Antimicrobial treatment of infections. Medical search. Frequent questions

Our research focuses on discovery and development of solutions for improving diagnosis and antimicrobial therapy of bacterial infections in veterinary medicine using a One Health approach. (nature.com)
The Innovative Medicines Initiative-funded "Collaboration for prevention and treatment of MDR bacterial infections" (COMBINE) consortium is establishing a validated and globally harmonized preclinical model to increase reproducibility and more reliably translate results from animals to humans. (frontiersin.org)
The "Collaboration for prevention and treatment of MDR bacterial infections" (COMBINE) project is part of the European Innovative Medicines Initiative (IMI) Antimicrobial Resistance (AMR) Accelerator. (frontiersin.org)
The goal of the Accelerator is to progress the development of new medicines to treat or even prevent resistant bacterial infections. (frontiersin.org)
IDSA convened a panel of six actively practicing infectious diseases specialists with clinical and research expertise in the treatment of antimicrobial resistant bacterial infections. (idsociety.org)
The emergence of antimicrobial resistance severely threatens our ability to treat bacterial infections. (frontiersin.org)
It is envisaged that these dual-functional materials will be capable of inhibiting biofilm formation when deployed as a coating on medical devices, protecting patients from bacterial infections, while simultaneously providing visual feedback to healthcare professionals if the material has reached the end of its anti-infective lifespan. (qub.ac.uk)
The main etiological factors associated with dental implant failures are related to bacterial infections and biomechanical factors (occlusal overload) 1,2 . (bvsalud.org)

Hence, there is a need for the accelerated development of new agents to treat and prevent infections caused by AMR pathogens ( WHO, 2021 ). (frontiersin.org)
Internationally, approximately 1.3 million deaths were estimated to be directly attributable to antimicrobial resistant bacterial pathogens in 2019[1]. (idsociety.org)
In the United States, antimicrobial resistant pathogens caused more than 2.8 million infections and over 35,000 deaths annually from 2012 through 2017, according to the Centers for Disease Control and Prevention (CDC) Antibiotic Resistance Threats in the United States Report[2]. (idsociety.org)
Conclusions: Region-specific surveillance studies provide additional information about the type of pathogens causing UTIs and their antimicrobial susceptibility patterns. (medscimonit.com)
Q: Why don't we have enough treatments for infections caused by resistant pathogens? (merck.com)
Characterization of blue light treatment for infected wounds: antibacterial efficacy of 420, 455, and 480 nm light-emitting diode arrays against common skin pathogens versus blue light-induced skin cell toxicity, Photobiomodul Photomed Laser Surg , 39(5):339-48, 2021. (the-scientist.com)
Infection of the kidneys may manifest as pyelonephritis (eg, fever, back pain, pyuria) without the usual urinary pathogens on routine culture (sterile pyuria). (msdmanuals.com)

In 2021, sexually transmitted infections (STIs) represented 1 of the highest health care burdens attributable to infectious diseases (other than COVID-19) among active component service members of the U.S. Armed Forces. (health.mil)

Objective To test and compare the efficacy of methenamine hippurate for prevention of recurrent urinary tract infections with the current standard prophylaxis of daily low dose antibiotics. (bmj.com)
Participants Women aged ≥18 years with recurrent urinary tract infections, requiring prophylactic treatment. (bmj.com)
Main outcome measure Absolute difference in incidence of symptomatic, antibiotic treated, urinary tract infections during treatment. (bmj.com)
A patient and public involvement group predefined the non-inferiority margin as one episode of urinary tract infection per person year. (bmj.com)
Incidence of antibiotic treated urinary tract infections during the 12 month treatment period was 0.89 episodes per person year (95% confidence interval 0.65 to 1.12) in the antibiotics group and 1.38 (1.05 to 1.72) in the methenamine hippurate group, with an absolute difference of 0.49 (90% confidence interval 0.15 to 0.84) confirming non-inferiority. (bmj.com)
Conclusion Non-antibiotic prophylactic treatment with methenamine hippurate might be appropriate for women with a history of recurrent episodes of urinary tract infections, informed by patient preferences and antibiotic stewardship initiatives, given the demonstration of non-inferiority to daily antibiotic prophylaxis seen in this trial. (bmj.com)
Before treatment of enterococcal infections, all suspected intravenous lines, intra-arterial catheters, and urinary catheters should be removed, if possible, and abscesses drained. (medscape.com)
Catheter-associated urinary tract infection (CAUTI) is a major preventable cause of harm for patients in hospital. (urotoday.com)
The primary outcome was incidence of symptomatic urinary tract infection for which an antibiotic was prescribed by 6 weeks. (urotoday.com)
It is recognized as one of the most important causes of both acute and chronic cases of community-acquired and hospital-associated infections including urinary tract infections, blood stream infections, soft tissue infections and 2 pneumonia. (who.int)
Unfortunately, the suspected cases of ear, wound and urinary tract report of emergence of vancomycin intermediate infections at both tertiary (UUTH) and secondary sensitive S. aureus (VISA) and vancomycin (GHIA) healthcare facilities in Akwa Ibom State. (who.int)
Background: Urinary tract infections are associated with substantial morbidity and recurrent infections. (medscimonit.com)
In this study, the resistance patterns of urinary isolates to commonly used antimicrobials were determined in order to evaluate the options for empirical antibiotic therapy of UTI in out- and in- patients. (medscimonit.com)
Researchers from Birla Institute of Technology and Sciences in India have revealed that garlic (Allium sativum) can be used to combat antimicrobial resistant urinary tract infections (UTI). (pharmaceutical-technology.com)
The report summarizes current information on the use of antimicrobial therapy for intra-amniotic infection, endometritis, bacterial endocarditis, sexually transmitted diseases (chlamydial infection, gonorrhea, syphilis, vaginal trichomoniasis, bacterial vaginosis and herpes) and urinary tract infections. (aafp.org)
Urinary tract infections in primary care. (umu.se)
De Vos: 'We have already identified certain signatures of species in urinary tract infections. (rug.nl)

