Antimicrobial resistance exposure to fluoroquinolones. Medical search. Frequent questions

The Import Alert provides that the use of antimicrobials during the various stages of aquaculture, including malachite green, nitrofurans, fluoroquinolones, and gentian violet, may contribute to an increase of antimicrobial resistance in human pathogens and that prolonged exposure to nitrofurans, malachite green, and gentian violet has been shown to have a carcinogenic affect. (wikipedia.org)
Identification of the pathogens responsible for different microbial infections and antimicrobial resistance patterns are important to help clinicians to choose the correct empirical drugs and provide optimal patient care. (biomedcentral.com)
Nosocomial or healthcare-associated infections caused by antimicrobial-resistant pathogens represent a serious burden and ongoing threat to patients' health and safety [ 1 ]. (biomedcentral.com)
METHODS: Antimicrobial susceptibility data were retrieved from two sources: pubMLST (https://pubmlst.org/) and Pathogenwatch (https://pathogen.watch/) for the following bacterial pathogens: Klebsiella pneumoniae, Salmonella enterica subsp. (itg.be)
If tetracycline resistance is associated with resistance to other antimicrobials in a range of bacterial species, then doxycycline PEP could have the unintended effect of selecting for resistance to other antimicrobials in these bacterial species.METHODS: Antimicrobial susceptibility data were retrieved from two sources: pubMLST (https://pubmlst.org/) and Pathogenwatch (https://pathogen.watch/) for the following bacterial pathogens: Klebsiella pneumoniae, Salmonella enterica subsp. (itg.be)
Indeed, experts view the promotion of antibiotic resistant bacteria as "by far the greatest human health risk" posed by the presence of pharmaceutical residues in the environment and note that, in addition to fostering the spread of resistant pathogens, antibiotic residues can also turn harmless environmental bacteria into carriers of resistance. (desdaughter.com)
The work package focusing on molecular studies generated new evidence about the changes effected by antibiotic therapy on commensal organisms or opportunistic pathogens in the oropharyngeal, nasal and gastro-intestinal flora and study AMR mechanisms and the dissemination of successful clones of fluoroquinolone-resistant, carbapenem-resistant or extended-spectrum beta-lactamase harboring Gram-negative bacteria, MRSA and fluoroquinolone-resistant viridans streptococci. (europa.eu)
The containment of the phenomenon of resistance towards antimicrobials is a priority, especially in preserving molecules acting against Gram-negative pathogens, which represent the isolates more frequently found in the fragile population of patients admitted to Intensive Care Units. (mdpi.com)
Internationally, approximately 1.3 million deaths were estimated to be directly attributable to antimicrobial resistant bacterial pathogens in 2019[1]. (idsociety.org)
In the United States, antimicrobial resistant pathogens caused more than 2.8 million infections and over 35,000 deaths annually from 2012 through 2017, according to the Centers for Disease Control and Prevention (CDC) Antibiotic Resistance Threats in the United States Report[2]. (idsociety.org)
The microorganisms mainly involved in the resistance process, so called the ESKAPE pathogens ( Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa, and enterobacteriaceae ) were the main targets. (biomedcentral.com)
The intestinal microbiota is considered to be a major reservoir of antibiotic resistance determinants (ARDs) that could potentially be transferred to bacterial pathogens via mobile genetic elements. (nature.com)
Here, we investigated human pathogens Escherichia coli causing Urinary Tract Infection [UTI] to explore the possible link between the abundance of mutations, and the exposure to fluoroquinolones. (indjst.org)
Pathogens and biological toxins in food generally cause illness within hours or days of exposure. (foodsystemprimer.org)

The prevalence of antimicrobial resistance in some Egyptian hospitals was high among Gram-negative, Gram-positive bacteria, and candida spp. (biomedcentral.com)
These associations include a higher prevalence of methicillin resistance in tetracycline resistant S. aureus, penicillin resistance in S. pneumoniae, macrolide and clindamycin resistance in S. pyogenes, fluoroquinolone resistance in S. enterica subsp. (itg.be)
Specifically, resistance to fluoroquinolones has increased its prevalence, a group of antibiotics widely used in urology. (bcan.org)
The study aimed at determination of the prevalence and pattern of antimicrobial resistance in Escherichia coli isolated in children admitted at health facilities in Moshi municipality, Tanzania. (researchsquare.com)
Seasonal variation in the prevalence and antimicrobial resistance of Campylobacter species in the Ethiopian dairy value chain was investigated. (usda.gov)

