Ap 2 protein. Medical search. Frequent questions

Additionally, epicatechin-induced NF-kB and Nrf2 were connected to reactive oxygen species intracellular levels and to the activation of cell survival and proliferation pathways, being phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) associated to Nrf2 modulation and ERK to NF-kB induction. (udl.cat)
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. (nih.gov)
This protein kinase is calcium-independent and phospholipid-dependent. (nih.gov)
This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and apoptosis. (antibodies-online.com)
Find TAO Kinase 2 Proteins with a specific Grade. (antibodies-online.com)
Find TAO Kinase 2 Proteins for a variety of species such as anti-Human TAO Kinase 2, anti-Mouse TAO Kinase 2. (antibodies-online.com)
Find TAO Kinase 2 Proteins validated for a specific application such as ELISA, SDS, WB, Func. (antibodies-online.com)
Each of these effects was blocked by tyrosine kinase inhibition with genistein or herbimycin A. Similarly, antisense oligodeoxynucleotide targeting of ERK1/2 mRNA inhibited BK-stimulated DNA synthesis. (nih.gov)
In contrast, protein kinase C inhibition or depletion had no effect on BK-induced c-fos mRNA, AP-1-DNA binding activity, or DNA synthesis. (nih.gov)
We here evaluated the effects of SP600125 (anthra[1,9- cd ]pyrazole-6 (2 H )-one), an inhibitor of c-Jun NH 2 -terminal kinase (JNK), on the activation of PSCs. (aspetjournals.org)
SP600125 inhibited interleukin-1β-induced JNK activity and activator protein-1 activation, but it did not affect the activation of extracellular-regulated kinase, p38 mitogen-activated protein kinase, and nuclear factor-κB. (aspetjournals.org)
African trypanosomes lack all components of the AP-2 complex, except for a recently identified orthologue of the AP-2-associated protein kinase 1, AAK1. (bvsalud.org)

AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). (wikipedia.org)
HPS-2 is caused by a mutation in the gene encoding the beta-3A subunit of the heterotetrameric AP3 complex ( AP3BA ), which assists in the vesicle formation from the trans-Golgi network or late endosome. (medscape.com)
sigma-adaptin subunit of adaptor protein complex 3 (AP-3) status:Confirmed UniProt:Q8T874 protein_id. (yeastrc.org)
Adaptor complexes medium subunit family status:Partially_confirmed UniProt:P90761 protein_id:CAB0279. (yeastrc.org)
Most naïve T cells do not express surface CTLA4 because of its binding to AP50, a subunit of the clathrin adaptor AP-2 protein ( 2 ). (snmjournals.org)
All these motifs are believed to bind to the sigma subunit of activated adaptin complexes (AP-1, AP-2 and AP-3). (eu.org)
They serve to initiate clathrin-mediated endocytosis or protein sorting and can work synergistically with the adaptin mu subunit binding YxxPhi-type motifs ( TRG_ENDOCYTIC_2 ). (eu.org)
In characterized eukaryotes, AAK1 phosphorylates the µ2 subunit of the AP-2 complex to enhance cargo recognition and uptake into clathrin-coated vesicles. (bvsalud.org)
HPS-2 is caused by a mutation in the gene encoding the beta-3A subunit of the heterotetrameric AP3 complex (ADTB3A), which resides on chromosome 5. (medscape.com)
Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 that plays a role in protein sorting in the late-golgi/trans-golgi network (tgn) and/or endosomes. (lu.se)

We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. (frontiersin.org)
We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein, nucleoprotein) and rabbit polyclonal anti-SARS-Cov-2 antibodies (envelope protein, membrane protein) to 55 different tissue antigens. (frontiersin.org)
We found that SARS-CoV-2 antibodies had reactions with 28 out of 55 tissue antigens, representing a diversity of tissue groups that included barrier proteins, gastrointestinal, thyroid and neural tissues, and more. (frontiersin.org)
This extensive immune cross-reactivity between SARS-CoV-2 antibodies and different antigen groups may play a role in the multi-system disease process of COVID-19, influence the severity of the disease, precipitate the onset of autoimmunity in susceptible subgroups, and potentially exacerbate autoimmunity in subjects that have pre-existing autoimmune diseases. (frontiersin.org)
In this mechanism, antibodies formed against SARS-CoV-2 would also bind to human tissue proteins leading to autoimmune reactivity. (frontiersin.org)

