Antitumor regulation antigen presenting cell. Medical search. Frequent questions

In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
Cluster of differentiation (CD) 4 + T cells are essential organizers of cell-mediated immunity, participating in each stage of the immune response. (spandidos-publications.com)
Their innate effector functions include cell lysis and secretion of chemokines and cytokines, while their adaptive immunity functions include B cell help, DC maturation, and provision of memory T cells. (wikipedia.org)
The current project titled Regulation of lipid-mediated immunity in the intestine aimed to explore the mechanisms regulating lipid-mediated immunity in the intestine. (europa.eu)
Taking this into consideration, this project has focussed in understanding the mechanisms controlling lipid-mediated immunity by examining the ILC-NKT cell crosstalk. (europa.eu)
As mentioned above, the project aimed to investigate the mechanisms regulating lipid-mediated immunity in the intestinal mucosa by examining the crosstalk between ILCs and NKT cells. (europa.eu)
However, this finding has triggered further interest in utilising tumour-specific MHC-II to harness sustained anti-tumour immunity through the activation of CD4 + T helper cells. (portlandpress.com)
a Mechanisms by which oncolytic viruses (OVs) stimulate antitumor immunity. (biomedcentral.com)
For instance, current studies suggest that tumor-infiltrating B lymphocytes (TIL-B) can promote anti-tumor immunity through their unique antigen-presenting mode, leading to the persistence of an immune "hot" TME involving T cells, bone marrow cells, and natural killer cells [ 11 ]. (biomedcentral.com)
Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis. (nih.gov)
Introduction B-cell chronic lymphocytic leukemia (CLL) is usually associated with profound defects in T-cell function resulting in failure of antitumor immunity and increased susceptibility to infections. (researchensemble.com)
How do C-type lectins tailor adaptive immunity following phagocytosis of apoptotic cells? (nature.com)
These findings suggested that Notch1 signaling in B16 melanoma cells might inhibit antitumor immunity by upregulation of TGF-β1. (biomedcentral.com)
There are compelling evidences to show that melanoma cells escape the host's immunity by actively developing multiple suppressive mechanisms within the cancer microenvironment [ 1 ]. (biomedcentral.com)
Banchereau, J. and Steinman, R. Dendritic cells and the control of immunity. (biomedcentral.com)
Classically activated macrophages (M1 macrophages) mediates host defense against several bacterial, viral and protozoal pathogens and they play a role in antitumor immunity [ 12 , 13 ]. (scientificarchives.com)
nitric oxide (NO), and reactive oxygen species (ROS), secretion of chemokines for recruitment of immune cells such as CCL2/MCP-1, and present antigens to T cells for the initiation of adaptive immunity [ 16 - 19 ]. (scientificarchives.com)
PA group is currently developing new anticancer vaccines based on the concept of immunogenic cell death and exploring the crosstalk between angiogenesis and antitumor immunity in melanoma. (euroacadti.eu)
Matthew Albert is Director of Research INSERM and Head of the Laboratory of Dendritic Cell Immunobiology at the Institut Pasteur, Paris, leading a team in the area of dendritic cell immunobiology and tumor immunity. (euroacadti.eu)
Moreover, it has been increasingly recognized for its ability to inhibit tumor growth and activate antitumor immunity. (medicineinnovates.com)
T cell immune receptor with immunoglobulin and ITIM domains (TIGIT) emerges as a key player in regulating adaptive and innate immunity, particularly in the context of tumor immune surveillance. (medicineinnovates.com)
Finally, the innate immunity or adaptive immunity is stimulated leading to regulation and inhibition of tumor growth. (thno.org)
set out to explore the role of different myeloid cell populations in the regulation of T cell immunity and PD-1/PD-L1 blockade. (acir.org)
CD4+ helper T (Th) cells play a critical role in shaping anti-tumor immunity by virtue of their ability to differentiate into multiple lineages in response to environmental cues. (oncotarget.com)
Agonistic anti-4-1BB antibodies have been reported to induce T cell mediated antitumor immunity. (bioxcell.com)
All FcgammaRs can crosslink anti-41BB antibodies to strengthen co-stimulation, but activating FcgammaR-induced antibody-dependent cell-mediated cytotoxicity compromises anti-tumor immunity by deleting 4-1BB(+) cells. (bioxcell.com)
Because tumor immunity is driven by many immune system components that can either decrease or promote growth, NKT cells with specific lipid targets in the brain could be ideal mediators of immunotherapy to suppresses malignancy. (cancer.gov)
Finally, because NKT cells have an innate response component and are often referred to as innate T-lymphocytes, Dr. Terabe's team hopes to elucidate the mechanisms behind tumor immunity in glioblastoma with a specific focus on NKT cells. (cancer.gov)

Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)
We have found that tumor-associated dendritic cells (DCs) are altered when TCF-1 is absent in mature CD8+ T cells. (hhs.gov)
After activation, these cells may upregulate several antigen-presentation, adhesion, and co-stimulation molecules that mimic dendritic cells, a particular type of APC. (wikipedia.org)
This stress condition can also lead to the attraction of immune cells, notably antigen presenting cells (APCs) (i.e. immature dendritic cells), natural killer cells (NK cells), and cytotoxic T-cells to the site of infection [ 5 , 6 ]. (biomedcentral.com)
T regulatory (Treg) cells, T helper cell balances, dendritic cells, macrophages, B cells, and natural killer (NK) cells can be considered as the most determinant dysregulated mediators in immunomodulatory status. (hindawi.com)
Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity. (nih.gov)
and the innate immune cells contain natural killer (NK) cells and dendritic cells (DCs) (Fig. 1 ). (biomedcentral.com)
Tregs targets are antigen presenting cells, such as dendritic cells, effector CD4(+) and CD8(+) lymphocytes but also effector antibody-producing B lymphocytes. (univ-brest.fr)
Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. (nwbio.com)
Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. (nwbio.com)
Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. (nwbio.com)
Phase I/II study of vaccination with electrofused allogeneic dendritic cells/autologous tumor-derived cells in patients with stage IV renal cell carcinoma. (nwbio.com)
Dendritic cell immunotherapy for patients with metastatic renal cell carcinoma: University of Tokyo experience. (nwbio.com)
Large-scale immunomagnetic selection of CD14+ monocytes to generate dendritic cells for cancer immunotherapy: a phase I study. (nwbio.com)
Babatz J, Röllig C, Löbel B, Folprecht G, Haack M, Günther H, Köhne CH, Ehninger G, Schmitz M, Bornhäuser M. Induction of cellular immune responses against carcinoembryonic antigen in patients with metastatic tumors after vaccination with altered peptide ligand-loaded dendritic cells. (nwbio.com)
Banchereau J, Ueno H, Dhodapkar M, Connolly J, Finholt JP, Klechevsky E, Blanck JP, Johnston DA, Palucka AK, Fay J. Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferon. (nwbio.com)
Maturation and trafficking of monocyte-derived dendritic cells in monkeys: implications for dendritic cell-based vaccines. (nwbio.com)
Vaccination of prostatectomized prostate cancer patients in biochemical relapse, with autologous dendritic cells pulsed with recombinant human PSA. (nwbio.com)
Bleumer I, Tiemessen DM, Oosterwijk-Wakka JC, Völler MC, De Weijer K, Mulders PF, Oosterwijk E. Preliminary analysis of patients with progressive renal cell carcinoma vaccinated with CA9-peptide-pulsed mature dendritic cells. (nwbio.com)
Dendritic cells (DCs) are highly specialized antigen-presenting cells endowed with the unique ability to not only present exogenous antigens upon exposure to MHC II, but also to cross-present these upon exposure to MHC I. This property was exploited to generate the tumor-specific CD8 cytotoxic lymphocyte (CTL) response in DCs-based cancer vaccine protocols. (biomedcentral.com)
Ridge, J.P., Di Rosa, F. and Matzinger, P. A conditioned dendritic cell can be a temporal bridge between a CD4 + T-helper and T-killer cell. (biomedcentral.com)
Recently, the lab of Dr. P. Agostinis documented that immunogenic cell death mediated by ER stress can be harnessed to develop novel and clinically relevant, next-generation dendritic cell-based immunotherapies for brain tumors. (euroacadti.eu)
He is also Leader of the Dendritic Cells (DC) Antigen Presentation research group. (euroacadti.eu)
His main scientific contributions in the last 10 years relate to antigen presentation in dendritic cells and immunotherapy. (euroacadti.eu)
Analysis of the tumor-infiltrating myeloid populations at days 3, 7, and 14 post tumor inoculation revealed that the majority of myeloid cells were macrophages, which far outnumbered cross-presenting dendritic cells (DCs). (acir.org)
4-1BB is a 39 kDa transmembrane protein expressed by T lymphocytes, NK cells, dendritic cells, granulocytes, and mast cells. (bioxcell.com)
1 CD1a is also expressed on dendritic cells and on thymocytes, with higher intensity in double-positive and with lesser in single-positive. (hcdm.org)
Cancer vaccines exploiting the in vivo delivery of tumour specific (neo-)antigens to cross-presenting dendritic cells to improve the immunotherapy for melanoma, breast cancer, lymphoma, glioblastoma and virus-driven tumours. (edu.au)
Alpha-galactosylceramide (α-GalCer) is a glycolipid that can be loaded into MHC-class-I-related CD1d molecules by dendritic cells and has been shown to stimulate invariant natural killer T (iNKT) cells. (tmu.edu.tw)
The maturation and cytokine production of dendritic cells will also be investigated after cultured with α-GalCer-incorporated liposomes in vitro. (tmu.edu.tw)