Antimicrobial-resistant bacteria can cause severe, hard-to-treat infections. (cdc.gov)
Metronidazole is also used to treat bacterial vaginosis (an infection caused by too much of certain types of harmful bacteria in the vagina) in women. (medlineplus.gov)
If you stop taking this medication too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics. (medlineplus.gov)
Antimicrobial resistance threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses, and fungi. (paho.org)
This is a superficial chronic infection caused by a bacteria called Corynebacterium minutissimus. (skintherapyletter.com)
While acquired resistance has received considerable attention, relatively little is known of intrinsic resistance that allows bacteria to naturally withstand antimicrobials. (frontiersin.org)
One approach suggested is to re-sensitize resistant bacteria to an antimicrobial agent by potentiating the efficacy of an antimicrobial with a helper-drug. (frontiersin.org)
The helper-drug can target gene products that by any mechanism aid bacteria to resist higher concentrations of an antimicrobial ( Pieren and Tigges, 2012 ). (frontiersin.org)
Besides the ability of bacteria to acquire antimicrobial resistance via horizontal gene transfer or spontaneous mutations, they can also be intrinsically resistant to antimicrobials ( Cox and Wright, 2013 ). (frontiersin.org)
After being exposed to antimicrobials, some bacteria survive and can become resistant to these medicines - this is called antimicrobial resistance, or AMR. (merck.com)
Today we're finding bacteria are developing resistance at a faster rate than we're developing new antimicrobials. (merck.com)
However, once these new treatments are available, they are used sparingly to prevent bacteria from developing resistance. (merck.com)
The researchers used colony-forming unit assays to track the number of bacteria growing in suspension in vitro after blue light treatment. (the-scientist.com)
Antimicrobial blue light versus pathogenic bacteria: mechanism, application in the food industry, hurdle technologies and potential resistance," Foods , 9(12):1895, 2020. (the-scientist.com)
Antibiotic-resistant bacteria are a growing problem in the 21st century, causing longer and more serious infections, and resulting in poor outcomes for vulnerable patients. (qub.ac.uk)
For many bacteria, biofilm formation is a key part of their pathogenic behaviour, and is especially important in the development of medical device-associated infection. (qub.ac.uk)
Bacteria from humans and animals continue to show resistance to antimicrobials, which is one of the world's biggest threats to public health and often involves the food chain according to a new report from two European public health agencies. (foodsafetynews.com)
According to the World Health Organization, antimicrobial resistance (AMR) is the ability of microorganisms such as bacteria, viruses and parasites to block the effectiveness of antimicrobial medicines, which include antibiotics, antivirals and antimalarials. (foodsafetynews.com)
We are concerned to see that Salmonella and Campylobacter bacteria in humans show high levels of antimicrobial resistance," Catchpole said. (foodsafetynews.com)
One out of four infections in humans are caused by Salmonella bacteria that show resistance to three or more antimicrobial medications commonly used in human and animal medicine. (foodsafetynews.com)

The primary aim of this systematic review is to summarize the current state of evidence of the implementation and outcomes of pediatric antimicrobial stewardship programs (ASPs) globally. (springer.com)
Health facilities in the state should institute effective antimicrobial stewardship, intensify surveillance and screening of Staphylococcus aureus for MRSA strains to guard against dissemination of multidrug resistant strains in both hospital and community settings because of the clinical implications. (who.int)

