AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceNamed GroupsHealth Care
Antilymphocyte SerumAnemia, AplasticImmunosuppressive AgentsGlobulinsTransplantation ConditioningCyclosporineTransplantation, HomologousGraft RejectionGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHistocompatibilityGraft SurvivalKidney TransplantationSerum GlobulinsVidarabineHemibody IrradiationMethylprednisoloneImmunosuppressionHistocompatibility TestingBusulfanBone Marrow TransplantationHand TransplantationSex Hormone-Binding GlobulinHematologic NeoplasmsCord Blood Stem Cell TransplantationDrug Therapy, CombinationTreatment OutcomeLymphatic IrradiationT-LymphocytesLymphohistiocytosis, HemophagocyticCyclophosphamideRabbitsInfectionLymphoproliferative DisordersLymphocyte DepletionMyeloablative AgonistsPancreas TransplantationAdrenal Cortex HormonesMyelodysplastic SyndromesSurvival RateAntibodies, NeoplasmAcute DiseaseTissue DonorsWhole-Body IrradiationRecurrenceTacrolimusTransplantation ChimeraAzathioprinegamma-GlobulinsRetrospective StudiesBlood Cell CountMycophenolic AcidPeripheral Blood Stem Cell TransplantationPrednisoneSurvival AnalysisAntibodies, MonoclonalFollow-Up StudiesHLA AntigensDisease-Free SurvivalLiving DonorsHorsesTranscortinImmunologic FactorsBlood TransfusionCytomegalovirus InfectionsThyroxine-Binding ProteinsMethotrexateSalvage TherapyProspective StudiesTime FactorsTransplantation, AutologousStem Cell TransplantationRemission InductionDelayed Graft FunctionPilot ProjectsHeart TransplantationGranulocyte Colony-Stimulating FactorAntibodies, Monoclonal, HumanizedThyroxine-Binding GlobulinLeukemia, Myeloid, AcuteIncidenceImmune SeraRho(D) Immune GlobulinCombined Modality TherapyAlpha-GlobulinsSeed Storage ProteinsImmunoglobulins, IntravenousRisk FactorsBeta-GlobulinsBlood Protein ElectrophoresisThymus Gland
Anti-lymphocyRabbit anti-thymocytCyclophosphamideBasiliximabATGAMAxicabtagene ciloleucelLymphocyteAplastic anemia2018ImmunosuppressionImmunosuppressantsInductionCyclosporinSerumTransplantationDecreasesImmunosuppressiveBonePatientsTreatmentHuman T cellsTHYMOGLOBULINEquineProphylaxisAnti-thymocyte globulinsGraft-versus-FludarabineLymphocyte globulinAntilymphocyteATGsKidney transplantationInjectionAcuteDoseRecipients
Anti-lymphocy1
  • A similar trial of anti-lymphocyte globulin showed a trend in reduction of acute graft versus host that was not statistically significant, but a reduction in chronic graft versus host. (wikipedia.org)
Rabbit anti-thymocyt3
  • We performed a phase II study of rabbit anti-thymocyte globulin and cyclosporine as first-line therapy for severe aplastic anemia. (haematologica.org)
  • Design and Methods Twenty patients with severe aplastic anemia treated with rabbit anti-thymocyte globulin were compared to 67 historical control cases with matched clinical characteristics treated with horse anti-thymocyte globulin. (haematologica.org)
  • Results Response rates at 3, 6 and 12 months were similar for patients treated with rabbit anti-thymocyte globulin or horse anti-thymocyte globulin: 40% versus 55% ( P =0.43), 45% versus 58% ( P =0.44) and 50% versus 58% ( P =0.61), respectively. (haematologica.org)
Cyclophosphamide1
  • Low-dose post-transplant cyclophosphamide (PTCy) in conjunction with anti-thymocyte globulin (ATG) appears as a potentially effective graft-versus-host disease (GVHD) prevention strategy in haploidentical hematopoietic cell transplant (haplo-HCT). (biomedcentral.com)
Basiliximab2
  • Outcomes after anti-thymocyte globulin vs Basiliximab induction before" by Muhammad Saad Hafeez, Muneeb Ul Haq et al. (aku.edu)
  • We compared the association of induction therapy, anti-thymocyte globulin [rabbit] (rATG) or basiliximab, with posttransplant rejection, graft and patient survival. (aku.edu)
ATGAM3
  • Two antithymocyte globulin (ATG) agents licensed for clinical use in the United States are Thymoglobulin (rabbit ATG, rATG, Genzyme) and Atgam (equine ATG, eATG, Pfizer). (wikipedia.org)
  • Anaphylactic reaction during prior administration of ATGAM or any other equine gamma globulin preparation. (pfizermedicalinformation.com)
  • ATGAM is an anti-thymocyte globulin that differs from thymoglobulin by being produced in horses rather than rabbits. (clinnephrologyjournal.com)