Once activated these Vδ2+ T cells potentially mimic professional APCs by processing and presenting antigens. (wikipedia.org)
Lately, it has been described a novel function for ILCs as antigen presenting cells (APCs) through MHC-II-dependent presentation of commensal-derived antigens (3-7). (europa.eu)
Despite increasing data during the last decades, how commensal lipids are handled by immune cells, the contribution of different APCs to lipid presentation, and their effects on mucosal NKT cells remain poorly understood. (europa.eu)
As a result of the progress of the project, it was found that NKT cell-APCs crosstalk is a key mechanism for the regulation of intestinal homeostasis. (europa.eu)
Virus-based immunostimulatory cytokine and chemokine expression can recruit and activate T cells, antigen-presenting cells (APCs), and natural killer (NK) cells, and subsequently, improve the therapeutic activity of OVs. (biomedcentral.com)
TIGIT is primarily expressed on T cells, natural killer cells (NK), and other antigen-presenting cells (APCs), exerting potent immunosuppressive effects by reducing immunostimulatory cytokines production. (medicineinnovates.com)
K562 cells expressing PD-L1, B7-1, or both were used as artificial APCs. (acir.org)
Together, these experiments showed that PD-L1 expression on antigen-presenting cells (APCs) played a role in antitumor T cell responses via PD-1 interactions. (acir.org)
4) TIGIT binds to CD155 on APCs to induce IL-10 production and decrease IL-12 production which indirectly inhibits T cells. (greatlakeshighereducationnow.com)
APCs, antigen-presenting cells. (greatlakeshighereducationnow.com)

TIME possesses distinct populations of myeloid cells and lymphocytes to influence the immune escape of cancer, the response to immunotherapy, and the survival of patients. (biomedcentral.com)
Induced pluripotent stem cell (iPSC)-derived macrophages (iMACs) are being used to make chimeric antigen receptor (CAR) macrophages for immunotherapy. (nature.com)
This work represents a novel approach for cancer immunotherapy by integrating nanotechnology and platinum-based therapeutics which not only efficiently exerts the chemotherapeutic cytotoxic effect on tumor cell but also restores immune response of immunological cells within the tumor microenvironment. (thno.org)
Recent evidence from pre-clinical studies evaluating immune-checkpoint inhibitors in various cancer cell-lines has suggested that combinatorial approaches may have superior survival outcomes compared to single-agent immunotherapy regimens. (biomedcentral.com)
PD-1 axis blockade has been proven time and again to be a successful immunotherapy for a wide variety of cancer types, and it is assumed to work by reversing or preventing T cell exhaustion. (acir.org)
The complex interplay between cancer cells and the TIME influences the outcome of immunotherapy and other anticancer therapy (Fig. 1 ). (biomedcentral.com)
Thus, further research is warranted to understand the role of tumor induced epigenetic modification of tumor infiltrating T-cells to develop effective anti-GBM immunotherapy. (oncotarget.com)
Understanding how NKT cells can promote tumor infiltration is key to utilizing immunotherapy in brain tumors. (cancer.gov)
Identify and validate new classes of tumour antigens that can constitute suitable targets for immunotherapy in various types of cancers. (edu.au)
One of the research areas at the MDC is immunology and inflammation, which covers tumor immunology, DNA repair in B lymphocytes, the role of tumor stroma-immune cell interaction in cancers, the role of innate immune cells in gliomas and neurodegenerative diseases, and the development of immunotherapy strategies. (mdc-berlin.de)

In addition, flu infection reduced PPARÎ³ expression in all mouse macrophages, including AMs, interstitial macrophages, and bone-marrow-derived macrophages but not in alveolar epithelial cells. (bvsalud.org)
Current research areas studied include the interactions between newly formed tumor cells and both innate and adaptive immune cells, the role of myeloid cells (e.g. macrophages, antigen presenting cells) in the regulation of the tumor microenvironment, how lymphocytes traffic to tumors, and how tumors hide from them, and the relationship between a patient's microbiome and their immune cells in different cancers. (virginia.edu)
Two decades later, pioneering studies suggested that lectin-like molecules constitutively expressed on the surface of macrophages can selectively recognize changes on glycans decorating the surface of apoptotic thymocytes, 4 , 5 although these studies likewise did not provide substantial insight into the mechanisms by which lectin-glycan interactions regulate cell death. (nature.com)
Macrophages and monocytes are the major target cells for Ehrlichia , although this bacterium can infect other cell types such as hepatocytes and endothelial cells [ 4 ]. (scientificarchives.com)
Macrophages are innate immune cells that play a key role in regulation of innate and adaptive immune responses against infections with several pathogens as they respond to pathogens and tissue injury, serve as antigen presenting cells priming the adaptive immune response, drive inflammation and host defense as well as repairing damaged tissue [ 5 - 7 ]. (scientificarchives.com)
Two major lineages are currently known: cells that are derived from myeloid progenitor cells in the bone marrow (BM) that give rise to blood-circulating monocytes that migrate to sites of host insult, and macrophages that are derived from the yolk sac and present in the tissues as resident macrophages [ 9 - 11 ]. (scientificarchives.com)
Examples of tissue-resident macrophages are alveolar macrophages in the lung and Kupffer cells in the liver. (scientificarchives.com)
These M2 macrophages are a strong inducer of T helper 2 (Th2) cells and/or regulatory T cells. (scientificarchives.com)
In tumors which had high levels of infiltrating CD11b + macrophages expressing the ADCC-activating FcgRIV, T REGS were selectively depleted in an FcgR-dependant manner, while effector T cells were instead expanded. (sanguinebio.com)
In lymph nodes lacking significant levels of these macrophages, frequencies of both effector T cells and T REGS were increased. (sanguinebio.com)
Tumor-associated T REGS expressedhigher levels of CTLA-4 than their effector T cell counterparts, or than T REGS present in the lymph node, indicating that higher CTLA-4 expression levels mediate ADCC via macrophages in the tumor. (sanguinebio.com)
Most intratumoral PD-L1 + myeloid cells were macrophages (~75%), while cross-presenting DCs accounted for less than 2% of this population by day 14 post tumor inoculation. (acir.org)
Together, these results indicated that despite their lower frequency, DCs played a bigger, and crucial role as a source of PD-L1 in PD-L1/PD-1 regulation of the antitumor response compared with the more abundant macrophages. (acir.org)
Furthermore, PD-L1/B7-1 interactions in cis on DCs, but not on macrophages, played a role in limiting PD-1 signaling and in activating T cells. (acir.org)
Tumors treated with Ad5/3-CMV-mCD40L also displayed an enhanced presence of macrophages and cytotoxic CD8(+) T cells but not B cells. (mek-inhibitors.com)

