• In this form of chemotherapy, commonly used drugs include cisplatin, oxaliplatin, and carboplatin, but several have been proposed or are under development. (wikipedia.org)
  • Approved platinum-based anticancer drugs cisplatin carboplatin oxaliplatin nedaplatin Platinum-based anticancer drugs in trials triplatin tetranitrate phenanthriplatin, a proposed new anticancer drug. (wikipedia.org)
  • Care must be taken to avoid inadvertent cisplatin overdose due to confusion with carboplatin or prescribing practices that fail to differentiate daily doses from total dose per cycle. (globalrph.com)
  • Tell your doctor if you are allergic to oxaliplatin, carboplatin (Paraplatin), cisplatin (Platinol) or any other medications. (medlineplus.gov)
  • Chemotherapeutic (antineoplastic) medications, particularly those containing platinum ( cisplatin and carboplatin ), can cause tinnitus and hearing loss. (msdmanuals.com)
  • Cisplatin and Carboplatin are drug of choice in HNC treatment. (waocp.com)
  • Systemic agents commonly prescribed in head and neck cancer treatment includes Cisplatin, Cetuximab and Carboplatin. (waocp.com)
  • However, if patient develops side effects because of cisplatin or patient overall health condition is not well at the start of treatment because of age factors and other co-morbid patients are prescribed cetuximab (targeted therapy) and last option is carboplatin (slightly less effective but cost-effective). (waocp.com)
  • that is, for a dose that usually requires a particular dose of cisplatin, four times more carboplatin is needed to achieve the same effectiveness" (p.193). (waocp.com)
  • Several analogs of cisplatin have been synthesized such as carboplatin and oxiplatin. (waocp.com)
  • We evaluated whether RT plus LDPF chemotherapy had an advantage in terms of survival and/or toxicity over RT plus standard-dose cisplatin and 5-fluorouracil (SDPF) chemotherapy in this study. (nih.gov)
  • Cumulative renal toxicity associated with cisplatin is severe. (globalrph.com)
  • Interferon and the chemotherapy agents dacarbazine, cisplatin, and vinblastine are approved by the US Food and Drug Administration (FDA) for use as adjuvant therapy in melanoma. (medscape.com)
  • Antineoplastic agents are employed to reduce tumor burden and induce remission. (medscape.com)
  • Gestational trophoblastic tumors are sensitive to many antineoplastic agents, especially those that act in the S phase or the M phase of the cell cycle. (medscape.com)
  • There are indications that certain antineoplastic agents at low dosages may exhibit abnormal pharmacological actions, such as promoting tumor growth. (researchsquare.com)
  • These findings urge further investigations to avoid the potential risks in current empiric continuous low-dose chemotherapy regimens with antineoplastic agents. (researchsquare.com)
  • This study observes a previously neglected pharmacological phenomenon and investigates its mechanism of that the continuous low-dose administration of some antineoplastic agents in certain dose ranges can promote tumorigenesis and tumor progression in vitro and in vivo , through stimulation of tumor cell functions directly as well as enhancement of tumor angiogenesis by BMDCs recruitment indirectly. (researchsquare.com)
  • However, the conventional chemotherapy with antineoplastic agents at the maximum tolerated dose (MTD) is typically administrated in short cycles, obligatorily separated by long treatment breaks (e.g., 3 weeks), and unfortunately accompanied by serious toxic side effects. (researchsquare.com)
  • Platinum-based antineoplastic drugs (informally called platins) are chemotherapeutic agents used to treat cancer. (wikipedia.org)
  • As studied mainly on cisplatin, but presumably for other members as well, platinum-based antineoplastic agents cause crosslinking of DNA as monoadduct, interstrand crosslinks, intrastrand crosslinks or DNA protein crosslinks. (wikipedia.org)
  • Platinum-based antineoplastic agents are sometimes described as "alkylating-like" due to similar effects as alkylating antineoplastic agents, although they do not have an alkyl group. (wikipedia.org)
  • DBL Cisplatin Injection belongs to a group of medicines known as antineoplastic or cytotoxic agents. (news-medical.net)
  • Cisplatin injection should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. (globalrph.com)
  • Pemetrexed is in a class of medications called antifolate antineoplastic agents . (ankr.us)
  • The course of CIHL is further influenced by the total cumulative dose of cisplatin and other ototoxic (co-)medication. (bvsalud.org)
  • This leaflet answers some common questions about DBL Cisplatin Injection. (news-medical.net)
  • DBL Cisplatin Injection is a platinum-containing medicine and is used as an anticancer drug to interfere with the growth of cancer cells and eventually destroy them. (news-medical.net)
  • DBL Cisplatin Injection may be used alone or with other anticancer therapies. (news-medical.net)
  • DBL Cisplatin Injection has been chosen as your therapy, as the benefits of treatment are expected to be greater than the unwanted or side effects. (news-medical.net)
  • The active ingredient in DBL Cisplatin Injection passes into breast milk and there is a possibility that your baby may be affected. (news-medical.net)
  • Do not dilute cisplatin in just 5% Dextrose Injection. (globalrph.com)
  • Cisplatin Injection is a sterile, multidose vial without preservatives. (globalrph.com)
  • Cisplatin injection is used to treat advanced cancer of the bladder, ovaries, or testicles . (pharmika.co.in)
  • TNF-α appears to play a central role in the cisplatin induced renal injury by activation of a large network of chemokines and cytokines in the kidney following cisplatin injection. (biomedcentral.com)