Clathrin adaptor proteins, also known as adaptins, are vesicular transport adaptor proteins associated with clathrin. (wikipedia.org)
Therefore, adaptor proteins are responsible for the recruitment of cargo molecules into a growing clathrin-coated pits. (wikipedia.org)
The two major types of clathrin adaptor complexes are the heterotetrameric vesicular transport adaptor proteins (AP1-5), and the monomeric GGA (Golgi-localising, Gamma-adaptin ear homology, ARF-binding proteins) adaptors. (wikipedia.org)
Two tyrosines in the cytoplasmic domain are required for association of CD229 with the adaptor proteins AP-2 (μ2 chain) and GRB-2 and both are required for CD229 internalization (8, 9). (rndsystems.com)

Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (wikipedia.org)
Pertussis toxin B-pentamer mediates intercellular transfer of membrane proteins and lipids. (uc.edu)
Endocytosis and/or vesicular sorting signals for membrane proteins. (eu.org)
Adaptin-binding acidic dileucine motifs and variants thereof occur almost exclusively on the cytosolic side of membrane proteins, mostly integral (transmembrane) proteins. (eu.org)

As its name suggests, this protein is a transcription factor, which means it attaches (binds) to specific regions of DNA and helps control the activity of particular genes. (medlineplus.gov)
Transcription factor AP-2α regulates genes that are involved in several cellular processes, such as cell division and the self-destruction of cells that are no longer needed (apoptosis). (medlineplus.gov)
Without this function, transcription factor AP-2α cannot control the activity of genes during development, which disrupts the development of the eyes, ears, and face and causes the features of branchio-oculo-facial syndrome. (medlineplus.gov)
The impaired function of specific organelles indicates that the causative genes encode protein complexes that regulate vesicle trafficking in the endolysosomal system including AP-3, BLOC-1, BLOC-2, and BLOC-3. (medscape.com)
Four such genes, HPS1, ADTB3A, HPS3, and HPS4, are associated with the 4 known subtypes of Hermansky-Pudlak syndrome: Hermansky-Pudlak syndrome type 1 (HPS-1), Hermansky-Pudlak syndrome type 2 (HPS-2), Hermansky-Pudlak syndrome type 3 (HPS-3), and Hermansky-Pudlak syndrome type 4 (HPS-4). (medscape.com)
Discover related pathways, diseases and genes to Intersectin 2. (novusbio.com)
Secretory epithelial cells display lactogenic differentiation which is characterized by the expression of milk protein genes, such as beta-casein or whey acidic protein (WAP). (biomedcentral.com)
Differentiating HC11 cells displayed lower expression levels of milk protein genes than mammary glands of mid-pregnant or lactating mice. (biomedcentral.com)
Downregulation of AP-2 transcription factor genes is not required for lactogenic differentiation of HC11 cells but may functionally be involved in aspects of lactogenic differentiation in vivo that are not reflected by the HC11 system. (biomedcentral.com)
The lactogenic differentiation of the secretory epithelial cells is characterized by the synthesis of lactose and milk fat and by the expression of milk protein genes, such as beta-casein or whey acidic protein (WAP). (biomedcentral.com)
The impaired function of specific organelles indicates that the causative genes encode proteins operative in the formation of lysosomes and vesicles. (medscape.com)

AP3 is responsible for protein trafficking to lysosomes and other related organelles. (wikipedia.org)

The following product was used in this experiment: COX7C Polyclonal Antibody from Thermo Fisher Scientific, catalog # 11411-2-AP. (thermofisher.com)
Intersectin 2 Antibody - Azide and. (novusbio.com)
human brain tissue were subjected to SDS PAGE followed by western blot with 51051-2-AP (GALC antibody) at dilution of 1:200 incubated at room temperature for 1.5 hours. (ptglab.com)
Immunohistochemical analysis of paraffin-embedded human gliomas using 51051-2-AP (GALC antibody) at dilution of 1:50 (under 10x lens). (ptglab.com)
Immunofluorescent analysis of (4% PFA) fixed SH-SY5Y cells using 51051-2-AP (GALC antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). (ptglab.com)
Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 10181-2-AP (ATG5 antibody) at dilution of 1:200 (under 10x lens). (ptglab.com)
Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 10181-2-AP (ATG5 antibody) at dilution of 1:200 (under 40x lens). (ptglab.com)
WB result of IFIT2 antibody (12604-1-AP, 1:300) with si-IFIT2 and si-Control transfected A431 cells. (ptglab.com)
A431 cells were subjected to SDS PAGE followed by western blot with 12604-1-AP (IFIT2 Antibody) at dilution of 1:300 incubated at 4 degree celsius over night. (ptglab.com)
HPR-2 antibody with the panspecific anti- cious circle of poverty and disease [ 5 ]. (who.int)

