Anti apoptotic. Medical search. Frequent questions

The Anti-apoptotic Ras signaling cascade is an intracellular signal transduction cascade that involves the Ras protein and inhibits apoptosis. (wikipedia.org)
The purposes of this study were to determine the effect of eccentric exercise-induced muscle damage on the induction of apoptosis in peripheral blood leukocytes and to investigate if the elevation in apoptotic leukocytes was mediated by changes in the concentration of anti-/pro-apoptotic proteins in circulation. (nih.gov)
In comparison to other forms of cell death, such as necrosis and pyroptosis, apoptosis usually promotes an anti-inflammatory response 3 . (nature.com)
IAV was able to induce monocyte apoptosis and apoptotic cell disassembly in both in vitro and in vivo settings. (nature.com)
Consistent with the anti-apoptotic function of BTK, treatment of leukemic cells with LFM-A13 enhanced their sensitivity to chemotherapy-induced apoptosis. (eurekaselect.com)
The release of mitochondrial-intermembrane-space pro-apoptotic proteins, such as cytochrome c , is a key step in initiating apoptosis. (biologists.com)
Many of the current efforts regarding anti-cancer drug development are focused on directing tumor cells to undergo apoptosis. (mdpi.com)
We identified a novel mode of communication by which apoptotic cells induce additional apoptosis in the same tissue. (elifesciences.org)
Apoptosis has been thought to resemble a form of silent suicide by cells, but more recent work suggests that apoptotic cells can also transmit signals. (elifesciences.org)
Curcumin, as the most active compound derived from the root of turmeric, exhibits strong anti-inflammation, antioxidant, and anti-apoptosis properties. (frontiersin.org)
The association between Fra-1, c-Jun and c-Fos expression levels and markers of proliferation [Ki-67, proliferating cell nuclear antigen ( PCNA )], anti- apoptosis (Bcl-2) was then investigated in the OKC serial tissue sections. (bvsalud.org)
This study revealed for the first time that Fra-1, c-Jun and c-Fos were overexpressed in OKCs and had a close correlation with proliferation and anti- apoptosis potential of OKCs. (bvsalud.org)
Tanaka, KI , Asanuma, M & Ogawa, N 2004, ' Molecular basis of anti-apoptotic effect of immunophilin ligands on hydrogen peroxide-induced apoptosis in human glioma cells ', Neurochemical Research , vol. 29, no. 8, pp. 1529-1536. (elsevierpure.com)
These results suggest that combination of genistein and guggulsterone may exert anti-obesity effects by inhibiting adipogenesis and inducing apoptosis in adipocytes. (pcom.edu)
To evaluate the anti-oxidant and anti-apoptotic effects of apigenin, we used H 2 O 2 and actinomycin D in the culture medium to create ROS and apoptosis. (ijfs.ir)
The results demonstrate that apoptosis induced by WC-Co involve both 'extrinsic' and 'intrinsic' apoptotic pathways and nanoparticle s exhibit higher cytotoxicity and apoptotic induction than fine particles. (cdc.gov)
Additionally, the anti-apoptotic protein Bcl-2 was elevated prompting us to study the effect of LTD4 on survival and apoptosis. (lu.se)

