Antioxidant stress response pathway. Medical search. Frequent questions

To transfer to the Costagliola lab expertise on the Nrf1 and Nrf2 pathways and their manipulation with pharmacological compounds. (unil.ch)
This review summarizes our knowledge about Nrf2 and HO-1 across different phyla suggesting their conservative role as stress-protective and anti-aging factors. (springer.com)
The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)
The present study aimed to investigate the potential hepatoprotective effects of diosmetin on hydrogen peroxide (H2O2)‑induced oxidative damage in L02 cells and attempted to evaluate the role of the nuclear factor erythroid 2‑related factor 2 (Nrf2)/antioxidant response element pathway in this process. (spandidos-publications.com)
The present study is the first, to the best of our knowledge, to demonstrate that activation of the Nrf2/NQO1‑HO‑1 signaling pathway maybe involved in the cytoprotective effects of diosmetin against oxidative stress. (spandidos-publications.com)
Zhang H, Davies KJA and Forman HJ: Oxidative stress response and Nrf2 signaling in aging. (spandidos-publications.com)
Leiser SF and Miller RA: Nrf2 signaling, a mechanism for cellular stress resistance in long-lived mice. (spandidos-publications.com)
Han MH, Park C, Lee DS, Hong SH, Choi IW, Kim GY, Choi SH, Shim JH, Chae JI, Yoo YH and Choi YH: Cytoprotective effects of esculetin against oxidative stress are associated with the upregulation of Nrf2-mediated NQO1 expression via the activation of the ERK pathway. (spandidos-publications.com)
Nguyen T, Nioi P and Pickett CB: The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. (spandidos-publications.com)
Resveratrol inhibits paraquat-induced oxidative stress and fibrogenic response by activating the Nrf2 pathway. (cdc.gov)
Nrf2 is an antioxidant-activated transcription factor that recently emerged as a critical regulator of cellular defense against oxidative and inflammatory lesions. (cdc.gov)
Here we analyzed the molecular mechanism of the fibrogenic response to PQ and its inhibition by Res and Nrf2. (cdc.gov)
Res strongly activated the Nrf2 signaling pathway and induced antioxidant response element-dependent cytoprotective genes. (cdc.gov)
The nuclear factor erythroid-derived two-like 2-antioxidant response element (Nrf2-ARE) pathway and its downstream antioxidant enzyme heme oxygenase-1 (HMOX1 or HO-1) play essential roles in H2 O2 -induced oxidative damage in human melanocytes. (nih.gov)
However, the link between Nrf2 promoter polymorphisms and susceptibility to oxidative stress-related diseases such as vitiligo is unknown. (nih.gov)
Skin cells also have an efficient detoxification mechanism called the Nrf2 pathway to eliminate free radicals. (clariant.com)
Containing two key glycosylated flavonoids directly involved in circadian clock maintenance - carlinoside and isoschaftoside - B-Circadin emulates the ability to resynchronize the circadian cycle within the skin cells, to regulate rhythm-dependent biological functions such as aquaporin-3 and Nrf2 pathway detoxification efficacy. (clariant.com)
Nrf2 Pathway Enhancer (Activator) by IP Formulas ," says Dr. Dave Scheiderer , Director of Education at Integrative Psychiatry, Inc. (integrativepsychiatry.net)
Nrf2 regulates the activity of a set of antioxidant and detoxifying genes that protect your body from the ravages of health conditions associated with high levels of oxidative stress, including most of the core conditions Dr. Dave treats most often: depression, schizophrenia, bipolar disorder, and Alzheimer's. (integrativepsychiatry.net)
Additionally, Brassica (TrueBroc ® ) is an important phytonutrient providing antioxidant support by activating the Nrf2/ARE pathways. (standardprocess.com)
OBJECTIVE- Sulforaphane is an activator of transcription factor NF-E2-related factor-2 (nrf2) that regulates gene expression through the promoter antioxidant response element (ARE). (diabetesjournals.org)
CONCLUSIONS- We conclude that activation of nrf2 may prevent biochemical dysfunction and related functional responses of endothelial cells induced by hyperglycemia in which increased expression of transketolase has a pivotal role. (diabetesjournals.org)
The antioxidant activity of GGD is associated with the promotion of Nrf2 nuclear translocation and the upregulation of antioxidant enzymes such as SOD, HO-1, and CAT. (bvsalud.org)

