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  • genome
  • These findings combined with the finding of viral-specific RNA indicate that portions of the viral genome are being expressed with a much greater frequency than previously appreciated. (biomedsearch.com)
  • The sfRNAs are a result of incomplete degradation of the viral genome by the exonuclease and are important for viral pathogenicity. (wikipedia.org)
  • infection
  • Polioencephalitis is a viral infection of the brain, causing inflammation within the grey matter of the brain stem. (wikipedia.org)
  • Infection is initiated when a viral particle contacts a cell with specific types of receptor molecules on the cell surface. (wikipedia.org)
  • She based her research on discovering if small portions of gene-stopping DNA (called antisense oligonucleotides) could be created to bind up the viral RNA in retroviruses like HIV so that the virus could not make more copies of itself to continue the infection. (wikipedia.org)
  • vaccine
  • From 1986 to 2014 he worked continuously as a viral vaccine expert and senior public health adviser for international health policy agencies such as the World Health Organization, the Joint United Nations Programme on HIV/AIDS, and the Bill & Melinda Gates Foundation. (wikipedia.org)
  • By this stage Esparza had attained hands-on command of many aspects of viral research techniques (i.e., virus-isolation, culture, serotyping, structure, genetic engineering and vaccine development) as well as project-management expertise while heading studies of a variety of human viral pathologies including enchephalitis, herpes, and rotaviruses. (wikipedia.org)
  • infections
  • Genetic Immunity works to create and commercialize immunotherapeutic biologics to treat chronic viral infections, allergies, and cancers to prolong the life of the patient and improve their quality of life. (wikipedia.org)
  • tissue
  • Over the past 15 years, a number of observations have culminated in the localization of viral antigens in liver tissue by the use of routine histology, immunohistochemistry, electron microscopy (EM), and immuno-electron microscopy (IEM). (springer.com)
  • Tissue Antigens. (wikipedia.org)
  • Research
  • During his undergraduate teenage years, Esparza teamed up with some of his teachers in viral research studies designed to characterize a large zoonotic outbreak of Venezuelan equine encephalitis affecting people and riding beasts in the nearby Guajira region and its surroundings. (wikipedia.org)
  • In 1986 Esparza was then recruited as a medical officer by the Division of Communicable Diseases of the World Health Organization, a position which implied worldwide supervising responsibilities of research projects involving various vector-borne viral diseases such as yellow fever, dengue, encephalitis and hemorrhagic fever. (wikipedia.org)
  • Context
  • Antigens normally presented endogenously in a nonstimulatory context could activate an autoimmune response if cell damage releases them for uptake by DCs. (biomedcentral.com)
  • virion
  • Following binding of viral envelope glycoproteins to cell membrane receptors, the virion is internalized and dismantled, allowing viral DNA to migrate to the cell nucleus. (wikipedia.org)
  • virus
  • Munz C, Bickham KL, Subklewe M, Tsang ML, Chahroudi A, Kurilla MG, Zhang D, O'Donnell M, Steinman RM: Human CD4 + T lymphocytes consistently respond to the latent Epstein-Barr virus nuclear antigen EBNA1. (biomedcentral.com)
  • E1 is similar to COOH-terminal domain of the Simian virus 40, plays a role in viral DNA replication maintaining plasmids within a cell. (wikipedia.org)
  • Experiments on transgenic mice are investigating the initial sites of viral replication in the host and how the virus moves from the bloodstream into the central nervous system. (wikipedia.org)
  • These complementary DNA pieces can bind to the HIV viral mRNA and prevent the HIV virus from replicating itself. (wikipedia.org)
  • Bovine viral diarrhea (BVD) or bovine viral diarrhoea (UK English), and previously referred to as bovine virus diarrhoea (BVD), is a significant economic disease of cattle that is endemic in the majority of countries throughout the world. (wikipedia.org)
  • The causative agent, bovine viral diarrhea virus (BVDV), is a member of the Pestivirus genus of the family Flaviviridae. (wikipedia.org)
  • Persistently infected animals are the most important source of the virus, continuously excreting a viral load one thousand times that shed by acutely infected animals. (wikipedia.org)
  • diseases
  • Our data may also explain the elevated serum GrB levels found in the early phase of various viral diseases. (jimmunol.org)
  • production
  • The UTR contains PKS3 pseudoknot structure which serves as a molecular signal to stall the exonuclease and is the only viral requirement for subgenomic flavivirus RNA (sfRNA) production. (wikipedia.org)
  • mechanism
  • If yes, this suggests a mechanism by which normally cryptic self antigens could become targets of autoimmunity in an inflamed microenvironment. (biomedcentral.com)
  • Products
  • Microbix Biosystems (TSX:MBX) agreed to supply an existing long-term customer with an increasing quantity of its viral antigen products over the next five years, with an option to extend that term. (biotuesdays.com)
  • Please note that the definition of "U" (units) may vary between manufacturers depending on what test they use to measure hepatitis A antigen in their products. (wikipedia.org)
  • various
  • There is considerable variability in the sensitivity, specificity, technical considerations, and turnaround time among the various methods, and each method may perform differently depending on the viral target. (asmscience.org)
  • type
  • For this reason, they are described as H1N1, H1N2 etc. depending on the type of H or N antigens they express with metabolic synergy. (wikipedia.org)
  • allows
  • This allows us to make appropriate husbandry decisions (for example, the maintenance of a single cat household or confinement of the cat indoors) in the event of a confirmed positive viral status. (sandcreekanimalhospital.com)