However, the tumor microenvironment (TME) imposes different mechanisms that facilitate the impairment of DC functions, such as inefficient antigen presentation or polarization into immunosuppressive DCs. (mdpi.com)
Regardless of the therapeutic approach, the heterogeneity of pancreatic cancer cells and the complexity of its tumor microenvironment contribute to the emergence of drug resistance. (frontiersin.org)
It was further demonstrated that Th17 cells could be induced and expanded in the tumor microenvironment through cytokines produced by the tumor cells. (spandidos-publications.com)
In addition, the LSCC microenvironment was identified as a strong Th17-cell inducer. (spandidos-publications.com)
More immune cells are infiltrating the tumor microenvironment of patients in the low-risk group, especially B cells. (biomedcentral.com)
Among the components of TME, distinct populations of innate and adaptive immune cells consist of tumor immune microenvironment (TIME). (biomedcentral.com)
Nature Immunology has commissioned a Series of Reviews to make sense of immune and cancer cell interactions, highlighting the utility of spatial and other OMIC technologies for analysis of the tumor microenvironment, immune cell dysfunction and how to counter it to enhance CAR-based and other immunotherapies, and more. (nature.com)
Some of the new approaches depend on tumor biology and aim specifically to inhibit tumor growth and metastasis by targeting the tumor microenvironment or vasculature (leaving normal cells unaffected) or focusing on specific protein or signal transduction pathways. (medscape.com)
Ipilimumab functions to increase the ratio of effector T cells to T REGS in the tumor microenvironment and has been shown to require binding to both types of T cells for maximal anti-tumor effectiveness. (sanguinebio.com)
First, the stimulatory or death signals are released from apoptotic tumor cells into the tumor microenvironment. (thno.org)
During the early phase of tumor development, immune cells could spontaneously infiltrate into the tumor microenvironment to evoke an immune response and fight against the growth of the tumor. (thno.org)
Accumulating research suggests that the tumor immune microenvironment (TIME) plays an essential role in regulation of tumor growth and metastasis. (biomedcentral.com)
Targeting tumor cells or the tumor microenvironment (TME) are the two major fundamental principles for antitumor therapies. (biomedcentral.com)
Sulfatide could assist in recruiting NKT cells to the tumor, even if the lipids undergo minor changes in the tumor microenvironment. (cancer.gov)
How is the tissue specificity of immune cells generated and how is it affected by environmental influences, plasticity and the tissue microenvironment? (mdc-berlin.de)
Dysregulation of various cells in the tumor microenvironment (TME) causes immunosuppressive functions and aggressive tumor growth. (biomedcentral.com)

The prevalence of Th17 cells and their receptors in patients with LSCC was studied using immunohistochemical analysis via tissue microarray technology. (spandidos-publications.com)
T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC) (APC). (wikipedia.org)
In this manner, the reduced detection of self MHC-I molecules by NK cell-inhibitory receptors coupled with an increase in activating signals by recognition of stress-induced surface ligands promote the cytolytic activity of NK cells. (biomedcentral.com)
On the other hand, the proliferation of oncolytic viruses into target cells and subsequent recognition of viral elements by pattern recognition receptors (PRRs) such as toll-like receptors can positively affect the development of the innate and adaptive immune responses against tumor cells (Fig. 1 ) [ 6 ]. (biomedcentral.com)
This exhausted state is also associated with increased expression of inhibitory receptors including programmed death-1 (PD1 CD279) CD160 (BY55) and CD244 (2B4).13 We hypothesized that chronic stimulation may result in T cells from patients with CLL becoming functionally "exhausted " similar to that reported in chronic viral infections. (researchensemble.com)
A major potential confounding factor is usually cytomegalovirus (CMV) seropositivity known to influence the major lymphoid subsets in healthy individuals with expanded populations of CMV-specific CD4+ Tnf and CD8+ T cells reported in CMV-seropositive (CMV+) CLL patients.14-17 Here we show that CD8+ T cells from patients with CLL exhibit defects in proliferation cytotoxicity and increased expression of inhibitory receptors irrespective of CMV serostatus. (researchensemble.com)
Glycosylation of classical death receptors fine-tunes cell death programs. (nature.com)
Here, the authors show that combining γ9δ2 TCR-mediated metabolic and co-stimulatory stress targeting by chimeric NKG2D or anti-CD277 co-receptors shapes transcriptomic heterogeneity of engineered T cells and is associated with improved control of solid tumors. (nature.com)
The receptors of Notch family play an important role in controlling the development, differentiation, and function of multiple cell types. (biomedcentral.com)
M2 cells play a role in down regulating the inflammatory mediators, up regulating the antiinflammatory mediators, expressing scavenging receptors (e.g. mannose receptor), phagocytizing apoptotic bodies and cellular debris, and promoting wound healing and tissue repair [ 17 ]. (scientificarchives.com)
Activating receptors contain cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAM) and activate the FcgR-expressing cell to mediate functions including antibody-dependant cell mediated cytotoxicity (ADCC) and phagocytosis of the antibody-labeled target cell. (sanguinebio.com)
Thus differential affinities of IgG subclasses to functionally different Fcg receptors are thought to mediate the variation in clinical effectiveness of different antibodies targeting the same antigen. (sanguinebio.com)
The peptide has been shown to interact with specific receptors on immune cells, including T-cells and antigen-presenting cells. (peptide-bioregulator.com)
To initially investigate a model system, the researchers generated Jurkat cells with chimeric receptors comprising an extracellular PD-1 domain, an intracellular human CD3ζ signaling chain, and a luciferase reporter gene. (acir.org)
We take a comprehensive approach to cellular engineering by developing new synthetic receptors, signal transduction cascades, and cellular response programs to enhance the safety and effectiveness of adoptive cell therapies. (ucsf.edu)
Hyperstabilization of T cell microvilli contacts by chimeric antigen receptors. (ucsf.edu)
Interestingly, we observed dysregulation of several ligands of T cell function genes in GBM tissue corresponding to the T-cell receptors that were dysregulated in tumor infiltrating CD4+ T-cells. (oncotarget.com)
The Mechanisms of TIGIT Co-Inhibition While all Rabbit polyclonal to VDAC1 co-inhibitory receptors have the ability to suppress T cell activation, they differ in potency, kinetics of expression and with respect to the cellular signaling pathways they alter. (greatlakeshighereducationnow.com)