The emergence of antimicrobial resistance in Streptococcus pneumoniae worldwide is an important public health issue because this organism is the leading cause of many infections, particularly community-acquired pneumonia. (cdc.gov)
In recent years, the emergence of fluoroquinolone resistance is being increasingly recognized among multidrug-resistant strains of S. pneumoniae . (cdc.gov)
Widespread and uncontrolled use of these done on Mueller-Hinton agar (Oxoid) by drugs has, however, led to the emergence of the modified Kirby-Bauer disk diffusion resistance against them also [ 1-3 ]. (who.int)
Reporting of susceptibility testing results is a key reference to choose the correct antimicrobial and avoiding the emergence of new antimicrobial resistance. (biomedcentral.com)
The emergence of antimicrobial resistance is a great challenge in preventing, controlling and treatment Gram-negative bacteria and has become a significant public health threat worldwide. (researchsquare.com)
Following the recommended treatment guidelines every time may help slow the emergence of antimicrobial resistance. (cdc.gov)
The pharmacodynamic study modelled the relationships between antibiotic exposure and AMR emergence over time for various classes of agents. (europa.eu)
The results obtained in this work do not exclude the importance of mutations in resistance to fluoroquinolones in S. aureus, yet they underline the contribution of efflux systems for the emergence of high-level resistance. (unl.pt)
The emergence of antibiotic resistance in bacteria commonly found in food animals has garnered attention globally for its potential contribution to human colonization with antibiotic resistant bacteria. (biomedcentral.com)
We included studies describing dosage adjustment and factors determining LVX pharmacokinetics, or pharmacokinetic-pharmacodynamic studies exploring how best to prevent the emergence of resistance to LVX. (dovepress.com)
Liu YY, Wang Y, Walsh TR, Yi LX, Zhang R. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study . (indjst.org)

Zoonotic resistant bacteria and resistance genes could be transferred not only to people with occupational livestock exposure but also other persons in the community through direct contact with animals, via the food chain or by environment [ 9 , 10 ]. (hindawi.com)
have been implicated as indicator bacteria species for the detection of antimicrobial resistance. (vin.com)
Antimicrobial resistance (AMR) development among Gram negative bacteria has become a significant public health threat worldwide. (researchsquare.com)
The recommended and available antimicrobials have shown to be losing their ability to kill most of the infectious bacteria by developing resistance and becoming difficult to treat patients (9). (researchsquare.com)
Some bacteria pose ability to produce enzymes such as Extended Spectrum β-Lactamase (ESBL), which is responsible for the resistance to cephalosporin and penicillin (10). (researchsquare.com)
The increase in circulating resistant strains of infectious bacteria make it difficult for the use of current available and recommended antimicrobial drugs (11). (researchsquare.com)
Resistance of Gram negative bacteria to the recommended and available antimicrobial drugs is a growing public health problem in different locations worldwide leading to increased morbidity and mortality to patients (12). (researchsquare.com)
Antimicrobial Resistance (AMR) is rampant among bacteria that cause healthcare- and community-acquired infections, driving up costs and increasing the difficulty of therapeutic management. (europa.eu)
Testing for resistance genes in bacteria is one way to fight the antibiotic crisis. (extherid.com)
for the remain- classes of antimicrobial agents and are also ing patients the stool request forms did not responsible for the dissemination of resist- have clinical details about the presenting ance to other Gram-negative bacteria in the complaint. (who.int)
We recommend an enhanced surveillance for antibiotic resistance in food products for the early detection of emerging resistant bacteria species in the food chain. (biomedcentral.com)
Extended spectrum beta lactamase (ESBL), an enzyme produced by some gram negative bacteria, poses a peculiar challenge for treatment as it confers resistance to penicillins, cephalosporins and monobactams [ 9 ]. (biomedcentral.com)
Multidrug resistance (MDR) bacteria is defined as non-susceptibility to one or more antimicrobials on three or more antimicrobial classes, while strains that are non-susceptible to all antimicrobials, are classified as extreme drug-resistant strains [ 2 ]. (biomedcentral.com)
In addition, exposure to soaps, disinfectants, medications, and ultraviolet light can modify the types and number of bacteria on the skin. (medscape.com)
Levofloxacin is a fluoroquinolone antibacterial indicated in adults (18 years of age and older) with infections caused by designated, susceptible bacteria and in pediatric patients where indicated (1, 12.4). (nih.gov)
While many bacteria have intrinsic, chromosomally encoded ARDs and the capability of increasing resistance through mutation, they can also enrich their resistance capabilities through the acquisition of exogenous ARDs located on mobile genetic elements (MGEs) such as plasmids, transposons or phages. (nature.com)
Technically, "antibiotic" refers only to antimicrobials derived from bacteria or molds but is often (including. (msdmanuals.com)

