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  • Component
  • Even if one component was lost at a particular point in time, the fraction of observed second, independent losses of additional components was high (75% of all complexes affected). (beds.ac.uk)
  • species
  • We computed interologs in 25 different species and predicted the composition of complexes. (beds.ac.uk)
  • Over the analysed species, the composition of most complexes was highly flexible and only 25% of all genes were never lost. (beds.ac.uk)
  • Function
  • Experimental and computational evidence indicate that consecutive addition and secondary losses of components played a major role in the evolution of some complexes, mostly without affecting the core function. (beds.ac.uk)
  • different
  • Complementary to this network view, protein complexes can be partitioned in a core which is modulated by different attachments. (beds.ac.uk)
  • By adding different attachments, isoforms of a complex are built, possibly with slightly different functions. (beds.ac.uk)
  • Our findings show that APC/C is composed of previously undescribed subunits, and raise the question of why metazoan APC/C is molecularly different from unicellular APC/C. (biologists.org)
  • responsible
  • The studied complex is responsible for mediating assembling of the UsnRNPs (uridine rich small nuclear ribonucleoproteins). (beds.ac.uk)