Aortic calcification calcific aortic valve disease aortic diseases. Medical search. Frequent questions

Postrheumatic aortic stenosis is another common cause of acquired aortic stenosis, and is a result of remote infection from group A streptococci that triggers an autoimmune process resulting in scarring of the valve leaflets. (medscape.com)
Radiation and ochronosis are rare causes of acquired aortic stenosis. (medscape.com)
Those with acquired aortic stenosis generally have a long latent period before the onset of the salient clinical manifestations of the disease: effort-related dyspnea (heart failure), angina, and syncope. (mhmedical.com)

Bicuspid and unicuspid aortic valve disease are congenital conditions. (medscape.com)
Bicuspid and unicommissural unicuspid valves generally function normally for the first few decades, after which superimposed degenerative changes occur, at a faster rate that normal trileaflet aortic valves. (medscape.com)
Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve. (yalemedicine.org)
The pathogenesis of aortic stenosis is most commonly progressive calcification and degeneration of a trileaflet or congenitally bicuspid valve. (mhmedical.com)
Aortic stenosis can be caused by congenital bicuspid aortic valve, scarred aortic valve of rheumatic fever, and wearing of aortic valve in the elderly. (digestivetracthealth.com)
Progressive wear and tear of a bicuspid valve present since birth (congenital). (digestivetracthealth.com)
Bicuspid aortic valve is the most common cause of aortic stenosis in patients under age 65. (digestivetracthealth.com)
About 2% of people are born with aortic valves that have only two cusps (bicuspid valves). (digestivetracthealth.com)
Although bicuspid valves usually do not impede blood flow when the patients are young, they do not open as widely as normal valves with three cusps. (digestivetracthealth.com)
Therefore, blood flow across the bicuspid valves is more turbulent, causing increased wear and tear on the valve leaflets. (digestivetracthealth.com)
About 10% of bicuspid valves become significantly narrowed, resulting in the symptoms and heart problems of aortic stenosis. (digestivetracthealth.com)
In patients with a bicuspid aortic valve (BAV), these degenerative changes occur at an earlier age as a consequence of the abnormal hemodynamics across the valve leaflets. (medscape.com)
A transesophageal echocardiogram showed a bicuspid aortic valve with thickened, calcific leaflets and severe regurgitation and a mobile vegetation attached to the mitral valve cordae with subvalvular calcifications. (cdc.gov)
There are three known causes of AS- progressive congenital wear and tear of a bicuspid valve, deterioration of the aortic valve in elderly people, and scarring of the aortic valve caused by rheumatic fever as a young adult or child. (cprtampa.training)
A bicuspid valve is the most common cause of AS. (cprtampa.training)

The most common cause of aortic stenosis in patients 65 years of age and over is called "senile calcific aortic stenosis. (digestivetracthealth.com)
In patients over age 65, protein collagen in the leaflets is lost and calcium deposits on them, this is called "senile calcific aortic stenosis. (cprtampa.training)

In November 2021, Vifor Pharma Group acquired Sanifit with its novel inhibitor of vascular calcification SNF472 for the treatment of calcific uremic arteriolopathy (CUA) and peripheral artery disease (PAD) in patients with end-stage kidney disease. (wikipedia.org)
Acquisition of Sanifit is for the continued clinical development and commercialization of SNF472, a novel, first-in-class intravenously administered inhibitor of vascular calcification, for the treatment of CUA and PAD in patients with end-stage kidney disease. (menafn.com)

Sources of cardioembolic embolism include valvular diseases, left ventricular and atrial thrombi, cardiac tumors, and paradoxical emboli, as well as other sources. (medscape.com)
Congenital aortic stenosis is classified as valvular, subvalvular, and supravalvular. (medscape.com)
Aortic stenosis (AS) is the most common valvular heart disease among Western populations and severe AS has an estimated prevalence of 3-4% among people older than 75 years of age. (cardiologyonline.com)
Innovations in Microscopic Imaging of Atherosclerosis and Valvular Disease -- Part III. (nshealth.ca)
Therefore, we are faced with an epidemic of aging and age-associated disease, not the least of which is valvular heart disease. (mhmedical.com)
The researchers, led by Nicholas Kassis, MD, Cleveland Clinic Foundation, Cleveland, Ohio, explain that aortic stenosis is the most common adult valvular disease in the developed world. (healthybodyart.com)

