AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation ScienceHealth Care
EthambutolAntitubercular AgentsMycobacterium tuberculosisMycobacteriumIsoniazidMycobacterium aviumMycolic AcidsPyrazinamideRifampinMycobacterium smegmatisMycobacterium InfectionsMicrobial Sensitivity TestsDrug CombinationsTuberculosisDrug SynergismMycobacterium bovisAntibiotics, AntitubercularMycobacterium kansasiiRifabutinMycobacterium avium ComplexDrug Therapy, CombinationRifamycinsAnti-Bacterial AgentsMycobacterium avium-intracellulare InfectionClofazimineEbenaceaeLaurusAristolochiaMycobacterium marinumSalicylanilidesEthionamideDrug InteractionsCeanothusLecythidaceaeDrug Evaluation, PreclinicalSantalaceaeAdhatodaCell EngineeringMycobacterium Infections, NontuberculousBCG VaccineFoeniculumTuberculosis, PulmonaryAmikacinMacrophagesClarithromycinCycloserineZiziphusDiarylquinolinesNontuberculous MycobacteriaAntineoplastic Combined Chemotherapy ProtocolsColony Count, MicrobialMycobacterium ulceransAnti-Infective AgentsMycobacterium fortuitumQuinolonesDose-Response Relationship, DrugProguanilMethenamineInhibitory Concentration 50Microbial ViabilityTuberculosis VaccinesPlant ExtractsAntimalarialsOfloxacinDapsoneFatty Acid Synthase, Type IILeprostatic AgentsArtemisininsDrug TherapyAntifungal AgentsMacrophage ActivationAntineoplastic AgentsLuminescent MeasurementsBacterial LoadCell SurvivalQuinolinesDrug Resistance, MicrobialFluoroquinolonesAtovaquoneCell Line, TumorDrug Screening Assays, AntitumorMolecular StructureMethylthioinosineCyclopentolateInterferon-gammaDrug AntagonismMice, Inbred BALB CCiprofloxacinTropicamideCellophaneStreptomycinStructure-Activity RelationshipMice, Inbred C57BLSulfamethoxazoleMagnetic Resonance SpectroscopyPyrimethamineMefloquineDrug ResistancePharmaceutical PreparationsBacterial Proteins
MycobacteriumTuberculosisRifampinPotentRegimenStrainsIsoniazidRifabutinResistanceConcentrationsTherapyEthambutolRifampicinResistantAgentsTreatmentVitroDAKLINZAInteractionsBedaquiline and delamanidInfectionsDosePatientsAntimicrobial drugsAntiretroviral drugsIntracellularAntibioticsTherapeuticAzithromycinIncidenceDMARDsAmikacinCompoundsActivitySide effectsTreatInfection
Mycobacterium9
Tuberculosis20
  • Clofazimine was originally intended as an anti-tuberculosis drug but proved ineffective. (wikipedia.org)
  • Tuberculosis remains a serious world-wide health threat which requires the characterisation of novel drug targets for the development of future antimycobacterials. (biomedcentral.com)
  • The situation regarding the control of tuberculosis has significantly worsened over the last decade, with the spread of strains resistant to multiple antimycobacterial agents. (biomedcentral.com)
  • Multidrug-resistant tuberculosis (MDR-TB) is also on the rise, especially in large cities, in those previously treated with antitubercular drugs, or in those who failed to follow or complete a drug regimen. (nurseslabs.com)
  • Current tuberculosis treatment regimen involves multiple drugs for a prolong period. (thsti.res.in)
  • These novel compounds in combination with the standard frontline anti-tubercular drugs would significantly enhance the success rate in tuberculosis therapy. (thsti.res.in)
  • Sirturo (Bedaquiline)® is a diarylquinoline antimycobacterial drug indicated as part of combination therapy in the treatment of adult and pediatric patients (12 to less than 18 years of age and weighing at least 30 kg) with pulmonary multi-drug resistant tuberculosis (MDR-TB). (pharmacyexam.com)
  • The history of tuberculosis (TB) changed dramatically after the introduction of antimycobacterial agents. (ijpsr.com)
  • Drug treatment is fundamental for controlling TB, promoting the cure of the patients and breaking the chain of transmission when the anti-tuberculosis drug regimen is completely and correctly followed. (ijpsr.com)
  • Anti-tuberculosis drug treatment started in 1944, when streptomycin (SM) and paraaminosalicylic acid ( PAS) were discovered. (ijpsr.com)
  • The study demonstrated that combined therapy was more effective and resulted in the first multidrug anti-tuberculosis treatment that consisted of a long course of both drugs. (ijpsr.com)
  • Since 1970, no new drug has been discovered for anti-tuberculosis treatment, which today seems insufficient to confront the disease 4 . (ijpsr.com)
  • This woman was admitted to isolation and started empirically on a 4-drug regimen in the ED. Tuberculosis was confirmed on sputum testing. (medscape.com)