R-ALA can also increase levels of glutathione, a fundamental compound in the body's natural antioxidant systems. (purebulk.com)
Some of the benefits associated with curcumin include immune system modulation, protection from oxidative stress, and support for the body's natural anti-inflammatory response. (medicinehunter.com)
Curcumin, the active compound extracted from turmeric root, is touted for its ability to mediate the body's natural response to physical, chemical, and emotional stressors. (blueskyvitamin.com)
Hemp Oil Complex™ provides 15 mg of phytocannabinoids and supports the endocannabinoid system and the body's natural inflammatory response function in softgel form. (standardprocess.com)

The increase in antioxidant capacity helps reduce inflammation and boosts cells' ability to defend against pathogens and oxidative stress. (purebulk.com)
Curcumin, a compound found in the spice turmeric, inhibits multiple inflammation pathways in the body. (medicinehunter.com)
The berry fruits are also capable of modulating signaling pathways involved in inflammation, cell survival, neurotransmission and enhancing neuroplasticity. (lww.com)
2001). Since oxidative stress and inflammation appear to be involved in brain aging and in neurodegenerative diseases (Casadesus et al. (lww.com)
Underlying pathogenic mechanisms in chronic kidney disease (CKD) include chronic inflammation, oxidant stress, and matrix remodeling associated with dysregulated nuclear factor- κ B, nuclear factor- κ B, and SMAD signaling pathways, respectively. (aspetjournals.org)
Important cytoprotective mechanisms activated by oxidative inflammatory conditions are mediated by nitrated fatty acids that covalently modify proteins to limit inflammation and oxidant stress. (aspetjournals.org)
Inflammation is a normal physiological response to injury, toxic agents, and infection characterized by redness, swelling, and pain. (integrativepsychiatry.net)
However, persistent and chronic inflammation as a result of a malfunctioning immune response can lead to autoimmunity and various illnesses such as heart disease, certain cancers, and Alzheimer's. (integrativepsychiatry.net)
It is an adaptive response that enhances recovery by conserving energy to combat acute inflammation. (biomedcentral.com)
Inflammation may provoke a Janus-faced response with a good, acute side, generating protective inflammation through sickness behavior and a bad, chronic side, for example, clinical depression, a lifelong disorder with positive feedback loops between (neuro)inflammation and (neuro)degenerative processes following less well defined triggers. (biomedcentral.com)
The systemic imbalance may occur under circumstances such as stress, and fatigue, which may trigger inflammatory responses in the body 3 and inflammation may cause unwanted health conditions. (standardprocess.com)
It has been shown that various dietary components may support key resolution pathways to inflammation, energy balance and metabolism via the ECS. (standardprocess.com)
Internal factors like stress, malnourishment, and inflammation can impair the skin's growth, maintenance, and ability to combat external factors. (naturalmedicinejournal.com)

The polyphenolic compound in oolong tea functions as an antioxidant and is therefore contributory in the removal of free radicals from our body. (organicfacts.net)
The capacity of the antioxidant gradient of keratinocytes is associated with attenuation of the action of related free radicals in both esthetics and health. (intechopen.com)
Antioxidants from fruits and vegetables fight harmful free radicals that can damage the cells and get rid of toxic substances in the body. (integrativepsychiatry.net)
You could slow aging, it followed, by neutralizing free radicals with antioxidant pills. (bigthink.com)
In general, plant-derived, botanical, cosmeceutical products tend to be antioxidant in action since these organisms must thrive in constant direct ultraviolet (UV) light, the Earth's most prolific manufacturer of free radicals. (jcadonline.com)
In order to prevent oxidative damage, the antioxidant system presents a group of cellular enzymes (SOD, catalase and glutathione system) responsible for the control of free radicals. (bvsalud.org)