Rheumatic valve disease is a rare cause of aortic stenosis in industrialized nations. (mhmedical.com)
The third cause of aortic stenosis is damage from rheumatic fever. (cprtampa.training)

Aortic stenosis can be caused by acquired conditions, be the result of a congenital malformation, or be a result of a combination of acquired and congenital processes. (medscape.com)

A gradient of between 20 and 40 mm Hg is considered moderate, and more than 40 mm Hg severe aortic stenosis, according to American Heart Association guidelines. (medscape.com)
Patients with severe calcific degenerative aortic stenosis can be categorized into three clinical groups at the time of diagnosis: those without evidence of congestive heart failure, those with chronic congestive heart failure, and those with acute heart failure requiring hospitalization. (medscape.com)
Those with end-stage renal disease, Paget disease, or severe familial hypercholesterolemia may present with calcific aortic stenosis at a younger age and are susceptible to more rapid progression of stenosis severity. (mhmedical.com)
The condition is marked by severe calcification causing leaflet immobility and outflow obstruction, a process that occurs over a mean duration of 8 years and leads to dramatically increased mortality if left untreated once symptoms develop. (healthybodyart.com)
Other high-risk cardiac sources of emboli, including left ventricular aneurysm, severe cardiomyopathy, aortic or mitral mechanical heart valve, severe calcific aortic stenosis (valve area (mayo.edu)
If severe AS is found, aortic valve replacement, either mechanical or bio-prostheses (from pigs or cows) is the usual treatment. (cprtampa.training)

Shklover J, McMasters J, Alfonso-Garcia A, Higuita ML, Panitch A, Marcu L, Griffiths L . Bovine pericardial extracellular matrix niche modulates human aortic endothelial cell phenotype and function. (mayo.edu)

Optical Molecular Imaging of Inflammation and Calcification in Atherosclerosis -- 6. (nshealth.ca)
PET/CT Imaging of Inflammation and Calcification in CAVD: Clinical Studies -- 11. (nshealth.ca)
Clinical Imaging of Cardiovascular Inflammation and Calcification -- 13. (nshealth.ca)
PET/CT Imaging of Inflammation and Calcification -- 16. (nshealth.ca)
The authors contend that "no diet, drug, or therapy has shown clinical trial evidence of reversing every measurable indicator of heart disease, including inflammation, clotting, and soft and hard plaques that contain calcium deposits. (alive.com)
PGRN has been introduced among the secreted growth factors as one related to wound healing, inflammation, and human embryonic development, as well as a wide variety of autoimmune diseases. (biomedcentral.com)
Although once thought to be a degenerative process, it is now recognized that calcific aortic stenosis is in fact an active disease process that shares similarities to atherosclerosis and involves inflammation, lipid accumulation, and calcification of the leaflets. (mhmedical.com)
Over time, inflammation, atherosclerosis and calcification thicken the aortic valve leaflets and restrict mobility. (medscape.com)

The velocity ratio (peak velocity in the left ventricular outflow tract/peak velocity across the aortic valve) was a supplementary criterion for aortic stenosis. (nih.gov)
Angiotensin-converting enzyme polymorphisms and their potential impact on left ventricular myocardial geometry after aortic valve surgery. (cdc.gov)
Influence of ACE I/D genotypes on left ventricular hypertrophy in aortic stenosis: gender-related differences. (cdc.gov)
Can angiotensin II +1675 G/A type 2 receptor gene polymorphism be a marker of left ventricular hypertrophy in patients with aortic stenosis? (cdc.gov)