The anti-apoptotic STAT pathway does not involve Ras. (wikipedia.org)
http://genesdev.cshlp.org/content/11/6/701.abstract "The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal" 1997 Zhuravliova, E. (wikipedia.org)
Hence, treatment strategies for orchitis should focus on the balance of inflammatory cytokines, removal of oxidative and apoptotic injury, and regulation of the PK2/PKR1 pathway. (hindawi.com)
On the other hand, in order to identify miR-BARTs that can activate the Wnt signaling pathway, I analyzed the PAR-CLIP data set of C666 cells and discovered nine anti-Wnt signaling targets of miR-BARTs, including seven novel genes and two pro-apoptotic genes identified above. (duke.edu)
Eiger is produced in apoptotic cells and, through activation of the c-Jun N-terminal kinase (JNK) pathway, is able to propagate the initial apoptotic stimulus. (elifesciences.org)
Akt also exerts anti-apoptotic results by activating endothelial nitric oxide synthase (eNOS) (Brazil, Yang and Hemmings, 2004) Provided the neuroprotective part from the PI3K/Akt pathway in cerebral ischemia, we hypothesized that HN's neuroprotective impact requires the activation from the PI3K/Akt pathway after cerebral I/R damage. (biomedigs.org)
The increased activation of Akt and BAD induced by hMMP2 in β-cells compared to controls, links this signaling pathway to the anti-apoptotic activity of hMMP2, a property that was reversible by both an hMMP2 inhibitor and antibody against integrin-β3. (illinois.edu)
Expression of the mouse Sp110 nuclear body protein (Sp110) upregulates the apoptotic pathway, which plays an essential role in enhancing host immunity to Mycobacterium tuberculosis ( Mtb ). (oncotarget.com)

In addition, the present study indicated that treatment with GP suppressed the I/R-induced increase in the pro-apoptotic protein levels of Bax and cytochrome c and the activity of caspase-3/8, as well as the I/R-induced decrease in the levels of anti-apoptotic protein Bcl‑2. (spandidos-publications.com)
This study illustrates the importance of the evolutionary conservation of structure, rather than sequence, in protein function and reveals a novel anti-apoptotic protein from orthopoxviruses. (ox.ac.uk)
We demonstrate that the viral antiapoptotic molecule M11L promotes cellular immune responses to the HIV envelope protein. (elsevierpure.com)
Humanin (HN) can be an anti-apoptotic peptide that suppresses neuronal cell death induced by Alzheimer's disease, prion protein fragments, and serum deprivation. (biomedigs.org)
2004) reported that HN BMS-790052 binds to a human being G BMS-790052 protein-coupled formylpeptide receptor-like-1 BMS-790052 (FPRL1), which induces chemotaxis of mononuclear phagocytes and prevents A-induced apoptotic cell loss of life by competitively inhibiting A binding to FPRL1. (biomedigs.org)
Moreover, overexpression of Sp110 promotes degradation of ribosomal protein Rps3a, resulting in upregulation of the activity of the pro-apoptotic poly (ADP-ribose) polymerase (PARP). (oncotarget.com)
display of almost 150 0 organic product components was carried out against all six anti-apoptotic Bcl-2 family members protein using fluorochrome-conjugated peptide ligands that imitate functionally-relevant PPIs. (healthyguide.info)
was the first anti-death gene found out and takes its new anti-cancer focus on class with significant implications for tumor biology.6 Multiple members from the human being Bcl-2 family members protein have already been identified including six anti-apoptotic members since. (healthyguide.info)
Little molecule BH3 mimetics that antagonize the discussion between anti-apoptotic Bcl-2 protein and CCNG2 pro-apoptotic BH3-just protein represent potential anti-cancer therapeutics.8 The explanation for screening organic item collections for substances focusing on the Bcl-2 family members protein has both a biological and a biophysical foundation. (healthyguide.info)
These include members of the Bcl-2 protein family, course, and extent of programmed cell death will aid man- which have both proapoptotic and antiapoptotic activity agement of patients with severe infections. (cdc.gov)

In particular, we will discuss the modifications in intrinsic and extrinsic apoptotic pathways caused by proteins encoded by HPV early genes. (mdpi.com)

