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  • right ventricle
  • Pulmonary atresia with Ventricular Septal Defect (PA-VSD) is identified by underdevelopment of the right ventricle. (wikipedia.org)
  • The Ventricular Septal Defect (VSD) is a second opening in the ventricular wall, which provides a way out for blood in the right ventricle . (wikipedia.org)
  • When this second opening does not exist, very little blood goes to the right ventricle, which is what causes it to be underdeveloped in PA-IVS, this defect can be determined before birth. (wikipedia.org)
  • Surgical management of these infants has evolved over the past 15 years with a tendency towards primary complete repair that includes closure of the ventricular septal defect, right ventricle-to-pulmonary artery patch or conduit, and, when present, recruitment of as many APCs as possible (4) . (onlinejacc.org)
  • In the present study, the coding exons and flanking introns of the heart and neural crest derivatives expressed transcript 1 (HAND1) gene, which encodes a basic helix‑loop‑helix transcription factor crucial for cardiovascular development, were sequenced in 158 unrelated patients with CHDs, and a de novo heterozygous mutation, p.K132X, was identified in a patient with double outlet right ventricle (DORV), as well as ventricular septal defect. (sld.cu)
  • genetic
  • Recent studies have demonstrated the pivotal roles of genetic defects in the pathogenesis of CHDs, and a great number of genetic mutations have been associated with CHDs. (sld.cu)