• These results demonstrate that ChoK plays an essential role in both normal human mammary epithelial cell proliferation and breast tumor progression. (aacrjournals.org)
  • Neoangiogenesis, i.e. the formation of new blood vessels, is provided via the production of chemoattractans, which redirect endothelial cells into the tumor tissue to enable tumor progression. (biomedcentral.com)
  • It has recently been demonstrated to inhibit tumor progression and metastasis in breast cancer models. (iiarjournals.org)
  • The mechanisms through which aberrant cellular CXCL1 levels promote specific steps in tumor growth and progression are unknown. (thno.org)
  • Furthermore, chemokines have been known to regulate multiple processes during tumor progression including primary tumor growth, tumor angiogenesis and development of metastatic disease [ 4 , 5 ]. (thno.org)
  • The underlying molecular mechanism of this anti-tumor effect was found to be by the specific inhibition of activity of oncogenic BRAFV600E in tumors that harbored the mutation. (wikipedia.org)
  • citation needed] further showed that inhibition of BRAF V600E activity by indole-3-carbinol resulted in downregulation of MITF-M by downstream signaling which caused a G1 cell cycle arrest leading to the observed antiproliferative effect. (wikipedia.org)
  • However, it is believed that direct antiproliferative action against tumor cells, inhibition of virus replication and modulation of the host immune response play important roles in antitumor and antiviral activity. (drugs.com)
  • Inhibition of MMPs has provided a significant increase in the survival rate in clinical trials, according to the frequent overexpression of MMPs in malignant tumors and the correlation with a highly aggressive phenotype and poor prognosis [ 8 - 10 ]. (biomedcentral.com)
  • On the other, mistletoe therapy can induce apoptosis (the process of natural cell death) in tumour cells, which results in the inhibition of tumour growth. (integratedmedicine.co)
  • Systemic administration of HL2401 in mice bearing bladder and prostate xenograft tumors retarded tumor growth through the inhibition of cellular proliferation and angiogenesis along with an induction of apoptosis. (thno.org)
  • Finally, the innate immunity or adaptive immunity is stimulated leading to regulation and inhibition of tumor growth. (thno.org)
  • Consistent with the in vitro activities, frankincense essential oil was effective in inhibiting tumor growth and inducing tumor cell apoptosis in a human BC mouse model. (spandidos-publications.com)
  • Intravenously injected radiolabeled anti-carcinoembryonic antigen monoclonal antibody into patients with colorectal cancer accumulated specifically in primary tumors, liver metastases, disseminated tumors and metastatic lymph nodes. (cancerprev.org)
  • This study is looking at the effectiveness of combining a PARP inhibitor called niraparib and an immunotherapy called dostarlimab for treating people with an inherited BRCA mutation (found with genetic testing) or a tumor mutation (found through tumor testing) who have breast, pancreatic, ovarian, fallopian tube or primary peritoneal cancer that is metastatic or advanced and cannot be removed by surgery (unresectable). (facingourrisk.org)
  • In particular, orthotopic models have a higher metastatic potential, and likely to result in detectable circulating tumor cells ( 11 , 12 ). (iiarjournals.org)
  • Here, we have investigated the role of ChoK in the development of breast cancer and found that ChoK is both necessary and sufficient for growth factor-induced proliferation in primary human mammary epithelial cells and an absolute requirement for the specific mitogenic response to heregulin in breast tumor-derived cells. (aacrjournals.org)
  • Artemisinin dimer oxime - dimer molecule synthesized from artemisinin possesses high bioavailability and marked in vitro anticancer activities against solid tumor-derived cell lines, endothelial cell proliferation, migration, and angiogenic processes. (wjtcm.net)
  • For example, a subset of astrocytoma cells with ultra-long, thin, and highly dynamic membrane protrusions named tumor microtubes are able to extend in the surrounding tissue for tumor cell invasion, proliferation, and connection between tumor cells ( 11 ). (frontiersin.org)
  • At the same time, a subpopulation of highly tumorigenic glioma stem cells (GSCs) with high plasticity and self-renewal properties contribute to tumor malignancy through their sustained proliferation, invasion, stimulation of angiogenesis, suppression of anti-tumor immune responses and chemo-resistance ( 12 ). (frontiersin.org)
