AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
MorphineEnkephalinsEnkephalin, Ala(2)-MePhe(4)-Gly(5)-Enkephalin, LeucineEnkephalin, MethionineMorphine DependenceReceptors, Opioid, muAnalgesics, OpioidDrug ToleranceNarcoticsNaloxoneEnkephalin, Leucine-2-AlanineEnkephalin, D-Penicillamine (2,5)-AnalgesicsNarcotic AntagonistsReceptors, OpioidReceptors, Opioid, deltaMorphine DerivativesEndorphinsPain MeasurementSubstance Withdrawal SyndromeLocus CoeruleusNaltrexonePeriaqueductal GrayPainReceptors, Neurokinin-3Injections, SpinalRats, Sprague-DawleyDose-Response Relationship, DrugReceptors, Opioid, kappaOpioid PeptidesEthylketocyclazocineNeurokinin BPain ThresholdCyclazocineTachykininsHyperalgesiaReceptors, TachykininDynorphinsSpinal CordAnalgesiaEtorphineBehavior, AnimalD-Ala(2),MePhe(4),Met(0)-ol-enkephalinSubstance PMorphinansOpioid-Related DisordersAnalgesics, Non-NarcoticAcetic AcidNeurokinin AFormaldehydeGuinea PigsNociceptionBenzomorphansReceptors, Neurokinin-2Injections, IntraventricularDrug ImplantsNucleus AccumbensOligopeptidesDrug InteractionsNociceptorsTegmentum MesencephaliNeuronsbeta-EndorphinBrainNociceptive PainRats, WistarBenzeneacetamidesDipyroneVentral Tegmental AreaMotor ActivityFentanylCarrageenanRNA, Transfer, GlyNalorphineGuanosine 5'-O-(3-Thiotriphosphate)Time FactorsDiprenorphineCodeineHot TemperatureArrestinsPiperidinesDrug Administration ScheduleRaphe NucleiRats, Inbred StrainsMice, Inbred ICRCarboxypeptidase HAdenylate CyclaseReceptors, N-Methyl-D-AspartateMice, Inbred C57BLPentazocinePyrrolidinesDisease Models, AnimalEdemaTyrosine 3-MonooxygenaseNeurokinin-1 Receptor AntagonistsExcitatory Amino Acid AntagonistsTramadolPain, PostoperativeReaction Time
RatsSelectiveMechanicalEffectActivityAnimals
Rats1
  • This study was designed to explore the antinociceptive activity of intrathecal clonidine alone or in combination with intrathecal morphine (1:3 fixed ratio) in nerve-injured rats. (nih.gov)
Selective1
  • These effects were blocked by DAMGO washout and pre-treatment with the selective μ-opioid receptor antagonist Cys 2 -Tyr 3 -Orn 5 -Pen 7 -amide. (biomedcentral.com)
Mechanical2
  • Two weeks following a chronic constriction injury of the saphenous nerve, mice developed a profound mechanical hypersensitivity in the paw innervated by the damaged nerve. (biomedcentral.com)
  • Importantly, μ-opioid receptor agonist [D-Ala 2 , N -Me-Phe 4 ,Gly 5 ]-ol-enkephalin (DAMGO) significantly elevated the mechanical thresholds of nociceptive Aδ and C fibres. (biomedcentral.com)
Effect1
  • The contributions of MOR and σ1R to its antinociceptive effect were verified by combined administration with the MOR antagonist naloxone and the σ1R agonist PRE-084, respectively. (bvsalud.org)
Activity2
  • It possesses antinociceptive activity. (curehunter.com)
  • In this model, intrathecal morphine shows no antiallodynic activity, as well as decreased antinociceptive potency and efficacy. (nih.gov)
Animals1
  • The aims, with this study, were to use nerve-injured animals to determine: (1) whether the antinociceptive potency and efficacy of intrathecal clonidine was altered, and (2) whether the combination of intrathecal morphine and clonidine would act synergistically to produce antinociception. (nih.gov)