[ 18 ] The strategy of triggering cells to enter into persister cell fate is to overproduce the toxins that inhibit cellular processes and growth, which is mediated by toxin-antitoxin modules. (medscape.com)
Toxin-antitoxin (TA) systems regulate fundamental cellular processes in bacteria and represent potential therapeutic targets. (figshare.com)
This plasmid contains toxin-antitoxin elements related to adaptation for growth, which might have emerged as a common vehicle indirectly mediating the spread of OXA-23 in CRAB. (frontiersin.org)
Serum3
In the early 1890s, Emil von Behring used serum from a hyperimmune horse (challenged with sublethal dose of Corynebacterium diphtheriae ) to develop equine diphtheria antitoxin (DAT), which seemed to confer passive immunity to patients with diphtheria ( 2 ). (cdc.gov)
The antitoxin produced from the contaminated serum was distributed and sold, resulting in the deaths of all 13 children. (usp.org)
Antibodies3
BoNT/A-mediated cleavage of SNAP-25 in the FN is prevented by intracerebroventricular delivery of antitoxin antibodies, demonstrating that BoNT/A physically leaves the motoneurons to enter second-order neurons. (jneurosci.org)
Consideration of antibodies as a therapeutic modality isn't new. (inscientioveritas.org)
495-497, 1975), MAbs were hailed as the 'Magic Bullet' that harnessed the therapeutic power of specific antibodies against specific diseases. (inscientioveritas.org)
BoNT6
However, not all the therapeutic benefits of the neurotoxin are explained by peripheral neuroparalysis, suggesting an action of BoNT/A on central circuits. (jneurosci.org)
These data highlight the ability of BoNT/A to selectively target and modulate specific central circuits, with consequent impact on its therapeutic effectiveness in movement disorders. (jneurosci.org)
By systematically changing the beliefs of kS, the 4-stage model simulated the speedy drop in NMJ function (0.01), the less fast starting point of paralysis in mice following we.m. shots (= 0.001), as well as the slow onset from the therapeutic ramifications of BoNT/A (and many related types represent a few of the most lethal chemicals known [1C3]. (exposed-skin-care.net)
Inhibition of the BoNT light chain metalloprotease (LC) has emerged as a new therapeutic strategy for the treatment of botulism that may provide an effective post-exposure remedy. (illnesshacker.com)
However, the currently licensed antitoxins are serotype-specific, mainly for BoNT/A and/or BoNT/B, while investigational BoNT/E and BoNT/A-G are also available. (cdc.gov)
Since these products will not protect the patient if the botulism is caused by any of the other serotypes, rapidly determining exposure to BoNT and serotyping the toxin involved are critical to choose the right antitoxin for treating the patient. (cdc.gov)
Botulism antitoxin2
Significant assets [8,9] have already been specialized in the largescale creation of heptavalent botulism antitoxin [10]. (exposed-skin-care.net)
In fact, before the advent of modern intensive care units and botulism antitoxin, people did die from botulism pretty commonly. (cdc.gov)
Diphtheria antitoxin4
Diphtheria antitoxin for therapeutic use is in limited supply. (cdc.gov)
One physician who had administered the diphtheria antitoxin lamented, "There I found that the little girl was suffering from tetanus (lockjaw). (usp.org)
While other strategies are being pursued to develop improved anthrax vaccines,' Dr. Schneemann said, 'none of these offer the distinct advantage of combining the function of a vaccine with a potent antitoxin. (patientcareonline.com)
In World War II, US soldiers were immunized with an antitoxin before arriving in France due to fears of the German army using Clostridium botulinum as a biological weapon. (biologydictionary.net)
Agam Rao] Botulism is treated with management in an intensive care unit, mechanical ventilation when needed, and botulinum antitoxin. (cdc.gov)
Botulinum antitoxin is most helpful if administered early during the patient's illness, so it's really important that physicians get that antitoxin as soon as possible when they find out about a patient's illness. (cdc.gov)
Bacteria4
The immunosuppressive microenvironment of solid tumors, in particular, creates a favorable niche for systemically administered bacteria to engraft and release therapeutic payloads. (nature.com)
To address this limitation, we engineer therapeutic bacteria to be controlled by focused ultrasound, a form of energy that can be applied noninvasively to specific anatomical sites such as solid tumors. (nature.com)
Here we describe the development of FUS-activated therapeutic bacteria in which a brief thermal stimulus activates sustained release of anti-cancer immunotherapy. (nature.com)
We have studied further classified grades of gonorrhceal allergic disease and bacteria with 15 m, the antitoxin. (memphiscfc.com)
Antibody1
Raxibacumab is also a monoclonal antibody therapeutic to treat illness caused by anthrax. (globalbiodefense.com)
Proteins3
International Therapeutic Proteins (known as ITP) was created in 2006. (wikipedia.org)
International Therapeutic Proteins is headquartered in the UK where administration, distribution and regulatory affairs are managed. (wikipedia.org)
The company's Australian subsidiary, called Australian Therapeutic Proteins, owns two farms in Tasmania totalling 500 hectares (1,235 acres). (wikipedia.org)
