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  • genes
  • ADRs induced by several drugs have been shown to have significant associations with specific alleles of human leukocyte antigen (HLA) genes. (hindawi.com)
  • In this review, we summarized the alleles of HLA genes which have been proposed to have association with ADRs caused by different drugs. (hindawi.com)
  • Pandemrix-induced narcolepsy is associated with genes related to immunity and neuronal survival. (nih.gov)
  • Through a collaborative team effort, researchers from National Taiwan University Hospital (Department of Internal Medicine and Department of Medical Genetics), National Taiwan University College of Medicine and Academia Sinica discovered the genes that cause antithyroid drug-induced agranulocytosis. (gov.tw)
  • patients
  • Thioamide-induced agranulocytosis is an uncommon but potentially life-threatening complication of which all prescribers and patients need to be aware. (bioscientifica.com)
  • PTU should be given cautiously to patients who are taking other medications that may cause agranulocytosis (e. (thefreedictionary.com)
  • A total of 87 patients seen at the Ito Hospital in Tokyo between 1983 and 2012 were found to have agranulocytosis. (thyroid.org)
  • After excluding patients with other possible causes, 67 patients were identified as having MMI or PTU-induced agranulocytosis. (thyroid.org)
  • None of the patients in the continuous treatment group who were exposed to the other drug developed side effects, whereas 9 of 10 patients in the 'gap' group exposed to the other drug developed minor side effects. (thyroid.org)
  • After re-starting MMI or PTU therapy following a 5 or month gap, patients should be observed for agranulocytosis for the first 3 months, similarly to those who start these drugs for the first time. (thyroid.org)
  • Procainamide (PA) is a drug that is used to treat tachycardia in post-operative patients or for long term maintenance of cardiac arrythmias. (pubmedcentralcanada.ca)
  • infection
  • For example, hypersensitivity to abacavir, a drug used for treating of human immunodeficiency virus (HIV) infection, has been proposed to be associated with allele 57:01 of HLA-B gene (terms HLA-B 57:01 ). (hindawi.com)
  • Agranulocytosis, a marked decrease in white blood cells which increases the risk for infection, is a rare complication of treatment with the antithyroid drugs. (thyroid.org)
  • adverse
  • Adverse drug reactions (ADRs) remain a common and major problem in healthcare. (hindawi.com)
  • It has been proposed that neutrophil myeloperoxidase (MPO) activates xenobiotics to reactive intermediates that mediate further events to produce an adverse drug reaction ( 11 ). (pubmedcentralcanada.ca)
  • 2018
  • Dependent on further input from the Data Safety Monitoring Board (DSMB) and the Food and Drug Administration (FDA), the Company stated that they intend on moving forward with the study and expect to report results in the first quarter of 2018. (empr.com)