were the first to demonstrate in obese mice and in humans with obesity that fat accumulation is positively associated with systemic oxidative stress, suggesting that the oxidative stress increase in people with obesity could be explained by reactive oxygen species (ROS) overproduction in adipose tissue [ 17 ]. (hindawi.com)
The effects of sulforaphane on multiple pathways of biochemical dysfunction, increased reactive oxygen species (ROS) formation, hexosamine pathway, protein kinase C (PKC) pathway, and increased formation of methylglyoxal were assessed. (diabetesjournals.org)
Increased oxidative stress due to high production of reactive oxygen species (ROS) is proposed to be involved in pathogenesis of SS 5 . (bvsalud.org)
Nonenzymatic antioxidant system also maintains the balance of reactive oxygen species (ROS), including vitamin C, carotenoids and fish oil. (bvsalud.org)
Differences between reactive oxygen species and antioxidant defense system unbalance the redox status. (bvsalud.org)

R-ALA is a potent antioxidant and supports the body's existing antioxidant defenses. (purebulk.com)
It is also a potent antioxidant. (medicinehunter.com)
Genistein is a potent antioxidant that inhibits lipid peroxidation and chemical and ultraviolet light B (UVB)-induced carcinogenesis. (jcadonline.com)

It is one of the most important detoxification pathways in the body and is also regulated by the circadian rhythm. (clariant.com)

Oxidative stress and mitochondrial dysfunction are important mechanisms of ventricular remodeling, predisposed to the development of diabetic cardiomyopathy (DCM) in type 2 diabetes mellitus. (mdpi.com)
These findings are completely original and very innovative because they address the long-standing questions of how oxidation is coupled to the metabolism of iodine, and how the protective mechanisms of thyrocytes against oxidative stress are linked to protective mechanisms against iodine overload. (unil.ch)
however, the hepatoprotective effects of diosmetin against oxidative stress, and the underlying molecular mechanisms, remain unknown. (spandidos-publications.com)
Inspired by the work of the 2017 Nobel Prize in Physiology or Medicine, awarded for discoveries on how molecular mechanisms control the circadian rhythm, Clariant Active Ingredients and its partner, BioSpectrum, have further advanced the knowledge of both the biological responses to this critical cycle and what occurs when it is disrupted. (clariant.com)
FIGURE 10-1 Conceptual framework of plausible pathways, including mechanisms and intermediate outcomes, by which exposure to e-cigarettes influences cancer outcomes. (nationalacademies.org)
We conducted a global transcriptional analysis of human glioblastoma cell response to infection with WNV during peak virus production to determine the crucial virus-host interactions that take place during a severe neuroinvasive attack and identify putative mechanisms involved in WNV pathogenesis. (cdc.gov)
While significant advances have been made in understanding the plant adaptation in stress environments, there are still challenges to translate this acquired knowledge for improved crop performance and productivity under stress environments due to complex genetics involving multitude of genes and stress tolerance mechanisms and interaction with numerous environmental factors pose. (eurekaselect.com)
Our findings suggest that fine PM enhances allergic inflammatory response in pulmonary tissue through mechanisms involving increased oxidative stress. (cdc.gov)

When the alga is subject to prolonged exposure to air, it suffers abiotic stresses. (mdpi.com)
Plant growth and productivity are limited by various types of abiotic stresses. (eurekaselect.com)
Different omics technologies have evolved during the last few decades to systematically analyze and correlate the changes in the genome, transcriptome, proteome, and metabolome to the variability in plant's response to abiotic stresses. (eurekaselect.com)

This blog entry generalizes on the concept of hormesis, discusses the multiple pathways through which hormesis takes place, and suggests a myriad of ways that ordinary people can take advantage of hormesis to maintain their health and possibly extend their lifespans. (anti-agingfirewalls.com)

Such phenotypes are often displayed by the synthesis of proteins that control the organism's structure and development, or that act as enzymes catalyzing specific metabolic pathways. (wikipedia.org)
Age-related and metabolic diseases such as type 2 diabetes (T2D) represent a source of cellular stress due to their disruptive effect on normal physiological processes and, therefore, can induce premature senescence ( 10 ). (frontiersin.org)
A well-balanced ECS encourages favorable conditions in the body system, impacting the body's ability to manage metabolic stress 1 and may support overall health and well-being. (standardprocess.com)