The objective of the present study was to investigate the time-dependent regulation by epicatechin on the activity of the main transcription factors (NF-kB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor (Nrf2)) related to antioxidant defence and survival and proliferation pathways in HepG2 cells. (udl.cat)
2009. Activator protein 2alpha suppresses intestinal tumorigenesis in the Apc(min) mouse. . (oregonstate.edu)

5. Clathrin/AP-2-Dependent Endocytosis: A Novel Playground for the Pharmacological Toolbox? (ellibs.com)
Conditional protein mislocalization combined with high-resolution imaging provides convincing evidence that K13 is involved in the formation of cytostomes, the structures involved in the endocytosis of host cytosol. (elifesciences.org)
AP2 is chiefly involved in endocytosis of cell surface proteins and their trafficking to early or late endosomes. (eu.org)
Selection and internalization of cargo via clathrin-mediated endocytosis requires adaptor protein complexes. (bvsalud.org)
In summary, our data suggest an unconventional role for a putative pseudokinase during endocytosis and/or vesicular trafficking in T. brucei, independent of AP-2. (bvsalud.org)

HPS3 is a biogenesis of the lysosome-related organelles complex (BLOC)-2 component. (medscape.com)
Ap-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. (lu.se)

Mu recognises tyrosine-based sorting signals within the cytoplasmic domains of transmembrane cargo proteins. (wikipedia.org)
The ap complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (lu.se)

Adaptins are distantly related to the other main type of vesicular transport proteins, the coatomer subunits, sharing between 16% and 26% of their amino acid sequence. (wikipedia.org)

Synapse proteomics data sets, such as those of the postsynaptic density (PSD) and associated protein complexes when combined with comparative genomics have provided unprecedented insights into the evolution of synapses. (nature.com)

The highest contents of precursors (proline, pyrroline-5-carboxylic acid and 1-pyrroline) which related to 2-AP biosynthesis were recorded in late season treatment compared with early season treatment and middle season treatment. (techscience.com)
The highest activities of enzymes (proline dehydrogenase, pyrroline-5-carboxylic acid synthetase and ornithine transaminase) which involved in 2-AP biosynthesis were also observed in late season treatment. (techscience.com)
Cyclooxygenase-2, which plays a key role in the biosynthesis of prostaglandin E 2 (PGE 2 ), is often up-regulated in CRC and in other types of cancer. (lu.se)
Cyclooxygenase-2, which plays a key role in the biosynthesis of prostaglandin E2 (PGE2), is often up-regulated in CRC and in other types of cancer. (lu.se)

Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
Heat Shock 70kDa Protein (HSP70), also known as Heat Shock 70kDa Protein 1A (HSPA1A), is a 641 amino acid (aa) member of the HSP70 family of molecular chaperones with a predicted molecular weight of 70 kDa. (novusbio.com)
BK (10(-9) to 10(-7) M) stimulated a rapid increase in tyrosine phosphorylation of multiple proteins with an estimated molecular mass of 120-130, 90-95, and 44-42 kDa. (nih.gov)
This binding, in turn, changes the G protein so that it discharges its GDP, and binds instead with GTP (the high-energy form of this molecular duo). (learn-biology.com)