Valve regurgitation and cusp calcification were assessed visually. (nih.gov)
Aortic regurgitation, mostly mild, was found in 29% of the entire study cohort. (nih.gov)
Rheumatic aortic stenosis usually occurs with some degree of aortic regurgitation. (digestivetracthealth.com)
CT is prone to artefact in older valves and showed no advantage over echocardiography for detection of vegetations or periprosthetic regurgitation. (shda.org.au)

Evaluation of valve disease is typically performed by echocardiography. (medscape.com)
42% women) with mild to moderate native aortic stenosis selected from the Cleveland Clinic Echocardiography Database from 2008 to 2016 and followed for a median duration of 69 months. (healthybodyart.com)
An echocardiography obtains images of heart chambers and valves, showing the damaged valve. (cprtampa.training)
Quantitative Modeling of the Mitral Valve by Three-Dimensional Transesophageal Echocardiography in Patients Undergoing Mitral Valve Repair: Correlation with Intraoperative Surgical Technique. (shda.org.au)
performed a retrospective analysis of 94 patients who underwent 3D transesophageal echocardiography prior to mitral valve repair to determine predictive parameters for surgical planning. (shda.org.au)
Echocardiography is the standard for follow-up of prosthetic heart valve (PHV) function, but has several well-known limitations. (shda.org.au)

In contrast to calcific aortic valve stenosis, the rheumatic valve shows adhesion, leaflet retraction, and commissural fusion. (mhmedical.com)
Along or just a few millimeters away from the free margins of the valve leaflets, small sessile nodules develop that also contribute to leaflet malcoaptation. (mhmedical.com)
Turbulence across the valve increases causing scarring, thickening, and stenosis of the valve once valve leaflet mobility is reduced by calcification. (digestivetracthealth.com)
Dysregulated phosphate calcium metabolism is a major determinant in the development of aortic leaflet sclerosis and calcified aortic stenosis, as triggered by impaired renal function, and in primary or secondary hyperparathyroidism , she reports. (healthybodyart.com)

Echocardiogram and cardiac catheterization are important tests in diagnosing and evaluating severity of aortic stenosis. (digestivetracthealth.com)
From this information, what can we learn about the disease progression and severity? (academicminute.org)
Treatment of aortic stenosis depends on the severity of the condition. (cprtampa.training)
Influence of angiotensin-converting enzyme gene insertion/deletion polymorphism on rheumatic valve involvement, valve severity and subsequent valve calcification. (cdc.gov)

