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  • cancers
  • In view of the foregoing, GM2 is expected to be an ideal antigen for specific immunotherapy of human cancers with either vaccination or MAbs. (aacrjournals.org)
  • Purpose: N -Acetylglucosaminyltransferase V (GnT-V), a key enzyme in the formation of branching of asparagine-linked oligosaccharides, is strongly linked to tumor invasion and metastasis of colon and breast cancers. (aacrjournals.org)
  • It is a rare malignant tumor that primarily develops in children, and accounts for approximately 1% of all cancers in children and 79% of all primary liver cancers under the age of 15. (wikipedia.org)
  • Tumor markers, chemicals sometimes found in the blood of people with cancer, can be helpful in diagnosing and monitoring the course of liver cancers. (wikipedia.org)
  • These tumour markers are found in primary liver cancers, as well as in other cancers and certain other disorders. (wikipedia.org)
  • CA-125 has found application as a tumor marker or biomarker that may be elevated in the blood of some patients with specific types of cancers, or other conditions that are benign. (wikipedia.org)
  • Increased stool (fecal) levels are being investigated as a method of screening for colorectal tumors, and EDTA plasma levels are undergoing testing for possible application in the follow-up of various cancers. (wikipedia.org)
  • The combination of Tumor M2-PK with the appropriate classical tumor marker, such as CEA for bowel cancer, CA 19-9 for pancreatic cancer and CA 72-4 for gastric cancer, significantly increases the sensitivity to detect various cancers. (wikipedia.org)
  • malignant
  • Publications] Y.Ibayashi: 'Effect of local administration of lymphokine-activated killer cells and interleukin-2 on malignant brain tumor patients' Neurologia medico-chirurgica. (nii.ac.jp)
  • My group molecularly interrogates gynecologic tumors to identify genes or proteins and their corresponding signaling pathways that contribute to malignant transformation, the pathology of the disease, recurrence and/or resistance to therapy. (massgeneral.org)
  • However, many of the biochemical characteristics initially thought to be closely associated with the malignant phenotype of cells in culture were subsequently found to be dissociable from the ability of those cells to produce tumors in animals. (nih.gov)
  • Furthermore, individual cells of malignant tumors growing in animals or in humans exhibit marked biochemical heterogeneity, as reflected in their cell surface composition, enzyme levels, immunogenicity, response to anticancer drugs, and so on. (nih.gov)
  • Recently, however, Hahn and colleagues 28 showed that ectopic expression of the human telomerase catalytic subunit (human telomerase reverse transcriptase [hTERT]) in combination with the oncogenes h- ras and SV40 virus large-T antigen can induce tumorigenic conversion in normal human epithelial and fibroblast cells, suggesting that disruption of the intracellular pathways regulated by these gene products is sufficient to produce a malignant cell. (nih.gov)
  • a rare malignant tumor in children. (wikipedia.org)
  • Upon discovery of a liver tumor, the main issue in the workup is to determine whether the tumor is benign or malignant. (wikipedia.org)
  • Many imaging modalities are used to aid in the diagnosis of malignant liver tumors. (wikipedia.org)
  • proteins
  • they are often proteins or other macromolecules (e.g. carbohydrates). (wikipedia.org)
  • Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. (wikipedia.org)
  • Lectins, or proteins that bind carbohydrates, can recognize specific oligosaccharides and provide useful information for cell recognition based on oligosaccharide binding. (wikipedia.org)
  • As the leukocyte rolls along the blood vessel wall, the distal lectin-like domain of the selectin binds to certain carbohydrate groups presented on proteins (such as PSGL-1) on the leukocyte, which slows the cell and allows it to leave the blood vessel and enter the site of infection. (wikipedia.org)
  • induce
  • To induce sustained immunity against both LeY and GD2, we developed a carbohydrate mimicking peptide (CMP) as a surrogate pan-immunogen that mimics both. (oncotarget.com)