Curcumin is a superstar plant compound with especially powerful antioxidant and anti-inﬂammatory properties. (medicinehunter.com)

Abstract: Reductive stress, caused by an excess of antioxidants, is linked with several pathological conditions, including cancer and neurodegenerative diseases. (edu.in)

Epididymal (visceral) and subcutaneous adipose tissue, gastrocnemius muscle, and plasma samples were collected to measure oxidative stress markers (advanced oxidation protein products (AOPP), oxidized low-density lipoprotein (oxLDL)), antioxidant system markers (ferric-reducing ability of plasma (FRAP), superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) activities), and prooxidant enzymes (NADPH oxidase and xanthine oxidase (XO) activities, myeloperoxidase content). (hindawi.com)
p62/Sequestosome 1 (p62) is a stress-induced protein that is involved in several different intracellular pathways, including regulation of aspects of protein degradation. (molvis.org)
Cellular stresses and abnormalities of protein and organelle degradation have been implicated in the pathogenesis of cataracts of many different etiologies. (molvis.org)
Here, we demonstrate that the endoplasmic reticulum stress sensor inositol-requiring enzyme 1 (IRE1α) and its substrate transcription factor X-box-binding protein 1 (XBP1) drive NK cell responses against viral infection and tumors in vivo. (cancerindex.org)
One important heat shock protein is discussed further in the blog entry HSP70 to the rescue The relatively recent blog entries Mitohormesis and Radiation hormesis define hormesis in more detail and discuss it as it relates to mitochondrial oxidative stress and stress induced by radiation. (anti-agingfirewalls.com)

Using mice and traditional 2D cell cultures, new factors have been identified that mediate responses of thyroid cells to various forms of stress encountered both during normal physiology of the thyroid gland and also during extreme conditions associated with thyroid disorders. (unil.ch)
To investigate in parallel the functions of these pathways in mice and in zebrafish using genetic means. (unil.ch)
Yan B, Ma Z, Shi S, Hu Y, Ma T, Rong G and Yang J: Sulforaphane prevents bleomycin-induced pulmonary fibrosis in mice by inhibiting oxidative stress via nuclear factor erythroid 2-related factor-2 activation. (spandidos-publications.com)
We therefore evaluated the ability of the peripheral clocks of the kidney, liver, and submandibular gland to be entrained by external stimuli including light, food, stress, and exercise in young versus aged mice using in vivo bioluminescence monitoring. (nature.com)
The aim of this study was to assess how exposure to fine PM collected from Sacramento, CA, shapes the allergic airway immune response in BALB/c mice undergoing sensitization and challenge with ovalbumin (OVA). (cdc.gov)

Further MR study with more genetic instruments for absolute circulating levels of antioxidants are needed to confirm our results. (frontiersin.org)

Evolution of immune response under chronic thermal stress. (edu.in)
The factors governing the development of neurologic disease, host immune response, patterns of clinical features, and outcomes are poorly understood in those infected with neurotropic flaviviruses ( 2 ). (cdc.gov)
Hemp Oil Complex is unique formulation of ingredients, a combination of well-balanced polyunsaturated fatty acids (PUFAs, omega-3 oil) delivering essential fatty acids needed for the formation of specialized lipid mediators for a healthy immune response. (standardprocess.com)
There are two hallmark phenotypes of allergic asthma: (1) inflammatory, due to a T helper cell type 2 (Th2)-mediated immune response resulting in elevated inflammatory cells in the airways, and (2) airway hyper-reactivity, during which volume and flow of inhaled air decreases as a consequence of airway constriction. (cdc.gov)

By inhibiting these enzymes, bromelain may help regulate the inflammatory response and contribute to improved joint function and mobility. (bcr.org)

Reductive stress by thiol antioxidants activates the hypoxia response pathway. (edu.in)
On a more macroscopic level it could represent the amount of whole-body radiation received due to an exposure event or to the amount of exposure to carbon monoxide or to stress due to being at high altitude (hypoxia). (anti-agingfirewalls.com)