This study aimed to assess the nasopharyngeal carriage of S. aureus in poultry and to investigate antimicrobial susceptibility and virulence-associated genes. (hindawi.com)
Preventive and containment measures should be implemented in order to limit the dissemination of resistance genes through the food chain and to reduce their increased rate. (hindawi.com)
Additionally, ST131 isolates showed a high content of other acquired resistance genes, and clade C/ST131 isolates carried characteristic QRDR mutations. (bvsalud.org)
A recent study has investigated the movement of antibiotic resistance genes between farm animals, soil and water in Finland. (desdaughter.com)
Addition of efflux inhibitors did not result in the full reversion of the fluoroquinolone resistance phenotype, yet it implied a significant decrease in the resistance levels, regardless of the type(s) of mutation(s) found in the quinolone-resistance determining region of grlA and gyrA genes, which accounted for the remaining resistance that was not efflux-mediated. (unl.pt)
The aims of this research work were to determine the patterns of antibiotic resistance in Escherichia coli isolates from the meat of wild or domestically reared pigeons from Spain, to detect the presence of virulence and antibiotic resistance genes, and to carry out a phylogenetic classification of the isolates. (mdpi.com)
Monitoring the trend of spread of ESBL positive E. coli through the food chain is necessary in settings where humans have routine contact with livestock and their products, because of the increased risk of spread of resistance genes in these interactions. (biomedcentral.com)
Gyr A and Par C genes, are known to cause resistance especially in Alterations in proteins of fluoroquinolones. (indjst.org)
We have determined partial sequences of the Gyr A and Par C genes of E. coli including the regions analogous to the quinolone resistance-determining region of the E. coli Gyr A gene. (indjst.org)
Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)
This report presents the status of AMR in Africa by analysing the main types of resistance and the underlying genes where possible. (who.int)

In November 2005, the testing program for aquaculture drugs was revised to include antibiotics such as chloramphenicol, fluoroquinolones, nitrofurans, and quinolones, as well as antimicrobial compounds like malachite green that are not approved for use in aquaculture fish. (wikipedia.org)
The misuse of antibiotics has also contributed to the growing problem of antibiotic resistance, which has become one of the most serious and growing threats to public health.12 Unlike other medications, the potential for spread of resistant organisms means that the misuse of antibiotics can adversely impact the health of patients who are not even exposed to them. (cdc.gov)
Similarly, between 1999 and 2003, Pseudomonas aeruginosa resistance to fluoroquinolone antibiotics increased from 23% to 29.5% in NNIS ICUs (74). (cdc.gov)
The high resistance pattern -especially in secondary microbial infections in COVID-19 patients- to most antibiotics used is a matter of great concern, portends an inevitable catastrophe, and requires continuous monitoring to avoid the evolution of new generations. (biomedcentral.com)
The excessive use of antibiotics or antifungals, empirical treatment without antimicrobial susceptibility testing and self-treatment lead to mutation and increased drug resistance [ 6 ]. (biomedcentral.com)
However, a wide variation in the use of periprocedural prophylactic antibiotics has been demonstrated, which frequently is incurred as an inappropriate selection of antimicrobials, inadequate schedule of administration or excessive duration of prophylaxis. (bcan.org)
The increase in multidrug resistance of antibiotics in recent decades has been associated with its misuse, resulting in an increased rate of morbidity and mortality, prolonged hospital stays and increased care costs. (bcan.org)
Neisseria gonorrhoeae , the bacterium causing gonorrhea, has progressively developed resistance to the antibiotics prescribed to treat it. (cdc.gov)
Following the spread of gonococcal fluoroquinolone resistance, the cephalosporin antibiotics have been the foundation of recommended treatment for gonorrhea. (cdc.gov)
Due to differences in the molecular epidemiology of resistance and availability of specific antibiotics internationally, treatment recommendations are geared toward antimicrobial resistant infections in the United States. (idsociety.org)
Monitoring resistance to antibiotics in wild animals may assist in evaluating tendencies in the evolution of this major public health problem. (mdpi.com)
Bacterial resistance to antibiotics is growing up day by day in both community and hospital setting, with a significant impact on the mortality and morbidity rates and the financial burden that is associated. (biomedcentral.com)
In this review we made an evaluation of present data regarding the new classes and the new molecules from already existing classes of antibiotics and the ongoing trends in antimicrobial development. (biomedcentral.com)
Bacterial resistance to antibiotics is growing up day by day in both community and hospital setting, increasing mortality and morbidity [ 1 ]. (biomedcentral.com)
Consideration must be given, however, to the risk of using antibiotics to include allergies, emerging resistance of multiple organisms, and adverse effects. (medscape.com)
The failure of the medical community to appropriately utilize antibiotics in the 20th century, resulting in the crisis of antibiotic resistance that confronts us, is a testament to the fact that providers are far from all-knowing. (medscape.com)
The belief that shortening a course of antibiotics can lead to bacterial resistance is widely accepted by clinicians and patients. (medicalnewsbulletin.com)
However, shorter durations of treatment reduces the exposure to antibiotics and can possibly reduce the incidence of resistance. (medicalnewsbulletin.com)

