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  • synaptic plasticity
  • Apamin, which selectively suppresses a component of the mAHP, increases neuronal excitability and facilitates the induction of synaptic plasticity at Schaffer collateral synapses and hippocampal-dependent learning. (jneurosci.org)
  • In addition to contributing to the IAHP, apamin-sensitive channels in CA1 neurons also affect the induction of synaptic plasticity and memory encoding. (jneurosci.org)
  • Several behavioral and electrophysiological studies indicate that SK-blockade by apamin may enhance neuron excitability, synaptic plasticity and long-term potentiation (LTP) in the CA1 hippocampal region, and for that reason, apamin has been proposed as a therapeutic agent in Alzheimer's disease treatment. (blogspot.com)
  • Our research suggests that apamin may increase the dendritic morphology in the hippocampus, which could be related to the neuronal excitability and synaptic plasticity enhancement induced by apamin. (blogspot.com)
  • suramin
  • IJPf is partially suramin and apamin sensitive, and it is abolished after desensitization with adenosine 5′-β-2-thiodiphosphate (ADPβS) and therefore considered purinergic, possibly through P2 receptors ( 35 ). (physiology.org)
  • Relaxations to ATP were almost abolished by apamin and suramin but not affected by PPADS. (arginine.ru)
  • neurons
  • as I note in the eighth chapter of Venomous , studies have found that apamin injected into the bodies of rats can alter the activity of dopamine-releasing neurons in their forebrains-which makes apamin one of a limited number of compounds we know of able to slip past the blood-brain barrier, and thus a promising candidate for a drug delivery strategy referred to as Trojan horse transit . (discovermagazine.com)
  • We further identify, that by considering alternate potassium dynamics, the dynamics display burst patterns that terminate via depolarization block, akin to those observed in vivo in VTA DA neurons and in substantia nigra pars compacta (SNc) DA cell preparations under apamin application. (frontiersin.org)
  • Examination of transgenic mice, each lacking one of the three SK channel genes expressed in the CNS, reveals that mice without the SK2 subunit completely lack the apamin-sensitive component of the ImAHP in CA1 neurons, whereas the IsAHP is not different in any of the SK transgenic mice. (jneurosci.org)
  • Application of apamin to CA1 neurons increases excitability, which can be seen as a shortened interspike interval, especially early in a burst of action potentials, and increases the number of action potentials for a given current injection. (jneurosci.org)
  • In the present work, Golgi-Cox stain protocol and Sholl analysis were used to study the effect of apamin on the dendritic morphology of pyramidal neurons from hippocampus and the prefrontal cortex, as well as on the medium spiny neurons from the nucleus accumbens and granule cells from the dentate gyrus of the hippocampus. (blogspot.com)
  • We found that only granule cells from the dentate gyrus and pyramidal neurons from dorsal and ventral hippocampus were altered in senile rats injected with apamin. (blogspot.com)
  • rats
  • In contrast, apamin did not block LTD induction using 1 Hz stimulation, suggesting that, in aged rats, the AHP does not influence LTD and LTP induction in a similar way. (jneurosci.org)
  • subunit
  • The effects of 1-EBIO and apamin are independent of the NADPH oxidase pathway, as demonstrated by using a PLB-985 cell line lacking the gp91 phox subunit. (pnas.org)
  • relaxation
  • Therefore, neither cytochrome P(450)-derived metabolites of arachidonic acid nor K(+) appear to mediate the EDHF-like relaxation to BK (i.e the non-NO, high [K(+)](o)/apamin-sensitive component) in bovine coronary arteries. (mysciencework.com)
  • Protease-activated receptors mediate apamin-sensitive relaxation of mouse and guinea pig gastrointestinal smooth muscle. (springer.com)
  • coronary
  • Apamin-sensitive, non-nitric oxide (NO) endothelium-dependent relaxations to bradykinin in the bovine isolated coronary artery: no role for cytochrome P450 and K+. (mysciencework.com)
  • channel
  • Detection and photoaffinity labeling of the Ca2+-activated K+ channel-associated apamin receptor in cultured astrocytes from rat brain. (semanticscholar.org)
  • article{Seagar1987DetectionAP, title={Detection and photoaffinity labeling of the Ca2+-activated K+ channel-associated apamin receptor in cultured astrocytes from rat brain. (semanticscholar.org)
  • Using whole-cell patch clamp electrophysiology, we identified an apamin-sensitive current in PLB-985 cells, consistent with an SK channel. (pnas.org)
  • The channel is blocked by apamin (By similarity). (uniprot.org)
  • Apamin Boosting of Synaptic Potentials in CaV2.3 R-Type Ca2+ Channel Null Mice. (gopubmed.org)
  • mechanism
  • Cytochrome P(450)-derived metabolites may be released at higher BK concentrations to act in parallel with NO and the high [K(+)](o)/apamin-sensitive mechanism. (mysciencework.com)
  • Brain
  • Preliminary research found this derivative of apamin improves upon the original toxin's ability to cross the blood-brain barrier and showed it was able to ferry proteins and even nanoparticles effectively, most likely because it is actively pulled across by transport proteins. (discovermagazine.com)
  • sensitive
  • Apamin-sensitive, non-nitric oxide (NO) endothelium-dependent. (mysciencework.com)
  • Previous work has shown the involvement of integrins and integrin-associated signaling pathways in activation of plasma membrane apamin-sensitive Ca 2+ -activated K + channels that results in membrane hyperpolarization of HAC after 0.33 Hz cyclical mechanical stimulation. (rupress.org)
  • In order to assess whether apamin-sensitive K + channels pl. (biomedcentral.com)