Scholars@Duke publication: A novel, non-apoptotic role for Scythe/BAT3: a functional switch between the pro- and anti-proliferative roles of p21 during the cell cycle. (duke.edu)
BAT3 modulates these pro- and anti-proliferative roles of p21 at least in part by regulating cyclin A abundance, as well as p21 translocation between the cytoplasm and the nucleus to ensure that it functions in the appropriate intracellular compartment during each phase of the cell cycle. (duke.edu)
The anti-proliferative and apoptotic effects of the antibody on prostate cancer (PC-3, Du-145 and LNCaP) and glioblastoma (U-87 MG and A-172) cell lines were investigated by MTT and Annexin V/PI assays. (researcher-app.com)
Overexpression of Fra-1, c-Jun and c-Fos in odontogenic keratocysts: potential correlation with proliferative and anti-apoptotic activity. (bvsalud.org)
Method: Anti-proliferative and apoptotic effect of various doses of essential oil from Ferula asafoetida was investigated on colon cancer cell lines i.e. (ac.ir)
Result: The potent anti-proliferative activity has been observed in both the cell lines. (ac.ir)
Our results suggest that although trisomy 8 cells are in a pro-apoptotic state, they are checked by the enhanced expression of anti-apoptotic signals which provide them with their proliferative advantage. (who.int)

Apoptotic cells can undergo a series of morphological changes to aid cell fragmentation, a process termed apoptotic cell disassembly 4 . (nature.com)

2002). Akt blocks apoptotic stimuli by inactivating pro-apoptotic proteins such as for example Poor, caspase-9, and glycogen synthase kinase-3. (biomedigs.org)
The Bcl-2 LDN-57444 proteins sequester and bind the pro-apoptotic BH3-only proteins such as for example Bim thus blocking cell death. (healthyguide.info)

CHX induces increases in immediate early gene mRNA levels, and can activate several different kinases and transcription factors that are also activated by various insults and in response to anti-apoptotic growth factors. (johnshopkins.edu)
Using studies in cell lines and in the context of a whole organism, we demonstrate that apoptotic cell recognition induces both an acute and sustained calcium flux within phagocytes and that such calcium flux is essential for engulfment. (aai.org)

ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)

No growth inhibition and apoptotic induction was detected for U-87 and A172 glioblastoma cells. (researcher-app.com)
The inhibition of cell growth and apoptotic induction effects in PC-3 cells were greater than Du-145 and LNCaP cells. (researcher-app.com)

To identify pro-apoptotic genes targeted by the five anti-apoptotic miRNAs, I validated one previously published target and identified nine novel targets by performing photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) in the EBV+ NPC cell line C666. (duke.edu)
Using FLuc 3'UTR indicator assays, I proved that the 3'UTRs of all seven newly identified anti-Wnt signaling genes were indeed targeted by the relevant miR-BARTs identified by PAR-CLIP. (duke.edu)
Total RNA was isolated on P16, and the relative abundance of mRNA of the crystallin structural genes, redox components, and apoptotic cascade were ascertained with real-time PCR with reference to the internal control β-actin . (molvis.org)
Real-time PCR analysis showed the crystallin genes ( αA- , βB1- , γD- ) and redox cycle components ( Cat , SOD-1 , Gpx ) were downregulated, the apoptotic components were upregulated, and antiapoptotic Bcl-2 was downregulated in Group II. (molvis.org)
C-PC treatment possibly prevented cataractogenesis triggered by sodium selenite, by regulating the lens crystallin, redox genes, and apoptotic cascade mRNA expression and thus maintains lens transparency. (molvis.org)
Moreover, knockdown in C. elegans of stim-1 and jph-1 , two genes linked to the entry of extracellular calcium into cells, led to increased persistence of apoptotic cells in the nematode. (aai.org)
Loss of these genes appeared to affect early signaling events, leading to decreased enrichment of actin adjacent to the apoptotic cell during corpse removal. (aai.org)

It has been proved that inhalation of methane also modulates leukocyte activation, affects key events of ischemia-reperfusion-induced oxidative stress, and has anti-inflammatory effects against ischemia-reperfusion damage [ 12 ]. (hindawi.com)
2004). We lately demonstrated that HNG protects against cerebral ischemia/reperfusion (I/R) damage by inhibiting apoptotic cell loss of life, reducing infarct quantity, and reducing neurological deficits in mice (Xu et al. (biomedigs.org)

