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  • DAAs
  • Hepatitis C virus variants with decreased sensitivity to direct-acting antivirals (DAAs) were rarely observed in DAA-naive patients prior to treatment," Journal of Virology , vol. 87, no. 3, pp. 1544-1553, 2013. (hindawi.com)
  • Telaprevir and boceprevir, licensed in 2011 for use in patients infected with HCV genotype 1, were the first direct-acting antiviral agents (DAAs). (bmj.com)
  • viral infections
  • This agent exhibits an antiviral activity either by inhibiting antagonistically the combination of various viruses with GSL molecules present on the surface of a host cell or by inhibiting or controlling expression of GSL, and thus can be used for preventing or treating various viral infections. (wipo.int)
  • topical
  • 21. The topical pharmaceutical composition of claim 20, wherein the effective antiviral concentration is in the range of approximately 0.1 wt. (patentgenius.com)
  • Research
  • 1986) "In vitro and in vivo activities of phosphate derivatives of 9-(1,3-dihydroxy-2-propoxymethyl guanine against cytomegaloviruses" Antiviral Research 6:299-308. (patentgenius.com)
  • Antiviral Research. (wikipedia.org)
  • At its founding in 1980, the company was named AntiVirals, Inc. After occupying several research laboratory spaces in Corvallis, the company opened a production laboratory in Corvallis, Oregon, in February 2002 and was renamed AVI BioPharma Inc. The company made headlines in 2003 when it announced work on treatments for severe acute respiratory syndrome (SARS) and the West Nile virus. (wikipedia.org)
  • therapeutics
  • However, clinical evaluation of therapeutics against infectious agents associated with high mortality, but low or infrequent incidence, is often unfeasible. (springer.com)
  • The potential use of such agents as anti-viral therapeutics represents an attractive strategy for repositioning drugs approved by US Food and Drug Administration (FDA) as readily available medical countermeasures (MCMs) against such biological threats. (springer.com)
  • AVI-7537 is an antiviral drug developed by Sarepta Therapeutics, which was effective in Ebola-infected monkeys. (wikipedia.org)
  • Diarrhea
  • Rotavirus is the most common infectious agent associated with diarrhea in the pediatric age group worldwide. (wikipedia.org)
  • clinical
  • Antiviral agents shorten the clinical course, prevent complications, prevent development of latency and subsequent recurrences, decrease transmission, and eliminate established latency. (medscape.com)
  • intravenous
  • PK of these agents following intravenous and oral dosing were evaluated in C57BL/6 mice, prairie dogs, guinea pigs and Cynomolgus monkeys. (springer.com)
  • diseases
  • W. E. G. Müller, Mechanisms of action and pharmacology: chemical agents, in: "Antiviral Agents and Viral Diseases of Man," G. J. Galasso, T. C. Merigan and R. A., Buchanan, eds. (springer.com)
  • Enterovirus 71 (EV71), one of the major causative agents for hand, foot and mouth disease (HFMD), is sometimes associated with severe central nervous system diseases. (wikipedia.org)
  • patients
  • In the absence of specific contraindications, amantadine and rimantadine are preferred for use in most patients because these two agents cost less than the other two. (umsystem.edu)