Without effective antimicrobials for prevention and treatment of infections, medical procedures such as organ transplantation, cancer chemotherapy, diabetes management and major surgery (for example, cesarean sections or hip replacements) become very high risk. (paho.org)
Antimicrobial Agents and Chemotherapy. (wikipedia.org)
Journal of Antimicrobial Chemotherapy. (wikipedia.org)
Without effective antimicrobials, there could be serious implications like patients being told their cancer chemotherapy treatments or hip replacement surgeries are too risky because of the chance of developing an untreatable infection. (merck.com)

What accelerates the emergence and spread of antimicrobial resistance? (paho.org)
Poor infection control, inadequate sanitary conditions, and inappropriate food-handling encourage the spread of antimicrobial resistance. (paho.org)

It is vital that we all renew our commitment to fight antimicrobial resistance by focusing on the key areas set out in the EU One Health Action Plan against antimicrobial resistance. (foodsafetynews.com)

The guidelines were reviewed in a session at the American Society of Health-System Pharmacists titled 'Beyond the Top Line: A Point-Counterpoint Discussion of the 2020 Antimicrobial Resistant Gram-Negative Infection Treatment Guideline. (pharmacytimes.com)

The research is expected to ensure clinical efficacy of antimicrobial treatment with minimal selection of antimicrobial resistance, thereby contributing to make informed decisions on future antimicrobial guidelines and policies. (nature.com)

Antimicrobial Treatment and Prophylaxis of Plague: Recommendations for Naturally Acquired Infections and Bioterrorism Response. (bvsalud.org)
This report provides CDC recommendations to U.S. health care providers regarding treatment , pre-exposure prophylaxis , and postexposure prophylaxis of plague . (bvsalud.org)
CDC considered individual expert input while developing these guidelines, which provide recommended best practices for treatment and prophylaxis of human plague for both naturally occurring disease and following a bioterrorism attack. (bvsalud.org)
CDC data also suggest that the incidence of MAI infection may be decreasing as a result of highly active antiretroviral therapy and antimicrobial prophylaxis. (medscape.com)
We aimed to evaluate the association between post-appendectomy SSI rates and the two most commonly used regimens for perioperative antimicrobial prophylaxis in Swiss children. (biomedcentral.com)

Antimicrobial resistant microorganisms are found in people, animals and the environment and can spread globally. (who.int)
As microorganisms develop more resistance to antimicrobial drugs, these approaches are becoming less effective. (the-scientist.com)

1.2 Why invest in prevention and control of sexually transmitted infections now? (who.int)
Two hospitals in Addis Ababa, Ethiopia, are demonstrating that even when access to resources is limited, commitment to infection prevention and control (IPC) practices makes combating antimicrobial resistance (AR) possible. (cdc.gov)
The Guideline for Infection Control in Hospital Personnel is part of the Guidelines for Prevention and Control of Nosocomial Infections. (cdc.gov)
UICC warmly welcomes the draft global strategy on infection prevention and control and applaud the secretariat on its thorough examination of the issue. (who.int)
An essential component in avoiding these deaths are good practices in infection prevention and control. (who.int)
The report from the European Food Safety Authority (EFSA) and the European Centre for Disease Prevention and Control (ECDC) highlights the impact of the reduced effectiveness of treatment options for people and animals raised for food. (foodsafetynews.com)

Argentina's Ministry of Health is implementing the first legislation in South America using a One Health framework to combat antimicrobial resistance (AR), representing Argentina's commitment to combating AR. (cdc.gov)

Through a series of virtual meetings, the panel developed commonly encountered treatment questions and corresponding suggested treatment approaches for each pathogen group. (idsociety.org)
In the United States, an estimated 1,568,000 new N. gonorrhoeae infections occur each year ( 141 , 838 ), and gonorrhea is the second most commonly reported bacterial communicable disease. (cdc.gov)
Among women, gonococcal infections are commonly asymptomatic or might not produce recognizable symptoms until complications (e.g. (cdc.gov)
As more experience is gained with the use of linezolid and tedizolid, daptomycin, and tigecycline, as well as the newer tetracycline antibiotics, these drugs may be used more commonly to treat VRE infections, although in many cases off-label. (medscape.com)
It should be emphasized that these guidelines represent the advice of CDC on questions commonly asked of the Hospital Infections Program, but are not intended to have the force of law or regulation. (cdc.gov)
For example, Escherichia coliurinary tract infections, and respiratory infections by Streptococcus pneumoniae or Haemophilus influenzae may not respond to antibiotics commonly used and require the use of more complex and expensive treatments. (paho.org)
The Laboratory of Chronic Airway Infection, led by Dr. Kenneth Olivier, focuses on bronchiectasis, a condition that damages the body's ability to clear mucus from the airways and increases risk of severe lung infections by nontuberculous mycobacteria (NTM), which commonly are found in wet environments such as streams, rivers, and marshes. (nih.gov)
Dr. Olivier's research focuses on bronchiectasis , a condition that damages the body's ability to clear mucus from the airways and increases risk of severe lung infections by nontuberculous mycobacteria (NTM), which commonly are found in wet environments such as streams, rivers, and marshes. (nih.gov)

