whereas decreased renal excretion of potassium leads to sustained hyperkalemia. (ccjm.org)
Thiazide diuretics increase the renal excretion of sodium, like all diuretics, increased renal excretion of potassium, and increase excretion of hydrogen ions, causing metabolic alkalosis. (medmastery.com)
[00:02:00] Unique to the thiazide diuretics is they decrease renal excretion of calcium, lower renal loss of calcium, which makes them useful to prevent kidney stones. (medmastery.com)
Among its other functions, this hormone has also been shown to promote sodium excretion into urine (natriuresis) via a direct action on the kidney itself. (ucc.ie)
Excretion of xenobiotics in insects is accomplished primarily by the Malpighian tubules (MTs). (silverchair.com)

[ 19 ] It is a cell surface transmembrane protein and a bidirectional transporter of primarily reduced folates, including MTX, ubiquitously expressed in many tissues, showing particularly high expression in absorptive tissues (intestine, kidney and placenta) either on apical and/or basolateral membranes. (medscape.com)
This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. (wikipedia.org)
7. The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane. (nih.gov)
Overall, these results provide valuable insights into the molecular mechanisms by which Cd impairs luminal protein reabsorption by renal proximal tubules. (nih.gov)
To determine the roles of GPR37L1 in renal sodium transport, we over-expressed the protein in human renal proximal tubule (RPT) cells (n=3). (gwu.edu)
Corin protein expression in human renal proximal convoluted tubules as shown by brown staining in immunohistochemistry. (silverchair.com)
By immunostaining and in situ hybridization, we found similar corin, pro-ANP/ANP and NPR-A protein and mRNA expression in human renal segments. (silverchair.com)
In the proximal tubules, corin protein was present in the apical membrane region underneath the brush border where the ANP-degrading protease neprilysin was abundant. (silverchair.com)
After its synthesis in the liver, 25(OH)D 3 is transported by DBP to the kidney where it is internalized by megalin, a transmembrane protein that acts as a surface receptor for DBP. (nature.com)
HN - 2022 BX - Adolescent Motherhood BX - Teen Mothers BX - Teenage Mothers FX - Pregnancy in Adolescence MH - ADP-Ribosylation Factor 6 UI - D000089982 MN - D8.811.277.40.330.300.400.100.50 MN - D12.776.157.325.515.100.550 MN - D12.776.476.338.400.100.50 MS - A member of GTP-binding protein of the large ras superfamily involved in regulation of membrane trafficking by modulating ENDOCYTOSIS and ACTIN CYTOSKELETON remodeling. (nih.gov)
Renalase is a protein secreted by the kidney into the blood(in humans, renalase gene expression is highest here, but is also detectable in the heart, skeletal muscle, and the small intestine)and has a catecholamine-metabolising activity (it metabolizes dopamine most efficiently, followed by epinephrine, and then norepinephrine). (diff.org)
Renalase is most abundant in the proximal tubules and it presents in the circulation of normal individuals, suggesting that renalase protein in the proximal tubules can be secreted via the basolateral membrane into the circulation where it catabolized its substrate(s), and thus, regulating catecholamine homeostasis at a systemic level. (diff.org)
It is possible that renalase also exerts its biological function at the lumen of renal tubules, since renalase is small protein which can be easily filtered to the lumen of nephron. (diff.org)
For this, the apical brush borders are equipped with a dedicated protein uptake pathway, involving the multiligand receptors megalin and cubilin. (simons-lab.de)
Our recent research in Drosophila has introduced a novel mechanism for the control of apical protein uptake with strong implications for proximal tubular cells. (simons-lab.de)
Therefore, we are studying how protein and lipid ligands from the tubular lumen can amplify a cycle of endocytosis and lysosome-to-nucleus signaling to satisfy the high metabolic needs of proximal tubular cells. (simons-lab.de)

The earliest detectable feature of diabetic nephropathy is a slight increase in proteinuria indicators (microalbuminuria), followed by continuous proteinuria causing inflammation and scarring of the renal tubulointerstitium, until the gradual loss of renal function. (medicilon.com)
This leptospiral interstitial nephritis results in both acute and chronic kidney damage and loss of renal function. (vin.com)

