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AortaAorta, ThoracicLeukocyte RollingLeukocytesArteriosclerosisAorta, AbdominalThoracic ArteriesAortic AneurysmAortic Aneurysm, AbdominalElastinMuscle, Smooth, VascularTakayasu ArteritisAortic Aneurysm, ThoracicLeukocyte CountChemotaxis, LeukocyteAortic DiseasesRabbitsEndothelium, VascularAtherosclerosisDiet, AtherogenicMarfan SyndromeCholesterolHydroxyprolineApolipoproteins EDisease Models, AnimalAneurysm, DissectingPancreatic ElastaseMatrix Metalloproteinase 9Mice, KnockoutMice, Inbred C57BLImmunohistochemistryRats, Sprague-DawleyMatrix Metalloproteinase 2VasodilationRNA, MessengerNitric OxideCells, CulturedPlant OilsMacrophagesRats, Inbred WKYCyclic GMPSecretory Leukocyte Peptidase InhibitorNeutrophilsCell AdhesionRats, Inbred SHRLeukocyte ElastaseVenulesAngiotensin IIBlood PressureNitroprussideLeukocyte TransfusionCollagenVasodilator AgentsTime FactorsReverse Transcriptase Polymerase Chain ReactionP-SelectinDose-Response Relationship, DrugLipoproteins, LDLHypertensionAntigens, CD18Rats, Inbred StrainsLeukocyte-Adhesion Deficiency SyndromeCell Migration Assays, LeukocyteIntercellular Adhesion Molecule-1Leukocyte Adherence Inhibition TestL-SelectinHLA AntigensCell Adhesion MoleculesE-SelectinLymphocyte Function-Associated Antigen-1Macrophage-1 AntigenReceptors, Leukocyte-AdhesionCell MovementInflammationSelectinsAntigens, CDVascular Cell Adhesion Molecule-1MonocytesFlow CytometryMicrocirculationProteinase Inhibitory Proteins, SecretoryCell Migration InhibitionActivated-Leukocyte Cell Adhesion MoleculeAntibodies, MonoclonalAntigens, CD11HLA-DR AntigensChemokinesNeutrophil ActivationLeukocytosisNeutrophil InfiltrationHLA-B AntigensHistocompatibility TestingLymphocytesIntegrin alpha4T-LymphocytesTumor Necrosis Factor-alphaHLA-A AntigensHLA-G AntigensTelomere ShorteningN-Formylmethionine Leucyl-Phenylalanine
Abdominal aortic aEndovascular aortic repairInfiltrationInflammationDecreased leukocyte countMouse aorticMitralBicuspidLeft ventricleExtravasationVascularAneurysmsAccumulationAdhesion moleculesEndothelial injuryCytokinesPlateletsGraftsValve diseaseOrgansMetabolitesPatientsValvesPhysiologicalLymphocytesCoronaryBasement MembranePerfusionPerivascularInfectionLesionPolymorphonuclearDiseasesCapillariesEdemaChronicMonocytesCardiovascular systemBloodMigrationTreatmentAntibodiesProteinsInfiltratesCerebral
Abdominal aortic a9
  • Intestinal ischemia-reperfusion (I-R) injury is a severe condition resulting from acute mesenteric ischemia, small bowel transplantation, abdominal aortic aneurysm, hemorrhage, trauma, septic shock, or severe burns. (blogspot.com)
  • Lately, it's been proven that PCAF appearance was elevated in abdominal aortic aneurysm tissues in comparison with healthy aorta tissues [19]. (campaignfornonviolentschools.org)
  • TLR2 2029C/T and TLR3 1377C/T and -7C/A Polymorphisms Are Associated with the Occurrence of Abdominal Aortic Aneurysm. (cdc.gov)
  • Common gene haplotypes of gelatinases and their tissue inhibitors in abdominal aortic aneurysm. (cdc.gov)
  • Polymorphisms in the IL-6 and TNF-a gene are associated with an increased risk of abdominal aortic aneurysm. (cdc.gov)
  • Smoking, Hypertension, and GG Genotype of the IL-6 rs1800796 Polymorphism are Independent Risk Factors for Abdominal Aortic Aneurysm in Han Population. (cdc.gov)
  • Systematic review of genome-wide association studies of abdominal aortic aneurysm. (cdc.gov)
  • An association between rs7635818 polymorphism located on chromosome 3p12.3 and the presence of abdominal aortic aneurysm. (cdc.gov)
  • Remodeling of abdominal aortic aneurysm sac following endovascular aortic repair: association with clinical, surgical, and genetic factors. (cdc.gov)
Endovascular aortic repair5
  • Recent reports have highlighted good prognostic outcomes with thoracic endovascular aortic repair. (biomedcentral.com)
  • However, thoracic endovascular aortic repair for infected thoracic aortic aneurysms is associated with an exacerbation of infection due to residual infected tissues. (biomedcentral.com)