  • While modern cephalosporins developed for broad spectrum antibacterial activities have never been pursued for tuberculosis (TB) therapy, we identified first generation cephalosporins having clinically relevant inhibitory concentrations, both alone and in synergistic drug combinations. (uc3m.es)
  • An analysis yesterday by researchers with the TB Alliance, Stop TB Partnership, World Health Organization (WHO), and other groups estimates that the recently approved BPaLM/BPaL treatment regimen for drug-resistant tuberculosis (DR-TB) could save governments up to $740 million a year, enough to supply more than 400,000 people with almost a year's worth of DR-TB treatment. (umn.edu)
  • Sixteen patients with TB-HIV co-infection received rifabutin 300 mg QD in combination with tuberculosis chemotherapy (initially pyrazinamide, isoniazid and ethambutol then only isoniazid), and were then randomized to receive isoniazid and LPV/r based ART with rifabutin 150 mg tiw or rifabutin 150 mg daily. (biomedcentral.com)
  • Child: For treatment of drug-resistant tuberculosis: 15-25 mg/kg daily or 50 mg/kg twice wkly. (medicscientist.com)
  • A quinoline-based antimycobacterial drug used (as its fumarate salt) for the treatment of pulmonary multi-drug resistant tuberculosis by inhibition of ATP synthase, an enzyme essential for the replica tion of the mycobacteria. (chemspider.com)
  • R207910) is an anti-tuberculosis drug which selectively inhibit the mycobacterial energy metabolism i.e. (chemspider.com)
  • Background: In the treatment of active tuberculosis, therapeutic drug monitoring (TDM) is used to optimize dosing that maximizes therapeutic benefit while minimizing toxicity. (bvsalud.org)
Rifampin1
  • Ideally, the management of TB among HIV-infected patients taking antiretroviral drugs requires a) directly observed therapy, b) availability of experienced and coordinated TB/HIV care givers, and in most situations, c) use of a TB treatment regimen that includes rifabutin instead of rifampin. (cdc.gov)
Potent3
  • RHB-104 is a proprietary antibiotic combination therapy in oral capsule formulation, with potent intracellular, anti-mycobacterial and anti-inflammatory properties. (drugdiscoverynews.com)
  • Limitation of Use: Not recommended for use in combination with other JAK inhibitors, biologic disease-modifying antirheumatic drugs (DMARDs), or with potent immunosuppressants such as azathioprine and cyclosporine. (nationaleczema.org)
  • The team aims to develop a potent antimycobacterial agent that can be administered orally and will test the new drug against TB and related pathogens in mice models. (breathinglabs.com)
Regimen3
  • Other antimycobacterial drugs may be added to the regimen of azithromycin at the discretion of the physician or health care provider. (buysumamed.com)
  • These persisters are refractory to anti-mycobacterial insult and can only be targeted by a strict regimen comprising of a combination of drugs for an unusually extended period. (thsti.res.in)
  • however, the treatment involves a first-line four-drug standard regimen for 6 months: an intensive phase comprising a 2-month regimen of isoniazid, rifampicin, pyrazinamide and ethambutol, followed by a continuous phase involving a 4-month regimen of isoniazid and rifampicin (Box 1 ). (nature.com)
Strains7
  • Zithromax is a macrolide antibacterial drug indicated for the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions. (buysumamed.com)
  • Prolong treatment leads to non-compliance and emergence of newer drug resistance strains. (thsti.res.in)
  • The availability of the complete nucleotide sequences of several MTB genomes allows to use the comparative genomics as a tool to study the relationships of strains and differences in their evolutionary history including acquisition of drug-resistance. (ijpsr.com)
  • multi-drug resistant strains and extensively drug-resistant strains. (ijpsr.com)
  • However, the challenge of a successful TB treatment remains daunting owing to the emergence of multidrug-resistant (MDR) TB - that is, resistance to at least both isoniazid and rifampicin - and extensively drug-resistant (XDR) TB, in which MDR strains develop resistance to any fluoroquinolone and at least one of the three second-line injectable drugs. (nature.com)
  • The current standard treatment for TB involves a combination of drugs taken over four to six months or much longer for drug-resistant strains. (breathinglabs.com)
  • Dr. Rohde's research aims to develop new treatments that shorten treatment times, eradicate drug-resistant strains and minimize side effects. (breathinglabs.com)
Isoniazid2
