Background: Fluoroquinolone (FQ) antibiotics are among the most potent second-line antitubercular drugs these days. (bvsalud.org)
Causative3
Considering the inefficacy and the high toxicity of the currently used drugs for the treatment of these infectious diseases, as well as the emergence of drug-resistant strains of the causative organisms, the development of new leishmanicidal and antitubercular agents is extremely important. (springeropen.com)
However, in the case of Mycobacterium tuberculosis ( Mtb ), the causative agent of tuberculosis (TB), Mtb -mediated drug metabolism plays a significant role in treatment outcomes. (nature.com)
and M. microti , the causative agent of TB in voles. (nature.com)
Development of new1
Considering the range of chemical reactions involved in the biosynthetic pathways of Mtb , information related to the biotransformation of antitubercular compounds would provide opportunities for the development of new chemical tools to study successful TB infections while also highlighting potential areas for drug discovery, host-directed therapy, dose optimization and elucidation of mechanisms of action. (nature.com)
Drugs1
So, in continuing our research of antileishmanial and antitubercular drugs, aminoquinoline/steroid conjugates ( 12 , 13, and 14) were regioselectively synthesized via 1, 3-dipolar cycloaddition of alkynes 3, 5 , and 7 with azide 12 . (springeropen.com)