  • A combined abscess debridement and pedicled tissue flap approach is useful for patients with poor surgical tolerance in whom infection control is difficult after thoracic endovascular aortic repair for infected thoracic aortic aneurysms. (biomedcentral.com)
  • Although open thoracic surgery (with infected lesion removal, prosthetic graft replacement, and pedicled tissue flap) has remained the main treatment for ITAAs until now, recent reports have highlighted good prognostic outcomes with thoracic endovascular aortic repair (TEVAR) [ 1 ]. (biomedcentral.com)
  • Thoracic endovascular aortic repair (TEVAR) has been chosen as a less invasive alternative for type B aortic dissections (TBADs). (biomedcentral.com)
Infiltration10
  • Histological analysis of unruptured IA tissue showed robust B and T lymphocyte infiltration in the WT group, while there were no differences in macrophage infiltration, IA diameter, and wall thickness. (biomedcentral.com)
  • Many of these changes are influenced by the infiltration of leukocytes into the vessel wall which can act to degrade the extracellular matrix (ECM) through the secretion of MMPs and promote VSMC phenotypic modulation via secretion of cytokines such as tissue necrosis factor (TNF), interleukin-1 beta, and interleukin-6 (IL-6) [ 13 ]. (biomedcentral.com)
  • Inflammatory cell infiltration (macrophages and T lymphocytes and subsequently B lymphocytes) is followed by tissue fibrosis which is present in all ruptured IA [ 16 ]. (biomedcentral.com)
  • A study of patient AAA tissue showed a reduction of VSMC markers, macrophage infiltration, and increased CD4+ and CD8+ T lymphocyte populations compared to healthy aorta. (biomedcentral.com)
  • Some years ago it was identified the presence of cross reactive antibodies in the surface of valve endothelium [6] and infiltration of T cell clones into the valve tissue [7]. (fortunejournals.com)
  • After cuff positioning, garcinol treatment led to reduced arterial macrophage and leukocyte adherence and infiltration after 3 times in comparison to neglected pets. (campaignfornonviolentschools.org)
  • It is a chronic inflammatory disease of the arterial wall, which is characterized by lipid accumulation, leukocyte infiltration and smooth muscle cell proliferation. (spandidos-publications.com)
  • Lipoxins, resolvins, protectins, and maresins are SPM derived from polyunsaturated fatty acids that limit excessive leukocyte infiltration and pro-inflammatory signals, stimulate innate microbial killing, and enhance resolution. (frontiersin.org)
  • Cardinal signs of resolution are: (1) limitation/cessation of PMN infiltration, (2) sequestration and counter-regulation of pro-inflammatory chemical mediators, (3) apoptosis of PMN and removal (e.g., by efferocytosis), (4) clearance of pathogens, inflammatory stimuli, and cell debris, and (5) tissue repair. (frontiersin.org)
  • The first event in acute inflammation is edema formation, followed by infiltration of PMN, and then monocyte and macrophages that clear PMN leading to resolution, which is essential for ensuring host protection and sparing from tissue damage. (frontiersin.org)
Inflammation6
  • Although inflammation can occur in response to any injury, including trauma, the most common known causes are infections, immunologic, or connective tissue disorders. (medscape.com)
  • Inflammation of the aorta can cause aortic dilation, resulting in aortic insufficiency. (medscape.com)
  • Archer, Order Tramadol With Paypal inflammation of the leukocyte count without visitors - assess possible blanching. (emoturismo.com)
  • The local and progressive inflammation mentioned above leads to tissue injury and cellular matrix disorganization that culminate in valvar dysfunction. (fortunejournals.com)
  • Acute inflammation is a protective process arising in vascularized tissues upon damages, altered homeostasis, and infections. (frontiersin.org)
  • Rheumatic fever causes inflammation of tissues and organs and can result in serious damage to the heart valves, joints, central nervous system and skin. (encyclopedia.com)
Decreased leukocyte count1
Mouse aortic2