Overall, the project will develop antimicrobial coatings which can reduce the risk of medical device-related infections. (qub.ac.uk)

Although brief descriptions of notable clinical trials, resistance mechanisms, and antimicrobial susceptibility testing (AST) methods are included, the document does not provide a comprehensive review of these topics. (idsociety.org)
In cases of suspected or documented treatment failure, clinicians should perform both culture and antimicrobial susceptibility testing because NAATs cannot provide antimicrobial susceptibility results. (cdc.gov)

Total contact casting is the preferred method for offloading plantar diabetic foot ulcers because it has most consistently demonstrated the best healing outcomes and is a cost-effective treatment. (medscape.com)
OBJECTIVE: The aim of this study was to describe and present the outcomes of a specific treatment protocol for aortic vascular graft and endograft infections (VGEIs) without explantation of the infected graft. (lu.se)
secondary outcomes were antimicrobial treatment duration, infection eradication, treatment failure despite antimicrobial treatment, and the development of aortic fistulation. (lu.se)
Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St. (medscimonit.com)
Fertility-Sparing Treatment in Gestational Choriocarcinoma: Evaluating Oncological and Obstetrical Outcomes. (medscimonit.com)

In contrast, chronic osteomyelitis, which is the most difficult diabetic foot infection to cure, requires surgical debridement before antibiotic therapy can be effective. (medscape.com)
In clinical practice, combination therapy with a cell wall-active agent and a synergistic aminoglycoside should be considered for treating serious enterococcal infections in critically ill patients and in those with evidence of sepsis , as well as in patients with endocarditis, meningitis, osteomyelitis, or joint infections. (medscape.com)
Today, this combination therapy is the only recommended treatment option available for gonorrhea. (cdc.gov)
Clinicians must follow gonorrhea dual therapy recommendations and can find the most up-to-date gonorrhea treatment guidance within CDC's STD Treatment Guidelines . (cdc.gov)
Not only is azithromycin part of the currently recommended therapy, it is the backbone of every alternative treatment. (cdc.gov)
This single centre retrospective analysis of patients with VGEIs without fistula selected for conservative treatment suggests that conservative management of aortic VGEIs with targeted antibiotic therapy without graft excision is potentially effective, and that antimicrobial treatment will not necessarily be needed indefinitely. (lu.se)
Antibiotic therapy is generally initiated empirically because early treatment decreases the rate of morbidity resulting from UTI. (medscimonit.com)
Manuka honey is superior to standard hydrogel therapy in the treatment of sloughy venous ulcers. (greenmedinfo.com)
The Committee on Educational Bulletins of the American College of Obstetricians and Gynecologists (ACOG) has released a report titled "Antimicrobial Therapy for Obstetric Patients" (Educational Bulletin No. 245). (aafp.org)
Many patients develop significant intolerance to the drugs, do not respond to standard treatment, or develop recurrent infections after discontinuing therapy. (nih.gov)
7 They used in vitro assays and a human wound skin model to assess whether blue light therapy reduces the P. aeruginosa burden and identified the specific intensities and treatment times needed to maximize antibacterial effects. (the-scientist.com)
Infections effecting the heart and blood vessels can be extremely dangerous, for which herbalism is not the most appropriate therapy. (healthy.net)
One of the commonest sights for infection in the body, but infections of the upper and lower respiratory system often respond well to herbal therapy. (healthy.net)
To date, CDC has not identified a confirmed case in the United States of unsuccessful gonorrhea treatment due to resistance to recommended therapy. (cdc.gov)

Welcome to the BSAC Winter Conference: Infection 2022. (bsac.org.uk)
This report summarizes incidence rates and trends of sexually transmitted infections (STIs) from 2014 to 2022 among active component service members of the U.S. Armed Forces. (health.mil)

In this study, we identified the intrinsic resistome to a broad spectrum of antimicrobials in the human pathogen, Staphylococcus aureus . (frontiersin.org)
We recently reported degradable broad-spectrum antimicrobial guanidinium-functionalized polycarbonates with unique antimicrobial mechanism - membrane translocation followed by precipitation of cytosolic materials. (ibm.com)

