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  • rupture
  • Here the authors show that tissue-specific inducible deletion of Rcan1 in vascular cell types predisposes to hypertension-mediated aortic rupture, intramural hematoma, and aneurysm, due to increased GSK-3b-mediated activation of ROCK and induction of a hypercontractile phenotype. (nature.com)
  • No stent graft-related complications were detected, although only in 1 case, an asymptomatic rupture of the Excluder connecting bar was found with a perforation of the fabric and an intra-aortic exposition of the bar itself. (ahajournals.org)
  • A break in all three layers of the aortic wall is termed a rupture. (harvard.edu)
  • 7 Nevertheless, TAA rupture is more common in the elderly, and as detailed in the sections that follow, type B aortic dissections, PAUs, and IMHs are more frequently seen in older patients. (ahajournals.org)
  • In aortic rupture, all three layers of the aortic wall burst, resulting in massive bleeding inside the body. (medicalxpress.com)
  • The term 'complicated' means persisting or recurrent pain, uncontrolled hypertension despite full medication, early aortic expansion, malperfusion, and signs of rupture (hemothorax, increasing periaortic and mediastinal hematoma). (acc.org)
  • hypertension
  • Collaboration is at the core of what we do since many of our patients have both aortic disease and high blood pressure (hypertension). (umms.org)
  • The risk of abdominal aortic aneurysms (AAAs) increases dramatically in the presence of the following factors: age older than 60 years, smoking, hypertension and Caucasian ethnicity. (uabmedicine.org)
  • This with genetic diseases like Marfan's, increasing incidence of hypertension, inflammatory disorders we are looking into an enormous number of potential patients in society which requires centers of excellence for treatment. (amrita.edu)
  • Atherosclerosis
  • Risk factors for TAD include poorly controlled high blood pressure, advancing age, male gender, atherosclerosis, inflammatory diseases that damage the blood vessels, and certain genetic conditions that weaken connective tissue, such as Marfan syndrome. (medicalxpress.com)
  • Although most investigators feel that aortic atherosclerosis is a leading cause of embolic disease, doubts have been raised. (ahajournals.org)
  • patients with aortic
  • Because the morbidity and mortality associated with open surgical repair of descending aortic replacement are much greater in the elderly population, there has been increasing interest in treating this group of patients with aortic stent grafting as an alternative to open repair. (ahajournals.org)
  • Multidisciplinary
  • Steve Harris traveled to Houston to consult with Milewicz and the clinical team at the Multidisciplinary Aortic and Vascular Disease Clinic. (redorbit.com)
  • Some people come to our Multidisciplinary Aorta Program because they have a genetic condition or other medical conditions that put them at greater risk for aortic disease. (henryford.com)
  • Multidisciplinary" means that experts from a variety of highly skilled specialties, each with experience treating different aspects of aortic disease, work together to care for your condition. (henryford.com)
  • Using a team approach to care, Henry Ford's Multidisciplinary Aorta Program provides advanced care and lifelong management for all types of aortic disorders. (henryford.com)
  • Our Multidisciplinary Aorta Program offers care for a range of aortic disorders helping you avoid life-threatening complications. (henryford.com)
  • In our center, a multidisciplinary approach to the evaluation and management of thoracic aortic disease is offered, involving specialists from cardiac and vascular surgery, cardiology, medical genetics and radiology. (barnesjewish.org)
  • 3. Patient selection should be performed on an individual basis according to anatomy, pathology, comorbidity, and anticipated durability of any repair, using a multidisciplinary approach, ideally in an aortic center. (acc.org)
  • left ventricle
  • The thoracic aorta begins where the left ventricle ends at the aortic valve and continues down through the chest. (harvard.edu)
  • In particular, the aortic valve controls the flow of oxygenated blood pumped out of the heart from the left ventricle into the aorta, the main artery leading to the rest of the body. (healthcentral.com)
  • In man, mammals, and birds, the aorta emerges from the left ventricle of the heart, forming an enlargement at its very beginning, called the aortic spindle, goes up (ascending aorta), turns back and to the left in man and mammals (arch of the aorta) and back and to the right in birds, and goes down (descending or dorsal aorta). (thefreedictionary.com)
  • One of these valves, the aortic valve , guards the passageway between the left ventricle and the aorta , your primary supply artery for oxygen-rich blood. (howstuffworks.com)
  • asymptomatic
  • 8. In asymptomatic thoracic aortic aneurysm (TAA) patients, TEVAR is indicated (by consensus) when the maximum diameter of the aneurysm exceeds 5.5 cm or if rapid expansion (>5 mm in 6 months) occurs. (acc.org)
  • occurs
  • An aortic aneurysm occurs when a portion of the aorta balloons out, increasing the diameter of the blood vessel by at least 50 percent at that spot. (medicalxpress.com)
  • It is important to recognize and treat thoracic aortic aneurysm before a life-threatening complication occurs. (barnesjewish.org)