  • Functional responses of ESC-EC were compared with those of cultured mouse aortic ECs. (ca.gov)
  • Related results may be observed using mouse IFN- and crazy type mouse aortic grafts implanted into IFN- receptor-deficient mouse hosts (15). (nefuri.com)
Mitral1
  • Rheumatic heart disease (RHD) is the major sequel and is characterized by valvar lesions that can cause regurgitation and/or stenosis mainly in mitral and aortic valves. (fortunejournals.com)
Bicuspid1
  • The bicuspid native aortic valve was resected the same day, and several bacterial patches were observed. (cdc.gov)
Left ventricle1
  • Systemic circulation carries oxygenated blood from the left ventricle, through the arteries, to the capillaries in the tissues of the body. (onteenstoday.com)
Extravasation1
Vascular5
  • Vascular endothelial dysfunction in thoracic aortic rings was attenuated by PMX53 treatment, but systolic blood pressure was unchanged in DOCA-salt rats. (edu.au)
  • Li C, Alfonso-Garcia A, McMasters J, Bec J, Weyers B, Uyesaka L, Griffiths L , Panitch A, Marcu L. Simultaneous intraluminal imaging of tissue autofluorescence and eGFP-labeled cells in engineered vascular grafts inside a bioreactor. (mayo.edu)
  • Subsequently, leukocytes and vascular soft muscle tissue cells (vSMCs) make pro-inflammatory cytokines which result in vSMC migration, proliferation and extracellular matrix development [1]. (campaignfornonviolentschools.org)
  • The vascular endothelium, the innermost layer of blood vessels, provides a dynamic interface between the circulating blood and various tissues/organs and thereby maintaining tissue homeostasis. (nature.com)
  • It has been shown that cigarette smoking stimulates chemokines in mast cells and upregulates vascular endothelial growth factor in lung tissue of pulmonary disease (13-14). (iranpath.org)
Aneurysms5
  • Lymphocytic infiltrates have been demonstrated in patient IA tissue specimens and have also been shown to play an important role in abdominal aortic aneurysms (AAA) and related diseases such as atherosclerosis. (biomedcentral.com)
  • The role of macrophages in IA formation and rupture has been well-characterized [ 17 ], yet the presence of other leukocyte populations has been noted in both IA and abdominal aortic aneurysms (AAA). (biomedcentral.com)
  • Open thoracic surgery (with infected lesion removal, prosthetic graft replacement, and pedicled tissue flap) has remained the main treatment for infected thoracic aortic aneurysms to date. (biomedcentral.com)
  • We discuss the control of refractory infections following endovascular treatment of infected thoracic aortic aneurysms. (biomedcentral.com)
  • Patients with infected thoracic aortic aneurysms (ITAAs) have a poor prognosis and are at a high risk of rupture. (biomedcentral.com)
Accumulation3
  • Leukocyte accumulation is a complex phenomenon that also involves endothelium-based adhesion molecules as well as leukocyte chemotaxis factors such as interleukin-8 (IL-8) [2,3]. (blogspot.com)
  • Increase in permeability of microvessels determines plasma fluid leakage and accumulation in tissues, leading to edema ( Figure 1 ). (frontiersin.org)
  • The work of Neufeld et al from the late 1960s demonstrated that mucopolysaccharide accumulation in fibroblasts from patients with Hurler and Hunter syndromes could be corrected by co-culturing them with fibroblasts or tissue extracts from patients with a different MPS. (medscape.com)
Adhesion molecules1
  • these signals activate leukocytes and microglia, leading to a substantial release of proinflammatory cytokines, upregulate the expression of leukocyte adhesion molecules, and stimulate the formation of chemokines. (hindawi.com)
Endothelial injury1
  • We have investigated gelsolin modulation in rat aortic SMC by immunohistochemistry, Western blotting and Northern hybridization using three models which are known to show modulation of actin isoform expression: development, aortic intimal thickening after experimental endothelial injury, and growth in culture. (unige.ch)
Cytokines1
  • A variety of cytokines, including TNF-α, interferon-γ, and IL-1β, are released from post-ischemic tissues [4]. (blogspot.com)
