AntibioticsGemcitabineChemotherapyAntineoplastic agentPotent antitumor activityAlkylating AgentsTumorNucleosideDrugsMethotrexateInhibitsMitomycinToxicityActivityCell'sAgentsTherapeuticPyrimidinesSubstancesReplicationCompoundsTreatmentsCellsShownGemcitabineInhibitorsInterfereMethotrexateAnticancerAnaloguesImmunosuppressiveHydroxyureaMetabolitesBone marrowCellularEffectsHumanCombination
Antibiotics7
- Antimetabolites may also be antibiotics, such as sulfanilamide drugs, which inhibit dihydrofolate synthesis in bacteria by competing with para-aminobenzoic acid (PABA). (wikipedia.org)
- Antitumor antibiotics are a class of antimetabolite drugs that are cell cycle nonspecific. (wikipedia.org)
- Examples of anthracyclines include: Daunorubicin Doxorubicin (Adriamycin®) Epirubicin Idarubicin Anti-tumor antibiotics that are not anthracyclines include: Actinomycin-D Bleomycin Mitomycin-C Mitoxantrone Phototrexate Antimetabolites, particularly mitomycin C (MMC), are commonly used in America and Japan as an addition to trabeculectomy, a surgical procedure to treat glaucoma. (wikipedia.org)
- Antitumor antibiotics prevent cell division by either binding to DNA to prevent the cells from duplicating or inhibiting RNA synthesis. (lls.org)
- Special considerations with anthracycline antitumor antibiotics? (freezingblue.com)
- Anthracycline antitumor antibiotics have a unique AE. (freezingblue.com)
- The presence of antitumor antibiotics within the structure of DNA induced failure to replicate DNA, impaired protein production through interference with transcription of messenger RNA, and chromosomal strand breaks caused by interference with the unwinding of DNA via topoisomerase. (vin.com)
Gemcitabine8
- Examples of cancer drug antimetabolites include, but are not limited to the following: 5-Fluorouracil (5-FU) 6-Mercaptopurine (6-MP) Capecitabine (Xeloda®) Cytarabine (Ara-C®) Floxuridine Fludarabine Gemcitabine (Gemzar®) Hydroxycarbamide Methotrexate Pemetrexed (Alimta®) Phototrexate Anti-metabolites masquerade as a purine (azathioprine, mercaptopurine) or a pyrimidine, chemicals that become the building-blocks of DNA. (wikipedia.org)
- The antimetabolite gemcitabine remains part of the standard of care but shows very limited antitumor efficacy. (nih.gov)
- We investigated the ability of the ATR inhibitor, AZD6738, to prevent the gemcitabine-induced intra-S-phase checkpoint activation and evaluated the antitumor potential of this combination in vitro and in vivo In PDAC cell lines, AZD6738 inhibited gemcitabine-induced Chk1 activation, prevented cell-cycle arrest, and restrained RRM2 accumulation, leading to the strong induction of replication stress markers only with the combination. (nih.gov)
- Gemcitabine is widely used as an antitumor agent in research labs and clinics. (transparencymarketresearch.com)
- Gemzar [gemcitabine hydrochloride (HCL)] is a nucleoside metabolic inhibitor that exhibits antitumor activity. (transparencymarketresearch.com)
- Here in this study, we screened a panel of chemotherapeutic agents for their possible antitumor activity in high-grade meningioma and discovered that high-grade meningioma cells show a preferential sensitivity to antimetabolites, in particular, to gemcitabine. (oncotarget.com)
- Together, our data demonstrate that gemcitabine exerts potent antitumor activity against high-grade meningioma through cytostatic and cytotoxic mechanisms. (oncotarget.com)
- The antimetabolite gemcitabine (Gem) is the most widely used form of chemotherapy for pancreatic cancer treatment, but is known to produce significant side effects when administered systemically. (ox.ac.uk)
Chemotherapy3
- thus, competitive inhibition can occur, and the presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer. (wikipedia.org)
- There are many types of chemotherapy drugs, including alkylating agents and antimetabolites. (medicalnewstoday.com)
- Base excision repair (BER) of DNA repair pathway has been implicated in resistance to both alkylating and antimetabolite chemotherapy. (survivornet.com)
Antineoplastic agent1
- It is an antimetabolite and antineoplastic agent. (transparencymarketresearch.com)
Potent antitumor activity1
- Considerable progress has been made in the search for novel nucleoside structures with anticancer and/or antiviral activity by modifications in the nucleobase and/or in the sugar moiety and several branched-chain sugar nucleosides have shown potent antitumor activity. (unicam.it)
Alkylating Agents1
- Drugs that exert their influence during a specific phase(s) of the cell cycle are called Cell cycle -specific (CCS) drugs and include antimetabolites, some alkylating agents and vinca alkaloids. (studylib.net)