Infections in patients with diabetes are difficult to treat because these patients have impaired microvascular circulation, which limits the access of phagocytic cells to the infected area and results in a poor concentration of antibiotics in the infected tissues. (medscape.com)
For this reason, cellulitis is the most easily treatable and reversible form of foot infections in patients with diabetes. (medscape.com)
Patients with mild infections can be treated in outpatient settings with oral antibiotics that cover skin flora including streptococci and Staphylococcus aureus . (medscape.com)
Some studies find that monotherapy is adequate treatment in many patients with enterococcal bacteremia without evidence of endocarditis. (medscape.com)
Vancomycin should be used in patients with a penicillin allergy or infections with strains that have high-level penicillin resistance due to altered PBPs. (medscape.com)
It is important to consider cutaneous infection with Mycobacterium avium-intracellulare (MAI, or MAC) in patients with antibiotic-resistant cellulitis, nonhealing nodules, and ulcers, as well as in patients who are immunosuppressed with evidence of disseminated MAI (DMAI) infection. (medscape.com)
Twenty-four (48%) patients were able to discontinue antibiotic treatment after a median of 16 months (range 4 - 81 months). (lu.se)
CONCLUSION: Identifying the microbiological aetiology in patients with aortic VGEI enables individualised, specific antibiotic treatment, which may be useful in patients with a VGEI excluded from surgery. (lu.se)
The cost of health care for patients with resistant infections is higher than care for patients with non-resistant infections due to longer duration of illness, additional tests and use of more expensive drugs. (paho.org)
This was a cross sectional hospital- vancomycin as the drug of choice in the treatment of based study involving 300 patients of all ages with 6 infections caused by MRSA. (who.int)
RÉSUMÉ L'émergence et la propagation rapide des souches de Klebsiella pneumoniae résistantes aux antibiotiques et porteuses du gène blaKPC codant la production de carbapénèmases ont compliqué la prise en charge des infections des patients. (who.int)
Patients who had an early postoperative infection are managed with débridement, replacement of the polyethylene (PE) insert of the acetabular/tibial component, retention of the prosthesis, and IV administration of antibiotics for 6 weeks. (medscape.com)
Patients who have an acute hematogenous infection are also managed with débridement, replacement of the PE insert, retention of the prosthesis if it is not loose, and IV administration of antibiotics for 6 weeks. (medscape.com)
Dr. Olivier's studies of respiratory ciliary function, conducted through the NIH Rare Diseases Clinical Research Network, led to the discovery of potential defects in nitric oxide synthesis as well as Toll-like receptor signaling associated with altered ciliary beat frequency in patients with idiopathic bronchiectasis and chronic NTM infection. (nih.gov)
Furthermore, infections are the second leading cause of death in cancer patients. (who.int)
Demographic data of the patients, results of stool exa amination for Giardia trophozoites before and after treatment, and drug sideaeffects were recorded. (who.int)

It also gives an overview of in vitro and in vivo activities of these antimicrobials and of resistance mechanisms described for M. hyopneumoniae towards these antimicrobials. (cabi.org)
Working out the nuances of a treatment regimen in vitro is an important first step towards future clinical translation. (the-scientist.com)
Specifically, in vitro antimicrobial activity and selectivity of guanidinium-functionalized polycarbonates containing the same number of guanidinium groups but of a shorter chain length and a structural analogue containing a thiouronium moiety as the pendent cationic group were evaluated. (ibm.com)

Identification of N. gonorrhoeae infections with reduced ceftriaxone susceptibility can be a sign of emerging resistance. (cdc.gov)

ABSTRACT The emergence and rapid spread of antibiotic-resistant Klebsiella pneumoniae isolates harbouring the blaKPC gene that encodes for carbapenemase production have complicated the management of patient infections. (who.int)
Following the recommended treatment guidelines every time may help slow the emergence of antimicrobial resistance. (cdc.gov)

Diagnosis of Mycoplasma hyopneumoniae infection and associated diseases. (cabi.org)
For infection diagnosis and treatment, the panel endorses the clinical practice guidelines of the Infectious Diseases Society of America. (medscape.com)
One chart review series of 47 children with cervical adenitis revealed a median age of 3 years at the time of MAI infection diagnosis. (medscape.com)
Because the early signs are non-specific, it is important to consider the diagnosis early in any patient with known TB exposure, infection, or disease, including past TB, and in all persons with compatible symptoms from high TB-burden locations. (msdmanuals.com)