  • In 1952, a third drug, isoniazid (INH), was added to the previous combination, greatly improving the efficacy of treatment, but which still had to be administered for 18 - 24 months. (ijpsr.com)
  • What [TB360 trade name] is and what it is used for [TB360 trade name] is a combination of two antimycobacterial agents, rifampicin and isoniazid. (who.int)
Rifabutin2
Resistance10
  • Despite early treatment with antimycobacterial combination therapy, drug resistance continues to emerge. (bvsalud.org)
  • Insufficient intracellular accumulation of active moieties allows for selective survival of mycobacteria with drug resistance mutations and accordingly promotes the development of microbial drug resistance. (uwc.ac.za)
  • Discovery of compounds with new mechanisms of action and physicochemical properties that promote intracellular accumulation, or compounds that act synergistically with other antimycobacterial drugs, has the potential to reduce and prevent further drug resistance. (uwc.ac.za)
  • The concomitant use of Daklinza and other drugs may result in known or potentially significant drug interactions, some of which may lead to loss of therapeutic effect of Daklinza and possible development of resistance, dosage adjustments of concomitant medications or Daklinza, possible clinically significant adverse reactions from greater exposures of concomitant drugs or Daklinza. (selectshopedpills.com)
  • The overexpression of Hsp27, which results in anti-apoptotic effects, has been linked to tumor resistance to cytotoxic drugs as well as the development of metastasis. (drugdiscoverynews.com)
  • The authors noted that antimicrobial resistance, driven by inappropriate use of antimicrobial drugs, is a public health threat. (umn.edu)
  • Patients who had never been treated with an anti-TB drug showed resistance. (ajgreenchem.com)
  • About 10% of all new TB infections are resistant to at least one anti-TB drug because monotherapy contributed to the resistance development, genuine anti-TB drug therapy has included the use of numerous drugs [ 13 ]. (ajgreenchem.com)
  • However, the exhaustive use of antibiotics and antifungal drugs has led to the emergence of drug resistance over time, thereby negating their efficacy. (docslib.org)
  • incidence Notably, of resistance concurrent to withantimicrobial the increased agents, incidence there has of been resistance a corresponding to antimicrobial decrease agents, in the there discovery has been and adevelopment corresponding of newdecrease drug in candidates the discovery [1]. (docslib.org)
Concentrations2
  • Drug-entrapped DPPC liposomes were tested at concentrations comparable to their relative minimum inhibitory concentrations (MIC). (sun.ac.za)
  • Solid Extracts, Tableted, or Encapsulated: Combinations of the above in different concentrations are available. (interactionsguide.com)
Therapy15
  • Combination therapy (ampicillin and either gentamicin or cefotaxime) is typically used in the initial treatment of newborns and young infants. (medscape.com)
  • For these reasons, antimycobacterial therapy relies on the combination of several drugs. (biomedcentral.com)
  • To this end, antimycobacterial activity, mechanism of action, and synergism in combination therapy were investigated for a series of polycyclic amine derivatives. (uwc.ac.za)
  • Soon after the introduction of the first anti-mycobacterial drugs, drug resistant bacilli started to emerge, but the launch of both combination therapy and new and more effective drugs seemed to be enough to control the disease. (ijpsr.com)
  • Numerous cephalosporins were synergistic with rifampicin, the cornerstone drug for TB therapy and ethambutol, a first-line anti-TB drug. (uc3m.es)
  • These infections are often recalcitrant to treatment and require therapy with multiple drugs for long duration. (microbialcell.com)
  • Patients with latent TB should be treated with standard antimycobacterial therapy before initiating KEVZARA. (kevzarahcp.com)
  • The most notable changes in these guidelines reflect both the findings of clinical trials that evaluated new drug regimens for treating and preventing TB among HIV-infected persons and recent advances in the use of antiretroviral therapy. (cdc.gov)
  • All HIV-infected patients undergoing treatment for TB should be evaluated for antiretroviral therapy, because most patients with HIV-related TB are candidates for concurrent administration of antituberculosis and antiretroviral drug therapies. (cdc.gov)
  • Treatment often requires extended courses of combination antibiotic therapy, frequently with surgical intervention. (statpearls.com)