From there, these waste molecules are transported into the lumen of the tubule by the MRP2 transporter. (wikipedia.org)
Studies of epithelial cell lines such as Madin-Darby canine kidney (MDCK) cells have, for instance, revealed polarity and apoptosis pathways contributing mechanistically to lumen formation 1 . (nature.com)
Identify the major morphological components of an epithelial tissue including lumen, interstitium, apical and basolateral membranes, and tight junctions. (mhmedical.com)
A wide range of charged, potentially toxic xenobiotics as well as endogenous organic ions are transported into the lumen by renal tissues of vertebrates and invertebrates. (silverchair.com)

11. Drug transporter expression profiling in a three-dimensional kidney proximal tubule in vitro nephrotoxicity model. (nih.gov)
We found that Cd reduced the transcriptional expression of megalin and ClC5 and, at the same time, increased the degradation of megalin and ClC5 proteins via the lysosomal pathway in an in vitro model of renal proximal tubular cells. (nih.gov)

Here we show that hPSC-KCs self-organize into kidney organoids that functionally recapitulate tissue-specific epithelial physiology, including disease phenotypes after genome editing. (nature.com)
Vander's Renal Physiology, 8e Eaton DC, Pooler JP. (mhmedical.com)
American Journal of Physiology: Renal Physiology , 295 (2), F556-67. (au.dk)

Uptake of neutral alpha- and beta-amino acids by human proximal tubular cells. (au.dk)

In contrast to earlier models that featured nephron-like structures, these advances have improved the differentiation efficiency and similarity to the human kidney. (j-organoid.org)
One functional component of the kidney, the nephron, carries out tasks such as filtration and reabsorption. (j-organoid.org)
Outline Introduction -History of diuretics -Diuretic Use -Role of the nephron Ion transport Diuretic pharmacology -Proximal convoluted tubule. (documents.pub)
GSK3β inhibition differentiates spheroids into segmented, nephron-like kidney organoids containing cell populations with characteristics of proximal tubules, podocytes and endothelium. (nature.com)
This is the third stop in the kidneys, as we wrap through the nephron, looking at sodium handling. (medmastery.com)
In the kidney, our main organ of interest, there are a number of different epithelial cells organized in segments along the nephron, and we are particularly interested in the proximal tubules. (simons-lab.de)

Epithelial cells of the proximal tubules have a very active endolysosomal system, and this is because its main task is to reabsorb virtually all the proteins that are filtered by the glomerulus. (simons-lab.de)

second, the cortical interstitium, which is the medium faced by the basolateral membranes of the tubular epithelia, has an osmolality and concentration of small solutes very close to those in plasma. (mhmedical.com)

Therefore, in the last few decades, numerous pharmacogenomics studies have been conducted to decode associations of SNPs in genes encoding MTX membrane transport proteins that could change MTX influx and/or efflux function and, consequently, could be responsible for MTX interpatient therapeutic outcomes variability, both regarding clinical response and/or adverse drug reactions (ADRs) occurrence. (medscape.com)
ABC proteins transport various molecules across extra- and intra-cellular membranes. (wikipedia.org)
Using mass spectrometry-based proteomics, 1037 SUMO1 and 552 SUMO2 sites, corresponding to 546 SUMO1 and 356 SUMO2 proteins, were identified from a modified mouse kidney DCT cell line (mpkDCT). (nih.gov)
The highly homologous ERM (ezrin/radixin/moesin) proteins, molecular cross-linkers which connect the cell membrane with the underlying cytoskeleton, have molecular weights of 81, 80 and 78 kDa respectively. (embl-heidelberg.de)
Aquaporins (AQPs), a family of membrane channel proteins involved in many body functions, are emerging among the targets of bioactive phytochemicals in imparting their beneficial actions. (frontiersin.org)
This review provides an update on the involvement of Aquaporins (AQPs), a family of membrane channel proteins with important role in many body functions, in the beneficial effects imparted by food polyphenols and herbal phytocompounds, both in health and disease. (frontiersin.org)
Aquaporins (AQPs) are channel proteins largely expressed in living organisms mediating the transport of water and some anaelectrolytes across biological membranes ( Agre, 2004 ). (frontiersin.org)
The absorption of LMW proteins occurs in the PTC through clathrin-mediated endocytosis via 2 multiligand receptors (megalin and cubilin) present in the PTC apical border. (medscape.com)
The low number of megalin at the PTC apical border explains the reduced endocytosis of low-molecular weight proteins that occur in Lowe syndrome. (medscape.com)
Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (nih.gov)