Furthermore, the proliferation of Th17 cells and Th17‑associated cytokines, including interleukin (IL)17, IL23 and RAR‑related orphan receptor γt, was analyzed by reverse transcription‑quantitative polymerase chain reaction. (spandidos-publications.com)
It contributes the gamma (γ) chain to the larger TCR protein (T-cell receptor). (wikipedia.org)
Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. (wikipedia.org)
In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. (wikipedia.org)
This region represents the germline organization of the T cell receptor gamma locus. (wikipedia.org)
Recombinant technology has allowed for the identification of the T-cell receptor gamma (TRG) gene that is found associated with the CD3 complex on the cell surface. (wikipedia.org)
Our data suggest that fetuin-A overexpression significantly enhances the invasive potential of the cells and also the expression of Toll like receptor 4 (TLR4) on these cells. (preprints.org)
It acts by binding to its receptor WSX-1 (also known as TCCR) and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. (rockland.com)
The HER (erbB) family of transmembrane receptor tyrosine kinases is one of the cytostatic targets in tumor cell growth and survival. (medscape.com)
This family, which includes epidermal growth factor receptor (EGFR), plays a pivotal role in normal cell growth, lineage determination, repair, and functional differentiation. (medscape.com)
They currently study angiogenesis and lymphatic vessels particularly in malignant tumors, focusing on the growth factor-receptor signaling and growth factor-mediated endothelial cell reprogramming. (euroacadti.eu)
CTLA-4 is related to the T cell co-stimulatory receptor CD28, and acts to suppress T cell function by competing with CD28 for binding to CD80 and CD86 on antigen presenting cells and recruiting inhibitory molecules into the TCR signaling synapse. (sanguinebio.com)
A second article in the same issue of The Journal of Experimental Medicine by Bulliard et al also explored the role of FcgR engagement on the effects of Ipilimumab as well as an agonistic antibody (DTA-1) targeting the T cell activating receptor GITR (TNFR glucocorticoid-induced TNFR-related protein), which is also expressed on both activated T cells and T REG s. (sanguinebio.com)
Presently, dual-immune checkpoint inhibition with anti-programmed death receptor-1/programmed cell death receptor- ligand-1 (anti-PD-1/PD-L1) plus anti-cytotoxic T lymphocyte associated antigen-4 (anti-CTLA-4) monoclonal antibodies (MoAbs) is being evaluated for a wide range of tumor histologies. (biomedcentral.com)
4-1BB is a TNF receptor family member that signals via a complex that includes TRAF family members and the c-IAPs to upregulate NF-kappaB and ERK, and has been implicated in memory T-cell survival. (bioxcell.com)
TAPIR: a T-cell receptor language model for predicting rare and novel targets. (preprintclub.com)

The present study investigated the expression of T helper (Th)17 cytokines in patients with laryngeal squamous cell carcinoma (LSCC) and their clinical significance in providing new therapeutic insights. (spandidos-publications.com)
TME comprises immune cells, stromal cells, and various cytokines [ 10 ], among which immune cells play a crucial role in tumor development. (biomedcentral.com)
Regulatory T lymphocytes (Tregs) correspond to different sub-populations of T cells that control immune responses due to the production of cytokines, such as IL-10 and with direct cell-to-cell contacts. (univ-brest.fr)
Therefore although CLL CD8+ T cells exhibit features of T-cell exhaustion they retain the ability to produce cytokines. (researchensemble.com)
For instance, melanoma cells evade T cell surveillance by creating an immunosuppressive environment via the production of cytokines such as transforming growth factor (TGF)-β1, vascular endothelial growth factor (VEGF) and IL-10, which recruit myeloid-derived suppressor cells (MDSCs) and T regulatory cells (Tregs). (biomedcentral.com)
Over lifetime, due to the action of several stressors such as DNA damage and telomere shortening, senescent cells accumulate in the organism and release a variety of pro-inflammatory cytokines responsible for low-grade inflammation. (frontiersin.org)
For example, antibodies specific to tumor antigens, adoptively transferred immune cells, therapeutic vaccines, and recombinant cytokines effectively boost the host immune system to recognize tumor cells as pathogens and eliminate them [ 1 - 3 ]. (thno.org)
The crosstalk between pro-tumorigenic immune cells, stromal cells, and cytokines helps to establish the pre-metastatic niche for disseminated circulatory tumor cells and facilitates metastasis. (biomedcentral.com)
While tumor expansion, contact-dependent or independent crosstalk between tumor and TIME affects the production of various cytokines that help in the polarization of antitumor immune response in the immunosuppressive TIME. (biomedcentral.com)
Together, our findings show that adenoviruses coding for CD40L mediate multiple antitumor effects including oncolysis, apoptosis, induction of T-cell responses, and upregulation of T(H)1 cytokines. (mek-inhibitors.com)
However, the limitations were found in clinical application that (1) iNKT cells failed to produce cytokines and proliferate when additional doses of α-GalCer were given by systemic route and (2) poor hydrophilicity of α-GalCer. (tmu.edu.tw)
Cytokines, antigen-specific antibodies and subtype antibodies of serum and nasal wash fluid will be analyzed in order to investigate the enhancement of the Th1/Th2 immune-modulatory pathway. (tmu.edu.tw)

The results revealed that the prevalence of Th17 cells in patients with LSCC was elevated in their primary tumors, as well as in peripheral blood, compared with that in healthy controls. (spandidos-publications.com)
The present study revealed that patients with LSCC have elevated levels of Th17 cells in their primary tumors and peripheral blood compared with those in healthy controls. (spandidos-publications.com)
Pathways to enhance T cell function in tumors. (virginia.edu)
Daily topical treatment with CWO induced dramatic regression of pre-malignant skin tumors and a two-fold reduction in cutaneous squamous cell carcinomas. (biorxiv.org)
SUMMARY BLURB Essential oil derived from the camphor tree acts by stimulating immune cell-dependent regression of skin tumors in a mouse model of cutaneous squamous cell carcinoma. (biorxiv.org)
RT has been shown to influence the expression of TIGIT in tumors, and the combination of RT with anti-TIGIT therapy has demonstrated promising antitumor effects. (medicineinnovates.com)
Furthermore, in immunocompetent mice bearing 4T1 cells tumors, Wpep-DGL/Pt activated immune cells and induced cell death proving their dual function of chemotherapeutic and immunomodulatory efficacy. (thno.org)
Consistent with in vitro observations, in mice with PD-L1-deficient MC38 colorectal tumors where only host cells were the source of PD-L1, antibody blockade of both PD-1/PD-L1 and PD-L1/B7-1 interactions reduced tumor growth, while blocking only PD-L1/B7-1 interactions slightly accelerated tumor growth due to an increased availability of PD-L1. (acir.org)
Most myeloid cells within tumors and tumor-draining lymph nodes expressed PD-L1 without co-expressing B7-1 (but still expressing B7-2, which does not interact in cis with PD-L1), thus leaving plenty of PD-L1 free to interact with PD-1 on T cells. (acir.org)
A similar PD-L1 expression distribution was observed in RNASeq data from human non-small cell lung cancer (NSCLC) tumors. (acir.org)
Interestingly, however, mature DCs in NSCLC tumors had the highest level of PD-L1 (and B7-1) expression on a per cell basis among intratumoral myeloid populations. (acir.org)
Analysis of T cell responses at day 10 post inoculation revealed increased frequency and number of CD8 + T cells within PD-L1-deficient MC38 tumors of PD-L1 KO and PD-L1 ΔDC mice compared to WT controls. (acir.org)
Synthetic cytokine circuits that drive T cells into immune-excluded tumors. (ucsf.edu)
They are unique cells that can be recruited to attack tumors and/or help other immune cells destroy malignant cells. (cancer.gov)
Dr. Terabe hopes to translate his knowledge on NKT cells to new cancer treatments that can help patients combat brain tumors more effectively. (cancer.gov)
Since tumors exhibit changes in the structure and concentration of lipids produced, NKT cell function can be crucial for recognizing this change. (cancer.gov)
Since joining the Neuro-Oncology Branch (NOB) to lead the Basic Immunology Research Program, he has focused on determining the role of natural killer T (NKT) cells in the context of brain tumors. (cancer.gov)

IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naïve but not memory CD4+ T-cells. (rockland.com)
Fusion cell vaccination of patients with metastatic breast and renal cancer induces immunological and clinical responses. (nwbio.com)
In fact, several studies have shown that T2D induces senescence in multiple types of cells, including fibroblasts and endothelial cells ( 11 , 12 ). (frontiersin.org)
CD40 ligand (CD40L, CD154) induces apoptosis of tumor cells and triggers several DZNeP research buy immune mechanisms, including a T-helper type 1 (T(H)1) response, which leads to activation of cytotoxic T cells and reduction of immunosuppression. (mek-inhibitors.com)
TIGIT can inhibit CD8+ T cell proliferation and activation by directly acting on TCR expression itself as engagement of TIGIT induces a down-regulation of the TCR- chain and molecules that comprise the TCR complex (18). (greatlakeshighereducationnow.com)
TIGIT expressed on CD4+ T cells induces IL-10 and suppresses IL-12 production by DCs CD155 ligation and thereby inhibits CD4+ T cell proliferation and IFN- production (21). (greatlakeshighereducationnow.com)

In the αβ T cell lineage, these chains are disulfide-linked and noncovalently associated at the cell surface of T lymphocytes. (wikipedia.org)
T cells expressing the γ-chain (TRG+ cells) make up 3-10% of normal adult peripheral blood lymphocytes, with the majority (>80%) being of the Vγ2Vδ2+ subtype (referred to as Vδ2+ T cells). (wikipedia.org)
MHC-I and MHC-II proteins are key components of the antigen presentation machinery responsible for neoantigen presentation to CD8 + and CD4 + T lymphocytes, respectively. (portlandpress.com)
Upon the stage of tumorigenesis, down-regulation of the major histocompatibility complex class-I (MHC-I) molecules and also the overexpression of the stress-induced ligands on the surface of malignant cells to avoid recognition by cytotoxic T-lymphocytes (CTLs), make them more sensitive to NK cell-mediated death. (biomedcentral.com)
TIME primarily consists of myeloid cells, lymphocytes and some other innate immune cells. (biomedcentral.com)
Regulatory lymphocytes: a new cooperation between T and B cells for a better control of the immune response]. (univ-brest.fr)
Regulatory B lymphocytes (Bregs) have been more recently described and likely represent different sub-populations of B cells that control the development of autoimmune and inflammatory diseases due to the production of IL-10 and using intercellular contacts. (univ-brest.fr)
Bregs targets encompass all the cells involved in the immune responses which are thus under a dual control by regulatory lymphocytes. (univ-brest.fr)
Notch1 expression in B16 melanoma cells inhibited the infiltration of CD8+ cytotoxic T lymphocytes and NK cells and reduced IFN-γ release in tumor tissue. (biomedcentral.com)
While there are various types of T-lymphocytes, NKT cells stand out for a few reasons. (cancer.gov)

Research at UVA has fundamentally contributed to these advances, beginning with the early identification of tumor proteins targeted by T cells in melanoma patients. (virginia.edu)
The aim of this study is to investigate the role of Notch1 signaling upon immune suppression induced by melanoma cells. (biomedcentral.com)
Melanoma cell line B16 cells were transfected by lentivirus containing mouse Notch1 gene or Notch1 shRNA to generate B16 cell line that highly or lowly expressed Notch1. (biomedcentral.com)
Downregulation or overexpression of Notch1 in B16 melanoma cells inhibited or promoted tumor growth in immunocompetent mice, respectively. (biomedcentral.com)
Our previous study has shown that interference of both Notch co-activation factor MAML1 blocks the activation of Notch pathway in both human and mouse melanoma cells, suggesting a potential new treatment strategy [ 6 ]. (biomedcentral.com)
Moreover, Notch1 and NRG1 expression in melanoma promoted cell growth by activating PI3Kinase/Akt signaling pathway and facilitating the accumulation of p27 [ 11 ]. (biomedcentral.com)
In this review, we summarize the current landscape of combination therapy with anti-PD-1/PD-L1 plus anti-CTLA-4 MoAbs for patients with melanoma and non-small cell lung cancer (NSCLC). (biomedcentral.com)
In addition to head and neck cancer, Phase II studies are ongoing in patients with malignant melanoma, pleural mesothelioma, ovarian cancer, and non-small cell lung cancer. (ultimovacs.com)

Wu and colleagues identify gene networks and transcription factors that control the differentiation of stem-like CD8+ CAR T cells into effector or exhausted CD8 + CAR T cells. (nature.com)
The Notch signaling is a highly conserved pathway that controls the differentiation, development and function of multiple cell types, such as stem cells [ 3 ]. (biomedcentral.com)
Furthermore, Bonothyrk Peptide has been found to enhance the maturation and differentiation of T-cells, thus improving their functionality. (peptide-bioregulator.com)
Analysis of specific genes involved in CD4+ differentiation and function revealed differential methylation status of TBX21, GATA3, RORC, FOXP3, IL10 and IFNG in tumor CD4+ T-cells. (oncotarget.com)
Our results suggest that GBM might induce epigenetic alterations in tumor infiltrating CD4+ T-cells there by influencing anti-tumor immune response by manipulating differentiation and function of tumor infiltrating CD4+ T-cells. (oncotarget.com)
One such mechanism involves the upregulation of immune checkpoints, such as programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1), cluster of differentiation 86 (CD86)/cytotoxic T-lymphocyte antigen 4 (CTLA-4) [ 16 ]. (biomedcentral.com)

Using the network pharmacology approach, we identified two clusters of genes involved in immune response (IL1A, IL2, and IL6R) and cell proliferation (CCND1, PPARG, and EGFR) mediated by biochanin A in CRC/COVID-19 condition. (bvsalud.org)
CLL CD8+ T cells showed functional defects in proliferation and cytotoxicity with the cytolytic defect caused by impaired granzyme packaging into vesicles and nonpolarized degranulation. (researchensemble.com)
Understanding the function of lectin-glycan recognition systems in cell death will facilitate the implementation of novel therapeutic strategies aimed at controlling unbalanced cell proliferation and survival in several pathologic conditions. (nature.com)
After the co-culture of B16 cells and CD8 + T cells, the effects of Notch1 on the proliferation and activation of T cells were assessed by CCK8 assay, CFSE dilution and Chromium-release test. (biomedcentral.com)
It could also enhance B16 cell-mediated inhibition of T cell proliferation and activation, and upregulate PD-1 expression on CD4 + and CD8 + T cells. (biomedcentral.com)
Even though GITR-activation in effector T cells promotes activities including cytokine production and proliferation, the agonistic properties of this antibody alone were not effective in the absence of activating FcgR engagement. (sanguinebio.com)

Compared with conventional cancer treatments, the main advantage of oncolytic virotherapy is its tumor-selective replication followed by the destruction of malignant cells without damaging healthy cells. (biomedcentral.com)
Cancer is not a chaotic malignant cell mass, but a delicate "hostile" organ, where many other cells are recruited and domesticated to become "accomplices", thereby protecting themselves from recognition and attack by the immune system [ 1 ]. (biomedcentral.com)
His research has been focusing on the characterization of the natural immune responses towards malignant cells. (euroacadti.eu)

Recombination of many different V segments with several J segments provides a wide range of antigen recognition. (wikipedia.org)
NKT cells, through TCR recognition of self- or commensal-derived lipids presented by CD1d, contribute to establish immune homeostasis and to anti-microbial, anti-tumour and autoimmune responses (10,11). (europa.eu)
At that time, glycobiology, which is the study of carbohydrates and their recognition by motif-specific carbohydrate-binding proteins or lectins, lagged far behind the studies that defined the structural and cellular biology of cell death. (nature.com)
Phage display technology, which combines the antigen recognition capabilities of recombinant proteins, holds immense potential in developing tumor-specific peptides. (medicineinnovates.com)
We have previously demonstrated that the C-type lectin macrophage galactose-type lectin (MGL), expressed by human antigen presenting cells, can distinguish healthy tissue from CRC through its specific recognition of Tn antigen. (oncotarget.com)