Antimicrobial susceptibility testing was performed according to CLSI guidelines. (biomedcentral.com)
METHODS: Antimicrobial susceptibility testing was performed by reference broth microdilution. (imperial.ac.uk)

Antimicrobial Agents Chemotherapy. (indjst.org)

More than half of the strains (54%) were resistant to penicillin, 29.4% to tetracycline, 23.5% to erythromycin, and 17% showed resistance to ciprofloxacin. (hindawi.com)
Also, a 3-month survey of 15 Brooklyn hospitals in 1999 found that 53% of A. baumannii strains exhibited resistance to carbapenems and 24% of P. aeruginosa strains were resistant to imipenem (10). (cdc.gov)
Moreover, about half of Staphylococcus aureus strains were MRSA isolates and reported low rates of resistance to glycylcycline and linezolid. (biomedcentral.com)
Wild birds with no prior history of exposure to antimicrobials were included in this study, yet resistant strains of Enterococcus were isolated from every bird. (vin.com)
Currently there are fewer antimicrobials available for treatment and prevention of some of bacterial infections (1).Antimicrobial resistance development in some of bacterial strains undermines empirical treatment regimens, thereby limiting choice of appropriate antibiotic (2).As this problem continues to grow, epidemiological surveillance is warranted to generate data that is reliable to understand the distribution of AMR among healthcare settings and geographical regions (3). (researchsquare.com)
Functional characterization of KPC-109 was performed investigating the impact of KPC-109 production on the β-lactam resistance phenotype of various Escherichia coli and Klebsiella pneumoniae strains, including derivatives of K. pneumoniae with OmpK35 and OmpK36 porin alterations. (imperial.ac.uk)
Brauer A, Telling K, Laht M, Kalmus P, Lutsar I, Remm M. Plasmid with Ciprofloxacin resistance gene Gyr A in ESBL-producing Escherichia coli strains isolated from pig slurry in Estonia . (indjst.org)
The primary outcomes were the incidence of urinary tract infection (UTI) and bacteremia with E. coli and with fluoroquinolone-resistant E. coli strains within 30 days after TBP. (paijournal.com)

Antimicrobial susceptibility and ESBL/carbapenemase production were determined. (bvsalud.org)
High resistance rate were observed on ampicillin, ceftriaxone, ceftazidime, cefuroxime, trimethoprim and ciprofloxacin among ESBL producing Escherichia coli. (researchsquare.com)
Multivariable analysis revealed that diabetes mellitus and recent cephalosporin exposure were the independent risk factors for baseline colonization by ESBL. (biomedcentral.com)
In particular, a specific strain of E. coli, sequence type 131 (ST131), has emerged globally as a major cause of fluoroquinolone-resistant and ESBL-producing E. coli UTIs. (ceufast.com)
In one study of E. coli clinical isolates from extraintestinal sites, predominantly urine, collected at Veterans Affairs (VA) laboratories across the U.S., the ST131 clone accounted for the majority of fluoroquinolone-resistant and ESBL isolates and was calculated to account for 28% of all VA E. coli isolates nationwide. (ceufast.com)
In the present document, guidance is provided on the treatment of infections caused by extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E), AmpC β-lactamase-producing Enterobacterales (AmpC-E), carbapenem-resistant Enterobacterales (CRE), Pseudomonas aeruginosa with difficult-to-treat resistance (DTR-P. aeruginosa), carbapenem-resistant Acinetobacter baumannii species (CRAB), and Stenotrophomonas maltophilia. (idsociety.org)
the current study to determine faecal car- riage of ESBL-producing organisms in a Multidrug resistance is increasingly seen in community setting. (who.int)
The aim of this study was to determine the microbial quality of raw meat, the antimicrobial susceptibility and Extended Spectrum Beta Lactamase (ESBL) production in E. coli isolates from raw meat. (biomedcentral.com)

Antimicrobial resistance mediating mutations associated with erythromycin is the customer feedback but azithromycin 1000 mg as respiratory infections. (amanovaraonlus.it)
M. genitalium isolates were tested for parC, gyrA and 23S rRNA resistance-associated mutations.In total, 180 patients (median age, 35 years) were included in this study, of whom 77.0% (97/126) harboured parC mutations, including 71.4% (90/126) with G248T(S83I) in parC, and 22.5% (27/120) harboured gyrA mutations. (stanford.edu)
These results suggest that triple mutations in clinical isolates of A baumannii contribute to the development of high levels of resistance to fluoroquinolones and that mutations in parC S80L or E84K (groups II and VII) may contribute to alterations in efflux pump activity in A baumannii . (ophrp.org)