These organic anions are transported from the blood into the endothelial cells of the renal proximal tubules by the OAT1 transporter. (wikipedia.org)

This effect is tissue-specific since the expression of the transporters is not affected in non-renal tissues. (elsevierpure.com)
Corin expression has been detected in non-cardiac tissues including the kidney. (silverchair.com)
It has been reported that L-carnitine inhibited free radical generation, prevented the damage due to fatty acid β-oxidation in mitochondria and protected tissues from impairment by renovating oxidized membrane lipids[ 10 ]. (ijpsonline.com)

Drugs that inhibit the MRP2 transporter can cause a buildup of organic anions inside renal proximal tubule cells. (wikipedia.org)
1. The limitations of renal epithelial cell line HK-2 as a model of drug transporter expression and function in the proximal tubule. (nih.gov)
9. Screening of Drug-Transporter Interactions in a 3D Microfluidic Renal Proximal Tubule on a Chip. (nih.gov)
17. Expression of Organic Anion Transporter 1 or 3 in Human Kidney Proximal Tubule Cells Reduces Cisplatin Sensitivity. (nih.gov)
19. ABC transporter expression profiling after ischemic reperfusion injury in mouse kidney. (nih.gov)
A single transporter NaDC1 has been assumed to be responsible for intestinal &renal citrate reabsorption. (grantome.com)
The overall objective of this application is to determine the mechanisms ®ulation of kidney proximal tubule apical citrate transport via a novel apical calcium-sensitive transporter, &the relative roles of NaDC1 &NaDC3. (grantome.com)
Aims are: 1) Define the novel calcium-sensitive citrate transporter &its role in the proximal tubule. (grantome.com)
Our working hypothesis, based on data in three proximal tubule cell lines, is that in addition to NaDC1, a novel calcium- sensitive dicarboxylate transporter is present on the apical side of the proximal tubule. (grantome.com)
SUMOylation of the renal hydrogen-coupled oligopeptide and drug co-transporter (Pept2) at one site (K139) was found to be highly regulated by aldosterone. (nih.gov)

Remarkable advances in genetic diagnosis expanded our knowledge about inherited tubulopathies and other genetic kidney diseases. (chikd.org)
This review suggests a simple categorization of inherited tubular disease, clarifies the concept of autosomal dominant tubulointerstitial kidney disease (ADTKD), and introduces novel therapies developed for tubulopathies. (chikd.org)
Failure of this pathway results in low-molecular-weight proteinuria, which is a hallmark of proximal tubulopathies (e.g. cystinosis and Dent's disease). (simons-lab.de)

6. Nephrotoxicity and Kidney Transport Assessment on 3D Perfused Proximal Tubules. (nih.gov)
Although Cd-induced nephrotoxicity is widely studied, the molecular mechanisms underlying the damage and subsequent regeneration of the renal tubular epithelium remain elusive. (nih.gov)
Nephrotoxicity may manifest as either proximal renal tubule dysfunction in the form of a partial or complete Fanconi syndrome or as decreased renal function leading to acute or chronic kidney injury. (rcpe.ac.uk)

Knockout of the polycystic kidney disease genes PKD1 or PKD2 induces cyst formation from kidney tubules. (nature.com)
An important goal of the lab is to employ the Drosophila model as an innovative toolkit for the rapid identification of novel genes for hereditary diseases, particularly in the area of kidney disease but also other diseases. (simons-lab.de)

Transport of the organic anion salicylate by the Malpighian tubules and gut of larval and adult fruit flies was studied using two salicylate-selective microelectrode methods. (silverchair.com)

