• 3. Our approach will use muscle contraction assays, current-clamp, voltage-clamp, patch- clamp, cloning &Xenopus oocyte expression and pharmacological agents, to characterize actions of cholinergic anthelmintics and the subtypes of their receptors. (grantome.com)
  • Previous studies have suggested that Ascaris suum ACR-16 nAChRs are a suitable target for the development of antinematodal drugs. (bvsalud.org)
  • During the course is presented the characteristic of the principal groups of drugs used in veterinary medicine: effects and mechanism of action (pharmacodynamics), disposition and fate of drugs in the body ( (pharmacokinetics), basic indications and contraindications to use particular groups of drugs in animals (foundations of pharmacotherapy), route of administration, adverse effect of drugs and pharmacodynamic and pharmacokinetic interactions of the agents. (wroc.pl)
  • Despite the availability of several preventive trunk-injection agents, no therapeutic trunk-injection agent for eradication of PWN currently exists. (jove.com)
  • Focusing on the mechanisms that confer resistance to individual HER2 targeting agents, we envisage therapeutic approaches to delay or overcome the evolvement of resistance in patients. (nih.gov)
  • Plinabulin is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 value of 9.8~18 nM in tumor cells under the development of Nereus Pharm. (bocsci.com)
  • It is a potent inhibitor of microtubule assembly and DNA topoisomerase II and it is a natural product that inhibits the polymerization of tubulin and has served as a prototype for the development of diverse antitumor agents in clinical use. (bocsci.com)
  • Using this HTS method, we screened 206 compounds with known activities, mostly antifungal, for antinematodal activities and identified HWY-4213 (1-n-undecyl-2-[2-fluorphenyl] methyl-3,4-dihydro-6,7-dimethoxy-isoquinolinium chloride), a highly water-soluble protoberberine derivative, as a potent nematicidal and antifungal agent. (jove.com)
  • It has also been shown to serve as a vascular disrupting agent to reduce newly established blood vessels. (wikipedia.org)
  • Docetaxel is an antineoplastic agent used to treat a broad spectrum of cancers, including breast cancer, non-small cell lung cancer, stomach cancer and prostate cancer. (thefreedictionary.com)
  • Solano F, Briganti S, Picardo M, Ghanem G (2006) Hypopigmenting agents: an updated review on biological, chemical and clinical aspects. (springer.com)
  • Docetaxel Injection is an antineoplastic agent intended for the treatment of breast cancer, non-small cell lung cancer ("NSCLC"), prostate cancer, gastric adenocarcinoma, and head and neck cancer. (thefreedictionary.com)
  • Docetaxel is a cytotoxic agent, which is related to its ability to promote the formation of microtubule bundles and induce sustained mitotic arrest, followed by. (bocsci.com)
  • Acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitors are currently in clinical development as potential lipid-lowering and antiatherosclerotic agents. (tudelft.nl)
  • s Closed System for Antineoplastic Agent Administration," was conducted by a team of nurses at the Abramson Cancer Center of the Hospital of the University of Pennsylvania, a National Cancer Institute-designated comprehensive cancer center with more than 55,000 doses of chemotherapy delivered per year. (thefreedictionary.com)
  • Yamamoto, Y. Carbohydrate-directed synthesis of silver and gold nanoparticles: Effect of the structure of carbohydrates and reducing agents on the size and morphology of the composites. (aijr.in)
  • In vitro activity of five tetracyclines and some other antimicrobial agents four porcine respiratory tract pathogens. (sciendo.com)
  • SAN DIEGO -- The antineoplastic agent letrozole is a promising alternative to clomiphene citrate as a frontline treatment for ovulation induction, results of a small prospective study suggest. (thefreedictionary.com)
  • A trial has also been made on the findings made over the past few years on the use of peptides as tissue regenerating agents through effective wound healing pathway. (aijr.in)