Enterica serovar Typhi and third-generation cephalosporin resistance in K. pneumoniae. (itg.be)
Enterica serovar Typhi and third-generation cephalosporin resistance in K. pneumoniae.CONCLUSION: These results suggest that studies evaluating the effects of doxycycline PEP should include the effects of doxycycline on resistance not only to doxycycline but also to other antimicrobials and in a broader array of bacterial species than has been included in doxycycline PEP studies thus far. (itg.be)
The study on AMR pattern at tertiary hospital in Tanzania showed that resistance of Klebsiella pneumoniae and Escherichia coli isolates to third generation cephalosporin were 38.5% and 29.3% respectively (15). (researchsquare.com)
The cephalosporin class of antimicrobial agents is known for its broad spectrum of activity, proven efficiency and favorable safety profile, making it the most commonly prescribed class of antimicrobials. (biomedcentral.com)

We would like to discuss with you the opportunities that the Commission has in the coming months to spearhead action against the global rise of drug resistance, including within the framework of its Proposal for a Regulation on veterinary medicinal products and its upcoming Strategic Approach to Pharmaceuticals in the Environment. (desdaughter.com)
Did you mean topic:"drug resistance, microglial" ? (nshealth.ca)
Consider factors for drug resistance, including previous antimicrobial use, and results of recent urine cultures. (ceufast.com)
When starting empiric antimicrobial therapy, make sure to consider factors for drug resistance, including previous antimicrobial use, and results of recent urine cultures. (ceufast.com)
Several initiatives to track drug resistance evolution have been developed. (jmir.org)
We designed and implemented the online Antimicrobial Resistance Trend Monitoring System (ARTEMIS) in a pilot network of seven European health care institutions sharing 70+ million triples of information about drug resistance and consumption. (jmir.org)
Multi-drug resistance (MDR) was identified in 22% of the isolates. (biomedcentral.com)
The report also includes a summary on the status of drug resistance for TB, HIV and malaria. (who.int)

No resistance to third generation cephalosporins was detected. (who.int)

A British study on antimicrobial resistance (AMR) estimated that 700,000 persons are dying each year worldwide due to antibiotic-resistant infections [ 4 ]. (hindawi.com)
Industrial food animal production facilities are known to be a source of human exposure to antibiotic-resistant S. aureus including methicillin-resistant S. aureus (MRSA) [ 5 , 6 ]. (hindawi.com)
CDC guideline "Management of Multi-Drug Resistant Organisms in Healthcare Settings" stated that control of multi-drug resistant organisms in healthcare "must include attention to judicious antimicrobial use. (cdc.gov)
Does antibiotic exposure increase the risk of methicillin-resistant Staphylococcus aureus (MRSA) isolation? (wikipedia.org)
In this work we used several methodologies to characterize the efflux activity of 52 S. aureus isolates resistant to ciprofloxacin collected in a hospital in Lisbon, Portugal, in order to understand the role played by these systems in the resistance to fluoroquinolones. (unl.pt)
IDSA convened a panel of six actively practicing infectious diseases specialists with clinical and research expertise in the treatment of antimicrobial resistant bacterial infections. (idsociety.org)
This study investigated the fluoroquinolone-resistant mechanism of 56 clinical cases of A baumannii infection from 23 non-tertiary hospitals, collected between 2004 and 2006. (ophrp.org)
In the last two decades multi drug resistant microorganisms (both hospital- and community-acquired) challenged the scientific groups into developing new antimicrobial compounds that can provide safety in use according to the new regulation, good efficacy patterns, and low resistance profile. (biomedcentral.com)
More- govina, according to methicillin resistance, over, the spread of community-acquired origin of isolates, age and gender of patients, methicillin resistant S. aureus (CA-MRSA) and to determine the antibiotic susceptibil- into hospitals has been reported, causing ity patterns. (medicinelakex1.com)
Recent reports suggest that infections due to fluoroquinolone-resistant Escherichia coli ( E. coli ) are an increasingly common complication of transrectal biopsy of the prostate (TBP) in the United States. (paijournal.com)
Our objective is to determine whether the incidence of infections due to fluoroquinolone-resistant E. coli after TBP has increased nationwide in the Veterans Affairs Health Care System and to identify risk factors for infection. (paijournal.com)
Secondary endpoints focused on the correlation between fluoroquinolone-resistance in all urinary E. coli isolates and post-TBP infection and risk factors for infection due to fluoroquinolone-resistant E. coli infection. (paijournal.com)
The increasing incidence of fluoroquinolone-resistant E. coli infections after TBP occurred in parallel with increasing rates of fluoroquinolone-resistance in all urinary E. coli isolates. (paijournal.com)
By multivariable logistic regression analysis, independent risk factors for fluoroquinolone-resistant E. coli UTI after TBP included diabetes mellitus, fluoroquinolone exposure, prior hospitalization, and prior cultures with fluoroquinolone-resistant gram-negative bacilli. (paijournal.com)
In the Veterans Affairs Healthcare System, the incidence of E. coli infection after TBP has increased significantly since 2000 due to a dramatic rise in infections with fluoroquinolone-resistant E. coli . (paijournal.com)
Antimicrobial resistant microorganisms are found in people, animals and the environment and can spread globally. (who.int)