Tumor4
- Antimetabolites can be used in cancer treatment, as they interfere with DNA production and therefore cell division and tumor growth. (wikipedia.org)
- For example, antimetabolites prevent tumor growth and the reproduction of certain body tissues with fast division rates such as gastrointestinal lining, hematopoietic cells and hair follicles. (studyproessay.com)
- CS-682 (1-(2-C-cyano-2-deoxy-β-D-arabino-pentofuranosyl)-N 4 -palmitoylcytosine) is a novel orally administered 2′-deoxycytidine-type antimetabolite, which has a wide spectrum of antitumor activity in human tumor xenograft models. (elsevierpure.com)
- To further investigate the structural determinants of 3'-Me-Ado required for the antitumor activity, in the first part of my PhD project, a number of 3'-C-methyl ribonucleosides with different purinic and pyrimidinic nucleobases and the 3'-C-methyl derivatives of the antitumor agents 5-fluorouridine and 9-( β-D-arabinofuranosyl)- adenine were synthesized and evaluated on human tumor cell lines. (unicam.it)
Nucleoside1
- It is a purine nucleoside antimetabolite . (bionity.com)
Drugs3
- Antimetabolite drugs are commonly used to treat leukemia, cancers of the breast, ovary, and the gastrointestinal tract, as well as other types of cancers. (wikipedia.org)
- In the Anatomical Therapeutic Chemical Classification System antimetabolite cancer drugs are classified under L01B. (wikipedia.org)
- These drugs are called antimetabolites. (webmd.com)
Methotrexate1
- Methotrexate is an antimetabolite that interferes with folate metabolism. (medscape.com)
Inhibits3
- An antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. (wikipedia.org)
- For example, a specific antimetabolite drug inhibits the enzyme such and such that is necessary for DNA replication. (studyproessay.com)
- Another useful antimetabolite is L-asparaginase, an enzyme that inhibits lymphoma cells with an absolute requirement for the pre-formed amino acid asparagine. (vin.com)
Mitomycin1
- Intraoperative antimetabolite application, namely mitomycin C (MMC) and 5-fluorouracil (5-FU), is currently being tested for its effectiveness of managing pterygium. (wikipedia.org)
Toxicity2
- We conducted a phase I study to define the toxicity, pharmacokinetics and antitumor activity of CS-682 in patients with advanced solid tumors. (elsevierpure.com)
- This chemical not only had antitumor activity in mice but it also produced remissions, without undue toxicity, in children who had acute leukemia. (cuny.edu)
Activity5
- Its antitumour activity is believed to be due to 3 mechanisms. (rxreasoner.com)
- Pemetrexed (Alimta) possesses broad antitumor activity. (cancernetwork.com)
- A previous structure-activity relationship study reported by us, identified the 3'-C-methyladenosine (3'-Me-Ado) as a mechanism-based RNR inhibitor endowed with a significant antitumor activity against a panel of human leukemia and carcinoma cell lines. (unicam.it)
- The biological results showed that the structure of 3'-Me-Ado is crucial for the antitumor activity of this type of ribose-modified nucleosides. (unicam.it)
- A further structure-activity relationship study of synthesized adenine 3'-C-methylribonucleosides containing different substituent at N6-amino group of nucleobase such as a cycloalkyl, aryl or heteroaryl group confirmed that any modification in the structure of 3'-Me-Ado is detrimental for the antitumor activity. (unicam.it)
Cell's1
- Antimetabolites stop a cell's DNA from duplicating, bringing cell reproduction to a halt. (reidhealth.org)
Agents2
- Two antimetabolites cause myeolosuppression that can be staved off with the administration of other agents. (freezingblue.com)
- These agents behave as antimetabolites that interact with a number of intracellular targets blocking the DNA chain elongation or interfering with biosynthesis of nucleosides and nucleotides, a limiting process in cell proliferation. (unicam.it)
Therapeutic1
- OXD-T antimetabolite with different therapeutic doses of administration affected the growth of hepatocellular carcinoma. (walshmedicalmedia.com)
Pyrimidines1
- Antimetabolites act during the S phase of the cell cycle, usually by mimicking normal purines and pyrimidines, which are the building blocks of DNA. (vin.com)
Substances1
Replication3
- Antimetabolites generally impair DNA replication machinery, either by incorporation of chemically altered nucleotides or by depleting the supply of deoxynucleotides needed for DNA replication and cell proliferation. (wikipedia.org)
- Because of this mode of action, most antimetabolites have high cell cycle specificity and can target arrest of cancer cell DNA replication. (wikipedia.org)