  • Likewise, the immunohistochemistry results showed significant decreases in tumor proliferation and vascularization in the treatment-group in comparison to the control-group of 26%(p≤0.05) and 32.2%(p≤0.05) respectively. (biomedcentral.com)
  • Glioblastoma (GBM) is a very aggressive primary malignant brain tumor and finding effective therapies is a pharmaceutical challenge and an unmet medical need. (frontiersin.org)
  • Firstly, the anatomical location and size of the tumor impact the extent of resection, as a fine balance must be achieved between the maximal removal of malignant tissue and minimal operative risk ( 6 ). (frontiersin.org)
  • Other preliminary studies suggest that intravesical mistletoe extract is safe and well-tolerated in patients with nonmuscle invasive bladder cancer 18 , and that mistletoe extract injection may be efficacious as chemical pleurodesis in patients with malignant pleural effusion 19 . (integratedmedicine.co)
  • In addition to CML treatment, bosutinib has shown some efficacy in selected patients suffering from advanced-stage solid tumors. (mdm2-receptor.com)
  • Because only a fraction of the cells in a tumor die with each treatment (fractional kill), repeated doses must be administered to continue to reduce the size of the tumor. (worldsbest.rehab)
  • This demonstrates that distant metastasis can occur during the early phase of tumor growth in these aggressive lesions. (biomedcentral.com)
  • During the early phase of tumor development, immune cells could spontaneously infiltrate into the tumor microenvironment to evoke an immune response and fight against the growth of the tumor. (thno.org)
  • Although the expression of MHC class I and II molecules can be upregulated by MSC exposure to inflammatory cytokines interferon-gamma (IFN- γ ) and tumor necrosis factor-alpha (TNF- α ), they are still unable to induce an immunological response [ 18 ]. (hindawi.com)
  • It has been shown to be effective at reducing signs and symptoms in adult patients with moderately to severely active RA who have had an inadequate response to therapy with 1 or more tumor necrosis factor (TNF) antagonists. (medscape.com)
  • In this study, the ability of CRPC cells to grow and develop in vivo tumors in an animal model was evaluated, in order to investigate the anti-tumor effect of desmopressin in combination with docetaxel. (iiarjournals.org)
  • The most widely used models are the human tumor xenograft mouse model. (wjtcm.net)
  • We also demonstrated that the combination of G-CSF and ATO significantly inhibited tumor growth in the xenograft mouse model. (biomedcentral.com)
  • Dosage of chemotherapy can be difficult: If the dose is too low, it will be ineffective against the tumor, whereas, at excessive doses, the toxicity (side-effects) will be intolerable to the person receiving it. (worldsbest.rehab)
  • The standard of care therapy for GBM consists in surgical resection of the tumor, followed by radiotherapy and adjuvant plus concomitant chemotherapy with Temozolomide (TMZ) (Stupp protocol) ( 3 ). (frontiersin.org)
  • Furthermore, the high refractoriness of liver cancer to treatments has been associated with the interaction of very complex and diverse mechanisms of chemoresistance, which can act synergistically to protect tumor cells from the chemotherapy agents [ 3 ] . (encyclopedia.pub)
  • Cytotoxic effects on tumour cells have been observed in animal models 4,5 . (integratedmedicine.co)
  • The researchers have explored the possibility to conjugate tumor-targeted cytotoxic nanoparticles and conventional antitumoral drugs in single pharmacological entities using CXCR4-targeted self-assembling protein nanoparticles based on two potent microbial toxins, the exotoxin A from Pseudomonas aeruginosa and the diphtheria toxin from Corynebacterium diphtheriae, to which oligo-floxuridine and monomethyl auristatin E respec- tively have been chemically coupled. (nanbiosis.es)
  • This work represents a novel approach for cancer immunotherapy by integrating nanotechnology and platinum-based therapeutics which not only efficiently exerts the chemotherapeutic cytotoxic effect on tumor cell but also restores immune response of immunological cells within the tumor microenvironment. (thno.org)
  • Results showed dose-related decreases in tumor susceptibility due to indole-3-carbinol (inferred by decreases in aflatoxin-DNA binding). (wikipedia.org)