Aortic sclerosis, which is clinically defined as valve thickening without obstruction to outflow, is the most prevalent valve disease in developed countries, being present in about 25% of patients over age 65 years. (medscape.com)
Bellamkonda K, Zogg C, Nassiri N, Sadeghi M , Zhang Y, Guzman R, Chaar C. Characteristics and 1-year outcomes of patients with rupture of small abdominal aortic aneurysms. (yalemedicine.org)
Coronary CT angiography (CCTA) is revolutionizing the noninvasive assessment of patients with suspected coronary artery disease (CAD). (cardiologyonline.com)
Transcatheter aortic valve replacement (TAVR) has revolutionized the treatment of aortic stenosis and is the treatment of choice for patients at prohibitive and high surgical risk. (ahajournals.org)
In patients receiving first‐generation valves, ≈12% of patients experienced a major vascular complication and 16% a life‐threatening bleed, as defined by the Valve Academic Research Consortium criteria. (ahajournals.org)
Vifor Pharma has announced the acquisition of Sanifit Therapeutics, a Spanish clinical-stage cardio-renal biopharmaceutical company focused on treatments for end-stage kidney disease patients with progressive vascular calcification disorders, and Inositec AG, a Swiss company, developing first-in-class non-dialysis treatments for soft tissue and vascular calcification disorders. (menafn.com)
Inositec's novel asset INS-3001, is a once-daily subcutaneous treatment for patients with vascular calcification disorders PAD and AVS, which are both major contributors to cardiovascular morbidity and mortality in affected patient populations. (menafn.com)
With INS-3001 daily subcutaneous dosing, patients with earlier stages of vascular calcification can be optimally treated, while end-stage kidney disease patients will benefit from the three times per week dosing regimen of SNF472. (menafn.com)
Vifor Pharma will be spearheading the vascular calcification field, emphasizing our strategic focus to bring innovative assets to patients with high unmet medical need as we strive to improve lives of people suffering from serious diseases around the world. (menafn.com)
Vifor Pharma is the ideal partner to take the development of Sanifit's calcification franchise forward and bring these novel treatments to patients as quickly as possible. (menafn.com)
This acquisition builds on years of hard work from the entire Inositec team and provides a strong foundation for improving outcomes for patients suffering from cardiovascular and vascular calcification disorders," said Mattias Ivarsson, Founder and Chief Executive Officer of Inositec, adding"Inositec's transition to a clinical-stage company represents an ideal time to partner with Vifor Pharma to accelerate the clinical development of INS-3001. (menafn.com)
Sanifit conducted a phase-IIb trial (CaLIPSO) in 274 patients to assess the effect of SNF472 on slowing arterial calcification, a major risk factor for cardiovascular disease in dialysis patients. (menafn.com)
Patients with aortic stenosis are usually given antibiotics prior to any procedures which might introduce bacteria into the bloodstream, such as dental procedures and surgeries. (digestivetracthealth.com)
Patients with aortic stenosis who have symptoms may require surgical heart valve replacement. (digestivetracthealth.com)
Why this aging process progresses to cause significant aortic stenosis in some patients but not in others is unknown. (digestivetracthealth.com)
Both patients underwent aortic valve replacement surgery. (biomedcentral.com)
These data highlight the need for ruling out Whipple's disease in patients with a history of arthralgia prior to initiation of biological agents in treatment of rheumatoid arthritis. (biomedcentral.com)
A symptomatic disease only develops in patients with partially defined immunologic defects, i.e. (biomedcentral.com)
1994. Pancreatitis in patients with end-stage renal disease. (uc.edu)
Immunoproteomic Identification of Noncarbohydrate Antigens Eliciting Graft-Specific Adaptive Immune Responses in Patients with Bovine Pericardial Bioprosthetic Heart Valves. (mayo.edu)
Oral calcium supplementation was associated with lower survival and a greater need for aortic valve replacement in elderly patients with mild to moderate aortic stenosis , a new study finds. (healthybodyart.com)
Aortic valve replacement was performed in almost half of the patients taking calcium, compared with only 11% of those not taking any supplements. (healthybodyart.com)
The risks of all-cause and cardiovascular mortality were also higher in patients supplementing with calcium who did not undergo aortic valve replacement. (healthybodyart.com)
As with many diseases, the most important thing for patients with aortic valve stenosis is careful monitoring. (cprtampa.training)
Research continues to improve lives of the people diagnosed with this disease and increase life expectancy of patients. (cprtampa.training)
Human leukocyte antigen (HLA) class I and II alleles in Turkish patients with rheumatic heart disease. (cdc.gov)
The combined effects of clinical factors and CYP2C9 and VKORC1 gene polymorphisms on initiating warfarin treatment in patients after cardiac valve surgery. (cdc.gov)
General agreement on the best anesthetic management of patients undergoing transcatheter aortic valve implantation (TAVI) is lacking. (shda.org.au)
Measures of ventilatory efficiency are prognostic of mortality in patients who may require transcatheter pulmonary valve implantation (TPVI), and speckle-tracking echocardiographic (STE) measures of RV function appear to improve after TPVI. (shda.org.au)

On the same day, Vifor announced the acquisition of Swiss-based Inositec who develops treatments for soft tissue and vascular calcification disorders and aortic valve stenosis (AVS). (wikipedia.org)
Through these acquisitions, Vifor Pharma will be able to serve a continuum of vascular calcification disorders at all stages of CKD. (menafn.com)
These acquisitions are a perfect fit for our expanding nephrology pipeline, which now includes vascular calcification inhibition treatments across various stages of non-dialysis CKD and even non-CKD patient populations. (menafn.com)
This agreement is a testament to the enduring commitment of our dedicated team and investors, as well as our unique approach to combat vascular calcification, which originated from the University of the Balearic Islands. (menafn.com)

