• Which alters the feeding of cancer patients, contributing to the anorexia, weight loss and malnutrition, which leads to a prognostic impact in a lower patient response to chemotherapy, radiotherapy and surgical treatment as well as increased toxic effects, impacting treatment discontinuation and therefore, morbidity and survival of patients. (clinicaltrials.gov)
  • Concurrent treatment with any other anticancer therapy, including chemotherapy, immunotherapy, radiotherapy (excluding radiotherapy with palliative intent on non-target lesions), targeted therapy, gene therapy, or patients planning to receive these treatments during the study. (knowcancer.com)
  • However, along with surgery, the mainstays of cancer treatment are radiotherapy and chemotherapy, both of which are genotoxic and mutagenic. (aacrjournals.org)
  • Another major adverse effect of radiotherapy and chemotherapy is mutagenesis, which can cause heritable genetic damage and diseases in the offspring of survivors ( 4 ). (aacrjournals.org)
  • Systemic treatment (chemotherapy) and local therapy (radiotherapy and surgery) are the current typical treatments for breast cancer [ 2 ]. (mdpi.com)
  • 1 This guideline for the prevention of oral and oropharyngeal mucositis was developed in order to prevent or reduce the severity of mucositis in children 0-18 years of age receiving cytotoxic chemotherapy or radiotherapy for cancer or undergoing HSCT. (bmj.com)
  • However, high-dose chemotherapy in solid tumor in order to boost the effect of anti-cancer therapy is always under controversy. (biomedcentral.com)
  • Phase II Study for the Evaluation of Bendamustine, Bortezomib and Dexamethasone (BBD) in the First-Line Treatment of Patients With Multiple Myeloma Who Are Not Candidates for High Dose Chemotherapy. (springer.com)
  • Importantly, the use of drugs (whether chemotherapy, hormonal therapy or targeted therapy) constitutes systemic therapy for cancer in that they are introduced into the blood stream and are therefore in principle able to address cancer at any anatomic location in the body. (wikipedia.org)
  • The goal of this protocol is to evaluate the safety and efficacy of an alternative systemic combination approach that omits or delays the use of chemotherapy in metastatic disease, while improving efficacy and durability of response. (mycancergenome.org)
  • subjects with metastatic progression within 1 year following completion of curative-intent chemotherapy are eligible if they have not received any additional lines of systemic therapy in the non-curative setting. (mycancergenome.org)
  • Immunotherapy could be combined with conventional chemotherapeutic modalities aimed at reducing tumor burden. (aacrjournals.org)
  • We therefore investigated whether such metronomic therapy with the alkylating agent cyclophosphamide (CTX) could be effectively combined with immunotherapy eliciting tumor-reactive CTLs. (aacrjournals.org)
  • Combining this immunotherapeutic regime with metronomic delivery of CTX resulted in antitumor activity that was dramatically enhanced over either treatment administered alone and was also significantly greater than combining immunotherapy with CTX administered by a maximum tolerated dose regime. (aacrjournals.org)
  • We show that the combination of metronomic administration of CTX with immunization provides antitumor responses that are dramatically enhanced over immunotherapy or chemotherapy alone and that are also enhanced over immunotherapy combined with CTX administered at the MTD. (aacrjournals.org)
  • Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs), or it may aim to prolong life or to reduce symptoms (palliative chemotherapy). (wikipedia.org)
  • Chemotherapy may be given with a curative intent or it may aim to prolong life or to palliate symptoms . (wikipedia.org)
  • This type of chemotherapy is used for curative intent. (wikipedia.org)
  • Docetaxel, when used alone, has demonstrated significant antineoplastic activity against tumor cells of advanced breast, ovarian, and lung cancer. (cancernetwork.com)
  • On the basis of the concept that a given dose of an antineoplastic compound would destroy a certain fraction of tumor cells, the efficiency of tumor chemotherapy, to a great extent, is dependent on the dosage of drugs and higher doses are supposed to be more effective. (biomedcentral.com)
  • Amsacrine is an alkylating antineoplastic agent that is highly active toward AML, unlike more conventional alkylators like cyclophosphamide. (wikipedia.org)
  • In this setting, it is often combined with other agents, such as: Cyclophosphamide (FLAMSA-CYC), and/or Busulfan or treosulfan (FLAMSA-BU or FLAMSA-TREO), and/or Melphalan (FLAMSA-MEL), and/or Total body irradiation, given shortly after the end of FLAMSA to prepare the patient for transplant. (wikipedia.org)
  • FLAG is a chemotherapy regimen used for relapsed and refractory acute myeloid leukemia (AML). (wikipedia.org)
  • The FLAMSA protocol is most often used as an induction part of a reduced-intensity conditioning regimen for patients eligible to undergo an allogeneic stem cell transplant. (wikipedia.org)
  • Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx ) is a category of cancer treatment that uses one or more anti-cancer drugs ( chemotherapeutic agents ) as part of a standardized chemotherapy regimen . (wikipedia.org)
  • The current standard-of-care regimen involves six weeks of radiation therapy with concurrent oral temozolomide chemotherapy, followed by monthly cycles of oral temozolomide chemotherapy. (cancertherapyadvisor.com)
  • Results We suggest cryotherapy or LLLT may be offered to cooperative children receiving chemotherapy or HSCT conditioning with regimens associated with a high rate of mucositis. (bmj.com)
  • Combined modality chemotherapy is the use of drugs with other cancer treatments , such as surgery , radiation therapy , or hyperthermia therapy . (wikipedia.org)
  • However, cytotoxic antineoplastic drugs or ionizing radiation generally result in side effects during treatment [ 3 , 4 ]. (mdpi.com)
  • After surgery, further treatment options depend on tumor grade, and range from observation alone to treatment with radiation and chemotherapy. (cancertherapyadvisor.com)
  • This cell population appears to be especially resistant to radiation and chemotherapy, and may partially explain the high rate of tumor recurrence following initial treatment. (cancertherapyadvisor.com)
  • In either case, treatment begins with maximum safe resection, which is followed by radiation therapy and chemotherapy. (cancertherapyadvisor.com)
  • Following encouraging preclinical results of taxoid combinations, this phase I, nonrandomized trial was designed to evaluate a 1-hour intravenous infusion of docetaxel (Taxotere) on day 1 combined with fluorouracil (5-FU) as a daily intravenous bolus for 5 consecutive days. (cancernetwork.com)
  • A woman being treated with docetaxel chemotherapy for breast cancer . (wikipedia.org)
  • The objective of this study is to describe the threshold of perception and recognition of basic tastes in patients with NSCLC before treatment with platin and paclitaxel-based chemotherapy and after the second cycle, and analyze the effect in the developement of dysgeusia, as well as the association between these and the nutritional status and quality of life. (clinicaltrials.gov)
  • Serum mesothelin is a useful early treatment response marker when measured serially during chemotherapy and may have a role in evaluating patients' treatment response. (ox.ac.uk)
  • Induction chemotherapy is the first line treatment of cancer with a chemotherapeutic drug. (wikipedia.org)
  • 08 Feb 2017 Protocol was amended to change in the treatment arm and change in time frame from 24 months to 48 months. (springer.com)
  • V. To explore the early and late immunologic consequences of combining ibrutinib with lenalidomide in relapsed and refractory CLL. (clinicaltrials.gov)
  • Exactly assessing tumor response to different dose of chemotherapy would help to tailor therapy for individual patients. (biomedcentral.com)
  • Dynamic CEUS for quantification of tumor perfusion could be used to evaluate tumor vascular response to different dose of chemotherapy. (biomedcentral.com)
  • Thus, exactly assessing tumor response to different dose of chemotherapy is urgently needed, which could not only be helpful to tailor therapy for individual patients, but also avoid wasting of medical resource. (biomedcentral.com)
  • It should be stressed that the majority of chemotherapy treatments compromise normal sexual function and often lead to prolonged infertility ( 5 ). (aacrjournals.org)
  • The term "salvage chemotherapy" reflects the limitation of current treatments for these individuals. (cancernetwork.com)
  • It has recently been reported that proliferating endothelial cells forming new blood vessels within tumors are sensitive to the cytotoxic effects of many antineoplastic agents. (aacrjournals.org)
  • This paper offers a review of neuroimaging investigations in chemotherapy-treated adult cancer patients, discussing the benefits and limitations of each technique and study design. (mdpi.com)
  • Combination chemotherapy involves treating a patient with a number of different drugs simultaneously. (wikipedia.org)
  • Life threatening toxicities of chemotherapies and immunosuppressants can occur with varying frequency depending on the agent suspected and underlying patient risk factors. (cancertherapyadvisor.com)
  • This study suggested that gallic acid is a bioactive component of S. Caulis with potential to be used in chemotherapy for breast cancer. (mdpi.com)
  • Change in interval TGV(baseline/after two cycles of chemotherapy) did not predict OS or chemotherapy response on CT. (ox.ac.uk)
  • INTERPRETATION: Neutrophil-lymphocyte ratio and baseline TGV predict prognosis in malignant pleural mesothelioma (MPM), but PET-CT is unhelpful in monitoring chemotherapy response. (ox.ac.uk)
  • A combined histological and genetic diagnosis is now recommended, incorporating key molecular traits such as 'IDH mutation' and '1p/19q codeletion' because of their influence on glioma development, prognosis and their ability to predict response to chemotherapy. (cancertherapyadvisor.com)
