The antisickling and antioxidant effects of the flowers of P. ellipticum (Kunth) Dugand (red) and P. ellipticum cultivar alba (white) were compared using an in vitro assay in 2% sodium metabisulfite sickling induction model, DPPH, and metal chelation assays. (bvsalud.org)
Extracts5
Methanol and aqueous extracts of Cyperus esculentus (tiger nut sedge), cultivated and sold in Nigeria, were investigated for their comparative in-vitro effects on sickle cell hemoglobin (hemoglobin-S) polymerization (gelation). (tfljournal.org)
doum fruit extracts contain high amount of flavonoids, phenols used as antioxidant and antibacterial activities which can alleviate the adverse effects of oxidative stress. (researchsquare.com)
The effects of oral administration of different doses ofCaricapapayaseed extracts on hematological parameters specifically red blood cells (RBC), packed cell volume (PCV), and hemoglobin concentration in male and female Wistar rats were examined. (researchwap.com)
These results reveal the potential role for both red and white flower extracts as possible antisickling agents in sickle cell anemia management. (bvsalud.org)
Hemostatic mixture of ipomoea balatas leaves, methods of preparation and use thereof - a Jinshuye styptic plant preparation, an invention made from the extracts of leaf and stems of Ipomoea batatas has qi and spleen invigorating effects, cooling the blood and stopping bleeding. (2beingfit.com)
Medicinal1
Some of medicinal plants are thought to be responsible for observed antisickling action for their high contain of phenolic compounds and antioxidant nutrients. (researchsquare.com)
Extract11
Piper guineense, Gongronema latifolium and Cymbopogon citratus (PGC) serve as an effective polyherbal antisickling extract used in the management of sickle cell disorder. (ajol.info)
This present study assessed the toxicity effect of the ethanol leaf extract of PGC in rats. (ajol.info)
The acute toxicity study of ethanol leaf extract of PGC up to the limit dose of 2000 mg/kg body weight of the animals used did not produce any signs and symptoms of toxic effects or mortality after 48 hrs. (ajol.info)
The result of acute toxicity indicates that the combined antisickling polyherbal PGC extract appeared to be safe and non- toxic. (ajol.info)
Therefore, the consumption of the antisickling polyherbal PGC extract orally should be used encouraged at lower doses and high doses should be avoided for the management of sickle cell disorder until subjected to further cytotoxicity evaluation. (ajol.info)
Other possible variations on the effects of Carica papaya seed extract due to sex is being investigated in this study. (researchwap.com)
Corresponding author: [email protected] Cell: +234 803 815 7392 Abstract In the present study, the dose related effect of the aqueous seed extract of Carica papaya Linn. (biolmedonline.com)
Also, the time-course effect of 400 mg/kg per oral of the extract were determined at 3 hr pre-, 0 hr, 1 hr post-, 3 hr post-, and 6 hr post-CCl4 induction, respectively, in addition to the untreated control and model control groups. (biolmedonline.com)
Based on the traditional use of Carica papaya seed in the treatment of poison related renal disease, the present study was designed to investigate the effect of graded oral doses (100 - 400 mg/kg/day) and the time-course effect of the aqueous seed extract of mature unripe Carica papaya (CPE) in CCl4 treated rats as a way of validating this folkloric use. (biolmedonline.com)
Preliminary phytochemical contents, as well as the acute toxicity effect of the extract, were investigated based on standard experimental methods. (springeropen.com)
Besides, the in vitro effects of the extract (8 × 10 −2 -640 × 10 −2 mg/ml) on the rabbit jejunum and guinea-pig ileum were evaluated. (springeropen.com)
Hemoglobin2
The 1 that has been most used is the bluebird bio, which has an antisickling recombinant hemoglobin…just like fetal hemoglobin with a very significant antisickling effect. (consultantlive.com)
Cetiedil then may represent an alternate type of antisickling agent, exerting its effect through changes in erythrocyte membrane cation permeability rather than directly modifying hemoglobin S. (unboundmedicine.com)
Toxicity1
In the present study, we investigated the free radical scavenging effects, the antioxidant and ion toxicity preventive effect of Xylopia aethiopica ( X. aethiopica ), a plant of the family of Annonaceae used as spice in Cameroon. (degruyter.com)
Adverse effects1
Furthermore, natural products are bio-friendly and have demonstrated higher safety properties compared to conventional therapies which are besieged with adverse effects [6-9]. (austinpublishinggroup.com)
Deleterious effects1
The second point is that initially they could not use GCSF in sickle cell because of the known deleterious effects. (consultantlive.com)
