Antitumor regimens immunotherapy adoptive. Medical search. Frequent questions

Multimodal immunogenic cell death (ICD) together with autophagy often induced by OVs not only presents potent danger signals to dendritic cells but also efficiently cross-present tumor-associated antigens from cancer cells to dendritic cells to T cells to induce adaptive antitumor immunity. (biomedcentral.com)
Combination with cyclophosphamide further induces ICD, depletes Treg, and thus potentiates antitumor immunity. (biomedcentral.com)
The antitumor immunity helps eliminate the uninfected cancer cells in primary and metastatic nodules, and enforce micrometastases in dormant state. (biomedcentral.com)
To determine the mechanisms of how innate immune activation via lymphodepletion potentiated antitumor T cell immunity, we utilized the pmel-1 melanoma mouse model. (biomedcentral.com)
Breakthroughs in anti-tumor immunity have led to unprecedented advances in immunotherapy, yet it is now clear that the tumor microenvironment (TME) restrains immunity. (elifesciences.org)
Apparently, this is due to the lack of stimulation of antitumor immunity during the mass decay of cancer cells and the release of antigens into the systemic bloodstream, as it happens with other tumors. (bookinghealth.com)

Cancer immunotherapies, including immune checkpoint inhibitors, would be one of the potential approaches to apply the results of genomic sequencing most effectively. (cancerbiomed.org)
Immunotherapy mainly includes immune checkpoint inhibitors (ICIs), such as inhibitors of PD-1 (programmed cell death 1)/programmed cell death ligand 1 (PD-L1). (nature.com)
Clinical use of a combination of radiotherapy and chemotherapy continues to increase, while the development of immunotherapy, such as checkpoint inhibitors, offers hope in improving treatment outcome. (hkmj.org)
This has led to the need for new immunotherapy-based approaches, including adoptive cell transfer (ACT), therapeutic vaccines, and novel immune checkpoint inhibitors. (biomedcentral.com)
This has resulted in the development of additional immunotherapy-based approaches, including adoptive cell transfer (ACT), therapeutic vaccines, and inhibitors of other immune checkpoints. (biomedcentral.com)
Thirty-nine (26%) were on treatment with immunotherapy, and 17 (11%) with BRAF-MEK inhibitors. (unav.edu)
Tyrosine kinase inhibitors and immunotherapy for lung cancer are the two major areas undergoing rapid development. (biomedcentral.com)
Herein, we summarize emerging agents including tyrosine kinase inhibitors, checkpoint inhibitors, and other potential immunotherapy such as chimeric antigen receptor T cell for non-small cell lung cancer attempting to provide insights and perspectives of the future in anticancer treatment. (biomedcentral.com)
Herein, we summarized the novel agents in tyrosine kinase inhibitors especially for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) inhibitors, checkpoint inhibitors, and other potential immunotherapy aiming to provide a landscape of emerging agents for NSCLC as well as insights and perspectives for the future in anticancer treatment. (biomedcentral.com)
The pancreatic tumor does not respond to cytokines, immune checkpoint inhibitors, and adoptive cell therapy. (bookinghealth.com)

Furthermore, similar to T cells, specific recognition and elimination of cancer cells by NK cells can be markedly enhanced through expression of chimeric antigen receptors (CARs), which provides an opportunity to generate NK-cell therapeutics of defined specificity for cancer immunotherapy. (frontiersin.org)
Insufficient persistence and effector function of chimeric antigen receptor (CAR)-redirected T cells have been challenging issues for adoptive T cell therapy. (biomedcentral.com)
Adoptive cell therapy (ACT) with chimeric antigen receptor T (CAR-T) cells can restore the activity of exhausted T cell through reprogramming and is widely used in the treatment of relapsed/refractory (r/r) hematological malignancies. (hindawi.com)
Promising immunotherapy strategies for Compact disc19-positive hematological malignancies are the adoptive transfer of T cells that are genetically improved to express Compact disc19-particular chimeric antigens receptors (Vehicles) or the infusion of bispecific antibodies that redirect citizen T cells to Compact disc197,8,9,10,11,12,13,14,15. (bso14.org)
Several types of ACT round out the immunotherapy arsenal, including chimeric antigen receptor (CAR) T-cell therapy, T-cell receptor (TCR) therapy, and tumor-infiltrating lymphocyte (TIL) therapy. (aacr.org)