  • In addition, intralesional injection with talimogene laherparepvec is approved for skin metastasis. (medscape.com)
  • In turn, de novo formed vessels enhance tumor invasion and metastasis through the production of MMP 2 and 9 and uPA, which further degrade ECM. (biomedcentral.com)
  • Nevertheless, the origin of MCC inside the subcutaneous tissue will be debatable. (inhibitorlibrary.com)
  • After 7 mo, the LDLR-/- mice developed massive xanthomatous infiltration of the skin and subcutaneous tissue. (jci.org)
  • Then these signals are engulfed as antigens and presented by antigen-presenting cells within the tumor-derived lymph nodes. (thno.org)
  • In vivo, Interferon alfa-2a, recombinant has been shown to inhibit the growth of several human tumors growing in immunocompromised (nude) mice. (drugs.com)
  • In this study, human tumor cells (NCI-H640, 1 × 10 7 in 100 μL) are implanted subcutaneously, or 1 × 10 7 in 50 μL in the thoracic cavity, in athymic nude mice (nu/nu). (wjtcm.net)
  • We successfully established subcutaneous and thoracic xenografts with human nonsmall cell lung cancer cell line xenografts in athymic nude mice in only 10 days. (wjtcm.net)
  • Following subcutaneous administration in mice, the nanohybrids distributed to the epidermis and hair follicles. (thno.org)
  • Wpep-DGL/Pt showed potent antitumor efficacy in MDA-MB-231 cells tumor-bearing nude mice with a deficient immune system, demonstrating targeted delivery of chemotherapeutics and the resultant cytotoxicity. (thno.org)
  • Furthermore, in immunocompetent mice bearing 4T1 cells tumors, Wpep-DGL/Pt activated immune cells and induced cell death proving their dual function of chemotherapeutic and immunomodulatory efficacy. (thno.org)
  • Anticytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a humanized antibody that overcomes CTLA-4-mediated T-cell suppression to enhance the immune response against tumors. (medscape.com)
  • Cancer immunotherapy approaches designed to surmount tumor suppression take into consideration the pivotal molecular processes involved in the activation of immune system. (thno.org)
  • Antiproliferative effects shown include slowing of cell division and reversion of tumor cells to a normal phenotype. (centerwatch.com)
  • 1 Using human cells in culture, Interferon alfa-2a, recombinant has been shown to have antiproliferative and immunomodulatory activities that are very similar to those of the mixture of interferon alfa subtypes produced by human leukocytes. (drugs.com)
  • The antiproliferative effect of vitamin D analogs on MCF-7 human breastcancer cells. (jamanetwork.com)
  • Occult tumor cells that can lead to loco-regional recurrence and distant metastases are the main reason for the poor prognosis of patients suffering from squamous cell carcinoma of the head and neck [ 1 ]. (biomedcentral.com)
  • Tumor cells utilize a complex set of molecular mechanisms in order to metastasize [ 2 ]. (biomedcentral.com)
  • Thus, as 'proof of principle', the aim of this study was to evaluate the effect of desmopressin and docetaxel on in vivo tumor growth and development in an orthotopic animal model using CRPC PC3 cells. (iiarjournals.org)
  • Myeloid immune cells, specifically tumor-associated macrophages (TAMs), may represent potential novel therapeutic targets in HCC, complementing current ablative or immune therapies. (cancerindex.org)
  • Nanomedicine pursues active targeting to selectively deliver antitumor agents to cancer cells, a novel approach that promises to revolutionize therapy by dramatically increasing drug concentration in target tumor cells. (nanbiosis.es)
  • Neuroendocrine neoplasms (NENs) are rare tumors originating from neuroendocrine cells and include a series of heterogeneous tumors. (biomedcentral.com)
  • This TK-deleted Raccoonpox virus was notably attenuated in normal primary cells but replicated efficiently in numerous tumor cell lines. (oncotarget.com)
  • These drawbacks may be explained, at least in part, by the various phenotypes and histological characteristics of tumor liver cells and its microenvironment [ 5 ] . (encyclopedia.pub)
  • For example, antibodies specific to tumor antigens, adoptively transferred immune cells, therapeutic vaccines, and recombinant cytokines effectively boost the host immune system to recognize tumor cells as pathogens and eliminate them [ 1 - 3 ]. (thno.org)
  • First, the stimulatory or death signals are released from apoptotic tumor cells into the tumor microenvironment. (thno.org)
  • No significant differences in EGFR were observed between diploid and aneuploid tumors, and between EGFR levels and tumor diameter, extracapsular infiltration or portal invasion. (cancerprev.org)
