Ap 1 transcription factor ap 1. Medical search. Frequent questions

Activator protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli, including cytokines, growth factors, stress, and bacterial and viral infections. (wikipedia.org)
The objective of the present study was to investigate the time-dependent regulation by epicatechin on the activity of the main transcription factors (NF-kB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor (Nrf2)) related to antioxidant defence and survival and proliferation pathways in HepG2 cells. (udl.cat)
This TF induction was dependent on signal transducer and activator of transcription-6 signaling and poly ADP ribose polymerase activity. (haematologica.org)
We have elucidated the molecular mechanisms involved in the increase in IL-6 expression caused by CXCL1 incubation in SFs, which was regulated by its receptor CXCR2, c-Raf and MAPK signaling components, and activator protein-1 (AP-1) transcriptional activation. (researchsquare.com)
c-Jun is one of three Jun family proteins making up the activator protein-1 (AP-1) transcription factor group. (rndsystems.com)
Coccidioides immitis meningitis in a patient with hyperimmunoglobulin E syndrome due to a novel mutation in signal transducer and activator of transcription. (cdc.gov)

The structure of AP-1 is a heterodimer composed of proteins belonging to the c-Fos, c-Jun, ATF and JDP families. (wikipedia.org)
The early response gene proteins, Fos and Jun family, are components of the transcription factor AP-1 that, depending on its composition, could be related with proliferation, differentiation or cellular death. (usp.br)
Genetic instability of tumor cells may lead to altered expression of apoptotic proteins and immune-regulatory molecules, such as transforming growth factor-beta. (medscape.com)
NF-AT proteins function in both signal transduction and transcription control. (bdbiosciences.com)
Various growth factors, cytokines, and extracellular matrix proteins are substrates for meprins. (embl-heidelberg.de)
This review summarizes some immunological factors involved in the development and control of this oral disease, such as: the participation of inflammatory cells in local inflammation, the synthesis of chemotaxis proteins with activation of the complement system and a range of antimicrobial peptides, such as defensins, cathelicidin and saposins. (bvsalud.org)

The AP-1 subunit Jun was identified as a novel oncoprotein of avian sarcoma virus, and Fos-associated p39 protein was identified as the transcript of the cellular Jun gene. (wikipedia.org)

Classical polarization is usually associated with a proinflammatory response, including the increased production of tumor necrosis factor (TNF)-α, IL-1, and IL-6. (haematologica.org)
The CD30 antigen is a type 1 transmembrane glycoprotein of the tumor necrosis factor receptor superfamily. (medscape.com)

Time-dependent activation of the AP-1 pathway, in concert with enhanced c-Jun nuclear levels and induction of Nrf2 translocation and phosphorylation were also demonstrated. (udl.cat)
The results reported here demonstrate that Fos is a direct target of miR-146a activity and that downregulation of the Fos-AP-1 pathway by miR-146a has the capacity to inhibit MMP-9 activity. (jefferson.edu)
Upon the occupancy of ACE2 by SARS-CoV-2, the increased serum level of free Angiotensin II (Ang II) due to a reduction of ACE2-mediated degradation promotes activation of the NF-kappa B pathway via Ang II type 1 receptor (AT1R), followed by interleukin-6 (IL-6) production. (kegg.jp)

Figure 1: Summary of estrogen receptor and RNA PolII binding sites and correlation with nucleotide and gene number. (nature.com)
Figure 4: Identification of enriched motifs within the estrogen receptor binding sites and validation of transcription factor binding. (nature.com)
Figure 5: Involvement of cooperating transcription factors at estrogen receptor binding sites. (nature.com)
Chemokine (CXC motif) ligand 1 (CXCL1) acts as a key chemoattractant for neutrophils by binding specifically to its corresponding G protein-coupled receptor chemokine (CXC motif) receptor 2 (CXCR2) (11, 12). (researchsquare.com)
The oligomerisation is essential for establishing appropriate connections to form signalling complexes with TNF receptor-1. (embl-heidelberg.de)
Refractory disseminated coccidioidomycosis and mycobacteriosis in interferon-gamma receptor 1 deficiency. (cdc.gov)
Loss-of-function mutations of the gene encoding fibroblast growth factor receptor 1 (FGFR1) have been described in patients with autosomal dominant Kallmann syndrome. (medscape.com)
[ 4 ] Of note, anosmin may enhance fibroblast growth factor signaling through the fibroblast growth factor receptor 1. (medscape.com)
Kim and Morshead, 2003), and the fibroblast that SSEA4 associated with CD133 can be used for growth factor (FGF) receptor 4 (Cai et al. (lu.se)