Exploring the contribution of efflux on the resistance to fluoroquinolones in clinical isolates of Staphylococcus aureus. (unl.pt)
http://www.ncbi.nlm.nih.gov/pubmed/?term=Exploring+the+contribution+of+efflux+on+the+resistance+to+fluoroquinolones+in+clinical+isolates+of+Staphylococcus+aureus. (unl.pt)
Antimicrobial resistance mediated by efflux systems is still poorly characterized in Staphylococcus aureus, despite the description of several efflux pumps (EPs) for this bacterium. (unl.pt)

BACKGROUND: A number of randomized controlled trials have found that doxycycline post exposure prophylaxis (PEP) can reduce the incidence of gonorrhoea, chlamydia and syphilis in men who have sex with men (MSM). (itg.be)
Explain the indication for post-exposure prophylaxis, and its efficacy. (cdc.gov)

During the coronavirus disease 2019 (COVID-19) pandemic, changes in hospital infection prevention and control and antibiotic stewardship strategies have had implications for nosocomial infection rates and antimicrobial resistance [ 3 ]. (biomedcentral.com)
Antimicrobial therapy aims to prevent resistance through several actions, which are collectively known as "antimicrobial stewardship", to be taken together, including the application of pharmacokinetic/pharmacodynamic (PK/PD) principles. (mdpi.com)
Antimicrobial stewardship programs are growing in all parts of the world because of the increased risk of antibiotic resistance. (medicalnewsbulletin.com)

Uropathogenic Escherichia coli (35%) were the most prevalent microbial isolates and showed high resistance rates towards penicillin, ampicillin, and cefixime, followed by Klebsiella spp. (biomedcentral.com)
The isolated Escherichia coli was identified and antimicrobial susceptibility test was done by using Kirby-Bauer disc diffusion method on Muller Hinton agar media. (researchsquare.com)
Therefore, this study aimed to determine the Escherichia coli carriages and patterns of antibiotic resistance in children admitted at selected health facilities in Moshi Municipality, Tanzania. (researchsquare.com)
Doumith M, Godbole G, Ashton P, Larkin L, Dallman T, Day M. Detection of the plasmid-mediated Gyr Agene conferring Ciprofloxacin resistance in human and food isolates of Salmonella enterica and Escherichia coli in England and Wales . (indjst.org)

Wentland MP: In memoriam: George Y. Lesher, Ph.D., in Hooper DC, Wolfson JS (eds): Quinolone antimicrobial agents, ed 2. (wikipedia.org)
Mycoplasma genitalium has a tendency to develop macrolide and quinolone resistance.We investigated the microbiological cure rate of a 7 day course of sitafloxacin for the treatment of rectal and urogenital infections in MSM.This open-label, prospective cohort study was conducted at the National Center for Global Health and Medicine, Tokyo, Japan from January 2019 to August 2022. (stanford.edu)
Analyses of quinolone resistance-determining region (QRDR) were done by sequencing. (ophrp.org)

The SATURN project had as aim to study the impact of antibiotic exposure on AMR with a multidisciplinary approach that bridges molecular, epidemiological, clinical and pharmacological research. (europa.eu)
Thus, the main global objectives of SATURN were to study the impact of antibiotic exposure on antimicrobial resistance (AMR) and to define strategies to improve knowledge on antibiotic selection pressure and judicious antibiotic use. (europa.eu)
The intestinal microbiota plays a pivotal role in this phenomenon as it harbours a vast diversity of bacterial species, some of them possessing antibiotic resistance determinants (ARDs) that may enable their survival under antibiotic exposure. (nature.com)

1.25/23.75 g), ciprofloxacin (5 g) and the distribution and antimicrobial drug ceftriaxone (30 g). (who.int)
The report on AMR in Africa revealed varying degree of AMR on the tested antimicrobials like amoxicillin 72.9%, trimethoprim/sulfamethoxazole 75%, gentamicin 22.1% and ceftriaxone 17.2% (14). (researchsquare.com)
Identification of N. gonorrhoeae infections with reduced ceftriaxone susceptibility can be a sign of emerging resistance. (cdc.gov)

In this study, our objective was to perform an extensive characterization of the human gut resistome (including the capacity of ARDs to transfer between species) and to assess its dynamics under various antibiotic exposures. (nature.com)