Human cytomegalovirus G protein-coupled receptor US28 promotes latency by attenuating c-fos. (uc.edu)
The engagement of CTLA4 by costimulatory molecules results in decreased T-cell receptor signaling, interleukin 2 transcription ( 3 ), and cell cycle arrest at the G1 stage, with the final result of inducing T-cell anergy ( 4 , 5 ). (snmjournals.org)
A G-protein coupled receptor is exactly what it sounds like. (learn-biology.com)
When a ligand (like epinephrine) binds with the receptor, the receptor activates the G-protein, which, in turn, activates a nearby membrane-embedded enzyme ("4"), which sends a signal into the cytoplasm. (learn-biology.com)
This receptor is a transmembrane protein. (learn-biology.com)
First, the G protein, now bound to GTP, disconnects from the receptor and floats away within the membrane. (learn-biology.com)
The receptor is a tertiary-level protein. (learn-biology.com)
As stated above, you should think back to allosteric binding sites on enzymes to imagine the mechanism involved with a G-protein coupled receptor. (learn-biology.com)
When the ligand (epinephrine) binds with the ligand-binding site, it causes a conformational change that ripples through the entire receptor protein. (learn-biology.com)

AP complexes connect cargo proteins and lipids to clathrin at vesicle budding sites, as well as binding accessory proteins that regulate coat assembly and disassembly (such as AP180, epsins and auxilin). (wikipedia.org)

The name "G protein" relates to the interaction between these proteins and either GTP or GDP, two energy-transfer molecules that function very similarly to ATP and ADP. (learn-biology.com)

Intersectin-2 is a cytoplasmic adapter protein that may provide a link between the actin assembly machinery and the endocytic membrance traffic, as well a control the production of clathrin-coated vesicles in terms of their invagination of budding. (novusbio.com)
This change in the receptor's cytoplasmic side enables it to bind with the G protein. (learn-biology.com)
It also shows a 22 aa transmembrane segment, and a 179 aa cytoplasmic domain with two immunoreceptor tyrosine-based switch motifs ITSMs (2, 3). (rndsystems.com)
Alternate splicing generates two additional isoforms that lack the juxtamembrane Ig‑like domain or short cytoplasmic region (2). (rndsystems.com)

These proteins are synthesized in the ribosomes, processed in the endoplasmic reticulum and transported from the Golgi apparatus to the trans-Golgi network, and from there via small carrier vesicles to their final destination compartment. (wikipedia.org)
Adaptor protein (AP) complexes are found in coated vesicles and clathrin-coated pits. (wikipedia.org)

In the present study, we examined the role of protein tyrosine phosphorylation and the mitogen-activated protein kinases, ERK1/2,in mediating BK-induced AP-1 and DNA replication in cultured rat mesangial cells. (nih.gov)

[ 6 ] Cells deficient in the HPS5 protein maintain early-stage melanosome formation and Pmel-17 trafficking. (medscape.com)
Among its diverse biological actions, the vasoactive peptide bradykinin (BK) induces the transcription factor AP-1 and proliferation of mesangial cells (S. S. El-Dahr, S. Dipp, I. V. Yosipiv, and W. H. Baricos. (nih.gov)
To explore whether the downregulation of AP-2alpha and AP-2gamma is of functional significance for lactogenic differentiation, we analyzed the expression of the AP-2 family members during the lactogenic differentiation of HC11 mammary epithelial cells in vitro. (biomedcentral.com)
HC11 cells express all AP-2 family members except AP-2delta. (biomedcentral.com)
In this report we analyzed AP-2 transcription factor expression in HC11 cells subjected to lactogenic differentiation conditions. (biomedcentral.com)
Detection:10181-2-AP 1:3000) with HeLa cells lysate 1760 ug. (ptglab.com)
However, poorly organized tumor vasculature, irregular blood flow, high interstitial pressure within the tumor tissue, and broad adverse effects on healthy cells limit the effectiveness of anti-cancer agents [ 1 , 2 ]. (plos.org)
CD229 is expressed on T and B cells, thymocytes, and more weakly on NK cells (2‑6). (rndsystems.com)
Hermansky-Pudlak syndrome was first noted in 1959 by Hermansky and Pudlak, who described 2 unrelated persons with albinism with lifelong bleeding tendencies and peculiar pigmented reticular cells in the bone marrow as well as in biopsy samples of the lymph node and the liver. (medscape.com)
The human bone morphogenet ic protein (rhBMP) developed by genetic engineering, was isolated by Urist, in 1965, and it is considered a substance capable of inducing differentiation of mesenchymal stem cells into osteoblasts, the cells that are responsible for the synthesis of bone matrix. (bvsalud.org)
We observed a significant up-regulation of 15-PGDH after treatment with LTC 4 , a CysLT 2 ligand, in colon cancer cells at both the mRNA and protein levels, which could be reduced by a CysLT 2 antagonist or a JNK inhibitor. (lu.se)
Furthermore, we also observed that LTC 4 , via the CysLT 2 /JNK signaling pathway, increased the expression of the differentiation markers sucrase-isomaltase and mucin-2 in colon cancer cells and that down-regulation of 15-PGDH totally abolished the observed increase in these markers. (lu.se)
In conclusion, the restoration of 15-PGDH expression through CysLT 2 signaling promotes the differentiation of colon cancer cells, indicating an anti-tumor effect of CysLT 2 signaling. (lu.se)

