FluorouracilChemotherapyPyrimidineToxicity of floxuridineNucleosideIntra-ArterialMetabolismDrugsINJECTIONLiverPOWDERClassListEffectsFUDRPyrimidine analogChemotherapyIntra-arterial infusionInfusionsSystemic therapyInfusionInjectionEnzymeDeoxyuridinePowderSynthesisPregnantHarmClassHttpsAgentsStomachTreatmentWorksPatientsIncreaseNormal
Fluorouracil6
- tell your doctor and pharmacist if you are allergic to floxuridine, fluorouracil, any other medications, or any of the ingredients in floxuridine injection. (medlineplus.gov)
- Nucleobase analogues Fluorouracil (5FU), which inhibits thymidylate synthase Floxuridine (FUDR) 6-azauracil (6-AU) Nucleoside analogues Cytarabine (Cytosine arabinoside) Gemcitabine Nucleotide analogues Pyrimidine Fluorouracil Floxuridine Gemcitabine Pyrimidine antimetabolites are commonly used to treat cancer by interfering with DNA replication. (wikipedia.org)
- Other examples include antagonists of purines (azathioprine, mercaptopurine, and thioguanine) and antagonists of pyrimidine (fluorouracil and floxuridine). (longdom.org)
- However, the application of floxuridine-deoxy-ribose (FUDR), a prodrug of 5-fluorouracil (5-FU) with a high liver extraction fraction, into the hepatic artery can cause several complications. (biomedcentral.com)
- In this study, we tested the inhibitory effects of six pyrimidine analogs (5-fluorouracil, floxuridine, 5'-deoxy-5-fluorouridine, 5-fluorouridine, gemcitabine, and cytarabine) on wild-type CU428 and conditional mutant NP1 Tetrahymena thermophila at room temperature and the restrictive temperature (37°C) where NP1 does not form the oral apparatus. (bvsalud.org)
- We found that the inhibitory effects from 5-fluorouracil could be reversed by uracil and thymine, from floxuridine could be reversed by thymidine, and from 5'-deoxy-5-fluorouridine could be reversed by uracil. (bvsalud.org)
Chemotherapy4
- Floxuridine injection should be given only under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. (medlineplus.gov)
- There are many types of chemotherapy drugs, including alkylating agents and antimetabolites. (medicalnewstoday.com)
- Hepatic artery infusion involves the continuous flow of floxuridine, a chemotherapy drug classified as an "antimetabolite" that destroys cancer cells by tricking them into thinking it is one of their genetic building blocks: RNA and DNA. (ucdavis.edu)
- We present two patients who developed this complication after placement of a catheter system into the gastroduodenal artery and initiation of regional chemotherapy with floxuridine. (biomedcentral.com)
Pyrimidine1
- Pyrimidine analogues are antimetabolites which mimic the structure of metabolic pyrimidines. (wikipedia.org)
Toxicity of floxuridine2
- palifermin increases toxicity of floxuridine by Other (see comment). (medscape.com)
- Pseudoaneurysms usually occur after mechanical damage of the vessel wall, but the chemical toxicity of floxuridine may add to the development of vascular impairment. (biomedcentral.com)
Nucleoside1
- It is a purine nucleoside antimetabolite . (bionity.com)
Intra-Arterial1
- when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. (curehunter.com)
Metabolism1
- Sulfanilamides, for example, are antimetabolites that disrupt bacterial, but not human, metabolism and are used to eradicate bacterial infections in humans. (longdom.org)
Drugs1
- Antimetabolites are drugs that interfere with one or more enzymes or their reactions that are necessary for DNA synthesis. (longdom.org)
INJECTION3
- Your doctor may not want you to receive floxuridine injection. (medlineplus.gov)
- You should not become pregnant or breast-feed while you are receiving floxuridine injection. (medlineplus.gov)
- If you become pregnant while receiving floxuridine injection, call your doctor. (medlineplus.gov)
Liver1
- Floxuridine is used to treat cancer of gastrointestinal (GI) tract (cancer of the stomach or intestines) that has spread to the liver. (medlineplus.gov)
POWDER1
- Floxuridine comes as a powder to be mixed with liquid to be continuously injected intra-arterially (into an artery) that supplies blood to the tumor. (medlineplus.gov)
Class1
- Floxuridine is in a class of medications called antimetabolites. (medlineplus.gov)
List1
- Many other medications may also interact with floxuridine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (medlineplus.gov)
Effects2
- floxuridine decreases effects of adenovirus types 4 and 7 live, oral by pharmacodynamic antagonism. (medscape.com)
- floxuridine decreases effects of influenza virus vaccine quadrivalent, adjuvanted by pharmacodynamic antagonism. (medscape.com)
FUDR6
- As well, the monophosphate of floxuridine, 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) inhibits the enzyme thymidylate synthetase. (wikipedia.org)
- Floxuridine first gained FDA approval in December 1970 under the brand name FUDR. (wikipedia.org)
- In contrast, fluorouracil (5-FU) and floxuridine (FUDR) have more typical antineoplastic activity and are important agents in regimens for several solid tumors. (nih.gov)
- Published in Cell , the study by Marian Walhout, PhD, and colleagues show that when a common research model, the roundworm Caenorhabditis elegan, is fed a diet of E. coli bacteria, the worms were one hundred times more sensitive to the chemotherapy drug floxuridine (FUDR) than worms who were fed different bacteria. (news-medical.net)
