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  • 2016
  • 2016) " Metabolite identification of the antimalarial piperaquine in vivo using liquid chromatography-high resolution mass spectrometry in combination with multiple data-mining tools in tandem ," doi: 10.1002/bmc.3689. (thermofisher.com)
  • vivo
  • Other investigations are planned to seek confirmation of these results and find out accurate information on this antimalarial activity in vivo, using infected rodent models, and to attempt to unravel phloeodictines' action mechanism. (innovations-report.com)
  • pyrimethamine
  • This led the World Health Organization (WHO) to recommend a package of affordable interventions including the use of the insecticide-treated nets (ITNs), the intermittent presumptive treatment (IPT) with sulfadoxine-pyrimethamine (SP), and the effective case management of clinical malaria with recommended antimalarials. (hindawi.com)
  • parasite
  • Several factors influence the emergence and spread of drug resistant malaria parasites, including the number of parasites exposed to a drug, the drug concentration to which the parasites are exposed, and the simultaneous presence of other antimalarials in the blood to which the parasite is not resistant. (who.int)
  • One particularly exciting aspect of this discovery is this new molecule' s ability to rapidly kill off all traces of the parasite, acting at least as fast as the best currently available antimalarial drug, ' said Dr Fuchter. (reportbuyer.com)
  • However, the work of Walter and Eliza Hall Institute researchers Dr Wilson Wong, Dr Jake Baum and colleagues in showing how emetine attaches to and blocks the molecular machinery that makes the proteins required for malaria parasite survival has revealed new approaches for antimalarial drug development. (eurekalert.org)
  • efficacious
  • In areas where the recommended antimalarial treatments remain fully efficacious, correct medicine use must be promoted, with special attention to expanding diagnostic testing, quality-assured treatment, and good patient adherence to the prescribed treatment. (who.int)
  • programme
  • Scientists specialized in natural substances, investigating the chemical structure and properties of the phloeodictines as part of the French malaria control research programme Pal +, have revealed antimalarial activity among phloeodictines extracted from the reef sponge Oceanapia fistulosa. (innovations-report.com)
  • researchers
  • A new book by researchers at the World Agroforestry Centre (ICRAF) and the Kenya Medical Research Institute (KEMRI), Common Antimalarial Trees and Shrubs of East Africa, provides a detailed assessment of 22 of the region's malaria-fighting trees and shrubs. (biologynews.net)
  • According to researchers, not all species of antimalarial trees are at risk, particularly those that grow wild in lowland and coastal areas. (biologynews.net)
  • potential
  • A team of scientists from the University of Cape Town's (UCT) Drug Discovery and Development Centre (H3-D) in South Africa, led by Prof. Kelly Chibale then scrutinised and explored the antimalarial potential of the series further. (innovations-report.com)
  • Mimicking the intramolecular hydrogen Bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents. (edu.au)
  • Research
  • Qinghaosu Antimalarial Coordinating Research Group. (springer.com)
  • Research released in anticipation of World Malaria Day finds that plants in East Africa with promising antimalarial qualities-ones that have treated malaria symptoms in the region's communities for hundreds of years-are at risk of extinction. (biologynews.net)
  • Antimalarial drug research and development (R&D) programmes are in operation across Europe and throughout the world, but too often these initiatives are uncoordinated and time and money is spent going over old ground. (eurekalert.org)
  • We will look at the global status of antimalarial drug discovery and use that information to ensure that the research agenda for antimalarials in Europe over the next decade is properly aligned with what's going on elsewhere in the world. (eurekalert.org)
  • identify
  • Scientists in the field have been able to identify at-risk tree species, including those that have antimalarial qualities, by monitoring deforestation in the region and by talking to herbalists and local communities. (biologynews.net)