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  • thoracic aorta
  • In the thoracic aorta, the impairment of vasorelaxation response to acetylcholine and atherosclerotic lesion was attenuated by DYSGT. (hindawi.com)
  • Vascular reactivity, nitric oxide (NO·) and reactive oxygen species (ROS) generation, co-immunoprecipitation were assessed in thoracic aorta from male wild-type (WT), B 1 - (B 1 R −/− ), B 2 - (B 2 R −/− ) knockout mice. (frontiersin.org)
  • First, we show that B 1 - and B 2 -kinin receptors form heteromers with nNOS and eNOS in thoracic aorta. (frontiersin.org)
  • Importantly, our results show that kinin receptors regulate ACh-induced relaxation via nNOS signaling in thoracic aorta with no changes in NO· donor-induced relaxation. (frontiersin.org)
  • Following the intervention, the thoracic aorta was dissected out from each animal and sectioned into rings, some of which were then mounted into an ex vivo wire tension myograph system. (avstim.com)
  • The effects of pressure-driven convection and vessel wall stretching in the pressure-related changes in low-density lipoprotein (LDL) and albumin transport across the arterial wall were studied in vitro in freshly excised rabbit thoracic aorta held at in vivo length and pressurized at 70, 120, or 160 mm Hg for 30 minutes. (ahajournals.org)
  • 8 To determine the relative contribution of pressure-driven convection and vessel wall stretching in the pressure-related changes in LDL and albumin transport across the arterial wall, we developed an experimental in vitro model that allows modification of the intraluminal pressure without changing the wall distension in rabbit thoracic aorta, using a rigid external support wrapped around the aortic wall. (ahajournals.org)
  • Moreover
  • Moreover, RBEE supplements attenuated structural changes of adipose tissue and normalized the expression of pro-inflammatory markers such as TNF-alpha, IL-6, IL-1β and iNOS and proinflammatory macrophage polarization of Zucker rats and diet induced obesity-mice. (us.es)
  • Arterial
  • We determined the effects of repeated episodes of air-jet stress (six episodes given 5 minutes apart) on mean arterial pressure and vascular resistances in the mesenteric bed and intact and sympathetically denervated hindlimb beds of conscious rats treated with saline or the nitric oxide synthesis inhibitor N ω -nitro- l -arginine methyl ester (L-NAME, 25 μmol/kg IV). (ahajournals.org)
  • Exposure of the rat to a noxious environmental stimulus such as AJS elicits a defense reaction that includes behavioral phenomena and hemodynamic changes, such as a modest increase in arterial blood pressure, tachycardia, vasoconstriction in the renal and mesenteric vascular beds, and marked vasodilation in the hindquarter bed. (ahajournals.org)
  • glucose
  • Although Yishen capsule could reduce urinary protein level, it has little effect on blood glucose level in the rats injected with STZ. (biomedcentral.com)
  • Figure 1: Age-dependent evolution of glucose metabolism in ZDF rats. (pelvipharm.com)
  • liver
  • The aim of this study was to investigate the possible protective effects of adalimumab (ADA) on cell damage in rat liver tissue during ischemia/reperfusion (I/R) injury of infrarenal abdominal aorta. (hindawi.com)
  • Triacylglycerol content decreased in the liver of Zucker-Lepr fa/fa rats that were fed L. rhamnosus , B. breve , or the mixture of B. breve and L. paracasei . (bestprobioticsforibs.com)
  • Likewise, the area corresponding to neutral lipids was significantly smaller in the liver of all four groups of Zucker-Lepr fa/fa rats that received probiotics than in rats fed the placebo. (bestprobioticsforibs.com)
  • vessels
  • Coronary blood flow commences through the aorta where oxygenated bloodstream flows in to the primary right and primary remaining coronary arteries and branches into smaller sized arteries, arterioles, capillaries, venules, as well as the blood vessels. (healthyconnectionsinc.com)
  • There can be an improvement when vessels of such rats are incubated with Tiron (a non-specific free of charge radical scavenger), recommending reactive air species like a system of endothelial dysfunction . (healthyconnectionsinc.com)
  • New research presented today at the Experimental Biology 2016 meeting in San Diego finds that aerobic exercise kept the blood vessels of stressed rats working normally. (avstim.com)
  • Blood vessels of exercising stressed rats enlarged more when stimulated than the blood vessels of stressed rats who did not exercise -- a sign of better vascular health. (avstim.com)
  • vasodilation
  • In this study, we examined whether air-jet stress-induced active sympathetic hindlimb vasodilation in conscious rats involves the release of preformed stores of nitric oxide-containing factors. (ahajournals.org)
  • In saline-treated rats, air-jet stress produced alerting behavior, minor changes in blood pressure, pronounced mesenteric vasoconstriction, and immediate and marked vasodilation in the sympathetically intact hindlimb but a minor vasodilation in the sympathetically denervated hindlimb. (ahajournals.org)
  • The progressive diminution of air-jet stress-induced vasodilation in the intact hindlimb of L-NAME-treated rats may be due to the use-dependent depletion of preformed stores of nitric oxide-containing factors that cannot be replenished in the absence of nitric oxide synthesis. (ahajournals.org)
  • protein
  • Notably, the activities of Nox and G6PD in the fa/fa rat heart were inhibited by chelerythrine, a protein kinase C inhibitor. (nih.gov)
  • Nitric
  • The obstruction of the aorta and consequent reperfusion leads to distant organ injury via multiple mechanisms including neutrophilic infiltration, the production of reactive oxygen species (ROS), the release of cytokines such as the tumor necrosis factor-alpha (TNF- ) and elevation of nitric oxide (NO) levels [ 2 - 4 ]. (hindawi.com)
  • Nitric oxide-dependent bradycardia in mutant analbuminemic rats. (biomedsearch.com)
  • chronic
  • Kent Lemaster, graduate student at West Virginia University, will present "Reversing the Effects of Chronic Stress on the Aorta with Exercise Training" on April 5. (avstim.com)
  • expression
  • We found that stent-induced vascular injury in obese, hyperlipidemic rats had increased neointimal heparanase expression and that the magnitude of this increase directly related to the extent of neointimal expansion. (ahajournals.org)
  • heart
  • Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the develo. (nih.gov)
  • Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. (nih.gov)