• The study was undertaken to determine the length of time between when a prescription for an oral antineoplastic agent is written by the provider and when the medication is received by the patient and to identify risk factors that significantly increase time to medication receipt. (hindawi.com)
  • PURPOSE/OBJECTIVES: To determine proof of concept of a mobile health (mHealth) intervention delivering text messages (texts) to self-manage among patients prescribed oral anticancer agents (OAs) and to examine preliminary efficacy on symptoms and medication adherence. (mhealthevidence.org)
  • Dacarbazine is in the alkylating agent and purine analog families of medication. (wikipedia.org)
  • This agent is pharmacologically classified as a human epidermal growth factor receptor type 1/epidermal growth factor receptor (HER1/EGFR) tyrosine kinase inhibitor. (medscape.com)
  • Mesna is a prophylactic detoxifying agent used to inhibit hemorrhagic cystitis caused by ifosfamide and cyclophosphamide. (medscape.com)
  • Patients with more extensive disease and progressive scarring require systemic therapy with prednisone and/or steroid-sparing agents, such as cyclophosphamide, azathioprine, cyclosporin, or mycophenolate mofetil. (medscape.com)
  • Among the antineoplastic agents employed in this project, cyclophosphamide, etoposide, vinblastine and vincristine were potently inhibited the CYP3A4, 2C19 and 2D6 mediated oxidative drug metabolism determined by the typical substrates corresponding to each CYP enzyme. (nii.ac.jp)
  • Amsacrine is an alkylating antineoplastic agent that is highly active toward AML, unlike more conventional alkylators like cyclophosphamide. (wikipedia.org)
  • In this setting, it is often combined with other agents, such as: Cyclophosphamide (FLAMSA-CYC), and/or Busulfan or treosulfan (FLAMSA-BU or FLAMSA-TREO), and/or Melphalan (FLAMSA-MEL), and/or Total body irradiation, given shortly after the end of FLAMSA to prepare the patient for transplant. (wikipedia.org)
  • This is a list of antineoplastic agents used to treat cancer. (wikipedia.org)
  • Here, we report that the antineoplastic agents, daunorubicin hydrochloride, etoposide, and vincristine sulfate inhibited the ability of 1,25(OH) 2 D 3 to cause the accumulation of mRNA for kidney 25-hydroxyvitamin D 3 24-hydroxylase (CYP24), an enzyme which catabolizes this hormone. (aacrjournals.org)
  • Our data show that daunorubicin hydrochloride, etoposide, and vincristine sulfate, three well-characterized antineoplastic agents, caused the accumulation of 1,25(OH) 2 D 3 in kidney cells. (aacrjournals.org)
  • Publications] Hua Li, Norimitsu Kurata, Yuki Nishimura, Mariko Iwase, Eiji Uchida and Hajime Yasuhara: 'The effect of antineoplastic agent vinblastine and vincristine on CYP3A4, CYP2C19 and CYP2D6 activity in human liver microsomes'Xenobiotica. (nii.ac.jp)
  • Vindesine has demonstrated activity in patients who have relapsed while receiving multiple-agent treatment that included vincristine. (pharmacycode.com)
  • Bevacizumab is generally given with other potent antineoplastic agents and to patients with hepatic metastases which makes it difficult to attribute serum enzyme elevations or clinically apparent liver injury to a specific agent being used. (nih.gov)
  • Analogues of naturally occurring antitumour agents, such as duocarmycins, represent a new class of highly potent antineoplastic compounds. (wikipedia.org)
  • however it was withdrawn from testing when no difference was detected in the duration of median survival as compared to the progestational agent megestrol acetate and research instead focused on the other third generation aromatase inhibitors anastrozole, letrozole and exemestane. (wikipedia.org)
  • Resminostat (4SC-201 or RAS2410) is an orally bioavailable inhibitor of histone deacetylases (HDACs), of which inhibitors are antineoplastic agents. (wikipedia.org)
  • Amsacrine also expresses topoisomerase inhibitor activity, specifically inhibiting topoisomerase II (compares with the better known agent etoposide). (wikipedia.org)
  • This agent is indicated for treatment of adults with metastatic basal cell carcinoma or with locally advanced basal cell carcinoma that has recurred following surgery, or those who are not candidates for surgery or radiation. (medscape.com)
  • Anti-Neoplastic pharmaceutical agents are used in combination with surgery, immunotherapy, radiotherapy, hormone therapy, targeted therapy for many solid tumors, especially metastatic. (sbwire.com)
  • Cell-cycle nonspecific antineoplastic agents (CCNS) refer to a class of pharmaceuticals that act as antitumor agents at all or any phases of the cell cycle. (wikipedia.org)
  • To investigate whether both anguidine-induced potentiation and protection of cells by different antitumor agents were due to its induction of complete suspension of cycle traverse, experiments were also conducted with plateau-phase cultures. (aacrjournals.org)
  • P. G. Baraldi, D. Preti, F. Fruttarolo, M. A. Tabrizi, R. Romagnoli: Hybrid molecules between distamycin A and active moieties of antitumor agents. (wikipedia.org)
  • When this drug is used as an alkylating agent, the mechanism of action of its active metabolites may involve cross-linking of DNA, which may interfere with the growth of normal and neoplastic cells. (medscape.com)
  • With the average cost of a new oral antineoplastic drug in 2012 approximating $10,000, paying for medications can be a significant out-of-pocket expense and burden for patients. (hindawi.com)
  • Although drug-induced lung injury has recently been the focus of interest in Japanese patients treated with molecular targeting agents, the clinical features of patients receiving sorafenib remain to be completely investigated. (uptodate.com)
  • Presently, there are about 50 antineoplastic agents that have been approved by the Food and Drug Administration of the United States. (workoutforfatloss.com)
  • The drug denileukin diftitox uses diphtheria toxin as an antineoplastic agent. (wikipedia.org)
  • Duocarmycin A Duocarmycin B1 Duocarmycin B2 Duocarmycin C1 Duocarmycin C2 Duocarmycin D Duocarmycin SA CC-1065 The DNA modifying agents such as duocarmycin are being used in the development of antibody-drug conjugate or ADCs. (wikipedia.org)
  • After intracellular metabolism to active nucleotide, this agent inhibits ribonucleotide reductase and competes with deoxycytidine triphosphate for incorporation into DNA. (medscape.com)
  • This agent inhibits chemotaxis of eosinophils and locomotion of neutrophils and impairs complement-dependent antigen-antibody reactions, which, in turn, may prevent inflammatory reactions. (medscape.com)
  • Monomethyl auristatin F is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. (wikipedia.org)
  • However, when used in conjunction with other antineoplastic agents before resection for colorectal hepatic metastases, bevacizumab has been associated with less hepatic toxicity from the other antineoplastic agents (such as oxaliplatin, fluorouracil and irinotecan) and has not been associated with an increase in perioperative complications or operative mortality. (nih.gov)
  • Fluorouracil is an antineoplastic anti-metabolite. (pharmacycode.com)
  • Carmofur (INN) or HCFU (1-hexylcarbamoyl-5-fluorouracil) is a pyrimidine analogue used as an antineoplastic agent. (wikipedia.org)