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  • gene function
  • The notice of allowance issued by the Canadian Intellectual Property Office is for a patent that covers basic use of antisense RNA in all cells and cellular material (eukaryotic and prokaryotic alike), and broadly covers methods for regulating gene function in all cells using antisense RNA. (freethesaurus.com)
  • regulatory
  • This overlapping gene organization, which produces sense-antisense transcript pairs, is capable of affecting regulatory cascades through established mechanisms. (frontiersin.org)
  • The regulatory abilities of the TP5 and TP6 elements are therefore not equally susceptible to the effects of elongated telomeres in the mutant Su(var)205 and Gaiano stocks. (genetics.org)
  • sequence
  • The antisense construct for the 5'-untranslated region with the most unique sequence for the L-plastin gene was more effective in down-regulation efficiency compared with the larger antisense construct in the coding region, which maintains homology to other members of the plastin gene family. (nih.gov)
  • Incomplete P elements do not produce the transposase because they lack part of the coding sequence. (genetics.org)
  • researchers
  • The Genetics Society of America (GSA), founded in 1931, is the professional membership organization for scientific researchers and educators in the field of genetics. (genetics.org)
  • The researchers found that the arteries of rats treated with the antisense therapy contained no detectable levels of c-myb RNA, while the arteries of rats treated with a control compound had high levels of the substance. (thefreedictionary.com)
  • Rats
  • Gene transfer of antisense B7.1 attenuates acute rejection against liver allografts in rats. (biomedsearch.com)
  • The aim of this study was to investigate whether downregulating the expression of B7.1 (CD80) in the donor livers by antisense B7.1 gene transfer could attenuate the acute immune rejection against liver allografts in rats. (biomedsearch.com)
  • METHODS: The liver grafts from 60 Dark Agouti rats were intraportally perfused with antisense B7.1 expression vector, before they were transplanted into Lewis rats. (biomedsearch.com)
  • RESULTS: Antisense gene transfer resulted in markedly downregulation of B7.1 in the donor livers, attenuated acute immune rejection against liver allografts, prolonged the survival time of rats, and decreased the number of infiltrating CD4+ and CD8+ cells in livers. (biomedsearch.com)
  • Evidence
  • Evidence was obtained to indicate that L-plastin protein levels were indeed decreased by the antisense expression. (nih.gov)
  • Natural
  • Here we searched for natural antisense transcript for sensorin (NAT-SRN), a neuropeptide expressed in the presynaptic sensory neurons of gill-withdrawal reflex of the marine snail Aplysia californica . (frontiersin.org)
  • Then, several chapters address how natural compounds can be used in biosynthetic engineering, antisense therapy , and motif hybridization. (thefreedictionary.com)
  • sense
  • Ty1 is transcribed in both sense and antisense directions. (pubmedcentralcanada.ca)
  • In this model, homology sites of Alu sequences helped duplicating a gene cassette encoding miRNAs, which in turn can target sense Alu sequences and thus alter the fate of free Alu elements. (nih.gov)
  • This is of great interest as Alu is a retro-element that can transpose in a cycle containing a free Alu transcript, which is always in sense orientation. (nih.gov)
  • hybrid dysgenesis
  • Individual P elements that were genetically isolated from wild-type strains were tested for their abilities to repress two aspects of hybrid dysgenesis: gonadal dysgenesis and mutability of a double-P element-insertion allele of the singed locus (snw). (genetics.org)
  • Thus, when P males are crossed to M females, P elements are introduced into offspring that inherit the M cytotype and hybrid dysgenesis occurs. (genetics.org)
  • invasion
  • These results suggested that overexpression of L-plastin might be functionally involved in prostate cancer invasion and metastasis, and raised the possibility that L-plastin gene-specific antisense delivery could potentially be a useful approach to interfere with prostate cancer progression in vivo. (nih.gov)
  • human
  • An analysis of 103906 Alu elements across 6 human chromosomes was carried out, using the presence of orthologous Alu elements in other primate species as a proxy for age. (peerj.com)
  • Were the Alu elements that have spread to fixation in human populations spread by a selective advantage that they conveyed? (peerj.com)
  • Section for Functional Genetics at the Institute of Human Genetics, University of Lübeck, Lübeck, Germany. (nih.gov)
  • At the Teratology Society's annual meeting held in June at Las Croabas, Puerto Rico, Ecker reported preliminary results from a human test of an antisense drug aimed at cytomegalovirus (CMV), a type of herpesvirus that can cause a vision-threatening eye infection for AIDS patients. (freethesaurus.com)
  • genomes
  • These traits are seen when P elements are activated in the germ line-an event that occurs in the hybrid offspring of crosses between males with P elements in their genomes and females without these elements. (genetics.org)
  • enhancer
  • Regulation of the cohesin-loading factor NIPBL: Role of the lncRNA NIPBL-AS1 and identification of a distal enhancer element. (nih.gov)
  • zygotic
  • Repression of gonadal dysgenesis was mediated by a maternal effect, or by a combination of zygotic and maternal effects generated by the P elements themselves. (genetics.org)
  • In all cases, repression of snw mutability appeared to be mediated by a zygotic effect of the isolated P element. (genetics.org)
  • structurally
  • Regulation by TP5 , a structurally incomplete P element at the X telomere, is more profoundly impaired than regulation by TP6 , a different incomplete P element inserted at the same site in a TAS repeat at the X telomere. (genetics.org)
  • Research
  • The research papers discuss such topics as hypofolatemia as a risk factor, reduced DNA repair capacity in laryngeal cancer subjects, antiangiogenic therapy of head and neck squamous cell carcinoma by vascular endothelial growth factor antisense therapy , p53-based immunotherapy of cancer, and imbalance in absolute counts of T lymphocyte subsets in patients with head and neck cancer and its relation to disease. (thefreedictionary.com)