The AP-1 transcription factor c-Jun is required for Ras-driven tumorigenesis in many tissues and is considered as a classical proto-oncogene. (figshare.com)

RA, but not these 'dissociating' retinoids, induced transcription of an interleukin-6 promoter-based reporter gene transiently transfected into HeLa cells together with RARs. (nih.gov)
Alternative polarization with interleukin-4 and IL-13 led to a macrophage phenotype characterized by increased tissue factor (TF) production and release and by an increase in extracellular vesicle production. (haematologica.org)
Furthermore, interleukin 8 and vascular endothelial growth factor were more strongly expressed in Colo357L3.6pl than Colo357FG cells, and these findings were confirmed in Colo357L3.6pl and Colo357FG orthotopic tumors. (duke.edu)
CONCLUSION: These results suggest that overexpression of TrkB and activation of mitogen-activated protein kinase and AP-1, which may in turn induce the expression of vascular endothelial growth factor and interleukin 8, may mediate the cardinal clinical features of locally aggressive growth and metastasis of pancreatic cancer. (duke.edu)
Negative transcriptional regulation of the human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT. (bioacademy.gr)
Prostaglandin E2 and other cyclic AMP elevating agents inhibit interleukin 2 gene transcription by counteracting calcineurin-dependent pathways. (bioacademy.gr)
In the present study, a SW1353 chondrosarcoma cell line was treated with interleukin (IL)‑1β and irisin. (spandidos-publications.com)
Wang JH, Shih KS, Wu YW, Wang AW and Yang CR: Histone deacetylase inhibitors increase microRNA-146a expression and enhance negative regulation of interleukin-1β signaling in osteoarthritis fbroblast-like synoviocytes. (spandidos-publications.com)

Mutations of the gene encoding fibroblast growth factor 8 have been found in a small minority of patients with autosomal dominant Kallmann syndrome. (medscape.com)

The AP-1 transcription complex controls the expression of a subset of genes that are expressed early in response to extracellular mitogenic stimuli or to stress. (medscape.com)
EXPERIMENTAL DESIGN: To identify the genes involved in pancreatic cancer metastasis, we analyzed the gene expression profiles between highly metastatic Colo357L3.6pl and parental Colo357FG pancreatic cancer cell lines using cDNA microarrays and confirmed differential gene expression by reverse transcription-PCR, Western blotting, and immunologic analysis of 54 samples from pancreatic cancer patients. (duke.edu)
The NF-AT family of transcription factors are regulators of early immune response genes in T cells following their activation by CD40L, FasL and interleukins including IL-2, -3, -4 and -5. (bdbiosciences.com)
In vitro , NF-AT cooperates with the mitogenic transcription factor AP-1 to induce multiple cytokine genes. (bdbiosciences.com)
Exons 1-6 of the WT1 gene encode the regulatory domain, which regulates expression of target genes, and exons 7-10 encode the 4 zinc fingers of the DNA-binding region of the WT1 protein. (medscape.com)
The WT1 protein mediates the mesenchymal-epithelial transition and differentiation during morphogenesis of the kidney and gonad by repressing genes that encode cell proliferation factors and by activating genes that encode markers of epithelial cell differentiation. (medscape.com)

Topical retinoids also demonstrate inhibition of various immune factors, including the activity of leukocytes, the release of pro-inflammatory cytokines and other mediators, and the expression of transcription factors and toll receptors involved in immunomodulation (Wolf, 2002). (medscape.com)
Progression of this disease occurs due to a combination of factors, including the presence of periodontopathic bacteria, high levels of proinflammatory cytokines, matrix metalloproteinases (MMPs), prostaglandin E2 (PGE2), low levels of anti-inflammatory cytokines including inter- leukin-10 (IL-10), transforming growth factor (TGF- β ) and tissue inhibitors of MMPs (TIMPs) (2,3). (bvsalud.org)

JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer. (figshare.com)

The growth factors TGF alpha, TGF beta, and IL2 have all been shown to stimulate c-Fos, and thereby stimulate cellular proliferation via AP-1 activation. (wikipedia.org)
NEPH1 triggers AP-1 activation similarly to nephrin but requires the presence of Tec family kinases for efficient transactivation. (nih.gov)
However, while the anti-inflammatory effects of dexamethasone treatment were due to the reduced activation of NF- κ B and AP-1, the ellagic acid treatment led to reduced BALF levels of IL-6 and increased levels of IL-10. (hindawi.com)
miR-146a is a microRNA whose transcript levels are induced in the heart upon activation of NF-κB, a transcription factor induced by pro-inflammatory molecules (such as TNF-α) that is strongly related to the pathogenesis of cardiac disorders. (jefferson.edu)
Aerosolized samples were analyzed and evaluated for in vivo acute toxicity, DNA damage, activation of AP-1 and NF-kappaB, and potential to generate ROS. (cdc.gov)
Saw blade blasted with silica also caused significantly greater levels of activation of two important transcription factors, AP-1 and NF-kappaB, involved in disease development. (cdc.gov)
They promote cell survival by the activation of downstream protein kinases and, finally, transcription factors of the NF-kB and AP-1 family. (embl-heidelberg.de)

2003. Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun. . (oregonstate.edu)

Chemokines and chemokine receptors are critical players in the disease processes of two inflammatory joint diseases: rheumatoid arthritis (RA) and osteoarthritis (OA) (1). (researchsquare.com)

[ 12 ] part of the AP-1 transcription factor complex involved in cell proliferation and apoptosis, in virtually all CD30 + lymphomas. (medscape.com)

Through the recent use of molecular and cellular assays and knockout animals, considerable progress has been made towards the understanding of the genetic, tissue-specific, and immunological factors that contribute to the development of ALI pathophysiology. (hindawi.com)

These data suggest that the epicatechin-induced survival effect occurs by the induction of redox-sensitive transcription factors through a tight regulation of survival and proliferation pathways. (udl.cat)
Calcium/calmodulin dependent protein kinase II downregulates both calcineurin and protein kinase C mediated pathways for cytokine gene transcription in human T cells. (bioacademy.gr)
The present results suggested that IL‑1β could decrease Col II expression and increase MMP‑13 expression at both the mRNA and protein levels, and also activate the Wnt/β‑catenin and NF‑κB signaling pathways in SW1353 cells. (spandidos-publications.com)

AP-1 transcription is deeply involved in the modulation of gene expression. (wikipedia.org)
Additionally, they can regulate gene expression by inhibiting the activity of other transcription factors, such as AP-1. (medscape.com)
Liacini A, Sylvester J, Li WQ, Huang W, Dehnade F, Ahmad M and Zafarullah M: Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes. (spandidos-publications.com)

16(1): 189, 2023 08 17. (bvsalud.org)

We therefore consider binding strengths a3 and a2 which determine how strongly OCT4-SOX2-NANOG and OCT4-SOX2 bind to OCT4, respectively, and e2 and e1, the binding strengths of the OCT4-SOX2-NANOG and OCT4-SOX2 complexes on the NANOG gene respectively (see Eq. (1) in the main text. (lu.se)
This is intuitively obvious, since the stronger that these complexes bind to OCT4, SOX2 and NANOG, the higher the transcription rate, and hence a smaller threshold of the environmental factor is required to turn the switch on. (lu.se)

AP-1 controls a number of cellular processes including differentiation, proliferation, and apoptosis. (wikipedia.org)
The AP-1 transcription factor has been shown to play numerous roles in cell growth and proliferation. (wikipedia.org)
C-jun has been shown to be essential for fibroblast proliferation, and levels of both AP-1 subunits have been shown to be expressed above basal levels during cell division. (wikipedia.org)
In colorectal cancer, propofol inhibits cancer cells proliferation and metastasis by regulating miR-124-3p.1/AKT3 [ 13 ]. (aging-us.com)
These results demonstrate differential sensitivity of standard cytotoxicity assessments on the PPP, thus (1) decoupling 'mitochondrial activity' as an interpretation of cellular formazan and Alamar Blue metabolism, and (2) demonstrating the implicit requirement for investigators to sufficiently verify interaction of these methods in routine cytotoxicity and proliferation characterization. (cdc.gov)