Hardening of the aortic valve, usually by degenerative calcification, with a jet velocity of less than 5 mm/second is considered aortic sclerosis and is asymptomatic. (medscape.com)
The incidence of symptomatic stenosis, a more advanced form of sclerosis that causes symptoms, is approximately 5 in 10,000 and is generally a disease of the elderly. (medscape.com)

He was given empiric vancomycin and ceftriaxone and underwent an aortic valve and aortic root replacement and mitral valve repair. (cdc.gov)

The pathologic findings, clinical symptoms, and treatment are similar to degenerative aortic stenosis in trileaflet valves. (medscape.com)
The idea that bacteria could be responsible for abnormal calcification in arteries, tissues, and organs is a very difficult concept to grasp in the context of a medical system that focuses on drugs and surgeries that treat the symptoms more often than the causes of disease. (alive.com)
When susceptible healthy animals are infected with pathogens from the pure culture, the specific symptoms of the disease must occur. (alive.com)

At present, the most common cause of valve replacement in the United States is aortic stenosis secondary to calcification. (medscape.com)
The prognosis is especially poor in the setting of acute heart failure, for which aortic valve replacement provides the least benefit. (medscape.com)
Impact of Complications During Transfemoral Transcatheter Aortic Valve Replacement: How Can They Be Avoided and Managed? (ahajournals.org)
Aortic stenosis, the narrowing of the aortic valve orifice caused by failure of the leaflets to open normally, is now the most common indication for valve replacement in North America and Europe. (mhmedical.com)
With no proven pharmacological therapy, aortic valve replacement is the only treatment modality. (healthybodyart.com)
When stratifying by osteoporosis status, the differences in rates of survival and aortic valve replacement persisted between the groups. (healthybodyart.com)
Strengthened by its large sample size and extended follow-up period, our study suggests that calcium supplementation does not confer any cardiovascular benefit, and instead may reflect an elevated overall risk of aortic valve replacement and mortality especially in those not undergoing aortic valve replacement," the authors say. (healthybodyart.com)
Identifying susceptible risk factors for valve calcification, which might be modified by noninvasive measures, such as targeted medication or dietary changes, instead of the purely mechanical surgical aortic valve replacement approach, is highly desirable," she adds. (healthybodyart.com)
It gives an overview of considerations for sedation in specific procedures such as TOE and transcatheter aortic valve replacement, as well as specific recommendations and guidelines derived from the new guidance document. (shda.org.au)

Intraoperatively, chronic changes in the aortic root near the right coronary cusp were observed and believed to be suggestive of a previous endocarditic process with a healed area of disruption. (cdc.gov)

Very rarely the heart is involved in the process of the disease, leading to culture-negative infective endocarditis. (biomedcentral.com)

The first patient was a 55 year-old Caucasian male with culture-negative Whipple-related adhesive pericarditis and endocarditis of the aortic valve. (biomedcentral.com)
Aortic valve endocarditis developed during treatment with tocilizumab. (biomedcentral.com)
The second patient was a 65-year-old male patient with no prior history of the classic Whipple's disease who presented with a culture-negative aortic valve endocarditis. (biomedcentral.com)
The increased recognition rate led to the insight that Whipple's endocarditis can occur without other classical manifestations of Whipple's disease [ 4 ]. (biomedcentral.com)
However, it may make significant contributions in detection of obstruction cause (pannus or thrombus), bioprosthesis calcifications, and endocarditis extent. (shda.org.au)