  • For patients with history of antimycobacterial therapy: Initial doses: 25 mg/kg/day for 60 days, thereafter reduce to 15 mg/kg/day. (medicscientist.com)
  • The combination therapy used showed efficacy and thus could serve as a reference treatment for kidney and lymph node M. xenopi infection. (degruyter.com)
  • administer herb short-term only, before recommencing drug therapy. (interactionsguide.com)
  • Considering the range of chemical reactions involved in the biosynthetic pathways of Mtb , information related to the biotransformation of antitubercular compounds would provide opportunities for the development of new chemical tools to study successful TB infections while also highlighting potential areas for drug discovery, host-directed therapy, dose optimization and elucidation of mechanisms of action. (nature.com)
  • Resistant - drug therapy. (bvsalud.org)
Ethambutol7
  • Zithromax should be taken at a daily dose of generic 500mg or brand 600mg, in combination with ethambutol at the recommended daily dose of 15 mg/kg. (buysumamed.com)
  • Purchase Ethambutol without a prescription or Generic Myambutol from 500mg.org and get exceptional drug on reduced global prices. (llclinic.com)
  • 500mg.org offers you the chance to purchase cheap Ethambutol 200, 400, 600, 800 mg online and also find out more about Ethambutol side effects, dosage information and drug interactions. (llclinic.com)
  • By contrast, the best on-line sources for prescription drugs like Ethambutol often have wide-ranging drug information right on the website, so consumers can get replies to their questions quickly and readily when they buy Ethambutol 200, 400, 600, 800 mg online, and they could easily print out the advice for future reference. (llclinic.com)
  • Ethambutol is really a bacteriostatic antimycobacterial drug which has ocular toxicity as a result of optic neuritis as the primary side effect. (llclinic.com)
  • Ethambutol has also been demonstrated be effective in curing drug resistant TB. (llclinic.com)
  • Ethambutol can be found in fixed dose combinations. (llclinic.com)
Rifampicin1
  • In the 70's, with the introduction of rifampicin (RIF) into the combination, treatment was shortened to just nine months. (ijpsr.com)
Resistant6
  • When this latent infection develops into an active disease, it is known as reactivation TB, which is often drug resistant. (nurseslabs.com)
  • Nonetheless, the emergence of a growing number of new cases of multi-drug resistant TB (MDR-TB) and even more alarming extensively drug-resistant TB (XDR-TB) cases have placed the eradication of TB as one of the major global challenges to overcome in the twenty-first century. (frontiersin.org)
  • To reduce the development of drug-resistant bacteria and maintain the effectiveness of Zithromax and other antibacterial drugs, Zithromax 600mg should be used only to treat infections that are proven or strongly suspected to be caused by susceptible bacteria. (buysumamed.com)
  • In addition, the prevalence of drug-resistant TB is increasing worldwide. (medscape.com)
  • The major obstacle in eradicating TB is the increasing incidence of drug-resistant TB. (nature.com)
  • By using folk knowledge, and by seeking scientific proof concerning this knowledge, it is possible to find substances that are both effective and less toxic to human health, and which are able to combat microorganisms that are commonly resistant to conventional drugs. (bvsalud.org)
Agents1
  • When possible, alternative agents with less drug interaction potential or use of therapeutic drug monitoring should be considered. (hiv.gov)
Treatment14
  • However, in the United States, clofazimine is considered an orphan drug, is unavailable in pharmacies, and its use in the treatment of MAC is overseen by the Food and Drug Administration. (wikipedia.org)
  • There is the potential for significant drug interactions and overlapping toxicities in patients receiving medications for treatment or prevention of opportunistic infections (OIs). (hiv.gov)
  • Table 5 provides clinicians with information regarding known or suspected drug interactions between drugs commonly used for treatment or prevention of HIV-associated OIs and treatment of HIV infection. (hiv.gov)
  • Recently, Food and Drug Administration (FDA) has approved VESIcare LS (Solifenacin succinate) oral suspension for the treatment of neurogenic detrusor overactivity (NDO) in pediatric patients aged 2 years and older. (pharmacyexam.com)
  • Daklinza is a drug for the treatment of hepatitis C (HCV). (selectshopedpills.com)