Extracellular signal-regulated kinases 1 and 2 were activated and Elk-1 and AP-1 DNA binding activity was induced in Colo357L3.6pl cells. (duke.edu)

In addition, dexamethasone treatment reduced IL-1 β . (hindawi.com)

AP-1 transcription factor has been shown to have a hand in a wide range of cellular processes, including cell growth, differentiation, and apoptosis. (wikipedia.org)

Epub 2002 Nov 1. (nih.gov)

Interestingly, AP-1 inhibition was accompanied by a reduction in matrix metalloproteinase (MMP)-9 mRNA levels in human cardiac cells. (jefferson.edu)
1 Thus, it is imperative to understand the mechanisms involved in inhibition of myocardial fibrosis. (dovepress.com)

During December 6, 2021-June 11, 2022, SARS-CoV-2 testing ≤1 day before departure or proof of recent COVID-19 recovery were required for passengers boarding U.S.-bound flights. (cdc.gov)

The WT1 protein is a transcription factor predominantly expressed in the embryonic kidneys and gonads. (medscape.com)
2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)

Factors and outcomes associated with the decision to treat primary pulmonary coccidioidomycosis. (cdc.gov)

Beginning December 6, 2021, all international air passengers boarding flights to the United States were required to show either a negative result from a SARS-CoV-2 viral test taken ≤1 day before departure or proof of recovery from COVID-19 within the preceding 90 days ( 1 ). (cdc.gov)

In contrast to monocytes, human macrophages did not show increased tissue factor expression upon stimulation with lipopolysaccharide and interferon-γ. (haematologica.org)
The main challenge for large bone defect repair and regeneration remains the inadequate recruitment of mesenchymal stem cells (MSCs), reduced vascularization, and decreased growth factors stimulation within the scaffold construct to support cell viability and tissue growth. (frontiersin.org)

AP-1 transcription factors are also associated with numerous physiological functions especially in determination of organisms' life span and tissue regeneration. (wikipedia.org)
1 Some tissue macrophages and precursors are already established embryonically in the yolk sac and fetal liver before the onset of definitive hematopoiesis. (haematologica.org)
College of Wisconsin, current era from 28 patients with septal defects who factor HEY2 in formalin fixed tissue taken from a Milwaukee, Wisconsin, USA underwent cardiac surgery and who were enrolled in our collection of hearts with atrial septal defects congenital heart disease tissue bank. (cdc.gov)
Abnormal samples can increase risk for poor data quality,15 we cardiac development appears to occur through a were interested in replicating these experiments process that is heterogeneous and complex, with using fresh frozen cardiac tissue instead of formalin both environmental and genetic risk factors.1 fixed tissue after decades of storage. (cdc.gov)

Many plant-derived secondary metabolites are capable of directly modulating inflammation by altering the production and activity of second messengers, the expression of transcription factors, and the expression of key proinflammatory molecules [ 6 - 8 ]. (hindawi.com)
The NMRD data show that all water molecules associated with the duplex, except the ®ve molecules in the spine, have residence times signi®cantly shorter than 1 ns at 4C. (lu.se)

Given that MMP-9 is an AP-1 target gene involved in cardiac remodeling, myocardial dysfunction and progression of heart failure, these findings suggest that miR-146a might be a new and promising therapeutic tool for treating cardiac disorders associated with enhanced inflammation in the heart. (jefferson.edu)
See Wilms Tumor: A Pediatric Oncology Success Story , a Critical Images slideshow, to help identify the clinical features, staging evaluation, prognostic factors, and therapeutic options for this disease. (medscape.com)

This makes TCF7L2 variants the strongest known genetic risk factors for T2DM. (medscape.com)

C-fos has also been shown to increase in expression in response to the introduction of growth factors in the cell, further supporting its suggested involvement in the cell cycle. (wikipedia.org)

Below are some of the other important functions and biological roles AP-1 transcription factors have been shown to be involved in. (wikipedia.org)