Finally, TBI was no longer needed to regress tumors in mice who were depleted of host CD4 + T cells, given a tripartite ACT regimen and then treated with low dose LPS. (biomedcentral.com)
Immune-inflamed tumors are called hot tumors, while the latter two are collectively referred to as cold tumors, and they respond poorly to immunotherapy. (nature.com)
However, not all patients respond to immunotherapy, acquired resistance remains a challenge, and responses are poor in certain tumors which are considered to be immunologically cold. (biomedcentral.com)
Dr. Martin Algarra areas main of interest have been the therapeutic development of immunotherapy and targeted therapies in Oncology, mainly in melanoma, sarcoma, and rare tumors. (unav.edu)
TILs represent the most developed strategy for neoantigen-targeting immunotherapy, and it is well known that this therapy has shown efficacy in infiltrating tumors, Svane said. (targetedonc.com)
In this report, the biologic functions of MDSC are defined and evidence linking MDSC with the response to cancer immunotherapies in solid tumors are reviewed. (iospress.com)
Tumor-infiltrating lymphocyte (TIL) therapy is a type of adoptive cellular therapy by harvesting infiltrated lymphocytes from tumors, culturing and amplifying them in vitro and then infusing back to treat patients. (biomedcentral.com)
Its diverse TCR clonality, superior tumor-homing ability, and low off-target toxicity endow TIL therapy unique advantages in treating solid tumors compared with other adoptive cellular therapies. (biomedcentral.com)
TIL therapy is a type of adoptive cellular therapy leveraging the patient's own immune system to treat tumors. (biomedcentral.com)
The trial is evaluating safety, tolerability, and efficacy of GEN-001, a next-generation neoantigen adoptive cell therapy, on solid tumors . (cgtlive.com)
Unlike chemotherapy or radiation which directly attack tumors, immunotherapy helps train the immune cells to recognize markers on cancer cells and boosts their killing capability. (theusaknowledge.net)

T cells expanded ex vivo from a CpG-treated culture demonstrated potent antitumor efficacy and prolonged persistence in vivo. (bmj.com)
This antitumor efficacy was accomplished without in vivo administration of TLR agonists or other adjuvants of high-dose interleukin (IL)-2 or vaccination, which are classically required for effective ACT therapy. (bmj.com)
Combination with other immunotherapy regimens improve overall therapeutic efficacy. (biomedcentral.com)
All chemotherapy regimens showed almost the same efficacy with objective response rate (ORR) of 19% and 7.9 m median overall survival (OS). (biomedcentral.com)
Combining tumor-specific adoptive T cell therapy to the aCTLA-4/aPD1/rIL2 or aCTLA-4/aPD1/aCD137 reg-imens enhances efficacy in a synergistic manner. (unav.edu)

Thus, besides developing direct immunostimulatory regimens, including dendritic cell-based vaccines, checkpoint-blocking therapies, and adoptive T-cell transfer, researchers have started to focus on the overall immunobiology of neoplastic cells. (ox.ac.uk)
But it can be boosted with a dendritic cell-based cancer immunotherapy, i.e. anti-tumor vaccine. (bookinghealth.com)

Conclusions Our results demonstrate a novel way to use TLR agonists to improve immunotherapy and reveal a vital role for B cells in the generation of potent CD8 + T cell-based therapies. (bmj.com)
Immunotherapy is one of the novel treatment modalities that include the checkpoint blockade therapy, personalized cancer vaccines, and adoptive T-cell therapies. (cancerbiomed.org)
While many successful immunotherapeutic regimens have relied on checkpoint inhibition, other immunotherapeutic approaches, such as adoptive cellular therapies (ACT), the use of bispecific antibodies, and targeting components of the tumor microenvironment, are showing promise in a variety of cancer types. (aacr.org)
We now need to know how we can improve the current immunotherapy strategies so that not only a subset of patients respond, but even more patients can benefit from these therapies," Sharma said. (aacr.org)
The use of cell therapies, drivers of immune response, and trends in immunotherapy were the focus of the Immunotherapy Bridge (November 30th-December 1st, 2022), organized by the Fondazione Melanoma Onlus, Naples, Italy, in collaboration with the Society for Immunotherapy of Cancer. (biomedcentral.com)
The use of cell therapies, drivers of immune response, and trends in immunotherapy were the focus of the Immunotherapy Bridge (November 30th-December 1st, 2022). (biomedcentral.com)