We aimed to evaluate sex differences in cardiorespiratory fitness in a relatively healthy population and its association with cardiovascular disease (CVD) events. (cardiologyonline.com)
PRACTICAL APPLICATIONS: Moringa oleifera has been a vocal appetite in mitigating cardiovascular disease induced by diabetes, but the formulation of a medicinal diet as an ameliorative route of attention to the pathology is fairly addressed, not talking of its combination with the synthetic antidiabetic drug, such as ACA. (bvsalud.org)
The primary thrust of the lab is on cardiovascular disease-the leading global cause of death. (fiu.edu)
She says the safety of artificial supplementary calcium intake has to be considered "in an individual and careful view," and that evaluation of underlying cardiovascular disease and risk factors should be taken into account when considering the prevention and treatment of osteoporosis. (healthybodyart.com)

With aging, protein collagen of the valve leaflets is destroyed, and calcium is deposited on the leaflets. (digestivetracthealth.com)

Regardless of the etiology, calcification of the aortic valve leads to stenosis, inevitably resulting in a fixed obstruction to LV emptying. (medscape.com)

These technologies serve as tools for the research and diagnosis of diseases such as age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy. (fiu.edu)
Progressive calcific degeneration of the trileaflet aortic valve is the most common cause of AS, especially in the elderly population. (medscape.com)

Pulmonary arterial hypertension is a group of diseases, probably with a genetic predisposition and possibly an environmental trigger, leading to elevated pulmonary arterial tree resistance, right heart failure, and a generally poor prognosis. (cardiologyonline.com)

In response to the progressive narrowing of the aortic valve opening, the LV myocardium becomes hypertrophic in order to generate increased pressure during systole and thus force blood past the obstruction. (medscape.com)
In an accompanying editorial , Jutta Bergler-Klein, professor of medicine and cardiology at the Medical University of Vienna, Austria, notes that calcification is the cardinal process driving a vicious cycle that propagates aortic valve stiffness and obstruction. (healthybodyart.com)

The age of persons treated actively for valve disorders is increasing. (nih.gov)
From the very beginning, Sanifit has been a pioneer of new approaches to treat calcification disorders, a huge area of unmet need. (menafn.com)

Currently the team focuses on developing non-destructive optical and mechanical techniques that can detect disease development and tissue injuries in vivo. (fiu.edu)

Similarly, since 1990 there has been mounting evidence that abnormal calcification may be caused by a bacterial organism about 1/100 the size of a conventional bacterium, called Nanobacterium sanguineum ("nano" is the Latin word for very small or minute). (alive.com)
While other microbes like Chlamydia and assorted fungi have been implicated in the development of abnormal calcification, research indicates that the more likely cause may be nanobacteria. (alive.com)
Most medical doctors believe that the cause of abnormal calcification is, as yet, unexplained. (alive.com)
Aortic stenosis is abnormal narrowing of the aortic valve. (digestivetracthealth.com)

Acquired stenosis of the aortic valve, which affects adults, is most often caused by calcification of the leaflets themselves and is considered an age-related or degenerative process. (medscape.com)
Rheumatic fever, caused by streptococcal bacteria, damages the valve leaflets themselves by making the edges of the leaflets fuse together. (cprtampa.training)

Other rare causes of aortic stenosis include connective tissues diseases such as systemic lupus erythematosus and ochronosis. (mhmedical.com)

The systolic aortic valve area was calculated by the continuity equation. (nih.gov)

The Anesthetic Management of Transcatheter Aortic Valve Implantation. (shda.org.au)

Imaging Insights into Mechanisms of Calcific Aortic Valve Disease (CAVD) and Calcification -- 9. (nshealth.ca)
The mechanisms by which some valves degenerate and become stenotic while others remain relatively normal are unknown but are probably related to genetic polymorphisms. (mhmedical.com)

Over time, excessive wear and tear leads to calcification, scarring, and reduced mobility of the valve leaflets. (digestivetracthealth.com)