  • One study data showed that mistletoe injections can attenuate airway inflammation and eosinophil infiltration in different types of cancers. (integratedmedicine.co)
  • Choline kinase (ChoK) is increased in human mammary tumors with high incidence, and this activation is associated with clinical variable indicators of greater malignancy. (aacrjournals.org)
  • The degree of malignancy of ovarian tumors was determined from examination of the glycoprotein fractions. (cancerprev.org)
  • Intron A has been shown to have intracellular, antiviral immunomodulatory, and antiproliferative effects, in-vitro and in-vivo. (centerwatch.com)
  • Tumor incidence (%) in C and RB 5% and RB 10% were 100, 55 and 64, respectively. (scialert.net)
  • 0.05) reduced the incidence of AOM induced colon tumors in Fisher 344 male rats. (scialert.net)
  • Colonic neuroendocrine neoplasms (NENs) are relatively rare tumors with an incidence rate of 0.11-0.21/100,000. (biomedcentral.com)
  • After seven days of subcutaneous tumor growth, FR-measurements were performed on each rat. (biomedcentral.com)
  • Compared to the control-group, the treatment-group that received the triple-therapy resulted in a reduction of tumor growth by 48.6% in size. (biomedcentral.com)
  • The triple-therapy is feasible and effective in reducing both tumor growth and vascularization. (biomedcentral.com)
  • In particular, compared with the placebo-group, the triple-therapy-group resulted in a reduction in tumor growth of 48.6% in size when assessed by CEUS and a significant reduction in the number of vessels in the tumor of 32% as assessed by immunohistochemistry. (biomedcentral.com)
  • Taken together, our results argue that CXCL1 plays an important role in sustaining the growth of bladder and prostate tumors via up-regulation of IL6 and down-regulation of TIMP4. (thno.org)
  • Chemokines have also been known to enhance epithelial-stromal interactions facilitating tumor growth and invasion [ 6 ]. (thno.org)
  • Raccoonpox virus was the most potent of the tested poxviruses and was highly effective in controlling cell growth in all tumor cell lines. (oncotarget.com)
  • In human colon cancer xenograft model, a single intratumoral inoculation of the recombinant Raccoonpox virus, in combination with 5-fluorocytosine administration, produced relevant tumor growth control. (oncotarget.com)
  • Supervision regarding CAPE through gavage significantly inhibited the actual tumour development of LNCaP xenografts within nude these animals. (inhibitorlibrary.com)
  • Several in vitro studies have demonstrated that artemisinin and its derivatives possess promising anticancer, antiproliferative, and antiapoptotic properties in tumor cell lines of colon, breast, and lung. (wjtcm.net)
  • Both LCRF-0004 and BMS-777607 demonstrated significant anti-tumor efficacy in vitro , however BMS-777607 was far superior to LCRF-0004. (frontiersin.org)
  • In the frame of the collaboration of three units of NANBIOSIS, researchers of CIBER-BBN Groups proposed a strategy to simultaneously deliver anticancer drug pairs, composed by a tumor-targeted protein nanoparticle and an antiproliferative drug, with specific activ-ity for the same type of cancer . (nanbiosis.es)
  • The researchers have shown that the combination of cell-penetrating and tumor cell-targeting peptides dramatically enhances precise tumor accumulation of protein-only nanoparticles intended for selective drug delivery, in mouse models of human colorectal cancer. (nanbiosis.es)
  • Collaborative membrane activity and receptor-dependent tumor cell targeting for precise nanoparticle delivery in CXCR4+ colorectal cancer. (nanbiosis.es)
  • Removal of more than 98% of the tumour volume ("total" resection) increases survival compared to subtotal or partial resection. (beatingcancercenter.com)
  • However, it's worth adding that my Chromogranin A (CgA) blood test (correlated to tumour mass) did not return to normal until after a liver resection 3 months later. (ronnyallan.net)
  • Although there is ample evidence that the chemotherapeutic drugs trigger an immune response, the efficient tumor rejection or regression is not guaranteed probably due to the massive immunosuppression within the tumor microenvironment. (thno.org)
  • Intron A is supplied as a solution for intramuscular, intralesional or subcutaneous injection. (centerwatch.com)
  • Patients with platelet counts of less than 50,000/mm3 should not be administered Intron A intramuscularly, but instead by subcutaneous administration. (centerwatch.com)