In the United States of America, the prevalence of the viral infection among 14-49-year-olds is 19%, and throughout the world, seropositivity rates are uniformly higher in women than in men and increase with age. (who.int)
The burden is greatest in the developing world, but industrialized nations can also be expected to experience an increased burden of disease because of the prevalence of non-curable viral infections, trends in sexual behaviour and increased travel. (who.int)
[ 1 ] Although the prevalence of MAI infection has increased following the epidemic of acquired immunodeficiency syndrome (AIDS), MAI infection remains a rare cause of skin disease. (medscape.com)

Millions of viral sexually transmitted infections also occur annually, attributable mainly to HIV, human herpesviruses, human papillomaviruses and hepatitis B virus. (who.int)
Antibiotics will not work for colds, flu, or other viral infections. (medlineplus.gov)
Examples of misuse include when they are taken by people with viral infections like colds and flu, and when they are given as growth promoters in animals or used to prevent diseases in healthy animals. (paho.org)

these infections include UTIs, most intra-abdominal infections, and uncomplicated wound infections. (medscape.com)
Intra-abdominal Infections: The Role of Piperacillin/Tazobactam. (wikipedia.org)

To determine the overall and procedure-specific incidence of surgical site infections (SSI) caused by Staphylococcus aureus ( S. aureus ) as well as risk factors for such across all surgical disciplines in Europe. (biomedcentral.com)
The detection of resistance to carbapenems in poultry and to linezolid in methicillin-resistant Staphylococcus aureus in pigs is alarming because these antibiotics are used in humans to treat serious infections," said Marta Hugas, EFSA's chief scientist. (foodsafetynews.com)

Primary cutaneous MAI infection generally occurs in hosts who are immunocompetent after traumatic introduction into the soft tissue. (medscape.com)
This coincidence concords with the fact that DMAI infection often occurs in association with HIV disease. (medscape.com)
Antimicrobial resistance occurs naturally over time, usually through genetic changes. (paho.org)
Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)
Meningitis often occurs in the absence of infection at other extrapulmonary sites. (msdmanuals.com)

Mark Wilcox, Microbiologist and Julian Sturdy, MP on the personal, clinical and political impact of managing multi-drug resistant infections. (bsac.org.uk)
Therefore, since it is a global public health problem involving several sectors, it also requires a global solution in the context of the One Health approach to achieve adequate control through the prevention, reduction, and mitigation of drug-resistant infections. (who.int)
Antimicrobial peptides against drug resistant Mycobacterium abscessus. (nih.gov)

Here we summarize the factors of variability that we identified in murine lung infection models used for antimicrobial efficacy testing, as well as the workshop presentations, panel discussions and the survey results for the harmonization of key experimental parameters. (frontiersin.org)
In the first section, infections of the lung are discussed, with a focus on bronchiectasis, lung abscess, and pneumatocele. (medscape.com)
Complications after surgical resection for lung abscess are infrequent and include atelectasis, bronchopleural fistula, and wound infection. (medscape.com)
Bronchiectasis and chronic lung infections caused by NTM in the United States are steadily on the rise but difficult to diagnose and treat. (nih.gov)
NTM lung infection treatment currently requires multiple drugs taken for months or even years. (nih.gov)
Progressive reduction in potency of antibiotics capable of treating MDR K. pneumoniae infections - including lung infection - as a consequence of escalating drug resistance provides the motivation to develop drug candidates targeting MDR K. pneumoniae. (ibm.com)
In this study, the structures of the polymers were optimized for the treatment of MDR Klebsiella pneumoniae lung infection. (ibm.com)
The in vivo efficacy studies showed that pBut_20 alleviated K. pneumonia lung infection without inducing damage to major organs. (ibm.com)
Taken together, pBut_20 is promising for treating MDR Klebsiella pneumoniae lung infection in vivo. (ibm.com)
The polymer with optimal composition alleviates Klebsiella pneumonia lung infection without inducing damage to major organs. (ibm.com)

Guidance documents are prepared by a small team of experts, who answer questions about treatment based on a comprehensive (but not necessarily systematic) review of the literature, clinical experience, and expert opinion. (idsociety.org)
To develop a comprehensive set of updated guidelines, CDC conducted a series of systematic literature reviews on human treatment of plague and other relevant topics to collect a broad evidence base for the recommendations in this report . (bvsalud.org)