Platelets2
  • Platelets, endothelial cells, and leukocytes become activated and, in turn, initiate the coagulation cascade while releasing various mediators. (medscape.com)
  • The Research area A (systemic, non-resident mechanisms) comprises factors, signals, and cells (such as leukocytes, red blood cells, platelets, and adipocytes) and their respective messengers, that are not originating from or residing in aortic tissue. (uni-bonn.de)
Grafts1
  • Importantly, human being IFN- is definitely directly mitogenic for SMCs in the intima and press of isolated human being coronary artery segments implanted as aortic interposition grafts in immunodeficient mouse hosts (13, 14). (nefuri.com)
Valve disease1
  • Vogl BJ, Niemi NR, Griffiths LG , Alkhouli MA, Hatoum H. Impact of calcific aortic valve disease on valve mechanics. (mayo.edu)
Organs1
  • The action predisposes organs, contains the cessation, signs hospital tissues, and is Fiscal therapy proteins. (siriuspixels.com)
Metabolites1
  • By analyzing the metabolic profiles of 14 different lamprey tissues, we show that two groups of metabolites in the buccal gland of lampreys, prostaglandins and the kynurenine pathway metabolites, can be injected into the host fish to assist lamprey blood feeding. (firstpointsoftware.com)
Patients2
  • Comparison of relative telomere length measured in aortic tissue and leukocytes in patients with end stage heart failure. (nel.edu)
  • The human leukocyte antigen B27 (HLA-B27) allele is present in 90% of White patients with ankylosing spondylitis, but it is also present in up to 10% of the general population depending on ethnicity. (msdmanuals.com)
Valves1
  • aortic, tricuspid ▪ Congenital cardiac defects ▪ Damage to valves due to rheumatic heart disease ▪ IV drug use (esp. (osmosis.org)
Physiological1
  • The physiological responses to haemorrhage in mammals are aimed at the preservation of blood pressure and tissue perfusion. (scialert.net)
Lymphocytes2
Coronary1
  • We previously demonstrated that factor XI (FXI) deficiency in mice reduced the atherosclerotic plaque area in coronary sinuses and the aortic arch. (spandidos-publications.com)
Basement Membrane1
  • Basement Membrane of Tissue Engineered Extracellular Matrix Scaffolds Modulates Rapid Human Endothelial Cell Recellularization and Promote Quiescent Behavior After Monolayer Formation. (mayo.edu)
Perfusion5
  • The resulting tissue edema may interfere with nutritive capillary perfusion and oxygen delivery. (silverchair.com)
  • To prove this hypothesis, the effects of isovolemic hemodilution (hematocrit 30%) with Ringer's lactate solution or dextran 60 on tissue perfusion and oxygenation were investigated in awake Syrian golden hamsters. (silverchair.com)
  • However, tissue perfusion determined by counting perfused capillaries per terminal arteriole was reduced by 62%, and mean tissue oxygen partial pressure decreased from 19 to 8 mmHg. (silverchair.com)
  • In this model, volume replacement with artificial colloids yielded hemodynamic stability and adequate tissue oxygen supply, whereas administration of crystalloids alone jeopardized tissue perfusion and oxygenation. (silverchair.com)
  • [3] Another study on the effects of an isotonic fluid load (30% of plasma volume) demonstrated a preferential increase in the extracellular fluid of lung (14%), gastric fundus (15%), large intestine (21%), and skin (28%), suggesting that the perfusion of these tissues may be affected. (silverchair.com)
Perivascular1
  • However, the only proven cross-reaction is with perivascular connective tissue. (wikipedia.org)
Infection2
  • Rheumatic fever is a systemic disease affecting the connective tissue around arterioles, and can occur after an untreated strep throat infection, specifically due to group A streptococcus (GAS), Streptococcus pyogenes. (wikipedia.org)
  • The main job of white blood cells, or leukocytes, is to fight infection. (onteenstoday.com)
Lesion1
  • The ApoE KO mice developed an advanced atherosclerotic lesion area in the aortic arch, which was reduced by 33% in the DKO mice. (spandidos-publications.com)
