• On the basis of a prior study demonstrating the efficacy and safety of aripiprazole in Taiwan population, we hence propose to apply a combined use of pharmacogenomics and therapeutic drug monitoring in the evaluation of the strategies of switching stable schizophrenia patients to aripiprazole from other antipsychotic agents. (clinicaltrials.gov)
  • Developing a protocol that has high probability of switching successfully schizophrenia patients to aripiprazole, which is effective in treatment refractory cases and has a markedly lower incidence of severe side effects, from other antipsychotics. (clinicaltrials.gov)
  • Thus, there is a continued need for new agents with improved efficacy and safety profile for the treatment of schizophrenia, bipolar disorder, and other types of psychosis. (aspetjournals.org)
  • Thus, it will be critical to fully understand the effects of different M1-selective allosteric modulators on coupling of M1 to different signaling pathways and to determine how this relates to electrophysiological effects of these agents and effects in animal models that predict efficacy in treatment of different domains of schizophrenia. (grantome.com)
  • Adherence to treatment with antipsychotic medication and health care costs among Medicaid beneficiaries with schizophrenia. (pharmacist.com)
  • Background Most evidence suggesting an association between schizophrenia, antipsychotic medications and diabetes has been based on retrospective studies not controlled for important confounders. (nuigalway.ie)
  • Developing a new drug which works in the same way, but without the side-effects, is a major part of clinical schizophrenia research which would be aided by knowing how clozapine actually works, and how it is different to other antipsychotics! (tamias.co.uk)
  • Vraylar carries a boxed warning that states the drug is not approved for patients with dementia-related psychosis and that elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. (empr.com)
  • First-generation antipsychotics, such as haloperidol, which mainly have dopamine D 2 antagonist action, are effective against positive symptoms, but they are relatively less beneficial in treating negative and associated mood symptoms ( Lieberman, 1993 ). (aspetjournals.org)
  • As a plausible explanation for the large interindividual variability in the pharmacokinetics of the neuroleptic agent haloperidol, the contributions of CYP3A isozymes (CYP3A4 and the polymorphic CYP3A5) predominantly involved in haloperidol bioactivation to the neurotoxic pyridinium species 4-(4-Chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-pyridinium (HPP + ) were assessed in human liver microsomes and heterologously expressed enzymes. (aspetjournals.org)
  • Lithium is considered a first-line agent for long-term prophylaxis in bipolar illness, especially for classic bipolar disorder with euphoric mania. (medscape.com)
  • brand names Clotepin, Clopiben), also known as octoclothepin or octoclothepine, is an antipsychotic of the tricyclic group which was derived from perathiepin in 1965 and marketed in the Czech Republic by Spofa in or around 1971 for the treatment of schizophrenic psychosis. (wikipedia.org)
  • Furthermore, preliminary studies suggest that representative compounds have efficacy in animal models that predict antipsychotic and cognition-enhancing effects. (grantome.com)
  • It is recommended that patients with risk factors for diabetes mellitus starting treatment with atypical antipsychotics should undergo fasting blood glucose testing at the beginning of treatment, and periodically thereafter. (drugs.com)
  • Patients who develop symptoms of hyperglycemia during treatment with atypical antipsychotics should undergo fasting blood glucose testing. (drugs.com)
  • Lurasidone showed potent effects predictive of antipsychotic activity, such as inhibition of methamphetamine-induced hyperactivity and apomorphine-induced stereotyped behavior in rats, similar to other antipsychotics. (aspetjournals.org)
  • The current agents, though helpful, only diminish the frequency and severity of positive psychotic symptoms by 20% to 30% and have less of an effect on the negative symptoms and the cognitive deterioration. (primarypsychiatry.com)
  • As I understand it, the so-called first-generation antipsychotics (FGAs) are, of course, still widely available and very effective in treating some of the key symptoms such as hallucinations and delusions. (levelofhealth.com)
  • The choice of agent depends on the presence of symptoms such as psychotic symptoms, agitation, aggression, and sleep disturbance. (medscape.com)
  • I feel there is something to be learned for my research from how antipyschotics and antidementia agents act on the brain to reduce the symptoms. (tamias.co.uk)
  • Another study, which analyzed Medicaid data from San Diego County from 1998 to 2000, shows that less than one-half of patients are adherent and persistent with antipsychotic therapy, with large numbers taking too few doses and about one-fifth of patients having their prescriptions refilled too frequently. (pharmacist.com)
  • Reserpine is an adrenergic blocking agent used to treat mild to moderate hypertension via the disruption of norepinephrine vesicular storage. (pharmacycode.com)
  • Adjunctive treatment with zonisamide (Zonegran) may help prevent weight gain in patients being treated with antipsychotics. (btpnews.com)
  • Patients with diabetes should be monitored for worsening control of blood glucose when treated with these agents. (drugs.com)
  • however, some patients required continuation of anti-diabetic treatment despite discontinuation of the atypical antipsychotic drug. (drugs.com)
  • When treating pediatric patients with atypical antipsychotic agents, weight gain should be monitored and assessed against that expected for normal growth. (drugs.com)
  • The timing of exposure to chemical agents during development affects the risk for malformations. (aafp.org)
  • ADMET studies coupled with a behavioral test using the amphetamine-induced hyperactivity model identified four compounds possessing drug-like profiles and having antipsychotic properties. (edu.au)
  • While all agents in the class have been shown to produce some changes, each drug has its own specific risk profile. (drugs.com)
  • Simultaneous use of multiple antipsychotic agents among inpatients-a trend on the upswing for 4 decades but unsupported by sound clinical evidence-results in longer hospitalizations and possibly more adverse effects but does not improve clinical outcomes, according to a recently published case-control retrospective analysis of data from the spring of 1998. (pharmacist.com)
  • In addition, our studies suggest that these agents may differentially regulate coupling of M1 to protein kinase pathways. (grantome.com)
  • In addition, we will determine the behavioral effects of M1 allosteric activators in rodent models that predict antipsychotic and cognition-enhancing effects. (grantome.com)
  • We will perform a series of studies in to systematically determine the effects of representative M1 allosteric activators on cell signaling and electrophysiological responses in forebrain neurons important for antipsychotic and cognition-enhancing effects of these agents. (grantome.com)
  • Although they are better tolerated and generally thought to be more effective than the older agents, the question remains: which ones should we choose to put on our formulary? (levelofhealth.com)