The study reveals a new pathway for molecular intervention against pulmonary oxidative injury and fibrosis. (cdc.gov)
DAMPs, damage-associated tissues and the molecular target structures and pathways. (cdc.gov)
PCs are a diverse group of plant micronutrients, some of which modulate physiologic and molecular pathways involved in energy metabolism. (medscape.com)

The purpose of this study was to compare the effects of two training modalities (moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT)) on the pro/antioxidant status of different tissues in obese Zucker rats. (hindawi.com)
This could result in ROS generation via different pathways in these tissues. (hindawi.com)
The Division has a leading international reputation for its research into how cells and tissues respond to stress caused by disease and also in response to treatment. (dundee.ac.uk)
Curcumin may support health in a wide variety of tissues in the body as it supports normal inflammatory balance and tissue protection via its antioxidant properties. (blueskyvitamin.com)
Several common features characterize these pathologies - among them are the redox balance and a notable inflammatory response that strongly alters the biochemical and functional characteristics of the affected tissues. (medscape.com)

encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
National and international regulation of recombinant DNA-modified, or "genetically engineered" (also referred to as "genetically modified," or GM), plants, including those with enhanced abiotic stress tolerance, is unscientific and illogical, a lamentable illustration of the maxim that bad science makes bad law. (eurekaselect.com)

Normally activated when protection is needed, the pathway plays a major role in the anti-oxidant defense mechanism that helps detoxify the skin. (clariant.com)

Research interests are in the area of antioxidants and gene expression and dietary chemoprevention strategies. (oregonstate.edu)

IRE1α-XBP1 were essential for expansion of activated mouse and human NK cells and are situated downstream of the mammalian target of rapamycin signaling pathway. (cancerindex.org)

The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. (cancerindex.org)

The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc. (cancerindex.org)

Vitamins are part of the antioxidant system of human skin, and are detectable in different layers, so the topical application can be an alternative to maintain the functionality of the system. (intechopen.com)
Antioxidant vitamins don't stress us like plants do-and don't have their beneficial effect. (bigthink.com)
Vitamins were strongly antioxidant in test tubes. (bigthink.com)
Termed nutricosmetics, these products currently include antioxidants like polyphenols, phytonutrients, and vitamins C and E, as well as structural components like hydrolyzed collagen and hyaluronan. (naturalmedicinejournal.com)

As signal transducer and activator of transcription (STAT) 3 phosphorylation directly regulates retinoic acid receptor-related orphan receptor (ROR) γ t, which is the master molecule of Th17, the Janus kinase (JAK)2-STAT3 pathway initiated by IL-6 is essential in the Th17 development. (hindawi.com)

In this context, we have outlined a project with the overall goal to combine the respective strengths and expertise of the two labs to elucidate the physiological and developmental functions and evolutionary aspects of the stress response pathway in the thyroid. (unil.ch)
After attaching to target cells, EVs can change the physiological state of recipient cells through various pathways. (biomedcentral.com)
Physiological manifestations like stress, and poor diet may negatively impact other systems in the body via specific cellular processes. (standardprocess.com)

Senescence is a stress-response cellular state characterised by proliferative arrest but active metabolism ( 7 ). (frontiersin.org)
To transfer to the Sykiotis lab the 3D follicle model established by the Costagliola lab in order to perform cell-based studies on the role of stress response pathways on iodine metabolism. (unil.ch)
Mattoo A.K., Minocha S.C., Minocha R., Handa A.K. (2010) Polyamines and cellular metabolism in plants: Transgenic approaches reveal different responses to diamine putrescine versus higher polyamines spermidine and spermine Amino acids 38:405-413. (purdue.edu)

Clove also contains tetraethylammonium chloride, gallic acid, phenolic acids, polyphenols, and flavonol glycosides with free radical scavenging/antioxidant activity [89]. (researchgate.net)

Hormesis is a process through which moderate stress induces a body response that is protective against insults, confers health and possibly even longevity benefits. (anti-agingfirewalls.com)