Toll-like receptor (TLR) agonists can invigorate antitumor T cell responses when administered directly to patients, but these responses often coincide with toxicities. (bmj.com)
Herein, we used TLR4 agonist LPS as a tool to address how and when to use TLR agonists to effectively improve cancer immunotherapy. (biomedcentral.com)
We also found that non-toxic TLR agonists MPL and CpG potentiated the antitumor activity of infused CD8 + T cells. (biomedcentral.com)
Collectively, our results identify how and when to administer TLR agonists to augment T cell-based immunotherapy in the absence or presence of host preconditioning for treatment of advanced malignancies. (biomedcentral.com)
In April 2022, HOOKIPA presented positive data at the 2022 American Association for Cancer Research Annual Meeting showing HOOKIPA's arenaviral immunotherapies induced potent T cell responses in novel combinations (such as co-stimulatory 4-1BB agonists or adoptive cell transfer) and against tumor self-antigens. (financialcontent.com)
CD137 agonists attain immunotherapeutic antitumor effects in cancer mouse models, and multiple agents of this kind are undergoing clinical trials. (unav.edu)

As one of the four major means of cancer treatment including surgery, radiotherapy (RT), chemotherapy, immunotherapy, RT can be applied to various cancers as both a radical cancer treatment and an adjuvant treatment before or after surgery. (nature.com)
We made substantial progress in 2022 as we work to develop our novel arenaviral immunotherapies against a variety of cancers and infectious diseases. (financialcontent.com)
In October 2022, HOOKIPA announced a strategic collaboration and license agreement to develop HB-700 for KRAS-mutated cancers and a second undisclosed novel immunotherapy candidate. (financialcontent.com)
These new approaches are focused on patients with an inadequate response to current treatments, with emerging evidence of improved responses in various cancers with new immunotherapy agents, often in combinations with existing agents. (biomedcentral.com)
Numerous clinical trials and real-world experience provide evidence of improved response and survival outcomes with multiple immunotherapy agents and different combinations in various cancers. (biomedcentral.com)
This study illustrates how rational approaches to the design of immunotherapies can help overcome the barriers to immune responses that are erected by a variety of cancers, not least ovarian cancer," said Coukos. (bionewscentral.com)
Cancer immunotherapy, the immune system's artificial stimulation, is an efficient method for the treatment of different cancers [ 13 ]. (biomedcentral.com)
After decades of research, immunotherapy has now emerged as a revolutionary approach against certain types of cancers. (theusaknowledge.net)

These cells can be activated ex vivo to exhibit a potent antitumor effector function. (biomedcentral.com)

Combination chemotherapy regimens, such as FOLFIRINOX and nab-paclitaxel plus gemcitabine, have demonstrated improved survival rates in advanced pancreatic cancer ( 7 , 8 ). (frontiersin.org)
ECOG1594 was the first trial comparing four different chemotherapy regimens for advanced non-small cell lung cancer (NSCLC) head to head [ 1 ]. (biomedcentral.com)

However, just like other immunotherapeutic regimens, a number of challenges remain for OVs-mediated cancer vaccines. (biomedcentral.com)

It is noted that T cell has great potential for immunotherapy of hematological malignancies. (hindawi.com)