  • It is advised to avoid pregnancy during combination treatment with Daklinza and sofosbuvir with ribavirin for 6 months after completion of treatment. (selectshopedpills.com)
  • The U.S. Food and Drug Administration and the European Medicines Agency have both granted RP101 Orphan Drug Designation for the adjunct treatment of pancreatic cancer. (drugdiscoverynews.com)
  • Under the terms of the deal, Fraunhofer IZI is conducting real-time monitoring of tumor engraftment, tumoricidal efficacy and response to treatment with RP101 in combination with standard-of-care chemotherapies. (drugdiscoverynews.com)
  • To evaluate the anti-mycobacterial activity as treatment outcomes (interim and final) of newer drugs Bedaquiline and Delamanid in confirmed or probable pulmonary MDR-TB over a 24-week treatment period. (who.int)
  • To compare the long-term safety, tolerability and efficacy of Bedaquiline, Delamanid and second line injectables in combination with OBR in confirmed or probable pulmonary MDR-TB cases, over 24 months baseline including a 6 month post treatment follow-up period (preferably also in subjects who prematurely discontinue from study drug and study procedures). (who.int)
  • By contrast, the interaction between TB and HIV infection became evident soon after the HIV epidemic commenced, and new associations continue to be recognised, including treatment-related complications and drug interactions 5 . (ersjournals.com)
  • Clinical and antioxidant efficacy of 4% mangosteen gel as a local drug delivery in the treatment of chronic periodontitis: A placebo-controlled, split-mouth trial. (medlineplus.gov)
  • INDIANAPOLIS, July 16, 2021 /PRNewswire/ - Eli Lilly and Company (NYSE: LLY) and Incyte (NASDAQ:INCY) announced today that the U.S. Food and Drug Administration (FDA) will not meet the Prescription Drug User Fee Act (PDUFA) action date for the supplemental new drug application (sNDA) for baricitinib for the treatment of adults with moderate to severe atopic dermatitis (AD). (nationaleczema.org)
  • In Morocco, TDM is not routinely used, yet low levels of anti-TB drugs can be associated with poorer treatment outcomes.Methods: We retrospectively checked our archives for patients with active TB for whom TDM was performed during 2014. (bvsalud.org)
Vitro1
  • ENGLISH ABSTRACT: In this thesis, research results are reported on the role of dipalmitoyl phosphatidyl choline (DPPC) and DPPC-liposomes on the in vitro permeability characteristics of various antimycobacterial drugs across porcine bronchial tissue. (sun.ac.za)
DAKLINZA5
  • The recommended dose of Daklinza is 60 mg taken orally once daily with or without food in combination with sofosbuvir for 12 weeks. (rxlist.com)
  • What Drugs, Substances, or Supplements Interact with Daklinza? (rxlist.com)
  • Our Daklinza (daclatasvir) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • Sustained virologic response (SVR12) rates are reduced in HCV genotype 3-infected patients with cirrhosis receiving DAKLINZA in combination with sofosbuvir for 12 weeks [see Clinical Studies ]. (rxlist.com)
  • Postmarketing cases of symptomatic bradycardia and cases requiring pacemaker intervention have been reported when amiodarone is coadministered with sofosbuvir in combination with another HCV direct-acting antiviral, including Daklinza. (selectshopedpills.com)
Interactions6
  • In particular, protease inhibitors and non-nucleoside reverse transcriptase inhibitors affect the CYP450 or other transporter systems and may be associated with clinically significant drug interactions. (hiv.gov)
  • The integrase inhibitor raltegravir is metabolized by UGT1A1 and may be a suitable option when trying to minimize interactions with other drug classes. (hiv.gov)
  • It is difficult to predict the interaction potential when three or more drugs with similar metabolic pathways are co-administered and there is substantial inter-patient variability in the magnitude of these interactions. (hiv.gov)
  • The drug interactions included in this table were selected on the basis of their potential clinical significance and are not inclusive of all potential drug interactions (see drug label and the drug interaction websites listed for complete information on drug interactions). (hiv.gov)
  • Please see Adult OI guidelines for information about drug interactions, including warnings about interactions between boceprevir and HIV protease inhibitors. (hiv.gov)
  • Due to system maintenance, the drug interactions feature you are attempting to access is temporarily unavailable. (medscape.com)
Bedaquiline and delamanid1
  • Cephalosporins were also synergistic with new anti-TB drugs such as bedaquiline and delamanid. (uc3m.es)