However, Hsp90 interferes with a number of molecules that up-regulate the intracellular level of survivin, raising the question that clinical use of Hsp90 inhibitors may indirectly induce survivin expression and subsequently enhance cancer anti-drug responses. (biomedcentral.com)
For example, over-expression of survivin has been shown to induce drug resistance against anti-mitotic compounds by stabilizing microtubule network in vincristine/colchicine-resistant oral cancer cells and down-regulation of it restores drug sensitivity to those compounds in the same cell line [ 9 ]. (biomedcentral.com)

Anti-apoptotic actions of cycloheximide: Blockade of programmed cell death or induction of programmed cell life? (johnshopkins.edu)
Dive into the research topics of 'Anti-apoptotic actions of cycloheximide: Blockade of programmed cell death or induction of programmed cell life? (johnshopkins.edu)
Anti-RNP antibodies can precede overt clinical manifestations of MCTD, but overt disease generally develops within 1 year of anti-RNP antibody induction. (medscape.com)
Catalase inhibits WC-Co-induced ROS as well as mitochondrial membrane permeability damage, indicating that H2O2 may play an important role in the cytotoxicity induced by WC-Co. Further studies indicated that WC-Co nanoparticle s elicited a higher cytotoxicity and apoptotic induction than fine particles. (cdc.gov)

The present study is aimed at investigating the anti-inflammatory, antioxidative, and antiapoptotic effects of methane on lipopolysaccharide- (LPS-) induced acute orchitis and its potential mechanisms. (hindawi.com)
Establishing which of these anti-apoptotic mechanisms of action of CHX is operative in each cell death paradigm is clearly essential for proper interpretation of experimental results. (johnshopkins.edu)

It was found that methane significantly prolonged rat survival, decreased the W/D ratio, alleviated LPS-induced histological changes, and reduced apoptotic cells in the testes. (hindawi.com)
Increasing evidences indicate that the imbalance among these pro- and anti-inflammatory molecules, such as interleukin-1 β (IL-1 β ), IL-6, tumor necrosis factor- α (TNF- α ), and IL-10, in testicular cells can result in orchitis [ 3 , 4 ]. (hindawi.com)
In this study, the inhibitory effects of a specific anti-RTF scFv were investigated and compared between three types of prostate cancer and two types of glioblastoma cells. (researcher-app.com)
Conclusions: Anti-RTFscFv significantly reduced the proliferation of the prostate cancer cells. (researcher-app.com)
The resistance of glioblastoma cells to anti-RTF scFv offers the existence of mechanism(s) that abrogate the inhibitory effect(s) of the antibody to RTF. (researcher-app.com)
Taken at face value, senile cataract is intimately associated with the increased risk of oxidative stress, which levies irrevocable changes in the lenticular proteins that impel the lens epithelial cells to the apoptotic phase. (molvis.org)
Moreover, M11L synergizes with CpG motifs to augment anti-HIV responses and stimulates robust expansion of central memory and effector memory CD8 + T-cells. (elsevierpure.com)
However, the ability of HPV-infected cells to resist apoptotic signals renders such therapies ineffective. (mdpi.com)
Apoptotic cells can produce signals to instruct cells in their local environment, including ones that stimulate engulfment and proliferation. (elifesciences.org)
We also show that during coordinated cell death of hair follicle cells in mice, TNF-α is expressed in apoptotic cells and is required for normal cell death. (elifesciences.org)
Although this process can occur in individual cells, apoptotic signals may also dictate the 'communal death' of many cells simultaneously. (elifesciences.org)
To explore whether apoptotic cells could communicate with other cells, Pérez-Garijo et al. (elifesciences.org)
found that TNF is produced by apoptotic cells in hair follicles, and that blocking TNF inhibits the death of other cells in the same cohort: this suggests that a common mechanism could regulate the communal death of cells in flies and mammals. (elifesciences.org)
Only more recently has it become clear that apoptotic cells are the source of signals that can have profound effects on their neighbors. (elifesciences.org)
To clarify the molecular basis of the cytoprotective properties of immunophilin ligands (IPLs), the anti-apoptotic effects of IPLs were determined in human glioma U251 cells. (elsevierpure.com)
GPI1046 and V10367, non-immunosuppressive IPLs (NI-IPLs), as well as FK506, an immunosuppressive IPL (I-IPL), had cytoprotective effects against hydrogen peroxide (H 2 O 2 )-induced apoptotic cell death in U251 cells. (elsevierpure.com)
We also show that calcium is crucial for the anti-inflammatory TGF-β response seen in phagocytes during engulfment of apoptotic cells. (aai.org)
Taken together, these data point to a previously unappreciated and evolutionarily conserved role for calcium flux at two distinguishable steps: formation of the phagocytic cup and internalization of the apoptotic cell, and the anti-inflammatory signaling induced in phagocytes by contact with apoptotic cells. (aai.org)
These findings suggest that inter- the apoptotic destruction of lymphocytes and dendritic ventions aimed at reducing the extent of immune cell apop- tosis could improve outcomes for a variety of severe cells could have a particularly adverse effect on disease human infections, including those caused by emerging outcome. (cdc.gov)
High-risk MDS cases had a significantly higher percentage of apoptotic CD34+ cells and anti-apoptotic survivin+ cells than controls, particularly for trisomy 8 cases. (who.int)
Trisomy 8+ cells showed a significant positive correlation with apoptotic CD34+ cells and capacity for colony formation. (who.int)
The essence of MDS is damage of In the current work we examined All our patients were of the high-risk colony-forming units [4], but the defect haematopoietic stem cells of high-risk group and none of them was eligible of the haematopoietic stem cells is not MDS cases for apoptotic and anti-apop- for stem cell transplantation. (who.int)