Together with data from the PK/PD analyses, information from the retrospective analysis will be used to propose the first ever clinical breakpoints for oral treatment of porcine diarrhoea. (nature.com)
One case report described primary MAI infection resulting in a clinical picture resembling lupus vulgaris. (medscape.com)
resistant S. aureus (VRSA) in clinical samples The study was approved by the Health Ethics impacted negatively on the efficacy of vancomycin Committee of the State Ministry of Health and the 6 leading to treatment failures. (who.int)
Tsukayama et al based their treatment of infections after total hip arthroplasty (THA) on the clinical presentation-that is, positive intraoperative cultures, early postoperative infection, acute hematogenous infection, or late chronic infection. (medscape.com)
Treatment protocols have been successfully used for these four clinical settings. (medscape.com)
Clinical use of potentiators have been applied successfully to the antimicrobial class of β-lactams, where β-lactamase inhibitors can significantly enhance the efficacy of β-lactams ( Drawz and Bonomo, 2010 ). (frontiersin.org)
Treatment of Nontuberculous Mycobacterial Pulmonary Disease: An Official ATS/ERS/ESCMID/IDSA Clinical Practice Guideline. (nih.gov)
Combined clinical resistance to critically important antimicrobials was observed at low to very low levels, ranging from 0.2 percent to 1 percent, in Salmonella, Campylobacter and E. coli in poultry. (foodsafetynews.com)

Rapid Infection Diagnostics in Cirrhosis (RIDiC): a novel molecular-based approach to address the ever increasing challenge of antimicrobial resistant infections in decompensated cirrhosis and acute-on-chronic liver failure. (bsac.org.uk)
If there is a chronic focus of infection it may take some form of colitis, please refer to that section. (healthy.net)
Tuberculosis (TB) Tuberculosis is a chronic, progressive mycobacterial infection, often with an asymptomatic latent period following initial infection. (msdmanuals.com)

In the wake of the report's release, European Commissioner for Health and Food Safety Vytenis Andriukaitis reaffirmed his commitment to tackle antimicrobial resistance. (foodsafetynews.com)

Each pathogen causes a wide range of infections that are encountered in United States hospitals of all sizes, and that carry with them significant morbidity and mortality. (idsociety.org)
Data on skin and soft-tissue infection caused by nontuberculous mycobacteria in Taiwan (1997-2008) suggest that MAI is an important pathogen. (medscape.com)
Knowledge of these intrinsic resistance determinants provides alternative targets for compounds that may potentiate the efficacy of existing antimicrobial agents against this important pathogen. (frontiersin.org)
Sulfathiazole is very effective for basic Fin Rot infections with Pseudomonas as the bacterial pathogen. (americanaquariumproducts.com)

however, treatment has been compromised by the evolution of antibiotic resistance to the antibiotics used to treat gonorrhea. (cdc.gov)

As an alternative to practice guidelines, IDSA endorsed developing more narrowly focused guidance documents for the treatment of infections where data continue to rapidly evolve. (idsociety.org)
For specific information concerning the evaluation and management of diabetic foot infections, including choices of antimicrobial agents, the reader is referred to authoritative guidelines published by the Infectious Diseases Society of America. (medscape.com)
The U.S. government stockpiles a variety of medical countermeasures to mitigate the effects of a bioterrorism attack (e.g., antimicrobials, antitoxins , and vaccines ) for which the 21st Century Cures Act mandates the development of evidence-based guidelines on appropriate use. (bvsalud.org)
The CDC guidelines were developed to provide a central reference for professionals involved in infection control that contains CDC recommendations and is easily accessible to the infection control personnel in hospitals. (cdc.gov)
Therefore, these data can serve as a basis to develop national country-specific guidelines for the empirical treatment of UTIs. (medscimonit.com)
Treatments should follow the guidelines given for Diarrhoea supported by the surface immune approach described previously. (healthy.net)
150 kg ) (see STI Treatment Guidelines ). (cdc.gov)
Health care providers should stay up to date on CDC treatment guidelines. (cdc.gov)

In an interview with Pharmacy Times, Thomas Lodise, PharmD, PhD, discussed new guidance released by the Infectious Diseases Society of America (IDSA) on the treatment of antimicrobial resistant gram-negative infections. (pharmacytimes.com)
Image: Garlic has been traditionally used for the treatment of diseases for thousands of years. (pharmaceutical-technology.com)
Developing various antibiotics led to the promising treatment of bacterial infectious diseases [ 1 ]. (hindawi.com)
The new report from EFSA and ECDC focuses on zoonotic resistance, which involves infections and diseases that can be transmitted from animals to people or, more specifically, a disease that normally exists in animals but that can infect humans. (foodsafetynews.com)

While sexually transmitted infections are mostly transmitted through sexual intercourse, transmission can occur also from mother to child during pregnancy and childbirth, and through blood products or tissue transfer, as well as occasionally through other non-sexual means. (who.int)
Given social, demographic and migratory trends, the population at risk for sexually transmitted infections will continue to grow dramatically. (who.int)