Microorganisms1
Marion Eberlin, 2018) Has a nutritive effect on the intestinal mucosa and an antitoxin effect on microorganisms. (vibcare.co.in)
Medicinal2
Against the background of the conflicting medicinal and therapeutic concepts promulgated in humoral pathology, cellular pathology, molecular pathology, and related fields including modern cybernetics, the German physician Dr. Hans-Heinrich Reckeweg formulated Homotoxicology in 1952. (urenus.com)
Products with therapeutic effects and containing medicinal ingredients, such as essential oils for treatment, hair tonic, anti Cellulite Cream, stretch marks removal cream, exothermic padding, etc. (joom.com)
Antidotes1
The company supplies antitoxins, antidotes to snake venoms and other biologics (biological therapeutics) to corporate and government clients. (wikipedia.org)
Acute1
A valuable therapeutic option for the treatment of acute diarrhea in children. (vibcare.co.in)
Anthrax6
At a therapeutic concentration, both completely protected the animals from anthrax lethal toxin. (patientcareonline.com)
Therefore, there is an urgent need for the discovery of antitoxin agents that would be effective at the end stage of anthrax. (infectioncontroltoday.com)
The U.S. Department of Health and Human Services' Office of the Assistant Secretary for Preparedness and Response (ASPR) this week announced it will add two types of anthrax antitoxin drugs to the Strategic National Stockpile (SNS) as options to treat inhalational anthrax. (globalbiodefense.com)
A five-year, $44.9 million agreement with Elusys Therapeutics of Pine Brook, New Jersey, BARDA will support production and future delivery of Elusys' anthrax antitoxin drug Anthim to the SNS. (globalbiodefense.com)
In addition, through a continuing agreement with GlaxoSmithKline BARDA will fund the production and delivery of the anthrax antitoxin drug Raxibacumab to replace expiring doses in the SNS. (globalbiodefense.com)
BARDA has funded advanced development and procurement of the drug under Project Bioshield since 2009 and in 2012 Raxibacumab became the first anthrax antitoxin to be approved by the FDA. (globalbiodefense.com)
Cosmetic1
Its therapeutic and cosmetic applications are vast and effective, but the risks it poses are clear. (theboar.org)
Injection1
Beginning in the late 19th century, an injection of antitoxin saved the lives of countless diphtheria patients, most of them children. (usp.org)
Intensive care1
And, even though intensive care units and antitoxin are around now, people still have scary symptoms, like paralysis. (cdc.gov)
Preparations2
Horse F(ab') 2 antitoxins and anti-rabies immunoglobulin preparations presented different amounts of protein. (biomedcentral.com)
Since several tissue-incompatible substances are usually involved during the development of a disease, the simultaneous use of several potentised "antitoxins", as present in the anti- homotoxic preparations, is justified. (urenus.com)
Organs1
To avoid damaging healthy organs, it is crucial that the therapeutic activity of microbes be targeted to tumors. (nature.com)
Exposure1
Treatment of botulism involves administration of therapeutic immunoglobulin product and is most effective when administered within 24 hr of exposure [1] . (cdc.gov)
Physicians2
Physicians who suspect botulism in a patient should immediately contact their health department so that an investigation can be started and also so that they can get antitoxin from CDC. (cdc.gov)
Physicians and patients trusted the antitoxin, but its purity hadn't been verified. (usp.org)
Diseases1
Rapid advances in synthetic biology are driving the development of genetically engineered microbes as therapeutic agents for a multitude of human diseases, including cancer. (nature.com)
Product1
The antitoxin becomes the fourteenth product to be added to the SNS under Project BioShield since 2004. (globalbiodefense.com)
Protein1
A dedicated protein separation facility is used for all antitoxin products. (wikipedia.org)
Treatment1
Treatment includes serotype-specific antitoxins, which must be administered early in the course of the intoxication. (cdc.gov)
Products1
Some non-pharmaceutical products that have (or claim to have) therapeutic, regulatory and health-stabilizing properties can be sold on the Joom. (joom.com)
Effects1
These processes are required to convert the gold into the therapeutic form (Monatomic Gold) and removing its bad effects on the body. (ayurtimes.com)
Cancer1
In a clinically relevant cancer model, ultrasound-activated therapeutic microbes successfully turn on in situ and induce a marked suppression of tumor growth. (nature.com)
Patients1
They do wonders when they're given to patients and have both licensed and off-label therapeutic uses for things like cervical torticollis, migraine headaches, and wrinkles, among other things. (cdc.gov)
Time1
We also created a quantitative romantic relationship between the starting point price of paralysis and enough time that's available to neutralizing antitoxins or various other non-permeable countermeasures to exert some inhibitory impact. (exposed-skin-care.net)
Development1
The European Centre for Disease Prevention and Control and the US Centers for Disease Control and Prevention encourage searching for new providers of equine DAT and promote the development of alternative antitoxins of human origin. (cdc.gov)