• Dialkylating agents can react with two different 7-N-guanine residues, and, if these are in different strands of DNA, the result is cross-linkage of the DNA strands, which prevents uncoiling of the DNA double helix. (wikipedia.org)
  • Monoalkylating agents can react only with one 7-N of guanine. (wikipedia.org)
  • The purpose of this study is to investigate the safety and efficacy of bevacizumab as an adjunctive treatment to trabeculectomy in open angle glaucoma patients and to compare this new drug to the most commonly used anti-scarring agent, mitomycin C. (clinicaltrials.gov)
  • At the time of surgery most surgeons use mitomycin C, which is an antimitotic and antifibrotic agent, to improve the results of the procedure. (clinicaltrials.gov)
  • In this study the investigators are trying, in addition to evaluating the efficacy and safety of this agent in result of trabeculectomy, compare this agent with mitomycin C. (clinicaltrials.gov)
  • Alkyl sulfonates are esters of alkane sulfonic acids with the general formula R-SO2-O-R'. They act as alkylating agents, some of them are used as alkylating antineoplastic agents in the treatment of cancer, e.g. (wikipedia.org)
  • androstanolone, stanolone) have also been marketed, including the following: Androstanolone benzoate (Ermalone-Amp, Hermalone, Sarcosan) Androstanolone enanthate (Anaboleen Depot) Androstanolone propionate (Pesomax) Androstanolone valerate (Apeton) The following esters of DHT have not been marketed: Dihydrotestosterone acetate Dihydrotestosterone butyrate Dihydrotestosterone formate Testifenon (chlorphenacyl DHT ester) is a nitrogen mustard ester of DHT that was developed as an alkylating antineoplastic agent but was never marketed. (wikipedia.org)
  • The following esters of other natural AAS have been marketed: Androstenediol dipropionate (Bisexovister, Bisexovis, Ginandrin, Stenandiol) Prasterone enanthate (DHEA enanthate) (Gynodian Depot (in combination with estradiol valerate)) Prasterone sulfate (DHEA sulfate) (Astenile, Mylis, Teloin) And the following have not been marketed: Androstenediol 3β-acetate Androstenediol 17-acetate Androstenediol diacetate Sturamustine is a nitrosourea ester of dehydroepiandrosterone (DHEA) that was developed as an alkylating antineoplastic agent but was never marketed. (wikipedia.org)
  • By common usage, the term chemotherapy has come to connote the use of rather non-specific intracellular poisons , especially related to inhibiting the process of cell division known as mitosis , and generally excludes agents that more selectively block extracellular growth signals (i.e. blockers of signal transduction ). (wikipedia.org)
  • Efficacy of agents with anti-angiogenic activity has already been demonstrated and the PDGF receptor target may also be pertinent in glioblastoma. (clinicaltrials.gov)
  • Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx ) is a category of cancer treatment that uses one or more anti-cancer drugs ( chemotherapeutic agents ) as part of a standardized chemotherapy regimen . (wikipedia.org)
  • In this project, we wish to evaluate the contribution of the MGMT methylation, evaluated in the tumor , in predicting the Objective Response (OR) in patients treated with ALKY and to evaluate a treatment with alkylating agents versus Oxaliplatin in patients with a duodeno-pancreatic or lung or unknown primitive NET. (clinicaltrials.gov)
  • This DIPG Biology and Treatment Study (DIPG-BATS) study incorporates a surgical biopsy at presentation using strict preoperative neurosurgical planning and stratifies participants to receive FDA-approved agents chosen on the basis of specific biologic targets. (clinicaltrials.gov)
  • Bendamustine is a well tolerable and very active agent in the treatment of Non Hodgkin's lymphoma. (clinicaltrials.gov)
  • Subjects previously treated with enzyme-induced antiepileptic drugs (EIAEDs) must have discontinued treatment with these agent(s) greater than or equal to 2 weeks prior to enrollment. (clinicaltrials.gov)
