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  • guanine
  • Dialkylating agents can react with two different 7-N-guanine residues, and, if these are in different strands of DNA, the result is cross-linkage of the DNA strands, which prevents uncoiling of the DNA double helix. (wikipedia.org)
  • Monoalkylating agents can react only with one 7-N of guanine. (wikipedia.org)
  • thyroid
  • Antineoplastic agents such as immunotherapies and targeted therapies are associated with thyroid dysfunction in 20%-50% of cancer patients taking them, according to a study published in the Journal of the National Cancer Institute . (medindia.net)
  • Some of these agents cause thyroid dysfunction, which physicians often overlook because of the complexity of the clinical picture in cancer patients. (medindia.net)
  • To understand the thyroid-related side effects of antineoplastic agents, their frequency, and underlying mechanisms, Ole-Petter Riksfjord Hamnvik, M.D., of the Division of Endocrinology, Diabetes, and Hypertension at Brigham and Women's Hospital in Boston, and colleagues reviewed articles on thyroid dysfunction in cancer patients. (medindia.net)
  • The researchers found that there are no known strategies to prevent thyroid disease in patients receiving these new antineoplastic agents, and that possible preventative measures may be more toxic than the thyroid disease itself. (medindia.net)
  • However, in this review, the authors provide their own recommendations for patients based on the pattern of abnormalities with each agent, in addition to recommending the monitoring of thyroid function tests in clinical trials of antineoplastic agents. (medindia.net)
  • The researchers also recommend several paths of research that should be pursued, namely knowledge of the biological effects of the antineoplastic agents on the thyroid, so they can identify possible preventative strategies and improve the proposed screening strategies. (medindia.net)
  • synthesis
  • Etomidate, an imidazole-derivative anesthetic agent, decreases corticosteroid synthesis in the adrenal cortex by reversibly inhibiting 17-20 yase and 11-beta-hydroxylase at non-hypnotic doses. (medscape.com)
  • clinical
  • The poor clinical response of lung tumours to CTX and DDP as reported in the literature is reflected in the lack of response of the tumour lines to these two agents. (springer.com)
  • drug
  • With the average cost of a new oral antineoplastic drug in 2012 approximating $10,000, paying for medications can be a significant out-of-pocket expense and burden for patients. (hindawi.com)
  • Hypersensitivity to a chemotherapeutic agent is defined as an unforeseen reaction whose signs and symptoms cannot be explained by the known toxicity of the drug [ 29 ]. (hindawi.com)
  • Next
  • The coupling agent PyBroP was next used under standard conditions, but only starting material ( 6 and 5-AQ) was detected after 100 h. (nih.gov)
  • several
  • Several management options are available to treating physicians: discontinuation of chemotherapy, premedication, prolonging of infusion duration, desensitization protocols, and replacement with a different platinum compound after performing skin tests that rule out cross-reactions among platinum agents. (hindawi.com)
  • Mitotane is an adrenolytic agent that acts by inhibiting 11-beta hydroxylase and several cholesterol side-chain cleavage enzymes. (medscape.com)
  • combination
  • Vasogenic cerebral edema is typically managed with corticosteroids (eg, dexamethasone), usually in combination with some form of antiulcer agent (eg, famotidine, ranitidine). (medscape.com)
  • A human epidermal growth factor receptor type 1/epidermal growth factor receptor (HER-1/EGFR) tyrosine kinase inhibitor used in combination with the antineoplastic agent gemcitabine for advanced pancreatic cancer in patients who have not yet received chemotherapy. (thefreedictionary.com)
  • effects
  • With the increasing use of oral agents, patients now have more responsibility for monitoring and reporting side effects to their health care providers [ 3 , 7 ]. (hindawi.com)
  • class
  • Agents in this class that decrease cortisol production and alter the peripheral metabolism of steroids may reduce morbidity. (medscape.com)
  • potential
  • An immunocytokine of the human monoclonal antibody fragment F16 (scFv) against the extra-domain A1 of tenascin-C fused, via a short 5-amino acid linker, to a recombinant form of the human cytokine interleukin-2 (IL-2) with potential immunostimulating and antineoplastic activities. (newyorkoncology.com)
  • result
  • Acute inhalation injury may result from frequent and widespread use of household cleaning agents and industrial gases (including chlorine and ammonia). (wikipedia.org)
  • active
  • Nearly all components of bohemic acid are anthracycline antibiotic agents active against Gram-positive bacteria, but not against Gram-negative bacteria, yeasts or fungi. (wikipedia.org)
  • high
  • Radiolableled amino acid-based agents are useful in PET brain tumor imaging because F-18 fluoro-deoxyglucose (F-18 FDG), commonly used in PET tumor imaging, is relatively insensitive for detecting tumors in the brain due the high levels of glycolytic metabolism in the normal cortex and to a lesser extent in white matter. (newyorkoncology.com)