Other apical mechanisms may both be important in conditions such as acidosis &hypercalciuria. (grantome.com)
We will use NaDC1 knockout mice &compare renal citrate reabsorption in the -/- to +/+ mice both under baseline &conditions of acidosis &hypercalciuria. (grantome.com)
These studies will establish new paradigms in understanding citrate reabsorption in both the kidney proximal tubule &the intestine, &how these paradigms are impacted in acidosis &hypercalciuria. (grantome.com)
Here we report a 50-year-old HIV-positive male on tenofovir who presented with proximal renal tubular acidosis and fracture of left neck of femur four years after initiation of the drug. (rcpe.ac.uk)
1 Proximal renal tubular acidosis is characterised by defective proximal tubular reabsorption associated with phosphaturia, glycosuria, aminoaciduria, bicarbonaturia resulting in hypophosphataemia, hypokalaemia and metabolic acidosis. (rcpe.ac.uk)
A novel missense mutation in the sodium bicarbonate cotransporter (NBCe1/SLC4A4) causes proximal tubular acidosis and glaucoma through ion transport defects. (xenbase.org)

Renal Physiol. (wikipedia.org)

CUBN ) as well as population-based studes on more common CUBN variants suggest that dysfunctional cubilin leads to chronic proteinuria with normal renal function. (simons-lab.de)

8. Renal Drug Transporters and Drug Interactions. (nih.gov)
15. Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor. (nih.gov)
slc5a8 and slc5a12 represent the high affinity and low affinity Na + /lactate co-transporters, respectively, in the kidney. (elsevierpure.com)
Here we show that these transporters are expressed in the apical membrane of the proximal tubular cells in mouse kidney, indicating that these transporters are likely to mediate the first step in the renal reabsorption of lactate. (elsevierpure.com)
Interestingly, the renal expression of both transporters is almost completely ablated in mice homozygous for the deletion of the transcription factor c/ebpδ. (elsevierpure.com)
Thus, the fortuitous double knock-out of slc5a8 and slc5a12 in kidney in c/ebpδ -/- mice reveals the physiologic role of these transporters in the renal handling of lactate and urate. (elsevierpure.com)
The maintenance of membrane potential mainly depends on the activities of cation channels and transporters. (mdpi.com)

We used quantitative polymerase chain reaction, Western blotting, the albumin endocytosis assay, and confocal microscopy to evaluate effects of Cd on the expression and regulation of megalin and ClC5 in cultured LLC-PK1 cells, a pig proximal tubular cell model. (nih.gov)
Our findings propose that lysosomal mTOR signaling - a major nutrient sensing pathway that controls metabolic decisions from the lysosomal surface - regulates the expression of megalin as well as the morphogenesis of the apical surface. (simons-lab.de)

The "small" conductance chloride channel in the luminal membrane of the rectal gland of the dogfish (Squalus acanthias). (mpg.de)
SGLT1 is widely expressed in numerous organs (the distal S3 segment of the proximal renal tubule, intestines, heart and skeletal muscles), while SGLT2 is expressed in the luminal surface of the S1 segment of the proximal tubule and alfa-pancreatic cells. (iscpcardio.org)

This results in AKT serine/threonine kinase (Akt) activation, membrane focal adhesion turnover, and increased epithelial cell migration. (biomed.news)

These results suggest that corin-mediated pro-ANP activation may occur in renal segments and that locally produced ANP may act in an autocrine manner to regulate sodium and water reabsorption in situ . (silverchair.com)
Such a renal corin/ANP autocrine mechanism may differ from the cardiac corin/ANP endocrine mechanism in regulating sodium homoeostasis under physiological and pathological conditions. (silverchair.com)
Sodium-alanine cotransport in renal proximal tubule cells investigated by whole-cell current recording. (mpg.de)
sults: sodium 133 mmol/L, potassium membrane regulator gene ( CFTR ) on He was readmitted 5 more times 3.4 mmol/L, chloride 100 mmol/L and chromosome 7. (who.int)
In rats perorally given sodium metasilicate nonahydrate (average daily dose of silicon of 0.1 mg/g body weight for the first six weeks, 0.2 mg/g body weight for the next six weeks, and 0.4 mg/g body weight for the last six weeks), serum and tissue (liver, kidney, lung, and aorta) silicon levels were significantly increased compared to those of controls. (nih.gov)