- One of these drugs was the antimetabolite FUDR, used to treat colon cancer. (news-medical.net)
- Intrahepatic artery infusion of fluorouracil is also associated with serum aminotransferase elevations or chemical hepatitis (in 5% to 7% of cases) and in biliary abnormalities, but it rarely causes biliary strictures or the sclerosing cholangitis-like syndrome that is common with floxuridine (FUDR) treatment. (nih.gov)
Pyrimidine analog2
- Specifically, floxuridine is a pyrimidine analog, classified as a deoxyuridine. (wikipedia.org)
- Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of cell division. (wikipedia.org)
Chemotherapy3
- Floxuridine injection should be given only under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. (medlineplus.gov)
- Apart from its use in chemotherapy, floxuridine is also used in aging research employing a C. elegans model, namely to stop growth and to prevent reproduction. (wikipedia.org)
- It is recommended that floxuridine be given only by or under the supervision of a qualified physician who is experienced in cancer chemotherapy and intra-arterial drug therapy and is well versed in the use of potent antimetabolites. (nih.gov)
Intra-arterial infusion4
- However, when floxuridine is given by continuous intra-arterial infusion its direct anabolism to floxuridine-monophosphate is enhanced, thus increasing the inhibition of DNA. (nih.gov)
- Pharmacokinetic data on intra-arterial infusion of floxuridine are not available. (nih.gov)
- Floxuridine for Injection, USP is effective in the palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means. (nih.gov)
- when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. (nih.gov)
Infusions1
- A second unique pattern of injury occurs with hepatic artery infusions of floxuridine, which can cause scarring and inflammation of the gallbladder and bile ducts manifested by acute, acalculous cholecystitis or by severe, high grade biliary strictures. (nih.gov)
Systemic therapy1
- However, one must incorporate antimetabolite systemic therapy into the picture. (oncolink.org)
Infusion1
- The quality of life and survival rates of individuals that receive continuous hepatic artery infusion of floxuridine for colorectal cancer metastases is significantly higher than control groups. (wikipedia.org)
Injection4
- Your doctor may not want you to receive floxuridine injection. (medlineplus.gov)
- You should not become pregnant or breast-feed while you are receiving floxuridine injection. (medlineplus.gov)
- If you become pregnant while receiving floxuridine injection, call your doctor. (medlineplus.gov)
- Each vial contains 500 mg of floxuridine which is to be reconstituted with 5 mL of sterile water for injection. (nih.gov)
Enzyme1
- This, coupled with the information that patients with a defective enzyme in breaking down 6-MP had a higher propensity in developing secondary brain tumors (43% versus 8% at 8 years), leads one to believe that the intensification of antimetabolite therapy plays a very large role in the adverse outcomes described in this paper. (oncolink.org)
Deoxyuridine1
- An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. (bvsalud.org)
Powder1
- Floxuridine comes as a powder to be mixed with liquid to be continuously injected intra-arterially (into an artery) that supplies blood to the tumor. (medlineplus.gov)
Synthesis1
- These agents are nucleoside analogues and are considered antimetabolites, interfering or competing with nucleoside triphosphates in the synthesis of DNA or RNA or both. (nih.gov)
Pregnant2
- Floxuridine may cause fetal harm when administered to a pregnant woman. (nih.gov)
- There are no adequate and well-controlled studies with floxuridine in pregnant women. (nih.gov)
Harm1
- Floxuridine may harm the fetus. (medlineplus.gov)
Class2
- Floxuridine is in a class of medications called antimetabolites. (medlineplus.gov)
- Floxuridine (also 5-fluorodeoxyuridine) is an oncology drug that belongs to the class known as antimetabolites. (wikipedia.org)
Https2
- 2023. https://www.drugguide.com/ddo/view/Davis-Drug-Guide/51309/all/floxuridine. (drugguide.com)
- 2023. https://peds.unboundmedicine.com/pedscentral/view/Davis-Drug-Guide/51309/all/floxuridine. (unboundmedicine.com)
Agents1
- Floxuridine should be used with extreme caution in poor risk patients with impaired hepatic or renal function or a history of high-dose pelvic irradiation or previous use of alkylating agents. (nih.gov)
Stomach1
- Floxuridine can also be prescribed for the treatment of kidney and stomach cancers. (wikipedia.org)
Treatment1
- The latter is brought about by treatment of larvae close to maturity with low doses of floxuridine that, even though allowing normal maturation, causes reproducing individuals to lay eggs that are unable to hatch. (wikipedia.org)
Works1
- Floxuridine primarily works by stopping the growth of newly born cells. (wikipedia.org)
Patients1
- Floxuridine therapy is contraindicated for patients in a poor nutritional state, those with depressed bone marrow function or those with potentially serious infections. (nih.gov)
Increase2
- fexinidazole and floxuridine both increase QTc interval. (medscape.com)
- floxuridine and pexidartinib both increase Other (see comment). (medscape.com)
Normal1
- Antimetabolites masquerade as pyrimidine-like molecules which prevents normal pyrimidines from being incorporated into DNA during the S phase of the cell cycle. (wikipedia.org)