  • Such strategies could produce organisms that perform multistep immune functions such as presenting antigen to and co-stimulating helper T cells in a specific manner, or providing integrated signals to B cells to induce affinity maturation and isotype switching during antibody production. (wikipedia.org)
  • Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. (wikipedia.org)
  • Antigens can be added to the antibody and can induce the dendritic cells to mature and provide immunity to the tumor. (wikipedia.org)
  • immunotherapy
  • The main objective of this project is to develop a novel immunotherapy for gliomas, in which glycolipid antigens are analyzed and quantified systematically and a set of appropriate antibodies would be selected according to the antigenic profile of an individual glioma. (nii.ac.jp)
  • Publications] T.Yamaki: 'The requirement of host immune response to tumor cells to achieve tumor eradication by intratumoral LAK cell infusion immunotherapy' Oncol. (nii.ac.jp)
  • These changes allow considering some gangliosides as tumor-associated antigens and they have been selected as possible target for active and passive immunotherapy [ 9 , 10 ]. (hindawi.com)
  • Active immunotherapy directs the immune system to attack tumor cells by targeting TAAs. (wikipedia.org)
  • epithelial
  • More recently, the study was extended to cutaneous melanomas and their metastases [ 12 ] and to epithelial tumors of the digestive system [ 13 ]. (hindawi.com)
  • Hepatic adenomas: These benign epithelial liver tumors develop in the liver and are also an uncommon occurrence, found mainly in women using estrogens as contraceptives, or in cases of steroid abuse. (wikipedia.org)
  • ovarian
  • To this end we utilize a well-established in vivo experimental system in which primary tumors collected from ovarian and endometrial cancer patients at the time of initial surgery are grown in NOD/SCID mice. (massgeneral.org)
  • Increased presence of Sialyl-Thomsen-nouveau antigen (STn), a TACA, correlates with worsened outcome and chemoresistance in ovarian cancer (OvCa). (massgeneral.org)
  • Ovarian teratomas represent about a quarter of ovarian tumors and are typically noticed during middle age. (wikipedia.org)
  • protein
  • The present invention relates to antigen-binding fragment (Fab) and a Fab-effector fusion protein or polypeptide comprising thereof. (patents.com)
  • He is known for his work on lectin structure and interactions, orientation and dynamics of cell surface carbohydrate receptors and protein folding, diabetes, anti-malarials and anti-cancer agents based on curcumin, flavonoids, etc. (wikipedia.org)
  • He discovered novel blood group and tumor antigen specific lectins and made original contribution towards elucidation of the energetics and mechanism of protein-sugar recognition. (wikipedia.org)
  • He delineated the molecular basis of carbohydrate recognition by legume lectins and demonstrated the novel C-H…O/N hydrogen bond in protein-sugar interactions. (wikipedia.org)
  • CA-125 (cancer antigen 125, carcinoma antigen 125, or carbohydrate antigen 125) also known as mucin 16 or MUC16 is a protein that in humans is encoded by the MUC16 gene. (wikipedia.org)
  • Further evidence that MUC16 can protect tumor cells from the immune system is the discovery that the heavily glycosylated tandem repeat domain of MUC16 can bind to galectin-1 (an immunosuppressive protein). (wikipedia.org)
  • Tumor restriction of Thomsen-Friedenreich antigen may therefore be determined either by the protein backbone or by the beta-glycosidic linkage of the carbohydrate structure to the protein. (wikipedia.org)
  • The dendritic cells are activated in the presence of tumor antigens, which may be a single tumor-specific peptide/protein or a tumor cell lysate (a solution of broken down tumor cells). (wikipedia.org)
  • The treatment consists of removal of antigen-presenting cells from blood by leukapheresis and growing them with the fusion protein PA2024 made from GM-CSF and prostate-specific prostatic acid phosphatase (PAP) and reinfused. (wikipedia.org)
  • The name selectin comes from the words "selected" and "lectins," which are a type of carbohydrate-recognizing protein. (wikipedia.org)
  • They have remarkably similar protein folds and carbohydrate binding residues, leading to overlap in the glycans to which they bind. (wikipedia.org)
  • receptors