Axicabtagene ciloleucel1
  • antithymocyte globulin rabbit, axicabtagene ciloleucel. (medscape.com)
Lymphocyte2
  • A rabbit anti-T lymphocyte globulin made by Neovii Pharmaceuticals is marketed outside of the United States under the name Grafalon. (wikipedia.org)
  • The COX-2 gene promoter polymorphism -765 delays CD4 T-cell reconstitution after lymphocyte depletion with antithymocyte globulins. (cdc.gov)
Aplastic anemia3
  • Anti-thymocyte globulin (ATG) is an infusion of horse or rabbit-derived antibodies against human T cells and their precursors (thymocytes), which is used in the prevention and treatment of acute rejection in organ transplantation and therapy of aplastic anemia due to bone marrow insufficiency. (wikipedia.org)
  • Background A combination of horse anti-thymocyte globulin and cyclosporine produces responses in 60-70% of patients with severe aplastic anemia. (haematologica.org)
  • Conclusions Despite reports suggesting differences in biological activity of different anti-thymocyte globulin preparations, rabbit and horse anti-thymocyte globulin appear to have a similar efficacy for up-front treatment of severe aplastic anemia. (haematologica.org)
20181
  • One 2018 study found that antithymocyte globulin was effective in about 50 percent of the MDS cases studied. (healthline.com)
Immunosuppression2
Immunosuppressants1
  • Antithymocyte globulin is in a large group of drugs known as immunosuppressants that weaken the body's immune response. (healthline.com)
Induction3
  • We analyzed data from a cohort of 889 first kidney graft recipients with ATG induction (86 with SSD [SSD(+)] and 803 without SSD [SSD(-)]) from the Données Informatisées et Validées en Transplantation data bank. (nih.gov)
  • Racial and socioeconomic disparities in pediatric heart transplant outcomes in the era of anti-thymocyte globulin induction. (bvsalud.org)
  • Background: Antithymocyte globulin (ATG) induction therapy is important for graft survival in high-risk recipients of kidney transplantation. (koreamed.org)
Cyclosporin1
  • Chemotherapy, antithymocyte globulins and cyclosporin have achieved remissions. (lu.se)
Serum1
  • Injected proteins such as antithymocyte globulin (used to treat organ transplant rejection) and rituximab (used to treat immune disorders and cancers) can cause serum sickness reactions. (medlineplus.gov)
Transplantation1
  • Application prospect of low-dose porcine anti-thymocyte globulin in HLA-matched sibling donor transplantation. (stembook.org)
Decreases2
  • antithymocyte globulin rabbit decreases effects of anthrax vaccine by pharmacodynamic antagonism. (medscape.com)
  • antithymocyte globulin rabbit decreases effects of BCG vaccine live by pharmacodynamic antagonism. (medscape.com)
Immunosuppressive2
  • Rabbit-generated antithymocyte globulins (ATGs), which target human T cells, are widely used as immunosuppressive agents during treatment of kidney allograft recipients. (nih.gov)
  • The most effective immunosuppressive regimen includes horse anti-thymocyte globulin (hATG) in combination with cyclosporine, a treatment which has been shown to be superior to either ATG or cyclosporine alone. (haematologica.org)
Bone1
  • You may take antithymocyte globulin to keep your immune system from attacking stem cells in your bone marrow. (healthline.com)
Patients1
  • this has created a theoretical basis for the use of antithymocyte globulin to target T cells in these patients. (elsevierpure.com)
Treatment2
  • We present a case of acute fulminant influenza B myocarditis in a pediatric patient that required mechanical circulatory support and improved only after treatment with antithymocyte globulin. (elsevierpure.com)
  • Taking ciclosporin as part of anti-thymocyte globulin treatment. (theaat.org.uk)
Human T cells1
THYMOGLOBULIN4
  • Two antithymocyte globulin (ATG) agents licensed for clinical use in the United States are Thymoglobulin (rabbit ATG, rATG, Genzyme) and Atgam (equine ATG, eATG, Pfizer). (wikipedia.org)
  • She underwent bone marrow transplantation from a matched unrelated donor after receiving conditioning with fludarabine, treosulfan, and thiotepa, together with thymoglobulin, a rabbit antithymocyte globulin. (aacc.org)