Time-dependent activation of the AP-1 pathway, in concert with enhanced c-Jun nuclear levels and induction of Nrf2 translocation and phosphorylation were also demonstrated. (udl.cat)
Intersectin-2 has also been known to have interactions with BCCIP, PTN, TBL3, MAP4K3, and SEMA6A in pathways such as the regulation of CDC42 activity pathway. (novusbio.com)
AP-1 pathway and that BK mitogenic signaling is critically dependent on protein tyrosine phosphorylation. (nih.gov)

N-hexane neurotoxicity: a mechanism involving pyrrole adduct formation in axonal cytoskeletal protein. (cdc.gov)
Cytoskeletal proteins as targets for organophosphorous compound and aliphatic hexacarbo n- induced neurotoxicity. (cdc.gov)

It covers the same content as Activity 1, but also includes concepts of protein structure, protein domains, and how the mutation location can affect phenotypic expression. (biointeractive.org)

2011. NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). . (oregonstate.edu)
Orthologous to human AP1AR (adaptor related protein complex 1 associated regulatory protein). (nih.gov)
for most human disease ( 2,15 ). (cdc.gov)
Recombinant Human Intersectin 2 GS. (novusbio.com)
51051-2-AP targets GALC in WB, IHC, IF,ELISA applications and shows reactivity with human, mouse samples. (ptglab.com)
Within the first two Ig‑like domains that are common to all SLAM proteins, human CD229 shares 24%‑39% aa sequence identity with human 2B4, BLAME, CD2F-10, CD84, CRACC, NTB-A, and SLAM. (rndsystems.com)
We also did selective epitope mapping using BLAST and showed similarities and homology between spike, nucleoprotein, and many other SARS-CoV-2 proteins with the human tissue antigens mitochondria M2, F-actin and TPO. (frontiersin.org)
The COVID-19 pandemic has placed an immediate call to action for medical researchers to investigate how SARS-CoV-2 can impact the worldwide human population. (frontiersin.org)
1994. Polychlorinated biphenyls, 1,1,1-trichloro-2,2 bis(p-chlorophenyl)ethane (p,p'-DDT) and 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE) in human plasma related to fish consumption. (cdc.gov)
The U.S. Department of Health and Human Services (HHS) established a SARS-CoV-2 Interagency Group (SIG) to enhance coordination among CDC, National Institutes of Health (NIH), Food and Drug Administration (FDA), Biomedical Advanced Research and Development Authority (BARDA), and Department of Defense (DoD). (cdc.gov)
To review the literature on the use and clinical viability of human morphogenetic protein for the jaws reconstruction. (bvsalud.org)
The aim of this study was to conduct a literature review on the use and clinical viability of human bone morphogenetic protein (rhBMP-2) for grafting bone in Dentistry. (bvsalud.org)

Less pronounced severity of immunodeficiency can be due to a novel 2 bp-deletion (c.3222_3223delTG) in the final exon of AP3B1 , causing a frameshift and thus a prolonged altered HPS2 protein. (medscape.com)
The place of the deletion is at the very C-terminal's end, preventing a complete loss of the HPS2 protein. (medscape.com)

Due to their large surface area and ability to interact with proteins and peptides, graphene oxides offer valuable physiochemical and biological features for biomedical applications and have been successfully employed for optimizing scaffold architectures for a wide range of organs, from the skin to cardiac tissue. (mdpi.com)

The latter dileucine motifs were implicated in membrane protein sorting to vacuoles or tonoplasts. (eu.org)
In fungi and plants, dileucine motifs are often responsible for the vacuolar or tonoplast localization of proteins carrying these motifs. (eu.org)