Scarring of the aortic valve due to rheumatic fever as a child or young adult. (digestivetracthealth.com)
Damage to valve leaflets from rheumatic fever causes increased turbulence across the valve and more damage. (digestivetracthealth.com)
The narrowing from rheumatic fever occurs from the fusion (melting together) of the edges (commissures) of the valve leaflets. (digestivetracthealth.com)
Angiotensin-converting enzyme genotype predicts valve damage in acute rheumatic fever. (cdc.gov)

Calcification is an intrinsic part of the degenerative process. (medscape.com)

Excessive fructose consumption exacerbates the progression of nonalcoholic fatty liver disease (NAFLD) by disrupting hepatic lipid homeostasis. (cabi.org)
Many types of cardiovascular diseases (CVDs) are associated with complex immune responses that can significantly contribute to their progression and remission. (biomedcentral.com)
Bergler-Klein points out that osteoporosis and lower bone mineral density have been associated with faster progression of aortic stenosis (AS), but in the present study, the mortality increase with calcium supplementation was independent of the osteoporosis status at entry. (healthybodyart.com)

Only a minority of those with potentially operable aortic valve stenosis undergo surgery. (nih.gov)

2017). Aortic stenosis. (mhmedical.com)

Calcific aortic valve disease occurs on previously normally-functioning valves, either bi- or trileaflet, and less commonly on unicuspid valves. (medscape.com)

Calcific lesions involving the mitral subvalvular apparatus were resected and tested by pathologic analysis. (cdc.gov)

Congenital aortic stenosis becomes symptomatic in childhood. (medscape.com)

Although entirely preventable, rheumatic heart disease (RHD), a disease of poverty and social disadvantage resulting in high morbidity and mortality, remains an ever-present burden in low-income and middle-income countries (LMICs) and rural, remote, marginalised and disenfranchised populations within high-income countries. (bmj.com)

Are heart disease, dental plaque, kidney stones, and a host of other calcium-deposit diseases really caused by an infection? (alive.com)
Researchers have been able to isolate nanobacteria from coronary artery disease plaque and have observed kidney stones in animals exposed to nanobacteria. (alive.com)
Some better known examples of pathological mineralization are kidney stones and calcific aortic valve disease. (academicminute.org)

Aortic stenosis occurs three times more commonly in men than women. (digestivetracthealth.com)

This study was undertaken to elucidate the prevalence of aortic valve abnormalities in the elderly. (nih.gov)
Calcific aortic valve stenosis constitutes a significant health problem in the elderly. (nih.gov)
Wear and tear of the aortic valve in the elderly. (digestivetracthealth.com)
Peptic ulcer disease in the elderly. (uc.edu)
The researchers point out that although it is a disease of the elderly, multiple modifiable risk factors for aortic stenosis have also been identified, including raised cholesterol levels, smoking, and increased serum ionized calcium, parathyroid hormone , and vitamin D3. (healthybodyart.com)

Cardiac PET Imaging in Coronary Artery Disease -- 15. (nshealth.ca)

Alcoholic liver disease (ALD), a spectrum of liver abnormalities induced by chronic alcohol abuse, continues to be the major cause of life-threatening liver disease in developed countries. (cabi.org)

Blood is pumped by the left ventricle across the aortic valve into the aorta and the arteries of the body. (digestivetracthealth.com)
The flow of blood to the arteries of the body is impaired when aortic stenosis exists. (digestivetracthealth.com)

In adults, three conditions are known to cause aortic stenosis. (digestivetracthealth.com)

