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  • sequences
  • As a result, hundreds of different natural cationic antimicrobial peptides (CAPs) with widely varying sequences have been described. (asm.org)
  • In this study, we designed a series of hybrid peptides FV7-LL-37 (17-29) (FV-LL), FV7-magainin 2 (9-21) (FV-MA) and FV7-cecropin A (1-8) (FV-CE) by combining the FV7 sequence with the small functional sequences LL-37 (17-29) (LL), magainin 2 (9-21) (MA) and cecropin A (1-8) (CE) which all come from well-described natural peptides. (pubmedcentralcanada.ca)
  • The cDNA sequences encoding all the three peptides were obtained from the cDNA library of scorpion venom gland and were deposited in the GenBank database. (ac.ir)
  • therapeutic
  • It is anticipated that greater understanding of these mechanisms will enable development of more sustainable antimicrobial compounds and new therapeutic approaches to the treatment of S. aureus skin infection and colonization. (mdpi.com)
  • bacterial cells
  • Many compounds act by compromising the mechanical integrity of the bacterial cell envelope, and our study introduces an AFM-based creep deformation technique to evaluate changes in the time-dependent mechanical properties of Pseudomonas aeruginosa PAO1 bacterial cells upon exposure to two different but structurally related antimicrobial peptides. (rsc.org)
  • We also show the validity of the proposed model by investigating the activity of two prototypical linear cationic peptides: magainin 2 amide (which is selective for bacterial cells) and melittin (which targets both mammalian and bacterial cells indiscriminately). (gla.ac.uk)
  • amino
  • These studies suggest that a peptide with these structural properties can be derived de novo by using only a few strategically positioned amino acids. (asm.org)
  • Various modifications such as substitutions of specific amino acids [ 14 ] and truncation of parental peptides [ 15 ] have been employed to improve antimicrobial activity and physiological stability and reduce cytotoxic effects simultaneously. (pubmedcentralcanada.ca)
  • Human being Neutrophil Peptides (HNP1-3) differ from each additional by LODENOSINE IC50 an In- airport terminal amino acid residue and were originally separated from azurophilic granules of neutrophils [12, (healthweeks.com)
  • genes
  • Binary vectors for Agrobacterium -mediated transformation were constructed to express the genes for antimicrobial peptides (APs) of the cectropin-melittin type under the control of the cauliflower mosaic virus 35S RNA promoter in plants. (springer.com)
  • immune system
  • These peptides are rapidly produced by macrophages and epithelial cells in response to infection or injury and can mediate inflammation and stimulate the immune system upon detection of pathogens (Menendez and Brett Finlay, 2007 ). (frontiersin.org)
  • human
  • The binding of a selection of short synthetic cationic antimicrobial peptides (CAPs) to human albumin with binding affinities in the μM range is described. (biomedcentral.com)
  • Human being Neutrophil Peptide 1-4 and Human being Defensin 5 and -6. (healthweeks.com)
  • The most promising peptide, compound 5, was selected and evaluated as an antifungal remedy for Candida albicans candidiasis in a human skin model and for the treatment of Trichophyton rubrum induced onychomycosis in an infected human nail model. (diva-portal.org)
  • In this study, we identify the human cationic peptide LL-37, found in abundance at sites of inflammation, as a potent modifier of DC differentiation, bridging innate and adaptive immune responses. (edu.au)
  • Andersen GN, Hagglund M, Nagaeva O, Frangsmyr L, Petrovska R, Mincheva-Nilsson L et al (2005) Quantitative measurement of the levels of melanocortin receptor subtype 1, 2, 3 and 5 and pro-opio-melanocortin peptide gene expression in subsets of human peripheral blood leucocytes. (springer.com)
  • We recently reported that a cationic peptide, T22 ([Tyr(5,12), Lys(7)]-polyphemusin II), specifically inhibits human immunodeficiency virus type 1 (HIV-1) infection mediated by CXCR4 (T. Murakami et al. (mendeley.com)
  • novo
  • These findings provide fundamental information toward the de novo design of an antimicrobial peptide useful for the management of infectious diseases. (asm.org)
  • alligator
  • Also, the number of cationic peptides hydrogel particles harvested from alligator serum was strongly influenced by the chemical structure of methacrylamide monomers and composition of the harvesting shell. (techconnectworld.com)
  • The effective parameters were then applied in the analysis of a complex mixture of peptides harvested from American alligator plasma using custom-made (Bioprospector) functionalized hydrogel particles. (nih.gov)
  • CAPs
  • Molecular models of the complexes between the peptides and albumin were constructed using docking experiments, and support the binding hypothesis and confirm the overall binding affinities of the CAPs. (biomedcentral.com)