Polymorphonuclear2
Diseases1
Capillaries1
  • From the tissue capillaries, the deoxygenated blood returns through a system of veins to the right atrium of the heart. (onteenstoday.com)
Edema1
Chronic1
  • Experiments were performed by using a chronic dorsal skinfold window giving access to skeletal muscle tissue (musculus cutaneus) with in vivo microscopy, quantitative video image analysis, and surface oxygen partial pressure electrodes. (silverchair.com)
Monocytes1
  • PMNs undergo rapid apoptosis and are actively removed by macrophages (MФs) differentiated from monocytes entering as a second wave in inflamed tissues in a process termed "efferocytosis" ( deCathelineau and Henson, 2003 ). (frontiersin.org)
Cardiovascular system1
  • like veins, lymph vessels transport lymph from body tissues to the chest, where it enters the cardiovascular system. (studystack.com)
Blood5
  • Combined with increased blood-brain barrier (BBB) permeability, this allows leukocytes to enter the ventricles in large numbers and remove the large amount of debris caused by cell death [ 11 , 12 ]. (hindawi.com)
  • We explore several physiologically relevant functions of ESC-derived EC (ESC-EC), such as its capacity to produce nitric oxide (NO), regulate permeability, activate and express surface molecules for the recruitment of leukocytes in response to inflammatory stimuli, migrate and grow new blood vessels, lay down extracellular matrix, and take up low-density lipoproteins. (ca.gov)
  • Blood tests revealed a markedly elevated leukocyte count, and contrast-enhanced computed tomography suggested a descending thoracic aortic pseudoaneurysm. (biomedcentral.com)
  • Materials are passed between the blood & tissue through the capillary walls. (studystack.com)
  • The vasomotor reactivity test on catfish aortic ring showed that kynurenine can also relax the blood vessels of the host fish, thus improving the blood flow of the host fish at the bite site. (firstpointsoftware.com)
Migration1
  • The high level of gelsolin in smooth muscle (SM) tissues and the down regulation with proliferation and migration raises the question as to whether gelsolin in these cells has functions other than the dynamic control of actin filament length. (unige.ch)
Treatment5
  • Biopsy and histologic/immunohistochemical examination of the affected tissue can aid in the diagnosis and determination of the extent of the disease, which in turn affect treatment management strategies. (medscape.com)
  • Likewise, treatment of (NZW×BXSB)F 1 mice with MTX enhanced AMPKα Thr172 phosphorylation and MnSOD, and reduced aortic intercellular adhesion molecule-1 expression. (bmj.com)
  • Importance in the tissues, the end, i shall have been treatment of clinical articles will welcome. (emoturismo.com)
  • Garcinol treatment decreased TNF-alpha and CCL2 manifestation, mainly because demonstrated about cultured leukocytes and vSMCs. (campaignfornonviolentschools.org)
  • The ultimate goal of the consortium is to improve prevention, detection and treatment of aortic disease. (uni-bonn.de)
Antibodies3
  • The underlying mechanism is believed to involve the production of antibodies against a person's own tissues. (wikipedia.org)
  • The antibodies which the immune system generates against the M protein may cross-react with heart muscle cell protein myosin, heart muscle glycogen and smooth muscle cells of arteries, inducing cytokine release and tissue destruction. (wikipedia.org)
  • Research more strongly supports the theory that the disease is caused by an interaction between antibodies produced to fight the group A streptococcus bacteria and the heart tissue. (encyclopedia.com)
Proteins1
  • Advanced glycation is a major pathway for the posttranslational modification of plasma and tissue proteins. (iospress.com)
Infiltrates1
  • Additional mitogens may be produced by the infiltrates of sponsor leukocytes or by graft cells, including ECs. (nefuri.com)
Cerebral1
  • Rates of IA formation and rupture were measured, and cerebral artery tissue was collected and utilized for histology and gene expression analysis. (biomedcentral.com)