Infections2
  • Overall, our data anticipate a biological role for human antimicrobial RNases in host response to mycobacterial infections and set the basis for the design of novel anti-tubercular drugs. (frontiersin.org)
  • Fluoroquinolone, for example, has been widely prescribed for many different types of infections, including those that may have been more appropriately treated with an alternative drug. (umn.edu)
Dose3
  • Results: The delivered particles and drug dose showed a high dependency from the preparation that was aerosolized. (sun.ac.za)
  • Immunotherapeutic outcomes of low-dose drug protocols ( not cytotoxic schedules) may be enhanced by concomitant administration. (interactionsguide.com)
  • High-dose drug effects on myelosuppression may be reduced. (interactionsguide.com)
Patients2
  • Nyvepria is indicated to decrease the incidence of infection, as manifested by febrile neutropenia, in patients with non-myeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a clinically significant incidence of febrile neutropenia. (pharmacyexam.com)
  • Then, we looked for cases with delay of TB conversion.Results: In total, 24 patients were identified, for whom TDM was performed, they all had low serum drug levels. (bvsalud.org)
Antimicrobial drugs1
  • Recently plants have been explored to obtain crude natural extracts for testing and further refinement to develop effective antimicrobial drugs. (biomedcentral.com)
Antiretroviral drugs1
  • In addition, WHO acknowledges the specialized input from HIV experts Kel y Dooley, Diane Havlir and Gary Maartens, on concomitant use of bedaquiline and antiretroviral drugs. (bvsalud.org)
Intracellular1
  • Compound selection was based on the presence of moieties with possible antimycobacterial activity, the inclusion of bulky lipophilic carriers to promote intracellular accumulation, and previously demonstrated bioactivity that potentially support inhibition of efflux pump activity. (uwc.ac.za)
Antibiotics1
  • The optimized antibiotics will be designed to resist enzymes the bacteria use to inactivate the drug while also destroying the bacteria's cell wall. (breathinglabs.com)
Therapeutic2
  • Possible additive effects of herb and drug allow sparing of drug, reduction of drug side effects, and enhanced therapeutic responses. (interactionsguide.com)
  • These to develop observations new drugs highlight with improvedthe urgent therapeutic need to develop efficacy new and drugs acceptable with improved safety. (docslib.org)
Azithromycin1
  • Zithromax (azithromycin tablets and oral suspension) contains the active ingredient azithromycin, a macrolide antibacterial drug, for oral administration. (buysumamed.com)
Incidence2
  • In the United States, the incidence is higher among the homeless, drug-addicted, and impoverished populations, as well as among immigrants from or visitors to countries in which TB is endemic. (nurseslabs.com)
  • Despite the fact that, it's a rare incidence of severe type of toxicity of the popular drug the probable consequences might be alarming for the health care fraternity who's rampantly utilizing this drug. (llclinic.com)
DMARDs1
  • moderately to severely active rheumatoid arthritis (RA) who have had an inadequate response or intolerance to one or more disease-modifying antirheumatic drugs (DMARDs). (kevzarahcp.com)
Amikacin1
Compounds1
  • For this series, the nature of the side chain, rather than the type of polycyclic carrier, seems to play a determining role in the antimycobacterial activity and cytotoxicity of the compounds. (uwc.ac.za)
Activity1
  • The aim of the present study was to investigate the antimycobacterial activity of two pro-glutathione (pro-GSH) drugs that are able to induce redox stress in M. avium and to modulate cytokine production by macrophages. (bvsalud.org)
Side effects2
  • Bone pain and pain in extremity are reported side effects of the drug. (pharmacyexam.com)
  • In recent decades, the use of natural products for pharmacological purposes has witnessed a significant increase worldwide due mainly to attempts to minimize the side effects caused by synthetic drugs 1 . (bvsalud.org)
Treat1
  • To study the effects of pathogens in humans and test drugs to treat humans with these pathogens it would be helpful to have a nonhuman animal, such as a mice, that has been genetically modified to be susceptible to infection. (powerpatent.com)
Infection1
  • Echinacea may theoretically be used to enhance cellular immunity during temporary drug withdrawal mandated by opportunistic infection. (interactionsguide.com)