A hormetic response to a stress not only maintains a functional internal environment but also improves it. (anti-agingfirewalls.com)
Aim: To evaluate the effect of astaxanthin, fish oil and association of them on enzymatic antioxidant system and functional parameters of salivary glands. (bvsalud.org)
Conclusions: Astaxanthin, fish oil and combination of them stimulated the antioxidant system and functional parameter of salivary glands, which could be beneficial to oral health. (bvsalud.org)

Thus, shared immuno-inflammatory pathways underpin the physiology of sickness behavior and the pathophysiology of clinical depression explaining their partially overlapping phenomenology. (biomedcentral.com)

Moreover, bromelain has shown potential in reducing edema (swelling) and promoting wound healing, suggesting its ability to modulate the inflammatory response in a broader context. (bcr.org)

Accumulating evidence supports the view that the role of MSCs in regenerative medicine is mainly achieved by the paracrine pathway rather than direct proliferation and differentiation at the injured site. (biomedcentral.com)

This study investigated the effect of the trans-resveratrol supplementation on the cardiac oxidative stress in rats exposed to cigarette smoke. (bvsalud.org)
Male Wistar rats were randomized into four groups: Control Group (CG), Exposure to Smoke Group (ESG), Antioxidant Group (AG) and Exposure to Smoke plus Antioxidant Group (ESAG). (bvsalud.org)

Stress, jetlag, shift working hours, intense lifestyles and even exposure to blue light emissions from ubiquitous electronic devices such as laptops, tablets and mobile phones, disrupt the body's circadian clock, which leads to the deregulation of the skin's circadian rhythm. (clariant.com)
Contributing factors to these conditions are poor diet, stress, a sedentary lifestyle, exposure to toxins, and genetic predisposition. (integrativepsychiatry.net)

Alpha-lipoic acid is an antioxidant that is made naturally in the body and also found in foods. (medlineplus.gov)
Because alpha-lipoic acid seems to work like an antioxidant, it might provide protection to the brain and also be helpful in certain liver diseases. (medlineplus.gov)

We produce native antioxidants, such as the molecule glutathione, to counteract this pro-oxidant threat. (bigthink.com)

Independent single-nucleotide polymorphisms (SNPs) significantly associated with circulating levels of diet-derived antioxidants (retinol, β-carotene, lycopene, vitamin C and vitamin E) were extracted as genetic instruments. (frontiersin.org)
Vitamin E has been proven to have antioxidant and moisturizing properties in the skin and can protect against the damage of UVB radiation, with emphasis on the reduction of acute erythema and photoaging. (intechopen.com)
But evidence has mounted to suggest that antioxidant vitamin supplements, long assumed to improve health, are ineffectual. (bigthink.com)

The dominant pathway in chloroplasts is, however, the one that produces NADPH, by the activity of ferredoxin NADP + oxidoreductase (FNR). (nature.com)
Experimental assays demonstrated that GGD possesses independent antioxidant activity both in vitro and in vivo. (bvsalud.org)
CONCLUSIONS: The study identified the active ingredients of GGD against influenza and demonstrated the beneficial role of GGD's antioxidant activity in treating flu. (bvsalud.org)
The supplementation of Trans-resveratrol attenuated the cardiac oxidative stress and increased the activity of catalase. (bvsalud.org)

Oxidative stress generated during such stressful conditions may damage DNA and proteins, and as a consequence the cellular processes are disturbed. (springer.com)
The nutrient signaling pathways are coupled to cellular processes, and the cross-talk between the two is critical in maintaining a well-balanced systemic function of the body. (standardprocess.com)

The major regulated secretory pathway involves large granules that are exocytosed in response to autonomic stimulation 4 . (bvsalud.org)
GGD also involves multiple antiviral pathways, such as hepatitis B, IAV, and Toll-like receptor pathways. (bvsalud.org)

however, the mechanism(s) by which PM enhances the allergic response remains to be determined. (cdc.gov)

Data from in vitro and animal studies suggest that among the sources of antioxidants, phytochemicals in berry fruits ( e.g. , anthocyanin and caffeic acid) have a beneficial role in brain aging and neurodegenerative disorders because of their anti-oxidative, anti-inflammatory, anti-viral and anti-proliferative properties (Youdim et al. (lww.com)
Perhaps you steer toward "superfoods," fruits, nuts, and vegetables advertised as "antioxidant," which combat the nasty effects of oxidation in our bodies. (bigthink.com)
Fruits and vegetables are indeed healthful but not necessarily because they shield you from oxidative stress. (bigthink.com)