The trends of antibiotic resistance and the toxinogenic S. aureus carried by the poultry intended for consumption in Tangier present a huge concern. (hindawi.com)
The data gathered by real-time fluorometric and RT-qPCR assays suggest that S. aureus clinical isolates may be primed to efflux antimicrobial compounds. (unl.pt)
All together, the results presented in this study show the potential role played by efflux systems in the development of resistance to fluoroquinolones in clinical isolates of S. aureus. (unl.pt)

Levofloxacin (LVX) is a broad-spectrum fluoroquinolone antibiotic. (dovepress.com)

However, in the presence of porin alterations commonly encountered in high-risk clonal lineages of K. pneumoniae, KPC-109 was able to confer clinical-level resistance to carbapenems as well. (imperial.ac.uk)
In Klebsiella pneumoniae (KP), modifications in the porin OmpK36 are implicated in increasing resistance to carbapenems. (imperial.ac.uk)

Antimicrobial Resistance and Infection Control 12(1), article number: 95. (cardiff.ac.uk)

Pseudomonas is more common in patients with health care exposures or instrumentation. (ceufast.com)
Pseudomonas aeruginosa Bacteremia: Risk Factors for Mortality and Influence of Delayed Receipt of Effective Antimicrobial Therapy on Clinical Outcome. (cmac-journal.ru)
Influence of carbapenem resistance on mortality and the dynamics of mortality in Pseudomonas aeruginosa bloodstream infection. (cmac-journal.ru)
Prospective multicenter study of the impact of carbapenem resistance on mortality in Pseudomonas aeruginosa bloodstream infections. (cmac-journal.ru)
Influence of Multidrug Resistance and Appropriate Empirical Therapy on the 30-Day Mortality Rate of Pseudomonas aeruginosa Bacteremia. (cmac-journal.ru)

The independent risk factors for CR-AB and/or CR-PA colonization were cerebrovascular diseases, previous hospitalization, transfer from another hospital/a LTCF and previous nasogastric tube use, whereas those for MRSA colonization were previous fluoroquinolone exposure and previous nasogastric tube use. (biomedcentral.com)

My research interests are in the field of Clinical Microbiology, including Clostridium difficile infection, human microbiome in health and diease and antimicrobial resistance. (exeter.ac.uk)

During 1994-2000, a national review of ICU patients in 43 states found that the overall susceptibility to ciprofloxacin decreased from 86% to 76% and was temporally associated with increased use of fluoroquinolones in the United States (96). (cdc.gov)
CIPRO XR (ciprofloxacin*) extended-release tablets contain ciprofloxacin, a synthetic antimicrobial agent for oral administration. (globalrph.com)
Phenotypically, Ciprofloxacin resistance was screened by micro broth dilution method. (indjst.org)

Fluoroquinolones, including levofloxacin, may exacerbate muscle weakness in patients with myasthenia gravis. (nih.gov)

There was substantial variability with regard to the susceptibilities for fluoroquinolones, aminoglycosides, macrolides and tetracycline. (vin.com)

Nowadays, the continuous development and the spread of bacterial resistances pose some questions about their future and represent a serious threat for their clinical utility, leading to an urgent requirement for new compounds. (biomedcentral.com)

6,7 This study evaluated the genotypic variability and the level of antimicrobial resistance of Enterococcus spp. (vin.com)

I have investigated many aspects of Clostridium difficile infection biology, including sporulation and germination, host immune responses, antimicrobial resistance, epidemiology and surveillance of novel transposable elements encoding antimicrobial resistance in C. difficile and other gut microorganisms. (exeter.ac.uk)
Surveillance of a novel erythromycin resistance determinant first isolated from Clostridium difficile ribotype 027, in human gut microorganisms. (exeter.ac.uk)

Screening should be performed at all anatomic sites of sexual exposure regardless of condom use , using pharyngeal swabs, rectal swabs, and either urethral/endocervical/ vaginal swabs or urine specimens. (cdc.gov)

In vitro susceptibility testing and molecular resistance testing may be useful to guide therapy, especially for disseminated infections if available. (medscape.com)

This feature is largely responsible for their biologic properties, including lack of a Gram stain reaction and nonsusceptibility to many commonly prescribed antimicrobial agents, including beta-lactams. (medscape.com)
The following antimicrobial agents are those that are most commonly to blame for UTIs. (ceufast.com)

Although brief descriptions of notable clinical trials, resistance mechanisms, and antimicrobial susceptibility testing (AST) methods are included, the document does not provide a comprehensive review of these topics. (idsociety.org)

In 2021, an intraoperative periaortic swab sample was confirmed positive for a Burkholderia species, and three of the thirty clinical staff-identified exposures were confirmed laboratory-acquired exposures. (cdc.gov)

These results suggest that increased candidemia in ICU patients is not attributable to possible alterations in the yeasts, but is more likely caused by a weakening of the patient's general condition after long exposure to infection. (bvsalud.org)