- Ataxia telangiectasia and Rad3-related protein (ATR), the apical kinase of the intra-S-phase DNA damage response, plays a central role in safeguarding cells from replication stress and can therefore limit the efficacy of antimetabolite drug therapies. (nih.gov)
Compounds1
- Both compounds proved to have an antitumor effect which was significantly enhanced in combination with insulin. (oncotarget.com)
Treatments1
- Calcitriol has been studied in various combination treatments and shown synergistic or additive antitumor activities. (jcancer.org)
Cells1
Shown1
- Antimetabolites have been shown to decrease fibrosis of operative sites. (wikipedia.org)
Gemcitabine2
- Examples of cancer drug antimetabolites include, but are not limited to the following: 5-Fluorouracil (5-FU) 6-Mercaptopurine (6-MP) Capecitabine (Xeloda®) Cytarabine (Ara-C®) Floxuridine Fludarabine Gemcitabine (Gemzar®) Hydroxycarbamide Methotrexate Pemetrexed (Alimta®) Phototrexate Anti-metabolites masquerade as a purine (azathioprine, mercaptopurine) or a pyrimidine, chemicals that become the building-blocks of DNA. (wikipedia.org)
- The TFO-directed UDS facilitated incorporation of the antimetabolite, gemcitabine (GEM), into the damaged oncogene, thereby potentiating the anti-tumor activity of GEM. (nih.gov)
Inhibitors4
- 7. [Combined antitumor therapy with polyamine biosynthesis inhibitors and mitomycin C]. (nih.gov)
- 18. [Antitumor effects of polyamine synthesis inhibitors based on major premise of treatment for human malignant tumor]. (nih.gov)
- The majority of chemotherapeutic drugs can be separated in to alkylating agents, antimetabolites, anthracyclines, plant alkaloids, topoisomerase inhibitors, and other antitumor agents. (radiation-therapy-review.com)
- In view of the role that TKs seem to play in the regulation of cellular metabolism [ 8 , 9 , 10 , 11 ], it is crucial to determine whether the antitumor activity of particular tyrosine kinase inhibitors (TKIs) is related to their effect at a given metabolic level. (biomedcentral.com)
Interfere3
- Antimetabolites can be used in cancer treatment, as they interfere with DNA production and therefore cell division and tumor growth. (wikipedia.org)
- Antimetabolites interfere with DNA and RNA by acting as a substitute for the normal building blocks of RNA and DNA. (cancer.org)
- Many of the antimetabolites used in the treatment of cancer interfere with the production of the nucleic acids, RNA and DNA. (cancerquest.org)
Methotrexate1
- and an antimetabolite, methotrexate. (researchgate.net)
Anticancer3
- 2. [Anticancer treatment with a combination of antimetabolites of polyamine and pyrimidine]. (nih.gov)
- 15. A novel anticancer treatment for xenoplanted human gastric cancer using polyamine antimetabolites in a low polyamine diet. (nih.gov)
- Classic antimetabolite anticancer drug with chemical structure similar to endogenous intermediates or building blocks of DNA or RNA synthesis. (medscape.com)
Analogues2
- Antitumor drug from the group of antimetabolites - analogues of folic acid. (ru-pills.com)
- Gold(I) analogues of a platinum-acridine antitumor agent are only moderately cytotoxic but show potent activity against Mycobacterium tuberculosis. (wakehealth.edu)
Immunosuppressive1
- Along with antitumor, it has immunosuppressive action. (ru-pills.com)
Hydroxyurea2
- Treatment for essential thrombocytosis (primary thrombocythemia) commonly includes the use of hydroxyurea, which is an antimetabolite similar in structure to naturally occurring compounds required for normal cell function. (medscape.com)
- Hydroxyurea capsules are used alone or in conjunction with other antitumor agents or radiation therapy to treat neoplastic diseases. (nih.gov)
Metabolites1
- In the cell, antimetabolites are mistaken for the metabolites they resemble, and are processed in the cell in a manner analogous to the normal compounds. (cancerquest.org)
Bone marrow1
- Tumors and healthy cells with high growth fractions (eg, bone marrow) are sensitive to inhibition by the antimetabolites. (medscape.com)
Cellular2
- This structural similarity allows many of the antimetabolites to serve as substrates for important cellular enzymes. (medscape.com)
- There are several different cellular targets for antimetabolites. (cancerquest.org)
Effects1
- 13. [Antitumor effects of polyamine antimetabolites with polyamine-free diet]. (nih.gov)
Human1
- 5. [Combined therapy of polyamine antimetabolite and nitrosourea in human gastric cancer]. (nih.gov)
Combination1
- 3. Enhanced antitumor efficacy with a combination of hyperthermochemotherapy and thermosensitization with polyamine antimetabolites in nude mice. (nih.gov)