In addition, chronic high salt diet increased the renal expression of prosaposin, a precursor for saposin C, a natural ligand for GPR37L1. (gwu.edu)
Ultrasonography of the abdomen and pelvis revealed chronic renal parenchymal changes and renal artery Doppler study was normal. (rcpe.ac.uk)
Plasma renalase is markedly reduced in patients with chronic kidney disease and end-stage renal disease, and in animal models of chronic kidney disease and salt-dependent hypertension. (diff.org)
Rats subjected to subtotal nephrectomy develop hypertension and chronic kidney disease, and exhibit low plasma and cardiac renalase, and abnormal renalase activation. (diff.org)
A popular theory suggests this mismatch between the modern diet and the nutritional requirements encoded in the human genome during evolution may contribute to chronic diseases such as hypertension, stroke, kidney stones, and bone disease. (ccjm.org)
Abnormalities in hepatic lipase in chronic renal failure: role of excess parathyroid hormone. (jci.org)
Post-heparin hepatic lipase activity is reduced in chronic renal failure (CRF). (jci.org)

Tenofoviris is actively transported into the mitochondria of proximal tubule cells of the kidney and thereby can lead to proximal tubular dysfunction in long-term use. (rcpe.ac.uk)
In 1992, Nussbaum and colleagues reported that mutations of OCRL1 caused the rare X-linked disorder oculocerebrorenal syndrome of Lowe (OCRL), or Lowe syndrome, which includes the diagnostic triad of congenital cataracts, neonatal or infantile hypotonia with subsequent mental impairment, and renal tubular dysfunction. (medscape.com)

These data provide in vivo evidence for the functional coupling between lactate reabsorption and urate reabsorption in the kidney. (elsevierpure.com)
Therefore, the regulation of NaCl reabsorption in the kidney has important implications for cardiovascular health and this research is complementary with the cardiovascular research thematics of both the College of Medicine and Health and the Biological Sciences Institute. (ucc.ie)

The expression was most abundant in the proximal convoluted tubules and the medullary connecting ducts. (silverchair.com)

14. A simple method for the isolation and detailed characterization of primary human proximal tubule cells for renal replacement therapy. (nih.gov)
Since the first publication on generating kidney-like cell aggregates from pluripotent stem cells, various modifications have been made to develop more complex and detailed kidney structures. (j-organoid.org)
Presently, kidney organoids contain not only nephrons and ureteric buds but also stromal cells. (j-organoid.org)
Also we will determine citrate transport rates &the extracellular calcium-sensitivity for the remaining citrate transport process found in proximal tubule cells grown from dissected proximal tubule segments from knockout mice. (grantome.com)
Using immunolabelling of mouse kidney sections Pept2 was localized to DCT cells in vivo . (nih.gov)
Human-pluripotent-stem-cell-derived kidney cells (hPSC-KCs) have important potential for disease modelling and regeneration. (nature.com)
Activation of nonselective cation channels in the basolateral membrane of rat distal colon crypt cells by prostaglandin E 2 . (mpg.de)
Characteristics of apical chloride channels in human colon cells (HT29). (mpg.de)
In addition, renalase can be directly secreted via the apical membrane by the proximal tubules, where it metabolize its substrate(s) that filtered through the glomeruli and generated de novo by the renal tubular cells such as dopamine. (diff.org)
Receptor-mediated endocytosis of albumin" article, using human cell models, biopsies, diabetic mouse models and transgenic mice to prove that ORAI expression silence impairs the reabsorption of albumin by renal epithelial cells and aggravates proteinuria. (medicilon.com)
Studies have pointed out that in the early stage of DN, affected by proximal tubular epithelial cells (PTECs), the resorption of damaged tubules is a possible cause of the development of proteinuria, but the underlying molecular mechanism is still unknown. (medicilon.com)
The membrane potential of small intestinal epithelial cells (IEC) is important to regulate the activity of SGLT1. (mdpi.com)
Guided by "real-world" human genetic data, we are particularly interested in exploiting renoprotective gene variants for therapeutic strategies and in understanding how kidney cells maintain fitness in stress conditions. (simons-lab.de)

This work demonstrates previously unknown systemic effects of PRA that includes IL-6-mediated upregulation of the hepatic acute phase response.NEW & NOTEWORTHY Prerenal azotemia (PRA) accounts for a third of acute kidney injury (AKI) cases yet is rarely studied in preclinical models. (bvsalud.org)