A non-myeloablative lymphodepleting preparative regimen with 5Gy TBI prior to an ACT regimen can induce destruction of B16F10 melanoma in mice by removing cytokine sinks, depleting suppressive T reg cells, transiently ablating myeloid derived suppressor cells (MDSCs) and activating the innate immune system [ 11 ]. (biomedcentral.com)
Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) has shown activity in melanoma, but has not been previously evaluated in metastatic non-small cell lung cancer. (nature.com)
In another phase 1/2 study (NCT00937625), adoptive cell therapy with TILs was examined in patients with metastatic melanoma who had progressed on prior treatment with high-dose IL-2 and ipilimumab (Yervoy). (targetedonc.com)
Anti-PD-1 therapy is a main treatment strategy for patients with metastatic melanoma, according to Svane, and, as such, it was important for investigators to examine whether adoptive cell therapy with TILs can be utilized in patients who had progressed on this therapy. (targetedonc.com)
Primary interests include clinical trials design and the design and analysis of biomarker and imaging studies especially in the areas of GI cancer, lymphoma, melanoma, transplant and cancer immunotherapy. (dukecancerinstitute.org)

Cancer immunotherapies, which target neoantigens, could lead to a precise treatment for cancer patients, despite the challenge in accurately predicting neoantigens that can induce cytotoxic T cells in individual patients. (cancerbiomed.org)
Multiple approaches are today being developed at Ludwig Lausanne and elsewhere to target neoantigens for cancer immunotherapy. (bionewscentral.com)

The third plenary session of the AACR Annual Meeting 2019 , titled "Manipulating the Immune System in Cancer Therapy," focused on recent advances in the field of immunotherapy. (aacr.org)

We then outline preclinical approaches that employ CAR-NK cells for GB immunotherapy, and give an overview on the ongoing clinical development of ErbB2 (HER2)-specific CAR-NK cells currently applied in a phase I clinical trial in glioblastoma patients. (frontiersin.org)
Alternative immunotherapy approaches have been investigated, including antitumor vaccines and adoptive transfer of CD19 CAR-T cells reported in this paper. (ashpublications.org)

Precise prediction of neoantigens should accelerate the development of personalized immunotherapy including cancer vaccines and T-cell receptor-engineered T-cell therapy for a broader range of cancer patients. (cancerbiomed.org)

Intratumoral immunotherapy strategies for cancer based on interleukin-12 (IL-12)-encoding cDNA and mRNA are under clinical development in combination with anti-PD-(L)1 monoclonal antibodies. (unav.edu)
For those who are ineligible for cisplatin-based regimens or experience progression of disease, in 2016-2017 the United States Food and Drug Administration approved five monoclonal antibodies that achieve immune checkpoint blockade by targeting the programmed cell death protein-1/programmed death-ligand 1 (PD-1/PD-L1) pathway. (iospress.com)

The use of a high dose cyclophosphamide post-transplant in a half matched or haploidentical donor hematopoietic stem cell transplantation reduces GVHD, even after using a reduced conditioning regimen. (wikipedia.org)
This will be completed after the patient had undergone a ludarabine/cyclophosphamide lymphodepletion regimen. (cgtlive.com)

Local administration or OV mediated-expression of ligands for Toll-like receptors can rescue the function of tumor-infiltrating CD8 + T cells inhibited by the immunosuppressive tumor microenvironment and thus enhances the antitumor effect. (biomedcentral.com)
In contrast, the microenvironment of lung cancer, which responds well to immunotherapy, contains 80 times more dendritic cells. (bookinghealth.com)

In the past few decades, systemic treatment for lung cancer remained to be cytoxicity agents with platinum-based regimens. (biomedcentral.com)

Two of the primary immunotherapies are immune checkpoint blockade (ICB) and adoptive cell transfer (ACT). (elifesciences.org)

Hence, continued advancements in diagnostic techniques, chemotherapy and radiation therapy regimens, targeted therapy strategies, and cachexia treatments will be critical for improving patient outcomes ( Figure 1 ). (frontiersin.org)
Indeed, similar to targeted therapy, patients may eventually develop resistance to immunotherapy [ 32 , 33 ] and some may even suffer hyperprogression after immunotherapy [ 34 , 35 ]. (biomedcentral.com)

We now investigate whether inhibition of Akt signaling during ex vivo expansion of CAR T cells can promote the generation of CAR T cells with enhanced antitumor activity following adoptive therapy in a murine leukemia xenograft model. (biomedcentral.com)

