Loading...
  • metabolite
  • 1. a substance bearing a close structural resemblance to one required for normal physiological functioning, and exerting its effect by interfering with the utilization of the essential metabolite. (thefreedictionary.com)
  • an·ti·me·tab·o·lite/ ( an″te- ) ( an″ti-mĕ-tab´o-līt ) a substance bearing a close structural resemblance to one required for normal physiological functioning, and exerting its effect by interfering with the utilization of the essential metabolite. (thefreedictionary.com)
  • mitosis
  • By common usage, the term chemotherapy has come to connote the use of rather non-specific intracellular poisons , especially related to inhibiting the process of cell division known as mitosis , and generally excludes agents that more selectively block extracellular growth signals (i.e. blockers of signal transduction ). (wikipedia.org)
  • They interfere with mitosis, resulting in chromosomal damage, mutation & suppression of normal immune response, by interfering with DNA cross-linkage. (slideplayer.com)
  • 3 Alkaloids: -These agents block microtubular precipitation which is necessary for mitosis, i.e. they bind with the tubulin thus interfere with the assembly of spindle proteins during mitosis. (slideplayer.com)
  • proteins
  • We have restricted the in- nitrosoureas, triazenes, platinum compounds and clusion of new compounds to those under clinical Non-specificDNA break: chemotherapyDNA-related proteins: chemotherapySpecificHormonal therapy, retinoidsInterferon aGene therapy Membrane receptorsExtracellular domain: MoAbIntracellular domain: small moleculesCytoplasmIntracellular pathways: small moleculesTubulin: chemotherapy * In this group, antisense therapy might also be developed in the future. (medpdffinder.com)
  • apoptosis
  • To a large extent, chemotherapy can be thought of as a way to damage or stress cells, which may then lead to cell death if apoptosis is initiated. (wikipedia.org)
  • immunosuppression
  • Other uses of cytostatic chemotherapy agents (including the ones mentioned below) are the treatment of autoimmune disease s such as multiple sclerosis and rheumatoid arthritis and the suppression of transplant rejection s (see immunosuppression and DMARD s). (askdefine.com)
  • cells
  • Chemotherapy, in its most general sense, refers to treatment of disease by chemicals that kill cells, specifically those of micro-organisms or cancer . (askdefine.com)
  • agents
  • Furthermore, we characterize a set of 17 antimetabolite agents in various contexts to investigate determinants of sensitivity to these agents. (biomedcentral.com)
  • This study comprehensively evaluated thousands of molecular features in their ability to act as predictive markers of sensitivity and found the TP53 mutational status as the most dominant marker for antimetabolite agents such as 5-FU and Gemcitabine. (biomedcentral.com)
  • It remains to be investigated whether any differences among antimetabolite agents can be captured in gene expression signatures of response and whether such gene expression signatures can add to our power of distinguishing subtypes with heterogeneous therapeutic outcome. (biomedcentral.com)
  • human
  • Here, we introduce a computational method for identifying gene expression signatures of response to chemotherapies and apply it to human tumors and cancer cell lines. (biomedcentral.com)
  • apply
  • The targeted-therapy revolution has arrived, but the principles and limitations of chemotherapy discovered by the early researchers still apply. (askdefine.com)