Appropriate antimicrobial therapy in critically ill patients -- 22. (nshealth.ca)

Hong Kong, Ireland, Canada, and Spain have reported increasing rates of fluoroquinolone resistance among S. pneumoniae ( 1 - 3 ). (cdc.gov)
So far, reports on fluoroquinolone resistance in S. pneumoniae have predominantly involved respiratory tract isolates, and whether this type of resistance is emerging among the invasive isolates is unknown. (cdc.gov)
In this study, we evaluated the comparative activities of five fluoroquinolones against invasive isolates of S. pneumoniae from Hong Kong that were collected during a period when fluoroquinolone resistance had increased rapidly among noninvasive respiratory isolates. (cdc.gov)
Cross resistance was found in 4 of 5 antimicrobials for K. pneumoniae, 1 of 2 for C. jejuni, 3 of 5 for S. enterica subsp. (itg.be)

Wild raptor isolates showed similar patterns of antimicrobial resistance when compared with isolates recovered from the captive raptor controls. (vin.com)

the subset of isolates that underwent antimicrobial susceptibility testing for cefiderocol were susceptible to this agent. (cdc.gov)

While tetracyclines, macrolides, lincosamides, and quinolones have historically been used for treatment of infections due to these organisms, acquired resistance is now well documented and varies according to drug, organism, and patient population. (medscape.com)

Several studies have compared fluoroquinolone treatment durations for community-acquired pneumonia (CAP) where the shorter duration was as effective as the longer duration. (medicalnewsbulletin.com)

Antimicrobial prophylaxis in urological procedures is aimed to reduce the risk of local and systemic postoperative infections such as urinary tract infection or surgical site infection. (bcan.org)
However, no recent randomized clinical trial has investigated antimicrobial prophylaxis for TURB. (bcan.org)
Effect of tenofovir-based HIV pre-exposure prophylaxis against HBV infection in men who have sex with men. (stanford.edu)

We determined the susceptibilities of 265 invasive isolates of pneumococci obtained during 1995 to 2001 in Hong Kong to 11 antimicrobial agents and their serotypes. (cdc.gov)
The FDA now enforces regulations in the US requiring testing of certain imported products for antimicrobial agents under Import Alert 16-131. (wikipedia.org)
During targeted sampling, from October 2006 through May 2007, FDA repeatedly found that farm-raised seafood from China was contaminated with antimicrobial agents that are not approved for use in the United States. (wikipedia.org)
We also found isolates belonging to the same clonal type that showed different responses towards drug exposure, thus evidencing that highly related clinical isolates may diverge in the efflux-mediated response to noxious agents. (unl.pt)
International Journal of Antimicrobial Agents. (indjst.org)

Under this premise, a randomized clinical trial is proposed to analyze the current panorama of UTI as a transcendent postoperative complication of TURB, under the context of the new emerging resistance parameters. (bcan.org)
In observational clinical studies, mortality, clinical cure, adverse events, and development of CZA resistance after exposure were generally similar in monotherapy and combination therapy groups. (bvsalud.org)
Pharyngeal and rectal gonorrhea screening can be considered in women based on reported sexual behaviors and exposure, through shared clinical decision making. (cdc.gov)
Personalized LVX therapeutics are necessary for the sake of better safety, clinical success, and avoidance of resistance. (dovepress.com)
Oxacillin-resistance �as confirmed by E-test (AB Biodisc, Laboratory for Sanitary and Clinical Solna, S�eden). (medicinelakex1.com)
This presentation will explain the role of laboratory professionals in detecting B. pseudomallei in clinical specimens and how to plan for possible exposure cases. (cdc.gov)

Anatomy1

Organisms51

Diseases32

Chemicals and Drugs81

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes41

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture5

Information Science5

Named Groups1

Health Care15

Geographicals10

Pathogens14

Prevalence5

Emergence11

Bacteria17

Genes11

Antibiotics18

Susceptibility testing was p2

CHEMOTHERAPY1

Strains8

ESBL8

Mutations3

Cephalosporin4

Drug resistance8

Cephalosporins1

Resistant16

Staphylococcus3

Post exposure pr2

Stewardship3

Escherichia4

Quinolone3

Antibiotic exposure3

Ceftriaxone3

Characterization1

Aureus3

Broad-spectrum1

Carbapenems2

Infection Control1

Pseudomonas5

Hospitalization1

Microbiology1

Ciprofloxacin3

Levofloxacin1

Aminoglycosides1

Compounds1

Genotypic1

Microorganisms2

Swabs1

Molecular1

Commonly2

Mechanisms1

20211

Attributable1

Critically ill1

Pneumoniae4

Isolates showed1

Underwent1

Infections due1

Community-acquired1

Prophylaxis3

Agents5

Clinical6