AP-1 activity is often regulated via post-translational modifications, DNA binding dimer composition, and interaction with various binding partners. (wikipedia.org)
Mechanistically, OGT O-GlcNAcylates JUN at multiple sites, which then leads to an attenuation of AP-1 transcriptional activity. (wustl.edu)
These changes correlated with a diminution in the DNA-binding activity of AP-1, the Fos-containing transcription factor complex. (jefferson.edu)

Compared with the control group, the expression of NOX2, nuclear factor-κB (NF-κB), and Snail was increased in vivo and in vitro but decreased with TMZ treatment. (dovepress.com)
2000). We of glial cell line-derived neurotrophic factor (GDNF) in models of have recently reported that this vector directs transgene expression to Parkinson's disease (Georgievska et al. (lu.se)

It has been hypothesized that the AP-1 may play a substantial role in the inflammation and immune response (Michel et al. (medscape.com)

Rheumatoid arthritis (RA), a common chronic systemic autoimmune disease, is characterized by synovial hyperproliferation and inflammatory/immune cell infiltration [ 1 , 2 ]. (hindawi.com)
genetic and environmental factors seem to increase the susceptibility of some individuals in developing this severe inflammatory disease (1) ( Fig. 1 ). (bvsalud.org)

This suggests critical roles for dietary and lifestyle factors. (mdpi.com)

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening syndromes that cause high morbidity and mortality [ 1 ]. (hindawi.com)

Brinkman et al5 examined whether the presence and foods.1,2 However, much less is known about the poten- severity of AD was predictive of the occurrence and mag- tial influence that skin challenges have on the systemic nitude of early and late asthmatic responses to inhaled immune response, in particular whether sensitization allergens. (cdc.gov)

2016 Oct 11:1-19. (tcd.ie)
2016 May;203(1):369-85. (tcd.ie)
Mucosal Immunol 9(1): 240-253, 2016. (upenn.edu)

Faienza MF, Brunetti G, Sanesi L, Colaianni G, Celi M, Piacente L, D'Amato G, Schipani E, Colucci S and Grano M: High irisin levels are associated with better glycemic control and bone health in children with type 1 diabetes. (spandidos-publications.com)
Transcription factor 7-like 2 ( TCF7L2 ) variants have been associated with type 2 diabetes mellitus (T2DM) in multiple ethnic groups. (medscape.com)

[ 27 ] the strongest predictors continue to be positive family history, increased body mass index, increased blood pressure, and increased serum levels of triglycerides, apolipoprotein A-1, and liver enzymes, all of which precede inception of metabolic syndrome . (medscape.com)

AP-1 was first discovered as a TPA-activated transcription factor that bound to a cis-regulatory element of the human metallothionein IIa (hMTIIa) promoter and SV40. (wikipedia.org)
Consider an example with a single gene that is autoregula- tory, i.e. the transcription rate is enhanced when it is bound by its own protein product, X. There are then four possible states of the system. (lu.se)
unbound, bound by the transcription factor X, bound by the RNAP and bound by both X and RNAP. (lu.se)

An in vitro model of EndMT was developed using human umbilical vein endothelial cells (HUVECs) via treatment with transforming growth factor-β (TGF-β) at 10 ng/mL for 24 h. (dovepress.com)
1 There are ease Prevention and Control Unit received reports of gas- currently six recognized norovirus genogroups, three of trointestinal il ness in patrons fol owing a banquet lunch which (GI, GII and GIV) cause human illness. (who.int)

Anatomy16

Organisms8

Chemicals and Drugs135

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes70

Disciplines and Occupations1

Information Science4

Activator6

Proteins6

Subunit1

Tumor necros2

Pathway3

Receptor9

Proto-oncogene1

Interleukin8

Fibroblast Growth1

Genes6

Cytokines2

JunD1

Activation7

Rats1

Receptors1

Cell proliferation1

Immunological factors1

Pathways3

Gene expression3

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SOX22

Proliferation5

Extracellular1

Dexamethasone1

Apoptosis1

20021

Inhibition2

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Embryonic2

Outcomes1

20211

Stimulation2

Tissue4

Molecules2

Therapeutic2

Genetic risk1

Involvement1

Biological1

Activity3

Expression2

Inflammation1

Inflammatory2

Roles1

Acute1

Immune1

20163

Type2

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Human2