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  • Gemcitabine
  • This study comprehensively evaluated thousands of molecular features in their ability to act as predictive markers of sensitivity and found the TP53 mutational status as the most dominant marker for antimetabolite agents such as 5-FU and Gemcitabine. (biomedcentral.com)
  • activity
  • Summary  The novel agent Irofulven (HMAF, NSC 683863) has demonstrated significant antitumor activity against solid tumors in various xenograft models and human clinical trials. (ebscohost.com)
  • The investigators assume similar antitumor activity in both arms. (clinicaltrials.gov)
  • Some authors have tested continuous administration schedules of capecitabine, showing better tolerance and apparently similar antitumor activity. (clinicaltrials.gov)
  • commonly
  • Antimetabolites, particularly mitomycin C (MMC), are commonly used in America and Japan as an addition to trabeculectomy , a surgical procedure to treat glaucoma . (wikipedia.org)
  • among
  • It remains to be investigated whether any differences among antimetabolite agents can be captured in gene expression signatures of response and whether such gene expression signatures can add to our power of distinguishing subtypes with heterogeneous therapeutic outcome. (biomedcentral.com)