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  • alpha 1-antitryps
  • Protease inhibitory activity in blood plasma was first reported in the late 1800s, but it was not until the 1950s that the serpins antithrombin and alpha 1-antitrypsin were isolated. (wikipedia.org)
  • fibrinogen
  • Pregnancy changes the plasma levels of many clotting factors, such as fibrinogen, which can rise up to three times its normal value. (wikipedia.org)
  • gene
  • More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. (genetex.com)
  • Heparan sulfate glucosamine 3-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS3ST1 gene. (wikipedia.org)
  • The most common ones are factor V Leiden (a mutation in the F5 gene at position 1691) and prothrombin G20210A, a mutation in prothrombin (at position 20210 in the 3' untranslated region of the gene). (wikipedia.org)
  • The HRG gene lies on location of 3q27 on the chromosome 3, spans approximately 11kb, and consist of 7 exons. (wikipedia.org)
  • Nephrotic
  • white lines (leukonychia) that extend all the way across the nail and lie parallel to the lunula The main signs of nephrotic syndrome are: A proteinuria of greater than 3.5 g /24 h /1.73 m2 (between 3 and 3.5 g/24 h /1.73 m2 is considered to be proteinuria in the nephrotic range) or greater than 40 mg/h/m2 in children. (wikipedia.org)
  • anticoagulation
  • Warfarin necrosis is also different from another drug eruption associated with warfarin, purple toe syndrome, which usually occurs three to eight weeks after the start of anticoagulation therapy. (wikipedia.org)
  • buffer
  • Note: The use of 3% PEG 6000 with 1.2% agarose in a suitable buffer (such as TBE or Tris-barbital pH >8.2) is recommended. (abcam.com)
  • protease
  • Protease inactivation results as a consequence of trapping the protease in an equimolar complex with antithrombin in which the active site of the protease enzyme is inaccessible to its usual substrate. (wikipedia.org)
  • activity
  • In antithrombin III deficiency, however, the activity of LMWH is not as reliable as in an otherwise healthy person. (medscape.com)
  • It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. (wikipedia.org)
  • blood
  • For example, the interaction between antithrombin and a particular 3- O sulfated HS motif is thought to modulate blood coagulation. (rupress.org)
  • One form of 3- O sulfated HS plays a critical role in the blood coagulation cascade. (rupress.org)
  • The diagnostic criteria require one clinical event (i.e. thrombosis or pregnancy complication) and two antibody blood tests spaced at least three months apart that confirm the presence of either lupus anticoagulant or anti-β2-glycoprotein-I (since β2-glycoprotein-I antibodies are a subset of anti-cardiolipin antibodies, an anti-cardiolipin assay can be performed as a less specific proxy). (wikipedia.org)
  • mice
  • However, a recent study of mice defective for this modification suggested that 3- O sulfation plays other biological roles. (rupress.org)
  • Instead, these mice showed postnatal lethality and intrauterine growth retardation, implying other physiological roles for 3- O sulfation. (rupress.org)
  • risk
  • We aimed (1) to describe the characteristics of patient-ventilator asynchrony in a population of critically ill children, (2) to describe the risk factors associated with patient-ventilator asynchrony, and (3). (springeropen.com)
  • form
  • A different form of 3- O sulfated HS is involved in the entry of HSV-1 into host cells and the fusion of infected cells. (rupress.org)