DiseasesChemicals and Drugs
CyclizineHistamine H1 AntagonistsTriprolidineHistamine H1 Antagonists, Non-SedatingPerphenazineAntiemeticsCetirizineLoratadinePostoperative Nausea and VomitingHistamine AntagonistsChlorpheniramineTerfenadineUrticariaAstemizole
DimenhydrinatePiperazineMeclizineAntiemetic50mgMarezineInverse agonistsNauseaTabletsBuclizinePromethazineMechanism of actCinnarizineHydrochlorideAnticholinergicClinicallyReceptorPrescribeMedicinesMedicationsMotion sicknessPregnancyAstemizoleVestibularAntivertigoSymptomsHigh dosesDrugOralPeripheral histamineCombinationAllergiesAllergicCoughDrugsActionSicknessTreatMedicineSecond-generationEffectsSafe
Dimenhydrinate3
  • Antihistamines (like dimenhydrinate, cyclizine): these may reduce nausea after surgery, but they make little or no difference to nausea and vomiting during surgery and vomiting after surgery. (cochrane.org)
  • Dimenhydrinate, diphenhydramine, cyclizine, or meclizine: take 1 hour before departure and continue during the trip. (tripprep.com)
  • Four over-the-counter medications that are approved in the US for this use are cyclizine (Marezine), dimenhydrinate (Dramamine), diphenhydramine (Benadryl), and meclizine (Bonine and Dramamine II). (tripprep.com)
Piperazine5
  • Cyclizine is a piperazine derivative with histamine H1-receptor antagonist (antihistamine) activity. (wikipedia.org)
  • Piperazine nucleus is found in many marketed drugs in the realm of antidepressants (amoxapine), antipsychotics (bifeprunox), antihistamines (cyclizine and oxatomide), antifungals (itraconazole), antibiotics (ciprofloxacin), etc . (rsc.org)
  • Piperazine ring-based compounds find their application in biological systems with antihistamine, anticancer, antimicrobial and antioxidant properties. (rsc.org)
  • Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. (pharmacycode.com)
  • First-generation antihistamine, piperazine derived drug with mild sedative effect. (drlact.com)
Meclizine2
  • Cyclizine was marketed as Bonine for Kids in the US, but was discontinued in 2012, and replaced with meclizine. (wikipedia.org)
  • MECLIZINE (Antivert�, Bonine�) is an antihistamine. (pharmacycode.com)
Antiemetic4
  • Cyclizine was quickly clinically found as a potent and long-acting antiemetic. (wikipedia.org)
  • Cyclizine was introduced to many countries as a common antiemetic. (wikipedia.org)
  • Cyclizine is an antihistamine drug used primarily for its anti-nausea and antiemetic actions. (medsnow.co.uk)
  • Mechanism of Action of Cyclizine Cyclizine produces Antiemetic action by its central action on Chemoreceptor trigger zone (CTZ). (rosheta.com)
50mg3
  • Cyclizine Hcl 50mg. (rosheta.com)
  • You can buy cyclizine 50mg tablets to treat most forms of nausea, however this article will be taking a look at when Cyclizine will be prescribed during pregnancy, how safe it is to take during pregnancy and who this medicine is suitable for? (medicinedirect.co.uk)
  • For treating nausea and vomiting during pregnancy, the recommended dose is Cyclizine 50mg up to 3 times daily as per NICE guidelines . (medicinedirect.co.uk)
Marezine1
  • As cyclizine hydrochloride tablets and cyclizine lactate solution for intramuscular or intravenous injection (brand names: Valoid in UK and South Africa and Marezine, Marzine and Emoquil in US). (wikipedia.org)
Inverse agonists3
  • It has been discovered that these H 1 -antihistamines are actually inverse agonists at the histamine H 1 -receptor, rather than antagonists per se . (wikidoc.org)
  • H 1 -antihistamines refer to compounds that inhibit the activity of the H 1 receptor.Since the H 1 receptor exhibits constitutive activity, H 1 -antihistamines can be either neutral receptor antagonists or inverse agonists. (illnesshacker.com)
  • The vast majority of marketed H 1 -antihistamines are receptor antagonists and only a minority of marketed compounds are inverse agonists at the receptor.Clinically, H 1 -antihistamines are used to treat allergic reactions and mast cell-related disorders. (illnesshacker.com)
Nausea11
  • Cyclizine, sold under a number of brand names, is a medication used to treat and prevent nausea, vomiting and dizziness due to motion sickness or vertigo. (wikipedia.org)
  • Gastroenteritis (diarrhea, nausea, vomiting) can occur with the ethanolamine class of antihistamines. (medscape.com)
  • Although ginger does not prevent motion sickness, it may reduce nausea without the sedation caused by antihistamines. (tripprep.com)
  • Cyclizine is an effective medicine used to treat nausea caused by vertigo, travelling, inner and middle ear problems, radiotherapy treatment, or after a surgery where general anaesthetic has been used. (medsnow.co.uk)
  • Cyclizine tablets, sold under a number of brand names, is a medication used to prevent and treat seasickness (nausea while travelling), nausea and vomiting after surgery or radiation, and to relieve nausea, vomiting and dizziness associated with Meniere's disease and other middle ear disorders. (medsnow.co.uk)