Single chloride channels in endosomal vesicle preparations from rat kidney cortex. (mpg.de)
L-carnitine preserved the structure of renal cortex, decreased inducible nitric oxide synthase and increased proliferating cell nuclear antigen reaction. (ijpsonline.com)
In the rest of this chapter we will describe the principles of epithelial transport that apply to all parts of the kidney, with particular emphasis on events in the cortex. (mhmedical.com)

Renal complexity is characterized by several functionally and structurally distinct segments. (j-organoid.org)
Here we examined corin, pro-ANP/ANP and natriuretic peptide receptor-A (NPR-A) expression in human renal segments. (silverchair.com)

Some of these complexes are delivered to the kidneys, where they are filtered by the glomeruli and reabsorbed by the proximal tubules ( Zalups and Ahmad 2002 ). (nih.gov)

Therefore, new therapeutic strategies that improve symptoms and reduce mortality and hospitalisations are needed for patients with T2D, HF and renal impairment. (iscpcardio.org)

The main goal of Matias Simons Lab is to understand the molecular mechanisms underlying kidney disease. (simons-lab.de)

Our working hypothesis is that NaDC1 is not the exclusive mechanism of citrate transport in the kidney &intestine. (grantome.com)

Cd concentrates in several vital organs, among which liver and kidney are the primary targets that accumulate and are affected adversely by this toxic heavy metal ( Zalups and Ahmad 2002 ). (nih.gov)
Tubules accumulate dextran and methotrexate transport cargoes, and express kidney injury molecule-1 after nephrotoxic chemical injury. (nature.com)

These can function to establish axes for differentiation in the embryo, or to perform barrier and transport roles in adult organs such as the kidney. (nature.com)
Previous study reported that L-carnitine acts as an antioxidant and protectant against oxidative damage in diverse organs including kidney[ 8 ]. (ijpsonline.com)
Embryogenesis of the kidney begins with the formation of an elongated pair of excretory organs similar in structure and function to the kidneys of lower vertebrates. (clinicalgate.com)
All these changes occur behind the peritoneum because the kidneys are retroperitoneal organs. (clinicalgate.com)

After 6 h of PRA, plasma interleukin (IL)-6 was significantly increased, kidney and liver histology were normal, kidney and liver lactate were normal, and kidney injury molecule-1 immunofluorescence was negative. (bvsalud.org)
Investigators reported that L-carnitine is a compound biosynthesized from the amino acids methionine, and lysine in kidney and liver. (ijpsonline.com)

CUBN -associated proteinuria was featured by high percentage of albuminuria, suggesting that cubilin could indeed be the main albumin receptor in the proximal tubules. (simons-lab.de)

The human kidney contains approximately one million nephrons, each composed of at least 20 different cell types. (j-organoid.org)

Its target receptor, melanocortin 3 receptor (MC3R), is expressed in the kidney. (ucc.ie)

Potassium channels in the basolateral membrane of the rectal gland of the dogfish (Squalus acanthias). (mpg.de)
Excessive intake of potassium can cause hyperkalemia but usually in the setting of impaired renal function. (ccjm.org)
Maintenance of total-body potassium content is primarily the job of the kidneys, with a small contribution by the gastrointestinal tract. (ccjm.org)
The normal kidney can secrete a large amount of potassium, making hyperkalemia uncommon in the absence of kidney disease. (ccjm.org)

Voltage-dependent InsP 3 -insensitive calcium channels in membranes of pancreatic endoplasmic reticulum vesicles. (mpg.de)
The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). (nih.gov)

The kidney is critical in the regulation of BP but there are no studies reporting the kidney expression and renal function of GPR37L1. (gwu.edu)
Assess renal function before initiating ZURAMPIC. (nih.gov)
Adverse reactions related to renal function have occurred after initiating ZURAMPIC. (nih.gov)
Monitor renal function at initiation and during therapy with ZURAMPIC, particularly in patients with eCLcr below 60 mL/min, and evaluate for signs and symptoms of acute uric acid nephropathy. (nih.gov)
1 , 2 Hyperkalemia is most commonly encountered in patients with decreased kidney function. (ccjm.org)

When more patients were described, the phenotype was expanded to include the renal tubular defects that comprise Fanconi syndrome , and an X-linked inheritance pattern was noted. (medscape.com)

We will determine the localization of NaDC3 in the proximal tubule &determine the calcium sensitivity on the apical surface. (grantome.com)