We are primarily using cytomegaloviruses to examine how the pathogens alter signaling pathways directed by G-protein coupled receptors (GPCRs) to facilitate robust replication in tissues important for host-host dissemination. (uc.edu)
They are ligands to the G-protein coupled receptors CysLT1R and CysLT2R, of which CysLT1R is associated with poor prognosis and CysLT2R with good prognosis for colorectal cancer patients. (lu.se)

Chevy Johnson, a resident of Broward County, Fla., holds the three Powerball tickets she purchased in the hope of winning the jackpot of over $1 billion, in Fort Lauderdale, Fla., on Monday, Oct. 2, 2023. (wlns.com)
2(1)2023. (bvsalud.org)

In accord with the stimulation of Elk-1 phosphorylation, BK induced c-fos gene expression and the production of Fos/AP-1 complexes. (nih.gov)
In addition, there are two ITSMs which mediate phosphorylation-dependent CD229 association with SAP and SHP-2 (10). (rndsystems.com)
LTC 4 induced 15-PGDH promoter activity via JNK/AP-1 phosphorylation. (lu.se)

Cross-reactivity occurs when amino acid sequence homology exists between a pathogen and self-tissue proteins ( 1 ). (frontiersin.org)

However, if either of these processes proceeds too slowly or fails, HSP70/HSPA1A can interact with the HSP40 co-chaperone protein and the CHIP/STUB1 Ubiquitin ligase (E3) to promote ubiquitination and degradation of the nascent polypeptide or denatured protein (3,4). (novusbio.com)
Center, Lund University, P.O. proteins bovine pancreatic trypsin inhibitor (BPTI) and ubiquitin. (lu.se)
For ubiquitin, labile protein deuterons contribute importantly to the 2H relaxation dispersion even in the neutral pD range. (lu.se)

clathrin assembly protein complex 1, me. (cornell.edu)

Students will form a hypothesis to explain how a change in amino acid sequence affects the functionality of the MC1R protein, and how that change might directly affect the coat color of the rock pocket mouse populations. (biointeractive.org)

Transcription factors AP-2alpha and AP-2gamma are downregulated during lactation, and their overexpression in transgenic mice impaired the secretory differentiation of the mammary epithelium, resulting in lactation failure. (biomedcentral.com)
These findings suggest a functional role of AP-2 transcription factors in preventing lactogenesis. (biomedcentral.com)

PGE 2 induces angiogenesis and tumor cell survival, proliferation and migration. (lu.se)

Methods and results This report describes an autosomal recessive form of spastic tetraplegic cerebral palsy with profound intellectual disability, microcephaly, epilepsy and white matter loss in a consanguineous family resulting from a homozygous deletion involving AP4E1 , one of the four subunits of the adaptor protein complex-4 (AP-4), identified by chromosomal microarray analysis. (bmj.com)

Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins. (nature.com)

These changes tend to occur in a region of the protein that allows it to bind to DNA. (medlineplus.gov)
Adaptins recognise and bind to clathrin through their hinge region (clathrin box), and recruit accessory proteins that modulate AP function through their C-terminal ear (appendage) domains. (wikipedia.org)

Conversely, it is thought to protect against several neurodegenerative diseases that are caused by the accumulation of misfolded proteins (11,12). (novusbio.com)

SP600125 inhibited platelet-derived growth factor-induced proliferation, inducible monocyte chemoattractant protein-1 production, and serum-induced type I collagen production. (aspetjournals.org)

Anatomy27

Organisms19

Diseases7

Chemicals and Drugs130

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes50

Disciplines and Occupations2

Information Science4

Kinase12

Subunit10

Antibodies5

Adaptor proteins4

Membrane proteins4

Genes11

Trafficking to lysosomes1

Antibody10

Activator2

Endocytosis5

Lysosome-related organelles2

Transmembrane cargo2

Vesicular1

Postsynaptic density1

Biosynthesis4

Molecular4

Receptor9

Lipids1

Molecules1

Cytoplasmic4

Vesicles2

Kinases1

Cells13

Pathway3

Cytoskeletal2

Mutation1

Human12

Hps22

Peptides1

Motifs2

Receptors2

20232

Phosphorylation3

Homology1

Ubiquitin3

Assembly protein1

Amino acid seq1

Transcription Factors2

Induces1

Chromosomal1

Schizophrenia1

Bind2

Diseases1

Proliferation1