  • ATO was also tested in non-APL AML patients in serveral clinical trials, combined with subcutaneous low-dose cytarabine or with ascorbic acid and decitabine [ 6 ]. (biomedcentral.com)
  • Since 2015, a medical device based on tumor-treating (TT)-Fields can also be applied on supratentorial GBM patients. (frontiersin.org)
  • Combination therapy showed a significant reduction in tumor volume and tumor/body weight. (wjtcm.net)
  • Results: Docetaxel treatment resulted in a significant reduction in tumor volume compared to control. (iiarjournals.org)
  • The combination therapy resulted in even more significant reduction (31.2%) in tumor volume. (iiarjournals.org)
  • a benign (noncancerous) tumor of glandular origin. (ashp.org)
  • It also inhibits dihydroorotate dehydrogenase, an enzyme in the de novo pyrimidine synthesis pathway and has antiproliferative activity. (medscape.com)
  • In 48 cases of squamous cell carcinoma of the larynx the thymidine labeling index was a more important predictor of survival (p=0.015) than prognostic DNA values and tumor stage. (cancerprev.org)
  • Numerous tumor cell lines were infected with ten non-vaccinia poxviruses to identify which virus displayed the most potential as an oncolytic agent. (oncotarget.com)
  • Cell viability indicated that tumor cell lines were differentially susceptible to each virus. (oncotarget.com)
  • Additionally, GBM is characterized by high inter-tumor and intra-tumor heterogeneity at a cellular, molecular, histological, and clinical level leading to very different responses to therapeutic agents and failure of targeted therapies ( 9 , 10 ). (frontiersin.org)
  • With a better understanding of molecular details in tumor immunology and tumor biology, tailored cancer immunotherapy is considered as a promising strategy for cancer treatment. (thno.org)
  • Melatonin (N-acetyl-5-methoxytryptamine) is an indoleamine with beneficial effects in a broad number of tumors, including the primary liver cancers hepatocarcinoma (HCC) and cholangiocarcinoma (CCA). (encyclopedia.pub)
  • Therefore, melatonin has a potential role in improving the current therapeutic landscape in these liver tumors. (encyclopedia.pub)
  • Primary liver cancer constitutes the sixth most prevalent type of tumor and is the fourth common cause of cancer-related mortality worldwide [ 1 ] . (encyclopedia.pub)
  • However, under different conditions researches have reported an increase in oxidative stress derived from melatonin treatment in these liver tumors, which could be attributed to the employ of higher doses of this indoleamine [ 18 ] [ 29 ] . (encyclopedia.pub)
  • Photoabsorbing agents such as nanoparticles need to reach the tumor site at therapeutic concentrations, crossing the blood-brain barrier upon systemic administration. (frontiersin.org)
  • Weekly subcutaneous injections of 1,2-dimethethyhydrazine into 6-week-old rats markedly increased thymidylate synthetase (TS) in the poorly differentiated, and thymidine kinase in the well-differentiated adenocarcinomas of the colon. (cancerprev.org)
  • In two different studies using xenografted mouse model of melanoma, they observed that subcutaneous injection of indole-3-carbinol could bring down tumor burden significantly. (wikipedia.org)
  • Israpidine seemed the most potent antiproliferative agent. (cancerprev.org)
  • Because of its species-restricted activity, it has not been possible to demonstrate antitumor activity in immunologically intact syngeneic tumor model systems, where effects on the host immune system would be observable. (drugs.com)
  • Our findings reveal a previously undocumented relationship between CXCL1, IL6 and TIMP4 in solid tumor biology. (thno.org)
  • The overall cisplatin tumor response rate and survival were comparable between groups. (omicsdi.org)
  • These findings suggest that the antiproliferative effects of aglepristone in canine mammary carcinomas are mediated by progesterone receptor isoform A. (biomedcentral.com)
  • Roferon-A (Interferon alfa-2a, recombinant) is a sterile protein product for use by injection. (drugs.com)
  • However, in tumors that expressed wild type BRAF, indole-3-carbinol did not cause any comparable antiproliferative effect. (wikipedia.org)
  • The differentiating, immunomodulating and cytostatic properties of these molecules contributed to this result, together with the antiproliferative effect of somatostatin, octreotide, and prolactin inhibitors. (beatingcancercenter.com)