  • Atrimustine (INN) (developmental code name KM-2210), also known as bestrabucil or busramustine, is a nitrogen mustard alkylating antineoplastic drug that was under development in Japan by Kureha Chemicals (now Kureha Corporation) for the treatment of breast cancer and non-Hodgkin's lymphoma as well as for the prevention of graft-versus-host disease in bone marrow transplant recipients. (wikipedia.org)
  • As of mid-2006, dacarbazine is commonly used as a single agent in the treatment of metastatic melanoma, and as part of the ABVD chemotherapy regimen to treat Hodgkin's lymphoma, and in the MAID regimen for sarcoma. (wikipedia.org)
  • Multi-drug resistance presents a significant problem in the clinical setting and agents that are less susceptible to these mechanisms can successfully be used in prolonged treatment protocols. (wikipedia.org)
  • Due to its chemical properties hydroxyurea was explored as an antisickling agent in the treatment of hematological conditions. (wikipedia.org)
  • Antineoplastic drugs kill susceptible sub-populations and the tumour mass may shrink as an initial response to the drug, resistant cancer cells will survive treatment, be selected and then propagate, eventually causing a cancer relapse. (wikipedia.org)
  • in these situations it may be the preferred myelosuppressive agent due to its relative lack of leukemogenic effects and hence the relative lack of potential for secondary hematologic malignancies to result from treatment. (wikipedia.org)
  • In the past, antimetabolites (e.g., cytarabine, hydroxyurea), alkylating agents, interferon alfa 2b, and steroids were used as treatments of CML in the chronic phase, but since the 2000s have been replaced by Bcr-Abl tyrosine-kinase inhibitors drugs that specifically target BCR-ABL, the constitutively activated tyrosine kinase fusion protein caused by the Philadelphia chromosome translocation. (wikipedia.org)
  • The 'alkylating-based' group will receive CapTem regimen (capecitabine and temozolomide, /4 week), alternatively LV5FU2 (folinic acid-5 fluorouracil)-dacarbazine (1x/2 week) or LV5FU2 (folinic acid-5-fluorouracil)-streptozotocine (1x/2 week). (clinicaltrials.gov)
  • Duocarmycin A Duocarmycin B1 Duocarmycin B2 Duocarmycin C1 Duocarmycin C2 Duocarmycin D Duocarmycin SA CC-1065 The DNA modifying agents such as duocarmycin are being used in the development of antibody-drug conjugate or ADCs. (wikipedia.org)
  • The agent was first investigated as a possible drug for use in melanoma, it was not found to be effective. (wikipedia.org)
  • Antineoplastic resistance, often used interchangeably with chemotherapy resistance, is the multiple drug resistance of neoplastic (cancerous) cells, or the ability of cancer cells to survive and grow despite anti-cancer therapies. (wikipedia.org)
  • There are two general causes of antineoplastic therapy failure: Inherent genetic characteristics, giving cancer cells their resistance, which is rooted in the concept of cancer cell heterogeneity and acquired resistance after drug exposure. (wikipedia.org)
  • Antineoplastic resistance, synonymous with chemotherapy resistance, is the ability of cancer cells to survive and grow despite different anti-cancer therapies, i.e. their multiple drug resistance. (wikipedia.org)
  • Epigenetic modifications in antineoplastic drug resistance play a major role in cancer development and drug resistance as they contribute to the regulation of gene expression. (wikipedia.org)
  • This unique structure is believed to damage tumor cells through the production of the weakly alkylating species formaldehyde, a product of CYP450-mediated N-demethylation. (wikipedia.org)
  • Alkylating agents (ALKY) are one of the main systemic treatments used, at least for advanced duodeno-pancreatic NETs, with a response rate of 30 to 40% and a median progression-free survival of 4 to 18 months. (clinicaltrials.gov)
  • P. G. Baraldi, D. Preti, F. Fruttarolo, M. A. Tabrizi, R. Romagnoli: Hybrid molecules between distamycin A and active moieties of antitumor agents. (wikipedia.org)