Espinosa-Diez C, Miguel V, Mennerich D, Kietzmann T, Sánchez-Pérez P, Cadenas S and Lamas S: Antioxidant responses and cellular adjustments to oxidative stress. (spandidos-publications.com)

I am currently interested in understanding the role of the antioxidant nutrients such as zinc in maintaining DNA integrity and cancer development. (oregonstate.edu)
4,5,6,7,8 Nutrients that may support healthy inflammatory response include omega-3 fatty acids, and antioxidants, from a whole food matrix in the form of phytonutrients. (standardprocess.com)

In addition, the developmental roles and the evolutionary conservation of the antioxidant response pathway in the thyroid remain unknown. (unil.ch)

Entrainment or phase adaptation is an important function of the circadian clock system that allows the adjustment of circadian dynamics in response to external stimuli. (nature.com)
2003). In agreement with these observations, there is evidence that increased oxidative stress plays an important role in the pathogenesis of neurodegenerative diseases such as AD, PD, ischemic diseases and aging (Esposito et al. (lww.com)
Therefore, assessment of the response of aflatoxigenic species to different temperatures is important to add information about the understanding of aflatoxin production by Aspergillus nomius and may help in the development of new strategies to prevent aflatoxin contamination. (researchgate.net)
As discussed later in this chapter, some studies have identified cytotoxicity of e-cigarette aerosols, potentially contributing to tissue repair and mitogenic response, which is another important pathway in the development of chemically induced cancers. (nationalacademies.org)
A later 2009 blog entry Hormesis and age retardation started out by saying "An important approach to retarding aging that I have not discussed explicitly so far is hormesis , challenging cells and body systems by mild stress resulting in them becoming stronger and resistant to aging( ref ). (anti-agingfirewalls.com)
the most important of them are conducted by anti-inflammatory, antioxidant activities, and antiallergic. (medscape.com)

The vertical axis represents relative risk, level of probable pathological organism response where normal level is 1. (anti-agingfirewalls.com)

Single cells and organisms may adapt to harmful oxidative stress conditions, through stress-activated factors. (springer.com)
Hu Y, Wang S, Wang A, Lin L, Chen M and Wang Y: Antioxidant and hepatoprotective effect of Penthorum chinense Pursh extract against t-BHP-induced liver damage in L02 cells. (spandidos-publications.com)
While primarily regulated by the brain, skin cells also possess their own circadian rhythm governing major biological responses which are known to follow this 24-hour clock. (clariant.com)
When the cells' circadian rhythm is desynchronized and under too much stress, they become overwhelmed and the detoxification pathway becomes less efficient. (clariant.com)
We analyzed the response of human glioma cells to West Nile virus infection by investigating host transcriptional changes. (cdc.gov)
Oxidants may be a primordial messenger of stress in our cells, and a little bit of stress, it turns out, may be good for us. (bigthink.com)

Anatomy18

Organisms14

Diseases3

Chemicals and Drugs126

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Psychiatry and Psychology1

Phenomena and Processes76

Technology, Industry, Agriculture3

Information Science3

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Nrf223

Body's natural4

Inflammation13

Free radicals6

Reactive oxygen5

Potent antioxidant3

Detoxification pathways1

Mechanisms8

Abiotic stresses3

Multiple pathways1

Metabolic3

Powerful antioxidant1

Abstract1

Protein5

Mice5

Levels of antioxidants1

Immune response4

Enzymes1

Hypoxia2

Molecular3

Tissues5

Regulation2

Defense1

Gene expression1

Downstream1

Genes1

Activates1

Vitamins4

Regulates1

Physiological3

Metabolism3

Polyphenols1

Protective1

Functional3

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Modulate the inflammatory1

Supports1

Rats2

Exposure2

Alpha Lipo2

Glutathione1

Vitamin3

Activity4

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Important6

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