  • Cyclizine is effective in providing relief to nausea. (medsnow.co.uk)
  • Cyclizine works by blocking histamine and muscarinic receptors in the vomiting centre which prevents disturbances in the middle ear from activating the vomiting centre and causing nausea, vertigo, and vomiting. (medsnow.co.uk)
  • In pregnancy NICE guidelines advise oral promethazine or oral cyclizine should be used as 1st line drug management of nausea and vomitting. (mrcoggoal.com)
  • There is no evidence to show that you are more likely to miscarry if you take cyclizine to treat nausea while pregnant. (medicinedirect.co.uk)
  • Cyclizine can be used to treat nausea that is caused by a number of different conditions, not just pregnancy. (medicinedirect.co.uk)
  • In summary, cyclizine is considered to be safe to take during pregnancy and can effectively treat the nausea that comes with morning sickness. (medicinedirect.co.uk)
Tablets1
  • an antihistamine drug used in sleeping tablets. (absp.org.uk)
Buclizine1
  • Meclizina, un derivado de piperazina H1 antagonista de los receptores similares a buclizine, cyclizine y la hidroxizina, es utilizado como un agente antivertigo / antieméticos. (pharmacycode.com)
Promethazine2
  • Prescribe an antihistamine (oral cyclizine or oral promethazine), or a phenothiazine (oral prochlorperazine), and reassess after 24 hours. (patient.info)
  • Where treatment with anti-emetics is required, the Royal College of Obstetricians and Gynaecologists (RCOG) recommends the antihistamines cyclizine and promethazine, or the phenothiazines prochlorperazine or chlorpromazine as first-line options. (uktis.org)
Mechanism of act1
Cinnarizine2
Hydrochloride2
  • Cyclizine is an antihistamine medicine and contains the active ingredient Cyclizine hydrochloride. (medsnow.co.uk)
  • The medicine's active ingredient, Cyclizine hydrochloride, effectively blocks the brain's vomiting centre receptors and prevents them from receiving signals from the vestibular area. (medsnow.co.uk)
Anticholinergic5
  • It is in the anticholinergic and antihistamine family of medications. (wikipedia.org)
  • Cyclizine exerts a central anticholinergic (antimuscarinic) action. (wikipedia.org)
  • Toxicity caused by first-generation antihistamines is usually due to their anticholinergic rather than their antihistamine properties. (medscape.com)
  • Urinary retention is a common anticholinergic adverse effect of the antihistamines. (medscape.com)
  • [3] [11] Scopolamine has also been shown to exert a greater impairment on episodic memory , event-related potentials , memory retention and free recall compared to DPH (an anticholinergic and antihistamine ). (wikipedia.org)
Clinically1
  • H 1 -antihistamines are clinically used in the treatment of histamine-mediated allergic conditions. (wikidoc.org)
Receptor7
  • While first-generation H1-receptor antagonists are responsible for the vast majority of antihistamine poisonings, the nonsedating H1-receptor antagonists also have been associated with serious toxicity. (medscape.com)
  • Cyclizine is a potent H1 receptor antihistaminic agent. (rosheta.com)
  • Explanation: Cyclizine is type of antihistamine that acts on the H1 receptor. (mrcoggoal.com)
  • In common use, the term "antihistamine" refers only to H 1 antagonists, also known as H 1 -receptor antagonists and H 1 -antihistamines. (wikidoc.org)
  • This lack of receptor-selectivity is the basis of the poor tolerability-profile of some of these agents, especially compared with the second-generation H 1 -antihistamines. (wikidoc.org)
  • H 1 -antihistamines can also reduce inflammation, since the expression of NF-κB, the transcription factor the regulates inflammatory processes, is promoted by both the receptor's constitutive activity and agonist (i.e., histamine) binding at the H 1 receptor. (illnesshacker.com)
  • Associated with the first generation H1-antihistamines and due to their lack of selectivity for the H1 receptor and anti-cholinergic activity. (slideshare.net)
Prescribe1
  • If your doctor does prescribe you cyclizine to take while breastfeeding, you should tell them immediately if your baby starts to sleep more than usual. (medicinedirect.co.uk)
Medicines5
  • The 3 main components of most cough and cold medicines are antihistamines, decongestants, and antitussives. (medscape.com)
  • Cyclizine is on the World Health Organisation's List of Essential Medicines. (medsnow.co.uk)
  • Cyclizine is considered to be one of the safest and most effective anti-sickness medicines. (medicinedirect.co.uk)
  • As with most anti-sickness medicines, you should only take cyclizine for as long as you need to. (medicinedirect.co.uk)
  • Cyclizine is prescribed by doctors for morning sickness when other medicines have not helped with the symptoms. (medicinedirect.co.uk)
Medications1
  • Allergy medications typically contain antihistamines, decongestants, or both. (medscape.com)
Motion sickness2