Nevertheless, ex vivo activation with cytokines can restore cytolytic activity of NK cells against GB, indicating that NK cells have potential for adoptive immunotherapy of GB if potent cytotoxicity can be maintained in vivo . (frontiersin.org)
NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
Background Adoptive T cell transfer (ACT) therapy improves outcomes in patients with advanced malignancies, yet many individuals relapse due to the infusion of T cells with poor function or persistence. (bmj.com)
CpG fostered the expansion of potent CD8 + T cells with the signature phenotype and antitumor ability via empowering a direct B-T cell interaction. (bmj.com)
Here we report that while exogenous administration of LPS was able to enhance adoptively transferred CD8 + T cells' tumor destruction, LPS treatment alone did not replace individual components of the tripartite ACT regimen, or obviate TBI. (biomedcentral.com)
In contrast, administering LPS after ACT potentiated the antitumor effectiveness of the regimen, thereby supporting the expansion of transferred tumor-specific CD8 + T cells over host CD4 + T cells. (biomedcentral.com)
In this review, we discuss the changes in irradiated cancer cells and immune cells in the TME under different RT regimens and describe existing and potential molecules that could be targeted to improve the therapeutic effects of RT. (nature.com)
One study reported an increased survival benefit with simultaneous RT compared with sequential administration, 8 while another study found no significant difference between the two strategies, 9 possibly because simultaneous RT plus immunotherapy and the administration of an ICI before RT may kill cancer cells as well a substantial number of immune cells, leading to poor systemic response and toxic side effects. (nature.com)
Anti-tumor activity was evaluated after adoptive transfer of the CD19CAR T cells into CD19+ tumor-bearing immunodeficient mice. (biomedcentral.com)
Once adoptively transferred into CD19+ tumor-bearing mice, Akti treated CD19CAR T cells exhibited more antitumor activity than did untreated CD19CAR T cells. (biomedcentral.com)
Genetically modified T cells expressing engager molecules might present a promising addition to current CD19-targeted immunotherapies. (bso14.org)
One potential technique to get Zoledronic Acid over these limitations may be the hereditary adjustment and adoptive transfer of T cells Zoledronic Acid that secrete diabodies20 or T-cell engagers (ENG T cells)21, since T cells can secrete substances at tumor sites positively, and persist for many weeks post infusion. (bso14.org)
In this scholarly study, we characterize ENG T cells particular for Compact disc19-positive malignancies (Compact disc19-ENG T cells) and present they are turned on and eliminate tumor cells within an antigen reliant manner, have the ability to recruit bystander T cells to tumor cells, and also have antitumor activity in preclinical versions. (bso14.org)
Adoptive T-cell therapy is established by taking tumor tissue from the patient and driving out the T cells from the tumor lesion, followed by initial TIL expansion. (targetedonc.com)
Ovarian cancer, like many other malignancies, has so far proved largely resistant to immunotherapies, most of which harness killer T cells, which destroy sick and infected cells. (bionewscentral.com)
3) Adoptive transfer of autologous CAR-T cells via infusion with or without prior lymphodepleting conditioning. (ashpublications.org)
suggesting that this substance could influence the response of cancer cells to immunotherapy. (biomedcentral.com)
Adoptive cell transfer involves engineering patient's own T-cells to create receptors on their surface that recognize specific tumor antigens. (theusaknowledge.net)
By targeting these critical regulators of immune response to cancer, immunotherapies augment the natural defenses of the body to attack malignant cells across multiple pathways. (theusaknowledge.net)
Due to their MHC-independence, γδ T cells can be applied in cellular immunotherapy also across HLA barriers. (explorationpub.com)
In this Special Issue, we will publish cutting edge papers dealing with various aspects of how γδ T cells interact with tumor cells, including translational perspectives for improving the clinical application of γδ T cells in immunotherapy. (explorationpub.com)