The processes of tumor initiation, expansion, and metastasis are governed by the TIME, where immunosuppressive and antitumor immune crosstalk play an important role. (biomedcentral.com)
During metastasis, tumor-derived exosomes help in the requirement and arrangement of immunosuppressive immune cells for favorable premetastatic niche formation and growth of metastases. (biomedcentral.com)
Type II NKT cells have an immunosuppressive effect, allowing the tumor cells to survive. (cancer.gov)

Single-cell sequencing is a high-throughput technique that enables detection of genomic, transcriptomic, and epigenomic information at the individual cell level, offering significant advantages in detecting cellular heterogeneity, precise cell classification, and identifying rare subpopulations. (frontiersin.org)
While the αβ lineage has been widely studied, the γδ lineage has not due to the minimal number of defined antigens, the unusual cellular responses to their environment, and the resulting challenge of identifying and studying this population in vivo. (wikipedia.org)
While CD3 complexes have been associated with cytolytic regulation, it is unclear whether TRG is also necessary for mediated cellular cytotoxicity. (wikipedia.org)
Cells infected with MA104 rotavirus and/or transfected with plasmids expressing NSP proteins, were analyzed for expression of cellular proteins related to NFκB and PPARÎ³ pathways and evaluated through the ELISA, luminescence, flow cytometry and Western blot techniques. (bvsalud.org)
10 Galectins can function inside the cells by modulating signaling pathways, 11 although they also act extracellularly by establishing multivalent interactions with cell surface glycans and delivering signals that lead to disruption of cellular homeostasis. (nature.com)
Because age-related cellular senescence and type 2 diabetes (T2D) have been recognised as risk factors for CRC development, the recent finding that type 2 diabetic patients present an elevated circulating volume of senescent cells raises the question whether type 2 diabetes facilitates the process of CRC tumorigenesis by inducing premature cell senescence. (frontiersin.org)
Since 2000 PA is the group leader of the Cell Death Research & Therapy lab, at the Department of Cellular & Molecular Medicine of the KU Leuven, and in 2008 she became Full Professor at the same Institution. (euroacadti.eu)
We also study the logic of natural cellular signaling systems, and the underlying principles of cellular communication and collective cell behavior during an immune response. (ucsf.edu)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Cellular inhibitor of apoptosis proteins (c-IAP) 1 and 2 are widely expressed ubiquitin protein ligases that regulate a variety of cellular functions, including the sensitivity of T cells to costimulation. (bioxcell.com)
The TME consists of various cellular components, including immune cells, stromal cells, and extracellular matrix, along with soluble factors and signaling molecules. (biomedcentral.com)

Moreover, single-cell sequencing provides unique insights into the mechanisms of pancreatic cancer metastasis and cachexia, paving the way for developing novel preventive strategies. (frontiersin.org)
It unlocks novel dimensions by uncovering elusive cell populations and tumor heterogeneities for early detection, unraveling mechanisms of treatment resistance, tailoring therapies to individuals, and illuminating metastasis and cachexia pathways, thereby opening fresh avenues for preventive strategies. (frontiersin.org)
Ongoing research investigates mechanisms invoked by cancer cells to abrogate MHC-I expression and attenuate anti-tumour CD8 + cytotoxic T cell response. (portlandpress.com)
This review provides a comprehensive overview of physiologically conserved or novel mechanisms utilised by tumour cells to reduce MHC-I or MHC-II expression. (portlandpress.com)
Oncolytic viruses (OVs) specifically induce cancer cells death by infection of and spreading on tumor cells through different mechanisms such as direct lysis effect or adjacent cells fusion. (biomedcentral.com)
however, mechanisms through which these bioactive compounds act on epithelial cells have not been identified. (biorxiv.org)
With the increased understanding of molecular mechanisms and basic pathways in the pathogenesis of squamous cell cancer of the head and neck , these pathways may be modified, and rational approaches in cancer therapy at the molecular level may be created. (medscape.com)
PA started her own research group in 1996 with a focus on mechanisms of cancer cell death induced by irradiation. (euroacadti.eu)
His laboratory is interested in the mechanisms involved in antigen presentation by DC, mainly related to cross presentation. (euroacadti.eu)
He seeks to understand the mechanisms of immune regulation in cancer patients. (cancer.gov)
The mechanisms of TIGIT co-inhibition of T cells are illustrated in Figure 1. (greatlakeshighereducationnow.com)
Open in a separate window Figure 1 Mechanisms of TIGIT inhibition in T cells. (greatlakeshighereducationnow.com)
TIGIT displays multiple PD 151746 inhibitory mechanisms in T cells. (greatlakeshighereducationnow.com)

Here the authors design a second-generation macrophage-specific CAR by integrating CD3ζ and toll/IL-1R (TIR) domains resulting in an M1-polarized CAR-iMAC with increased antitumor functions. (nature.com)
Regulation of immunomodulatory functions by granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in vivo. (nwbio.com)

This study investigated whether BRD4 inhibition can alter the immunomodulatory and antitumor effects of radiation therapy (RT). (preprints.org)

Our overarching goal is to understand the cell-autonomous regulation of stem-like CD8+ TILs, their crosstalk with other cells in the TME, and how together they govern the activation of proficient anti- tumor CD8+ T cell responses and ICB efficacy. (hhs.gov)
Early studies have indicated its potential in enhancing the efficacy of immune checkpoint inhibitors and improving antitumor immune responses. (peptide-bioregulator.com)
A series of in vitro and in vivo analyses, including physical and chemical characterizations, targeting property, biosafety, and antitumor efficacy of Wpep-DGL/Pt were systematically carried out. (thno.org)
Wpep-DGL/Pt showed potent antitumor efficacy in MDA-MB-231 cells tumor-bearing nude mice with a deficient immune system, demonstrating targeted delivery of chemotherapeutics and the resultant cytotoxicity. (thno.org)
Costimulation of T cell responses with monoclonal antibody agonists (mAb-AG) targeting 4-1BB showed robust anti-tumor activity in preclinical models, but their clinical development was hampered by low efficacy (Utomilumab) or severe liver toxicity (Urelumab). (bioxcell.com)

Therefore, addition of BRD4 inhibition significantly enhanced the systemic antitumor responses of local RT. (preprints.org)
Both ILC2 and ILC3 populations are able to internalize and present peptide antigens on MHC-II and control T cell responses (3-7). (europa.eu)
In this case, the stimulation of endoplasmic reticulum (ER) stress and subsequent immunogenic cell death (ICD) process in OVs-infected cells elicit a range of anti-tumor immune responses. (biomedcentral.com)
Thymus glands are responsible for the production and maturation of T-cells, which play a vital role in immune responses. (peptide-bioregulator.com)
Bonothyrk Peptide's ability to enhance T-cell function and modulate immune responses makes it an attractive candidate for combination therapies with existing immunotherapeutic agents. (peptide-bioregulator.com)
The regulation of immune responses through MoAbs is a ground-breaking therapeutic strategy in oncology. (biomedcentral.com)
1 Interestingly, CD1a participates in bee and wasp venom allergy and in antitumor immune responses. (hcdm.org)
property of TIGIT blockade is that it enhances not only anti-tumor effector T-cell responses, but also NK-cell responses, and reduces the suppressive capacity of regulatory T cells. (greatlakeshighereducationnow.com)
By exploiting the most advanced technologies (nanoparticle-based vaccines, neo-antigens identification and validation, etc.), suitable preclinical models, and investigation of anti-tumour immune responses in cancer patients, we are developing innovative strategies potentially able to improve current approaches. (edu.au)
Tumour neo-antigen-specific immune responses in oesophageal cancer long-term survivors: proof-of-concept for improved personalised therapeutic strategies. (edu.au)
Project aiming at characterizing the role of neo-antigen immune responses in mouse and human breast cancer. (edu.au)
Project aiming at characterising tumour neo-antigen-specific immune responses in oesophageal adenocarcinoma patients with long-term survival. (edu.au)
However, cancer cells exploit these checkpoints to evade immune surveillance and suppress antitumor immune responses. (biomedcentral.com)
iNKT cells have emerged as important contributors to the regulation of immune responses, T cell activation, and anti-tumor activity. (tmu.edu.tw)
Thus, α-GalCer-incorporated liposome is capable of improving the delivery of antigen to antigen-presenting-cell and inducing effective immune responses via various routes. (tmu.edu.tw)