  • Antihistamines are frequently used and are relatively safe and effective for the prevention and treatment of mild to moderate motion sickness, though nearly all cause some drowsiness. (tripprep.com)
  • Used to treat motion sickness and dizziness.Belongs to a class of drugs called antihistamines. (patientassistance.com)
Pregnancy4
Astemizole1
  • Astemizole (marketed under the brand name Hismanal ) is a second generation antihistamine drug which has a long duration of action. (wikidoc.org)
Vestibular1
  • Meclizina se usa en el tratamiento de las náuseas, vómitos, , Y los mareos asociados con la cinetosis y el vértigo de las enfermedades que afectan el aparato vestibular. (pharmacycode.com)
Antivertigo1
  • Cyclizine produces antivertigo action by decreasing the excitability of middle ear labyrinth. (rosheta.com)
Symptoms2
  • Before using Cyclizine for morning sickness, it is recommended making certain lifestyle adjustments which may help to ease your symptoms of morning sickness. (medicinedirect.co.uk)
  • In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. (drlact.com)
High doses2
  • [12] Some antihistamines may also act as deliriants in high doses. (wikipedia.org)
  • Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women. (drlact.com)
Drug4
  • The drug Diconal is a combination of cyclizine and the opioid dipipanone. (wikipedia.org)
  • Cyclizine may be prepared by the Eschweiler-Clarke methylation of diphenylmethylpiperazine or by reaction of benzhydryl bromide with 1-methylpiperazine in acetonitrile to form the hydrobromide salt of the drug. (wikipedia.org)
  • an antihistamine drug used to relieve travel and postoperative sickness. (absp.org.uk)
  • Adverse drug reactions are most commonly associated with the first-generation H 1 -antihistamines. (wikidoc.org)
Oral3
  • LD50 = mg / kg (por vía oral en ratas). (pharmacycode.com)
  • Antihistamines like cyclizine and tripelennamine are sometimes mixed with morphine to increase both, a potentially dangerous practise via unsupervised injection but one used medically with oral opioid administration and under direct supervision of a doctor and nurse via the IV and SC routes in particular. (dieutridau.com)
  • 3] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. (drlact.com)
Peripheral histamine1
  • The newer second-generation H 1 -antihistamines are far more selective for peripheral histamine H 1 -receptors and have a far improved tolerability profile compared to the first-generation agents. (wikidoc.org)
Combination2
  • Some people using methadone recreationally combine cyclizine with their methadone dose, a combination that is known to produce strong psychoactive effects. (wikipedia.org)
  • and sympathomimetics (often used in combination with antihistamines). (cdc.gov)
Allergies1
  • Antihistamines are drugs which treat allergic rhinitis and other allergies. (illnesshacker.com)
Allergic1
  • H 1 -antihistamines can be administered topically (through the skin , nose , or eyes ) or systemically, based on the nature of the allergic condition. (wikidoc.org)
Cough2
  • Antihistamines and cough and cold preparations, respectively, rank seventh and twenty-third on the list of substance categories most frequently involved in human exposures in the United States. (medscape.com)
  • The authors of the American College of Chest Physicians Updates on Cough Guidelines (2006) recommend that, for cough associated with the common cold, first-generation antihistamine-decongestants are more effective than newer, non-sedating antihistamines. (wikidoc.org)
Drugs2
  • Cyclizine was developed in the American division of pharmacy company Burroughs Wellcome (today GlaxoSmithKline) during a research study involving many drugs of the antihistamine group. (wikipedia.org)
  • Some second-generation antihistamines, notably cetirizine, can interact with CNS psychoactive drugs such as bupropion and benzodiazepines. (illnesshacker.com)
Action1
  • Agents where the main therapeutic effect is mediated by negative modulation of histamine receptors are termed antihistamines - other agents may have antihistaminergic action but are not true antihistamines. (wikidoc.org)
Sickness2
Treat1
Medicine3
  • Cyclizine is a category of medicine called an antihistamine. (medsnow.co.uk)
  • Cyclizine is generally considered to be a safe medicine to take while pregnant. (medicinedirect.co.uk)
  • Cyclizine can be taken if you are breastfeeding, but you should talk to your doctor beforehand as small amounts of this medicine is filtered into the breast milk. (medicinedirect.co.uk)
Second-generation1
  • Second-generation antihistamines cross the blood-brain barrier to a much lower degree than the first-generation antihistamines. (illnesshacker.com)
Effects1
  • While H 1 -antihistamines help against these effects, they work only if taken before contact with the allergen. (wikidoc.org)
Safe1
  • Cyclizine may not be the first recommendation for doctors, but it has been found to be effective and safe for pregnant women. (medicinedirect.co.uk)