See also Aortic Stenosis , Pediatric Valvar Aortic Stenosis , Pediatric Rheumatic Heart Disease , and Pathology of Rheumatic Heart Disease . (medscape.com)
Macrophages and dendritic cells are also present in normal heart valves. (biomedcentral.com)
Aortic stenosis is narrowing of the aortic valve, impeding delivery of blood from the heart to the body. (digestivetracthealth.com)
Aortic stenosis can cause chest pain, fainting, and heart failure leading to shortness of breath. (digestivetracthealth.com)
The heart is a muscular pump with four chambers and four heart valves. (digestivetracthealth.com)
Heart valves are thin leaflets of tissue which open and close at the proper time during each heart beat cycle. (digestivetracthealth.com)
The main function of these heart valves is to prevent blood from flowing backwards. (digestivetracthealth.com)
Picture of heart and valves -- aortic valve stenosis. (digestivetracthealth.com)
The progressive disease causing aortic calcification and stenosis has nothing to with healthy lifestyle choices, unlike the calcium that can deposit in the coronary artery to cause heart attack. (digestivetracthealth.com)
Effect of cyclic deformation on xenogeneic heart valve biomaterials. (mayo.edu)
Aortic stenosis in some cases can lead to heart failure and sudden death. (cprtampa.training)
With the damaged aortic valve the heart has trouble keeping up with the blood pressure drop, leading the patient to faint. (cprtampa.training)
Shortness of breath due to heart failure is thought to be the most worrying sign of aortic stenosis. (cprtampa.training)
The Journal of heart valve disease 2002 Jul 11 (4): 478-84. (cdc.gov)
The Journal of heart valve disease 2002 Nov 11 (6): 830-6. (cdc.gov)
The Journal of heart valve disease 2003 Jul 12 (4): 475-81. (cdc.gov)
The Journal of heart valve disease 2003 Jan 12 (1): 7-10. (cdc.gov)
The Journal of heart valve disease 2003 Nov 12 (6): 687-95. (cdc.gov)
The Journal of heart valve disease 2004 Jul 13 (4): 574-81. (cdc.gov)
The Journal of heart valve disease 2004 Jan 13 (1): 33-7. (cdc.gov)
The Journal of heart valve disease 2005 May 14 (3): 277-81. (cdc.gov)
The Journal of heart valve disease 2007 May 16 (3): 293-9. (cdc.gov)
Human leukocyte antigen (HLA) class II association with rheumatic heart disease in Pakistan. (cdc.gov)
The Journal of heart valve disease 2007 May 16 (3): 300-4. (cdc.gov)
The Journal of heart valve disease 2007 Sep 16 (5): 495-503. (cdc.gov)
The Journal of heart valve disease 2009 May 18 (3): 262-7. (cdc.gov)
The Journal of heart valve disease 2012 Sep 21 (5): 5. (cdc.gov)
The Journal of heart valve disease 2013 Jan 22 (1): 133-41. (cdc.gov)
Multimodality Imaging Assessment of Prosthetic Heart Valves. (shda.org.au)

This chest pain is caused by the higher pressure needed to pump blood through the damaged aortic valve and oxygen demand of the thickened muscle. (cprtampa.training)

The impacted genes are involved in diseases including Alzheimer's, obesity and familial cancers, highlighting the importance of VNTRs for understanding the genetic basis of complex diseases. (escholarship.org)

Anatomy12

Diseases34

Chemicals and Drugs8

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes4

Health Care8

Acquired aortic stenosis3

Bicuspid15

Senile calcific aortic stenosis2

Inhibitor of vascular calcification2

Valvular6

Cause of aortic stenosis2

Stenosis can be caused1

Severe6

Human aortic1

Inflammation8

Left ventricular4

Regurgitation4

Echocardiography6

Leaflet4

Severity4

Patients29

Vascular4

Sclerosis2

Mitral valve1

Symptoms3

Replacement9

Cusp1

Infective endocarditis1

Endocarditis5

Cardiovascular disease4

Protein collagen1

Etiology1

Degeneration2

Arterial1

Obstruction2

Disorders2

Mechanical1

Abnormal4

Leaflets themselves2

Systemic lupus erythem1

Systolic1

Transcatheter1

Mechanisms2

Wear and tear l1

Rheumatic fever4

Degenerative process1

Progression3

Undergo1

20171

Trileaflet1

Subvalvular1

Symptomatic1

Mortality1

Kidney stones3

Commonly1

Elderly5

Coronary artery1

Abnormalities1

Arteries2

Adults1

Heart29

Chest pain1

Familial1