In this review, we will discuss the current status and future direction of implementing cancer precision medicine in the clinical setting, specially focusing on the personalized immunotherapies. (cancerbiomed.org)
Human clinical trials that investigate possible MDSC modulators are highlighted, and therapeutic strategies to leverage MDSC biology in bladder cancer immunotherapy are outlined. (iospress.com)
Researchers led by Ludwig Lausanne's Sara Bobisse, Alexandre Harari, Lana Kandalaft and Director George Coukos analyzed responses to the combination therapy of 18 patients with advanced ovarian cancer who had previously participated in a clinical trial evaluating a therapeutic regimen that incorporated the personalized cancer vaccine. (bionewscentral.com)
Patients enrolled in the trial received a therapeutic regimen that was shown to be promising in the previous clinical study . (bionewscentral.com)

Lymphodepletion enhances adoptive T cell transfer (ACT) therapy by activating the innate immune system via microbes released from the radiation-injured gut. (biomedcentral.com)
We develop a multifocal HCC model to test immunotherapies by introducing c-myc using hydrodynamic gene transfer along with CRISPR-Cas9-mediated disruption of p53 in mouse hepatocytes. (unav.edu)
Adoptive transfer studies confirmed the immune-memory effect as transplant of splenocytes from tumor-free mice into naïve recipients provided the ability to resist tumor growth. (prohostbiotech.com)

The emergence of immunotherapy has recently disrupted the paradigm of traditional cancer treatment (including the three traditional treatments RT, chemotherapy, and surgery), and immunotherapy functions by activating the body's immune system to fight cancer. (nature.com)
Nevertheless, current treatment regimens are connected with significant long-term and severe toxicities5. (bso14.org)
4 The overall response rate (ORR) achieved with this regimen was 42%, and patients who achieved a CR demonstrated a long duration of response (DOR) to treatment, according to Svane. (targetedonc.com)
Additionally, results from a meta-analysis that examined studies that administered adoptive cell therapy with TILs at treatment centers worldwide showed that durability of response can be experienced with this treatment if a CR is achieved. (targetedonc.com)
It is not possible to describe the exact regimen because the treatment is not yet standardized. (bookinghealth.com)
Immunotherapy represents an exciting new frontier in cancer treatment. (theusaknowledge.net)
While still early days, immunotherapy promises to change the face of cancer treatment as more applications are found across various cancer types. (theusaknowledge.net)
In this blog, we explore the different types of immunotherapies, their mechanisms of action, current uses in cancer treatment, limitations, and the exciting future possibilities of this transformative therapy. (theusaknowledge.net)

Antitumor effects of agonist anti-CD137 mAbs are critically dependent on the integrity of cIAPs in cancer mouse models, and cIAPs are also required for signaling from CARs encompassing CD137's cytoplasmic tail. (unav.edu)

As shown by multiplex tissue immunofluorescence and intravital microscopy, combined immunotherapy treatments enhance T cell infiltration and the intratumoral performance of T lymphocytes. (unav.edu)

Expanded understanding of the basic biology of T cell activation has enabled immunotherapy to combat cancer, and T cell metabolism now offers the opportunity to optimize and improve these therapeutic strategies. (elifesciences.org)

In patients with no BRAF mutation (ie, wild-type BRAF ), current guidelines from the National Comprehensive Cancer Network (NCCN) recommend single-agent immunotherapy with the programmed cell death-1 (PD-1) inhibitor pembrolizumab or nivolumab or combination therapy with nivolumab plus ipilimumab. (medscape.com)
A Ludwig Cancer Research study has shown that combining adoptive T cell therapy (ACT) with an innovative, personalized cancer vaccine under development at the Lausanne Branch of the Ludwig Institute for Cancer Research can benefit patients with late-stage, drug-resistant ovarian cancer. (bionewscentral.com)
Though not a double-blind, placebo-controlled trial, the study's findings suggest the benefits of the combination therapy were significant: the median overall survival time of patients who completed the regimen was 14.2 months, compared to a median historical survival of six months or less for comparable patients receiving fourth- and fifth-line chemotherapy. (bionewscentral.com)
CLL patients, with bulky disease that recurred after at least 1 prior chemotherapy regimen, were enrolled in a phase 1 trial. (ashpublications.org)

Inhibition of Akt signaling during ex vivo priming and expansion gives rise to CD19CAR T cell populations that display comparatively higher antitumor activity. (biomedcentral.com)

Anatomy23

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20191

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