  • ALG (Thymoglobulin) and antithymocyte globulin (ATG) are less commonly used antilymphocyte antibody preparations. (pharmapedia.pk)
  • Antilymphocyte antibodies include polyclonal preparations, such as equine antithymocyte globulin (ATGAM) and rabbit antithymocyte globulin (Thymoglobulin), and the monoclonal antibody preparations muromonab-CD3 (OKT3) and anti-CD52 (Alemtuzumab). (pharmapedia.pk)
Equine2
  • 13. A prospective comparison of murine monoclonal CD-3 (OKT3) antibody-based and equine antithymocyte globulin-based rejection prophylaxis in cardiac transplantation. (nih.gov)
  • These medicines include antithymocyte globulin-equine and antithymocyte globulin-rabbit. (stlukesonline.org)
Prophylaxis2
  • 8. Effect of prophylaxis with low-dose anti-thymocyte globulin on prevention of acute kidney allograft rejection. (nih.gov)
  • ACIP recommends that prophylaxis for the prevention of rabies in humans exposed to rabies virus should include prompt and thorough wound cleansing followed by passive rabies immunization with human rabies immune globulin (HRIG) and vaccination with a cell culture rabies vaccine. (cdc.gov)
Anti-thymocyte globulins2
  • Both agents are immune-suppressing drugs known as anti-thymocyte globulins (ATGs). (nih.gov)
  • 7. Long-term evolution of lymphocytes subsets after induction therapy based on continuous versus discontinuous administration of anti-thymocyte globulins in renal-transplant patients. (nih.gov)
Graft-versus-1
  • Anti-thymocyte globulin was associated with decreased incidence of acute graft- versus -host disease, higher non-relapse mortality, decreased overall and progression-free survival. (haematologica.org)
Fludarabine1
  • His conditioning regimen consisted of busulfan, fludarabine, and antithymocyte globulin. (cdc.gov)
Lymphocyte globulin2
  • A rabbit anti-T lymphocyte globulin made by Neovii Pharmaceuticals is marketed outside of the United States under the name Grafalon. (wikipedia.org)
  • A similar trial of anti-lymphocyte globulin showed a trend in reduction of acute graft versus host that was not statistically significant, but a reduction in chronic graft versus host. (wikipedia.org)
Antilymphocyte2
  • 17. 20-year follow-up results of a randomized controlled trial comparing antilymphocyte globulin induction to no induction in renal transplant patients. (nih.gov)
  • Antilymphocyte globulin (ALG) and antithymocyte globulin (ATG) are produced by extracting immunoglobulins from animals (usually horse or rabbit) that have been immunized with human lymphocytes or thymocytes, respectively. (pharmapedia.pk)
ATGs1
  • Chemotherapy (VP16) or, more recently, antithymocyte globulins (ATGs) (10 mg/kg for 5 d) and cyclosporin A, have achieved remissions, and the use of intrathecal methotrexate injections transiently helps treat the neurocerebral involvement. (medscape.com)
Kidney transplantation1
  • 1. [Low-dose antithymocyte globulins in kidney transplantation: results of a protocol of intermittent administration]. (nih.gov)
Injection1
  • Our range of products include mylotarg gemtuzumab ozogamicin 5mg injection, thymogam 25 mg inj antithymocyte globulin, enzalutamide obnyx 40mg zydus, mito mitomycin 40 mg by neon, razumab ranibizumab injection in kolkata and cabozantinib cabdual 60mg. (medesy.co.in)
Acute1
  • BACKGROUND/AIMS: Anti-thymocyte globulin (ATG) treatment for acute T-cell mediated rejection (TCMR) can increase the risk of cytomegalovirus (CMV) infection. (koreamed.org)
Dose3
  • Single-dose 10 mL vial containing 25 mg of anti-thymocyte globulin (rabbit) lyophilized, sterile powder. (nih.gov)
  • New results from the TrialNet Clinical Research Network (TrialNet) show that low-dose anti-thymocyte globulin (ATG) slowed the decline of insulin production and resulted in better blood glucose control for two years in people newly diagnosed with type 1 diabetes compared to those treated with a placebo. (nih.gov)
  • 11. Preoperative single-bolus high-dose antithymocyte globulin as induction therapy in sensitized renal transplant recipients. (nih.gov)
Recipients1
  • Antithymocyte globulin was added for UCB recipients to address the HLA differences. (northwestern.edu)