  • Such combination therapy may be most useful when "metronomic" doses of antineoplastic drugs are used, thereby potentially avoiding some of the immunosuppressive effects of these drugs. (aacrjournals.org)
  • The approach combines two potentially effective and previously studied strategies: androgen receptor blockade and immune checkpoint therapy. (mycancergenome.org)
  • To a large extent, chemotherapy can be thought of as a way to damage or stress cells, which may then lead to cell death if apoptosis is initiated. (wikipedia.org)
  • CTX, 3 an alkylating agent commonly used in chemotherapy, is paradoxical in this regard. (aacrjournals.org)
  • The South West Area Mesothelioma and Pemetrexed trial: a multicentre prospective observational study evaluating novel markers of chemotherapy response and prognostication. (ox.ac.uk)
  • An immunization protocol using injection of recombinant DNA followed by injection of recombinant modified vaccinia virus Ankara strain was used to initiate a specific CTL response in mice capable of providing resistance to challenge with the murine melanoma B16.F10. (aacrjournals.org)
  • The use of microbubble-based contrast agents combined with contrast specific imaging modalities has considerably improved the visualization of microvascular perfusion that is undetectable with traditional Doppler techniques. (biomedcentral.com)
  • Recent studies have shown that some conventional antineoplastic drugs can be exploited for antiangiogenic capacities, a strategy that requires drugs to be administered at regular intervals. (aacrjournals.org)
  • We investigated the antineoplastic activity of AF in 4 canine lymphoid tumor derived cell lines through measurements of proliferation, apoptosis, thioredoxin reductase (TrxR) activity and generation of reactive oxygen species (ROS), and detected the effects of AF when combined with conventional cytotoxic drugs using the Chou and Talalay method. (biomedcentral.com)
  • METHODS: Consecutive patients with MPM who were considered fit for first-line chemotherapy were prospectively recruited. (ox.ac.uk)
  • FINDINGS: Seventy-three patients were recruited (58 chemotherapy/15 comparator arm). (ox.ac.uk)
  • Although a breakthrough with significant impact on advanced cancer survival is still in the future, current work has focused on improving the therapeutic index of the agents administered, especially to patients who have received prior anthracycline-based chemotherapy. (cancernetwork.com)
  • As more chemotherapy-treated cancer patients are reaching survivorship, side-effects such as cognitive impairment warrant research attention. (mdpi.com)
  • Continued investigations may yield better long-term quality of life outcomes by supporting patients' self-reports, and revealing brain regions being affected by chemotherapy. (mdpi.com)
  • Many patients report experiencing cognitive changes while undergoing chemotherapy. (mdpi.com)
  • Patients have coined terms like chemo fog and chemo brain to refer to these changes, indicating their assumption that chemotherapy is the causative factor. (mdpi.com)
  • Over the last decade, several studies have been conducted in cancer patients to investigate the effects of chemotherapy on cognition, most finding that chemotherapy-treated patients perform more poorly on neurocognitive tests than non-exposed controls [ 1 - 20 ]. (mdpi.com)
  • Moreover, a synergistic antiproliferative effect was observed when AF was combined with lomustine or doxorubicin. (biomedcentral.com)
  • Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity ). (wikipedia.org)
  • Many of the side effects of chemotherapy can be traced to damage to normal cells that divide rapidly and are thus sensitive to anti-mitotic drugs: cells in the bone marrow , digestive tract and hair follicles . (wikipedia.org)
  • The investigators want to find out what effects, good and/or bad, Hu3F8 combined with rIL2 has on cancer. (clinicaltrials.gov)
  • By common usage, the term chemotherapy has come to connote the use of rather non-specific intracellular poisons , especially related to inhibiting the process of cell division known as mitosis , and generally excludes agents that more selectively block extracellular growth signals (i.e. blockers of signal transduction ). (wikipedia.org)
  • Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer , which is called medical oncology . (wikipedia.org)
  • The investigators also want to find out more about how Hu3F8 works and how effective it is in attacking the disease when combined with rIL2. (clinicaltrials.gov)
  • Multiple in vitro studies have recently suggested that AF may possess antineoplastic properties. (biomedcentral.com)
  • The purpose of this study is to find out if 'humanized 3F8' (Hu3F8) when combined with interleukin-2 (rIL2) is safe for treating neuroblastoma and other cancers. (clinicaltrials.gov)
  • When a life threatening toxicity of a chemotherapy agent or immunosuppressant agent is suspected or confirmed, initially the offending agent should be discontinued. (cancertherapyadvisor.com)