Furthermore, we identified a commonly used antipsychotic, Haloperidol, as an inhibitor of apoptotic monocyte disassembly, which could impair IAV propagation via ApoBDs and lessen disease severity. (nature.com)

We demonstrated that, although not affecting tumor proliferation, cytoplasmic ERβ2 expression was indeed associated to a lower apoptotic rate in ovarian cancer cases. (unicatt.it)

In conclusion, the present study indicated that GP effectively protected against I/R-induced hepatic injury via its anti-oxidative and anti-apoptotic bioactivity. (spandidos-publications.com)
Apigenin has different biological activities such as anti-oxidative, anti-inflammatory, anti-cancer and anti-tumorigenic properties ( 4 , 5 ). (ijfs.ir)

Together, this study reveals a previously unrecognised function of apoptotic monocyte disassembly in the pathogenesis of IAV infections. (nature.com)
The structure also reveals that N1 has a constitutively open surface groove similar to the grooves of other anti-apoptotic Bcl-2 proteins, which bind the BH3 motifs of pro-apoptotic Bcl-2 family members. (ox.ac.uk)

An acute bout of moderate intensity downhill running altered CK activity, Bax concentration and the Bax/Bcl-2 ratio in circulating leukocytes resulting in a greater apoptotic response at 24- and 48-h post-exercise compared to level grade running or a second downhill run. (nih.gov)
Gypenoside (GP), the predominant component of Gynostemma pentaphyllum, exhibits a therapeutic effect on chronic hepatic injury, fibrosis and fatty liver disease via its anti-inflammatory and anti‑oxidant activity. (spandidos-publications.com)
Structure-activity studies were reported for seven synthetic analogs of phorboxazole A. Out of these, two showed potent anti-cancer activity. (eurekaselect.com)
Promising anti-mitotic agents with pro-apoptotic activity include inhibitors of the tyrosine kinase BTK. (eurekaselect.com)
Here we examined the expression of lncRNAs during erythropoiesis and identified an erythroid-specific lncRNA with anti-apoptotic activity. (elsevierpure.com)
Conclusion: The essential oil shows potent anti-cancer activity and shows the role in gene regulation to attenuate the colon cancer. (ac.ir)
Certainly examples of natural basic products concentrating on Bcl-2 have already been discovered including people that have known anti-cancer activity. (healthyguide.info)

abstract = "BCL2A1 is an anti-apoptotic member of the BCL-2 family that contributes to chemoresistance in a subset of tumors. (edu.au)