The combination has been shown to be effective in both gentamicin-resistant and gentamicin-sensitive isolates and in both native and prosthetic valve infections. (medscape.com)
Among Escherichia coli isolates, nitrofurantoin, cephalosporins, and penicillin/betalactams were the best options for therapeutic treatment because of the presence of a rate of resistance to cotrimoxazole and fluoroquinolones of over 10%, while the most active drug against Pseudomonas aeruginosa was piperacillin/tazobactam. (medscimonit.com)

Deep-skin and soft-tissue infections are also usually curable, but they can be life threatening and result in substantial long-term morbidity. (medscape.com)

The polymers with optimal compositions and varying hydrophobicity were assessed against 25 clinically isolated K. pneumonia strains for antimicrobial activity and killing kinetics. (ibm.com)

250 mg per 10 gallons every 48 hours (24 hours for severe issues) with a 25% water change before each treatment. (americanaquariumproducts.com)
In some countries at least one in three Campylobacter coli infections were multidrug-resistant to important antibiotics, leaving very few treatment options for severe infections. (foodsafetynews.com)

95%), a Gram stain of urethral discharge or secretions that demonstrate polymorphonuclear leukocytes with intracellular gram-negative diplococci can be considered diagnostic for infection with N. gonorrhoeae among symptomatic men. (cdc.gov)

Multidrug resistant (MDR) Klebsiella pneumoniae is a major cause of healthcare-associated infections around the world, with attendant high rates of morbidity and mortality. (ibm.com)

As a result, the medicines become ineffective and infections persist in the body, increasing the risk of spread to others. (paho.org)
As a result, standard treatments become ineffective, infections persist and can easily spread. (foodsafetynews.com)

Intrinsic resistance to antimicrobials has traditionally been attributed to reduced permeability of the cell envelope, presence of inactivating enzymes or efflux pumps that can extrude the antimicrobial agents ( Cox and Wright, 2013 ). (frontiersin.org)
However, efflux pumps inhibitors have not yet been approved for treatment of human infections due to tolerability issues ( Fernebro, 2011 ). (frontiersin.org)

Although azithromycin is part of the recommended antimicrobial treatment for gonorrhea, a recent analysis of gonorrhea specimens from CDC's sentinel surveillance system, the Gonococcal Isolate Surveillance Project (GISP), shows declining susceptibility to azithromycin. (cdc.gov)

Antimicrobial resistance is an increasingly serious threat to global public health that requires action across all government sectors and society. (paho.org)
Antimicrobial resistance (AMR) remains an alarming public health threat worldwide. (who.int)
Antimicrobial resistance (AMR) is a threat to cancer care and is undermining the significant progress made in cancer treatments. (who.int)

Epidemiology of Mycoplasma hyopneumoniae infections. (cabi.org)
Due to differences in the molecular epidemiology of resistance and availability of specific antibiotics internationally, treatment recommendations are geared toward antimicrobial resistant infections in the United States. (idsociety.org)

Nitrofurantoin is effective in the treatment of enterococcal UTIs, including many caused by VRE strains. (medscape.com)
When the MIC is unknown or greater than 0.25 mg/L, high-dose daptomycin (10-12 mg/kg) in the treatment of enterococcal endocarditis appears to reduce the development of daptomycin-resistant strains. (medscape.com)

Anatomy8

Organisms44

Diseases38

Chemicals and Drugs96

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes30

Disciplines and Occupations3

Technology, Industry, Agriculture4

Humanities1

Information Science2

Health Care16

Bacterial infections8

Pathogens7

20211

Urinary17

Bacteria20

Stewardship2

Chemotherapy4

Spread of antimicrobial resistance2

Fight antimicrobial resistance1

20201

Efficacy of antimicrobial1

Prophylaxis5

Microorganisms2

Prevention and control6

Combat antimicrobial1

Commonly8

Develop antimicrobial1

Susceptibility Testing2

Outcomes5

Therapy14

20222

Broad spectrum2

Patients16

Vitro3

Gonorrhoeae infections1

Emergence2

Diagnosis4

Prevalence3

Viral3

Intra-abdominal infections2

Staphylococcus2

Occurs5

Drug-resistant3

Lung10

Systematic2

Clinical8

Chronic3

Tackle1

Pathogen4

Antibiotic Resistance1

Guidelines8

Diseases4

Sexually transmitte2

Isolates2

Soft-tissue infections1

Pneumonia1

Severe2

Gram-negative1

Multidrug-resistant1

Ineffective2

Efflux2

Surveillance1

Threat3

Epidemiology2

Strains2