Cystic fibrosis (CF) is an autosomal recessive condition caused by the mutation of the cystic fibrosis trans-membrane regulator gene (CFTR) on chromosome 7. (who.int)

It is expressed on the apical membrane of the renal proximal tubule and plays a major role in NaCl and HCO3 absorption. (nih.gov)
These data provide evidence for an obligatory role for slc5a8 and slc5a12 in the renal absorption of lactate. (elsevierpure.com)
3) Determine the role of NaDC1 in renal reabsorption &intestinal absorption of citrate. (grantome.com)

Stretch-activated non-selective cation channels in the antiluminal membrane of porcine cerebral capillaries. (mpg.de)
Small and maxi K + channels in the basolateral membrane of isolated crypts from rat distal colon: single-channel and slow whole-cell recordings. (mpg.de)
Ion Channels in Mammalian Proximal Renal Tubules. (mpg.de)
Properties of single K + channels in the basolateral membrane of rabbit proximal straight tubules. (mpg.de)

A second is the recapitulation during human ontogeny of kidney types (the equivalent of organ isoforms) that are terminal forms of the kidney in lower vertebrates. (clinicalgate.com)

Some renal tubules showed cytoplasmic vacuolations, loss of brush borders, hemorrhage and mild congested blood capillaries. (ijpsonline.com)

Our central hypothesis is that the novel citrate reabsorptive process functions to limit citrate transport in the proximal tubule when calcium is increased. (grantome.com)
Based on our surprising preliminary data, we will determine if NaDC3 is expressed on the apical membrane &accounts for calcium- sensitive citrate reabsorption. (grantome.com)
These outcomes are expected to have an important impact since understanding the regulation of citrate transport in the proximal tubule will dramatically improve strategies in the prevention of calcium stones. (grantome.com)

The nucleoside phosphonate adefovir is a MRP2 inhibitor that has been linked to kidney disease. (wikipedia.org)
ADTKD is a recently characterized disease entity involving tubules. (chikd.org)
Once they develop end-stage kidney disease, the treatment is often more difficult than other kidney diseases. (medicilon.com)
canagliflozin, empagliflozin and dapagliflozin) demonstrated noninferiority compared with placebo in the MACE primary composite end point and that they reduced the risk of HHF and of progression of renal disease, regardless of the presence of atherosclerotic CVD or HF at baseline. (iscpcardio.org)

These organoids mimic the structural similarities and developmental processes of the kidneys, while reflecting their physiological properties. (j-organoid.org)
In this review, we discuss the induction protocols for kidney organoids and tubuloids, as well as their potential applications in understanding kidney development, renal pathogenesis, and drug screening. (j-organoid.org)

Prerenal azotemia (PRA) is a major cause of acute kidney injury and uncommonly studied in preclinical models. (bvsalud.org)
However, much concerns of threats of rhabdomyolysis, acute kidney injury, diabetes mellitus, and memory loss have been encouraged some researchers to identify more accurately the side effects of statins[ 3 ]. (ijpsonline.com)

Anatomy37

Organisms19

Diseases17

Chemicals and Drugs114

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes40

Disciplines and Occupations2

Technology, Industry, Agriculture3

Information Science3

Distal convol5

Plasma membrane7

Intracellular3

Collecting duct5

Glomerular8

Secretion10

Excretion10

Protein16

Loss of renal function2

Lumen4

Vitro2

Physiology3

Uptake1

Nephron6

Glomerulus1

Basolateral membranes1

Proteins10

Endothelial cells1

Tissues3

Transporter10

Tubulopathies3

Nephrotoxicity3

Genes2

Anion1

Acidosis6

Physiol1

Normal renal function1

Transporters7

Megalin2

Luminal2

Epithelial cell1

Sodium5

Chronic7

Dysfunction2

Reabsorption in the kidney2

Abundant1

Cells13

Hepatic1

Cortex3

Segments2

Glomeruli1

Impairment1

Mechanisms1

Intestine1

Accumulate2

Organs4

Liver2

Albumin1

Human kidney1

Receptor1

Potassium4

Endoplasmic reticulum2

Function5

Defects1

Sensitivity1

Mutation1

Absorption3

Channels4

Vertebrates1

Brush1

Calcium3

Disease4

Organoids2

Acute kidney2