In conclusion, we provide in vivo mechanistic evidence for an antiapoptotic function of mitochondrial ERβ2, a finding supporting the value of its cytoplasmic expression as an unfavorable prognostic biomarker for serous ovarian cancer. (unicatt.it)
The same was also confirmed in the expression studies which shows significant upregulation of the antiapoptotic characteristics and down regulation of pro-carcinogenic factors. (ac.ir)

The results of viable and apoptotic blastomeres quantity, the ZP thickness, and the percentage of blastocysts and hatched blastocysts were significantly more favorable in the apigenin group, rather than the control group (P (ijfs.ir)

Additionally, methane suppressed and promoted the production of pro- and anti-inflammatory cytokines, respectively. (hindawi.com)

Thus, the immunosuppressive effect is not essential for the cytoprotective properties of IPLs, and IPLs have multiple beneficial properties such as the anti-apoptotic effect, GSH-activating effect, and NTF-activating effect, although the anti-apoptotic effect of NI-IPLs is independent of the regulation of apoptotic activators such as caspase-3. (elsevierpure.com)
Interestingly, WC-Co particles also induced Bcl-2, an anti-apoptotic factor, up-regulation. (cdc.gov)

Therefore, we utilised IAV infection as a model to further dissect the functional consequence of the disassembly of apoptotic monocytes. (nature.com)

Enhanced pro-apoptotic and anti-adipogenic effects of genistein plus g" by Jeongyeh Yang, Mary Anne Della-Fera et al. (pcom.edu)

The aim of this study was to evaluate the effect of apigenin on the number of viable and apoptotic blastomeres, the zona pellucida (ZP) thickness and hatching rate of pre-implantation mouse embryos exposed to H2O2 and actinomycin D. (ijfs.ir)

To investigate the function of apoptotic monocyte disassembly, we used influenza A virus (IAV) infection as a proof-of-concept model, as IAV commonly infects monocytes in physiological settings. (nature.com)

Purpose: The current investigation was conducted with the aim to elucidate and determine the anti-cancer efficacy in vitro on colon carcinoma human cell lines and to determine its probable mode of action. (ac.ir)

Methane-rich saline (MS), which is safer and more portable than methane gas, also has powerful anti-inflammatory, antioxidative, and anti-apoptotic properties [ 15 ]. (hindawi.com)

Apoptotic monocytes generate long membrane protrusions that exhibit a unique 'beads-on-a-string' morphology, termed beaded apoptopodia, which undergo a segmentation-like event to fragment into an abundance of ApoBDs. (nature.com)

The results suggest that the selected anti-RTF scFv antibody could be an effective new alternative for prostate cancer immunotherapy. (researcher-app.com)

Over time, some patients with MCTD also develop anti-Sm autoantibodies-an expansion of the autoimmune response known as epitope spreading. (medscape.com)

Golgi anti-apoptotic proteins (GAAPs) are evolutionarily conserved cell death regulators. (cam.ac.uk)

So, in this study, we evaluated for the first time the impact of apigenin on some morphological indicators of pre-implantation mouse embryos including ZP thickness, viable and apoptotic blastomere quantity and hatching rate. (ijfs.ir)

Although the formation of ApoBDs has been speculated to aid the efficient clearance of apoptotic debris and intercellular communication, the function of ApoBDs are yet to be fully defined. (nature.com)

Calcium plays a key role as a second messenger in many cell types, but a role for calcium signaling during apoptotic cell removal is unclear. (aai.org)

The results suggest that apigenin may protect mouse embryos against H2O2 and actinomycin D. So that it increases the number of viable blastomeres and decreases the number of apoptotic blastomeres, which may cause expanding the blastocysts, thinning of the ZP thickness and increasing the rate of hatching in mouse embryos. (ijfs.ir)

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