  • Cisplatin is an alkylating agent that inhibits DNA synthesis and, thus, cell proliferation by causing DNA cross-links and denaturation of the double helix. (medscape.com)
  • Anthracycline antineoplastics inhibit DNA and RNA synthesis by steric obstruction. (medscape.com)
  • The present study was undertaken to assess the effect of rosiglitazone, a PPARγ agonist and an anti-inflammatory agent, on cisplatin induced nephrotoxicity, and its anticancer activity in DMBA induced breast cancer rats. (biomedcentral.com)
  • To best of our knowledge this is the first report which shows that pre-treatment of rosiglitazone synergizes the anticancer activity of cisplatin and minimizes cisplatin induced nephrotoxicity in DMBA induced breast cancer. (biomedcentral.com)
  • Plasma concentrations of the parent compound, cisplatin, decay monoexponentially with a half-life of about 20 to 30 minutes following bolus administration of 50 or 100 mg/m2 doses. (globalrph.com)
  • We conclude that cisplatin probably does not cause autonomic dysfunction, at least not in rats, in doses commonly used and which are known to cause a peripheral sensory neuropathy. (amsterdamumc.org)
  • Cisplatin is a drug of choice, given either in a three weekly or weekly dose (in case of side effects develop with three weekly doses). (waocp.com)
  • Doxorubicin is an anthracycline antineoplastic that causes DNA strand breakage through effects on topoisomerase II and direct intercalation into DNA, which causes DNA polymerase inhibition. (medscape.com)
  • Regimens of radiotherapy and chemotherapy that contain cisplatin improve the rates of survival and progression-free survival among women with locally advanced cervical cancer. (nih.gov)
  • Cisplatin is in a class of medications known as platinum-containing compounds . (ankr.us)
  • Topotecan belongs to the group of medicines called antineoplastics. (mayoclinic.org)
  • This application of cisplatin was developed by pediatric oncologist Roger Packer in the early 1980s. (wikipedia.org)
  • Cisplatin is used in variety of tumors including cancers of the ovaries, testes, and solid tumors of the head and neck. (waocp.com)
  • Gemcitabine is used in combination with cisplatin for the treatment of advanced or metastatic bladder cancer. (medscape.com)
  • It is also used in combination with cisplatin to treat cancer of the cervix that has come back and cannot be treated with surgery or radiation. (mayoclinic.org)
  • Rosiglitazone pre-treatment to cisplatin increases the expression of p38, PPAR-γ in mammary tumours and shows maximum tumour reduction. (biomedcentral.com)
  • The pemetrexed will be given over 10 minutes and the cisplatin infusion takes about two hours. (ankr.us)
  • Pretreatment hydration with 1 to 2 liters of fluid infused for 8 to 12 hours prior to a cisplatin dose is recommended. (globalrph.com)
  • Avoid becoming pregnant by using effective birth control during your treatment with cisplatin and for at least 26 weeks after you stop treatment (at least 31 weeks if have kidney disease). (news-medical.net)
  • It is recommended that you use effective contraception while you are using cisplatin and for at least 14 weeks after you stop treatment (at least 19 weeks if you have kidney disease). (news-medical.net)
  • Before you start pemetrexed and cisplatin, take medicines to help reduce side effects. (ankr.us)
  • Effective antineoplastic used in patients with chemotherapy-resistant malignant GTN. (medscape.com)
  • Cisplatin-induced oxidative stress and shifting of calcium from mitochondria to within the cell are another mechanism through which drug exerts its anti-cancerous effects [7]. (waocp.com)
  • Males: Tell your doctor or pharmacist if your partner intends to become pregnant while you are being given cisplatin, or shortly after you have stopped treatment. (news-medical.net)
  • NOTE TO THE PHARMACIST- Exercise caution to prevent inadvertent cisplatin overdosage. (globalrph.com)
  • Long non-coding RNA ENST00000457645 reverses cisplatin resistance in CP70 ovarian cancer cells. (geneticsmr.com)
  • The authors investigated the development of cisplatin-induced hearing loss (CIHL) over time in children with cancer by age and examined the influence of other clinical characteristics on the course of CIHL. (bvsalud.org)
  • Cisplatin is an antineoplastic agent (cancer medicine). (pharmika.co.in)
  • Pemetrexed and cisplatin can be given with other cancer drugs. (ankr.us)
  • Antineoplastic drug cisplatin remains the drug of choice for various solid tumours including breast cancer. (biomedcentral.com)
  • Since the growth of normal body cells may also be affected by cisplatin, other effects may also occur (see Side Effects). (news-medical.net)
  • As the possible harmful effects to the infant are not known, breastfeeding is not recommended while you are receiving cisplatin. (news-medical.net)
  • The neurotoxic side-effects of cisplatin affect predominantly the large, myelinated fibres of peripheral nerves, leading to a sensory neuropathy. (amsterdamumc.org)
  • What side effects can cisplatin and pemetrexed cause? (ankr.us)
  • It is recommended that you and your doctor discuss your need for cisplatin treatment during pregnancy and the possible risks and benefits of using cisplatin during pregnancy. (news-medical.net)
  • Furthermore, cisplatin induced changes in histone acetylation, phosphorylation and methylation of histone H3 in mammary tumours was ameliorated by pre-treatment of rosiglitazone. (biomedcentral.com)
  • Note: Needles or intravenous sets containing aluminum parts that may come in contact with cisplatin should not be used for preparation or administration. (globalrph.com)