Possess2
These plants have also been reported to possess antisickling, antiparasitic and antiseptic activities and have been known to be used to treat other ailments including toothache, sexual impotence, gonorrhoea, malaria, dysmenorrhoea, urinary and venereal diseases and abdominal pain. (islamicteachings.org)
This could possibly mean that the phytomolecules present in Millettia aboensis possess stimulatory effect on red blood cell production and could probably be used as a therapeutic agent in the treatment of anaemia. (soapboxscience.org)
Hypoglycemic1
Additionally, it covers up-to-date information on in-vitro anti-cancer and anti-gout and in-vivo anti-microbial properties, anti-oxidant, anti-sickling, hepatoprotective, hypolipidemic, hypoglycemic, and anti-gout effects. (microbiologyjournal.org)
Activities2
Both red and white flowers exhibited antioxidant and antisickling activities. (bvsalud.org)
Hplc profiling, in vitro antisickling and antioxidant activities of amino acids from black bean seeds (phaseolus vulgarus l. (journalcra.com)
Agent3
3] So that the higher antioxidant property of an antisickling agent enables it to reduce oxidative stress that contributes to sickle cell crisis. (researchsquare.com)
Due to its chemical properties hydroxyurea was explored as an antisickling agent in the treatment of hematological conditions. (wikipedia.org)
Hess G, Nordyke RJ, Hill J, Hulnick S. Effect of reimbursement changes on erythropoiesis-stimulating agent utilization and transfusions. (jefferson.edu)
Agents1
Antioxidants (scavengers of free radicals) are thought to be major components of these antisickling action thus different antisickling agents have different degrees of effect according to amount of antioxidant. (researchsquare.com)
Humans1
Phytomolecules are naturally derived secondary metabolites present in plants and are responsible for eliciting pharmacological or toxicological effects in both animals and humans. (soapboxscience.org)
Understanding urea assimilation and its effect on lipid production and fatty acid composition of Scenedesmus sp. (google.co.in)
Properties2
Cetiedil, a drug reported to relieve painful crises in sickle cell anemia, has direct antisickling properties in vitro. (unboundmedicine.com)
AU - Berkowitz,L R, AU - Orringer,E P, PY - 1982/1/1/pubmed PY - 1982/1/1/medline PY - 1982/1/1/entrez SP - 283 EP - 8 JF - Blood cells JO - Blood Cells VL - 8 IS - 2 N2 - Cetiedil, a drug reported to relieve painful crises in sickle cell anemia, has direct antisickling properties in vitro. (unboundmedicine.com)
Property1
Using the coordinates of R2 state HbA(2), we modeled the structure of T state HbA(2) which allowed us to address the structural basis of the antisickling property of HbA(2). (rcsb.org)
Side effects1
And, as of yet, there have been no side-effects discovered. (xickle.com)
Beneficial1
There are various nutrients that can have a beneficial effect on enhancing immune system function and Moringa oleifera certainly qualifies in this category due to the ability to provide several of these phytonutrients. (weebly.com)
Plant2
The bioassay test showed that Treculia africana, a plant being part of the diet of the bonobos, inhibits the sickling of red blood cells in vitro in hypoxic conditions and can serve as a source of bioactive metabolites for promoting an antisickling nutritherapy in Democratic Republic of the Congo. (issr-journals.org)
Thus, it opens up new perspectives for the treatment of this hemoglobinopathy through modulating effects of secondary metabolites of plant origin on the epi-genome. (issr-journals.org)
Management1
An interrupted time-series analytical design was used to assess the effects of the withdrawal of capitation on selected variables from the secondary District Health Information Management System (DHIMS 2) of public hospitals between January 2015 and December 2019. (anafrimed.net)
Occluded blood1
Hydroxyurea also suppresses the production of granulocytes in the bone marrow which has a mild immunosuppressive effect particularly at vascular sites where sickle cells have occluded blood flow. (wikipedia.org)
Plants1
These results confirm the evidence of great ape pathological condition and then these could be considered as a biological model for testing and/or validating the self-medication hypothesis and the anti-hemolytic effects of plants consumed by NHP that could be profitable to the sickle cell individuals. (issr-journals.org)
Analysis1
2002. Stanley effect of nonstationarities on detrended fluctuation analysis. (scar.ac.cn)
Studies1
Previous studies have shown that Carica papaya has antisickling effects (Sofoworaet al. (researchwap.com)
Give1
Its chewing sticks are obtained either from the stems or the roots and they give a warm pungent and numbing effect on the palate. (islamicteachings.org)