These cells are tumor antigen-specific, exhibit polyfunctional effector capacity, and increase in proportion upon various ICBs across different cancer types. (hhs.gov)
Although the transcription factor TCF-1 plays an important role in the maintenance and effector function of these cells, we have found that TCF-1 expression in CD8+ T cells is not requisite for positive response to ICB in all tumor contexts. (hhs.gov)
These molecules were most highly expressed in the expanded populace of effector T cells in CLL. (researchensemble.com)
Thus, the mechanism of action of Ipilimumab has been presumed to involve releasing anti-tumor effector T cells from CTLA-4-inhibition and/or limiting T REG activity in the tumor and therefore resulting in an increase in the ratio of effector T cells/ T REG s within the tumor. (sanguinebio.com)
sought to clarify the mechanism by which Ipilimumab functions to alter the ratio of effector T cells/ T REG s in a murine tumor model. (sanguinebio.com)
Here, we show that effector and memory T cells from mice expressing a dominant negative E3-inactive c-IAP2 (c-IAP2(H570A) ) have impaired signaling downstream of 4-1BB. (bioxcell.com)
Iron is critical for mucosal-associated invariant T cell metabolism and effector functions. (preprintclub.com)

There is a hypothesis that γδ T cells process these pathogenic antigens, transport them to draining lymph nodes, and then present the antigens to activate αβ T cells and other immune effectors. (wikipedia.org)
Then these signals are engulfed as antigens and presented by antigen-presenting cells within the tumor-derived lymph nodes. (thno.org)

In conclusion, Th17 cells have a substantial impact on the carcinogenesis of LSCCs, and could serve as a potential therapeutic target to modulate the anti‑tumor response in these carcinomas. (spandidos-publications.com)
It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet. (rockland.com)
IL-35 is composed of EBI3 and the p35 subunit of IL-12 and has been reported to have therapeutic effects against collagen-induced arthritis by expanding the population of regulatory T cells and suppressing Th17 cells. (rockland.com)
This approach set the basis for therapeutic strategies aimed at eliminating aberrantly glycosylated cancer cells. (nature.com)
In the Roybal Lab we harness the tools of synthetic and chemical biology to enhance the therapeutic potential of engineered immune cells. (ucsf.edu)
Multidimensional control of therapeutic human cell function with synthetic gene circuits. (ucsf.edu)
The study investigates Ultimovacs' therapeutic cancer vaccine, UV1, in combination with pembrolizumab versus pembrolizumab alone, as first-line treatment for patients with recurrent or metastatic PD-L1 positive head and neck squamous cell carcinoma (HNSCC). (ultimovacs.com)
There are still significant barriers to therapeutic success because of tumor-specific antigens (TA) and toxicities associated with treatment [ 19 ]. (biomedcentral.com)

The Vδ2+ T cells recognize small non-peptide antigens, but unlike αβ T cells, these antigens do not need to be processed by antigen-presenting cells or presented by classical major histocompatibility complex (MHC) molecules. (wikipedia.org)
TME consists of cell component, the extracellular matrix (ECM) and abundant soluble signaling molecules. (biomedcentral.com)
The surface of the living cells is decorated by a complex layer of glycosylated molecules that store relevant biological information. (nature.com)
Various techniques have been developed for targeting cancer cells: gene therapy, monoclonal antibodies (MAbs), antibody toxin conjugates, small-molecule inhibitors, antisense molecules, and tumor vaccines. (medscape.com)

However, TIGIT exerts its functions not only by direct cell-intrinsic inhibitory signaling, but like CTLA4 which blocks binding of its co-stimulatory counterpart CD28 to their shared ligands CD80 and CD86, also in an indirect way. (greatlakeshighereducationnow.com)

Targeted molecular therapy, like therapy with monoclonal antibodies, gene therapy, and other therapies, has limited or nonexistent side effects on normal cells of the body, unlike present modalities such as surgery, chemotherapy, and radiotherapy. (medscape.com)
How can our knowledge of the immune system be applied to develop innovative therapies, including the identification of novel antigens for immune therapies and gene repair strategies in monogenic immune diseases? (mdc-berlin.de)

[ 1 ] Early stage head and neck squamous cell carcinoma (HNSCC) is treated relatively well with single-modality therapy (either surgery or radiation alone). (medscape.com)
Go to Imaging of Nasopharyngeal and Laryngeal Squamous Cell Carcinoma and Head and Neck Squamous Cell Carcinoma for complete information on these topics. (medscape.com)
Head and neck cancer is the seventh most common type of cancer worldwide, and squamous cell carcinoma (HNSCC) represents about 90 percent of these patients. (ultimovacs.com)

BRD4 inhibitor expanded CD4+ and CD8+ T cell populations and reduced the population of monocytic myeloid-derived suppressor cells (M-MDSCs). (preprints.org)
These defects were not restricted to expanded populations of cytomegalovirus (CMV)-specific cells although CMV seropositivity modulated the distribution of lymphocyte subsets the functional defects were present irrespective of CMV serostatus. (researchensemble.com)
The B27 antibody is useful for immunofluorescent staining and flow cytometric analysis to identify and enumerate IFN-γ producing cells within mixed cell populations. (bdbiosciences.com)
Thus, even for functionally different (antagonistic versus agonistic) immunotherapeutic antibodies targeting these same T cell populations, FcgR-mediated ADCC of T REG s appears to be a critical mechanism for anti-tumor effects. (sanguinebio.com)
The ratio of pro- to antitumor immune populations in the TIME plays a critical role in the regulation of tumor progression and metastasis. (biomedcentral.com)
Circulating PD-1+TIGIT+CD8+ T-cell populations are negatively correlated with overall survival rate and progression-free survival rates in patients with hepatitis B virus associated HCC (HBV-HCC) (63). (greatlakeshighereducationnow.com)
Transcriptomic profiling of T-cell populations in non-muscle invasive and muscle invasive bladder cancer. (lu.se)

Memory Th1 cells modulate heterologous diseases through innate function. (preprintclub.com)

Nonetheless, in addition of source of protein antigens, commensal bacteria are a source of lipids capable to activate the lipid-reactive cells named natural killer T (NKT) cells (8,9). (europa.eu)

Their expression in tumour cells is modulated by a complex interplay of genomic, transcriptomic and post translational factors involving multiple intracellular antigen processing pathways. (portlandpress.com)
Upon binding its ligand 4-1BBL, 4-1BB provides costimulatory signals to both CD4 and CD8 T cells through the activation of NF-κB, c-Jun and p38 downstream pathways. (bioxcell.com)

Flow cytometry was used to investigate the percentage of Th17 and Th1 cells in peripheral blood mononuclear cells. (spandidos-publications.com)
Expression of IFN-γ by stimulated human peripheral blood mononuclear cells (PBMC). (bdbiosciences.com)

Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. (nature.com)
What is the precise role of intracellular and extracellular galectins in the control of cell death programs? (nature.com)

cutaneous exposure to antigen in atopic dermatitis may enhance the development of asthma. (cdc.gov)

To demonstrate specificity of staining, binding by the FITC Mouse Anti-Human IFN-γ antibody was blocked by preincubation of fixed/permeabilized cells with excess Purified Mouse Anti-Human IFN-γ antibody (Cat. (bdbiosciences.com)
His research currently focuses on natural killer T (NKT) cells, a lesser-known component of the immune system with the response rate of the innate immune system but the antigen specificity of the adaptive immune system. (cancer.gov)
Second, NKT cells mount a response as quickly as the innate immune system, while retaining the antigen specificity of T-cells in the adaptive immune system. (cancer.gov)
Project aiming at exploiting our Clec9A-targeting vaccination platform to enhance co-stimulation and in vivo persistence of CAR-T cells with dual specificity. (edu.au)

3) or disrupts CD226 homo-dimerization PD 151746 to inhibit CD226-mediated T cell activation. (greatlakeshighereducationnow.com)

Sharpe and colleagues devise a conditional gene deletion model in mice for rapid sequential, combinatorial and lineage-specific interrogation of gene function in hematopoietic cells. (nature.com)
The goal of gene therapy is to introduce new genetic material into cancer cells that selectively kills them without causing toxicity to the surrounding cells. (medscape.com)
Analysis of lineage specific genes revealed differential methylation and gene expression in tumor CD4+ T-cells. (oncotarget.com)

Stem cells reside in niches where crosstalk between stem cells and other cells in the niche regulates not only their maintenance and function but also the function of niche cells. (hhs.gov)
The oncogenic communication with tumor cells and through the crosstalk of autocrine and paracrine components in almost all tumor types are responsible for this phenomenon. (biomedcentral.com)
The stromal component interacts with tumor cells in complex crosstalk to support tumor growth. (biomedcentral.com)

CTLA-4 is a negative regulatory molecule expressed by activated T cells as well as by negative regulatory T cells (T REG s). (sanguinebio.com)

J Cell Immunol. (scientificarchives.com)
2015). "c-IAP ubiquitin protein ligase activity is required for 4-1BB signaling and CD8(+) memory T-cell survival" Eur J Immunol 45(9): 2672-2682. (bioxcell.com)
Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A. Nat Immunol. (hcdm.org)

ECM is a macromolecular substance secreted by cells into the extracellular space and constitutes a complex network that supports tissue structure and the physiological activities of cells, including collagen, elastin fibrils, proteinases, proteoglycans (PGs), glycoproteins and glycosaminoglycans (GAGs). (biomedcentral.com)

Type I NKT cells have an immune promoting effect, resulting in tumor cell lysis. (cancer.gov)

A key mechanism of immune evasion deployed by tumour cells is to reduce neoantigen presentation through down-regulation of the antigen presentation machinery. (portlandpress.com)
The discovery of MHC-II on tumour cells has been less characterized. (portlandpress.com)

It has been confirmed that naïve (uncommitted) CD4 + T cells can be induced to different specific lineages according to the local cytokine, including towards T helper (Th)1, Th2, Th17 and T regulatory (Treg) cells ( 7 ). (spandidos-publications.com)

The CD1 family: serving lipid antigens to T cells since the Mesozoic era. (hcdm.org)
CD1a, as other members of the CD1 family, is involved in the immune response by presenting self and non-self lipid and glycolipid antigens to T cells. (hcdm.org)
Another focus of the lab is sulfatide, a lipid in the myelin sheath that can be recognized by NKT cells. (cancer.gov)
In this project, α-GalCer was incorporated into the lipid bilayer of the liposome, while the galactose molecular was expressed on the surface of the liposome to form a targeting liposome antigen-carrier with immunemodulatory effect. (tmu.edu.tw)

Overall, single-cell sequencing has immense potential in promoting early diagnosis, guiding personalized treatment, and preventing complications of pancreatic cancer. (frontiersin.org)
Emerging single-cell sequencing technologies will undoubtedly enhance our understanding of the complex biology of pancreatic cancer and pave the way for new directions in its clinical diagnosis and treatment. (frontiersin.org)
Applications of single-cell sequencing technology in the diagnosis and treatment of pancreatic cancer. (frontiersin.org)
Single-cell sequencing technology transforms the landscape of pancreatic cancer diagnosis and therapy. (frontiersin.org)
Interleukin (IL)17-producing Th17 cells, which are different from Th1 and Th2 cells, have been described as serving critical roles in inflammation and autoimmune diseases, as well as in cancer development ( 8 - 11 ). (spandidos-publications.com)
The present studies were undertaken to address the role of fetuin-A in the growth and invasion potential in a triple negative breast cancer (TNBC) cell line, MDA-MB-468. (preprints.org)
A murine breast cancer cell line was implanted into BALB/c mice. (preprints.org)
Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer (NSCLC) and is the leading cause of cancer death worldwide. (biomedcentral.com)
Lung cancer is the leading cause of cancer-related deaths worldwide, with non-small cell lung cancer (NSCLC) accounting for about 85% of cases and lung adenocarcinoma (LUAD) being the most common subtype [ 1 ]. (biomedcentral.com)
Establishment of a BRAF V595E-mutant canine prostate cancer cell line and the antitumor effects of MEK inhibitors against canine prostate cancer. (go.jp)
The goal of specific molecular targets in cancer therapy is to create a "magic bullet" that selectively kills cancer cells. (medscape.com)
As our understanding of the molecular biology of HNSCC continues to develop, we can target the specific components of cancer cells that are not found in normal cells. (medscape.com)
Ideal targets should be both specific to cancer cells and commonly found in cancer cells. (medscape.com)
Dr. Allison is a leader in the field of immunology, particularly in developing ways to help the immune system recognize and destroy cancer cells. (euroacadti.eu)
Therefore, understanding the TME and its immune cell components are equally important as cancer cell characteristics for tumor eradication. (biomedcentral.com)
Tumor-infiltrating immune cells are an important component of the TIME and are a significant predictor of cancer patients' survival. (biomedcentral.com)
During the tumor initiation stage, cancer cells escape from immune surveillance. (biomedcentral.com)
The enzyme is essential for the ability of cancer cells to proliferate. (ultimovacs.com)
The DKFZ is a multidisciplinary center covering cancer biology from basic molecular and cell biology to clinical research and care. (mdc-berlin.de)
This review examines how LSD1 modulates different cell behavior in TME and emphasizes the potential use of LSD1 inhibitors in combination with ICB therapy for future cancer research studies. (biomedcentral.com)

Anatomy22

Organisms13

Diseases21

Chemicals and Drugs127

Analytical, Diagnostic and Therapeutic Techniques and Equipment42

Phenomena and Processes36

Disciplines and Occupations1

Information Science3

Health Care3

Immunity28

Dendritic30

APCs10

Immunotherapy10

Macrophages15

Microenvironment16

Receptors18

Receptor16

Cytokines12

Tumors17

Induces6

Lymphocytes10

Melanoma8

Differentiation6

Proliferation6

Malignant3

Recognition5

Immunosuppressive3

Cellular11

Mechanisms13

Macrophage2

Immunomodulatory1

Efficacy5

Responses15

Effector7

Lymph nodes2

Therapeutic8

Molecules4

CD861

Therapies2

Squamous cell carc3

Populations7

Modulate1

Activate1

Pathways2

Peripheral blood mononuclear2

Intracellular2

Cutaneous1

Specificity4

Inhibit1

Gene3

Crosstalk3

Regulatory T cel1

Immunol3

Tissue1

Tumor cell1

Tumour2

Cytokine1

Lipid4

Cancer20