  • doi:10.1016/j.ecl.2009.07.004 PMID 19716998 Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation. (wikipedia.org)
  • 2017
  • In 2017 Kymriah (or tisagenlecleucel), a chimeric antigen receptor (CAR) therapy, was approved by FDA to treat acute lymphoblastic leukemia. (wikipedia.org)
  • biochemical
  • Publications] B.O.Choi: 'Biochemical analysis of cytokine effect on the glycosphingolipid expression of human glioma cell lines' Tumor Res.28. (nii.ac.jp)
  • sarcoma
  • Tumors of the blood vessels (angiosarcoma and hemangioendothelioma, embryonal sarcoma and fibrosarcoma are produced from a type of connective tissue known as mesenchyme. (wikipedia.org)
  • antibodies
  • The induction of antibodies to these antigens and related types would therefore be of clinical benefit by providing sustained immunity to inhibit metastatic outgrowth. (oncotarget.com)
  • Our preliminary data utilizing these novel highly specific STn antibodies suggests that STn is present in a significant subset of OvCa cells and tumors. (massgeneral.org)
  • reactivity
  • We are now focusing on the glycolipid analysis of surgical specimens of glioma tissue as well as on the factors participating in the antibody reactivity against those antigens. (nii.ac.jp)
  • In contrast to the studies performed in the past, immunohistochemical results using this antibody 82-A6 did not exhibit a reactivity clearly restricted to tumors. (wikipedia.org)
  • binds
  • A method for treating a tumor by administering an antibody or antibody fragment that binds specifically to stage-specific embryonic antigen 4, and an agent. (patents.com)
  • Also known as huC242 it binds the CanAg antigen. (wikipedia.org)
  • It is typically linked to one of several cytotoxic agents, yielding antibody-drug conjugates : Cantuzumab mertansine Cantuzumab ravtansine "HuC242 binds to the extracellular domain of the tumor-associated carbohydrate antigen known as CanAg (a novel glycoform of MUC1). (wikipedia.org)
  • responses
  • Our work to date provides evidence to suggest the clinical course of the primary tumor mimics the behavior and responses we have seen in our explants further supporting the potential clinical utility of our xenograft model. (massgeneral.org)
  • immune response
  • One way that MUC16 helps the growth of tumors is by suppressing the response of natural killer cells, thereby protecting cancer cells from the immune response. (wikipedia.org)
  • cells
  • They are ubiquitous in nature and can be considered as one of the unique antigens expressed across pathogens and cancer cells. (frontiersin.org)
  • The ultimate criterion that establishes whether or not cells have been transformed, however, is their ability to form a tumor in an appropriate host animal. (nih.gov)
  • Some of these characteristics may be seen both in transformed cells in culture and in tumors growing in vivo in experimental animals or patients. (nih.gov)
  • When M2-PK is mainly in the dimeric form, which is the case in tumor cells, all phosphometabolites above pyruvate kinase accumulate and are channelled into synthetic processes which branch off from glycolytic intermediates, such as nucleic acids, phospholipids and amino acids, important cell building blocks for highly proliferating cells such as tumor cells. (wikipedia.org)
  • Active cellular therapies usually involve the removal of immune cells from the blood or from a tumor. (wikipedia.org)
  • alternatively, immune cells can be genetically engineered to express a tumor-specific receptor, cultured and returned to the patient. (wikipedia.org)
  • Dendritic cells are antigen presenting cells (APCs) in the mammalian immune system. (wikipedia.org)
  • Dendritic cells can also be activated in vivo by making tumour cells express GM-CSF. (wikipedia.org)
  • This can be achieved by either genetically engineering tumor cells to produce GM-CSF or by infecting tumor cells with an oncolytic virus that expresses GM-CSF. (wikipedia.org)
  • In patients who lack the Lewis antigen (a blood type antigen on red blood cells), which is about 10% of the Caucasian population, CA 19-9 is not expressed, even in those with large tumors. (wikipedia.org)
  • Each selectin has a carbohydrate recognition domain that mediates binding to specific glycans on apposing cells. (wikipedia.org)
  • They are a type of germ cell tumor (a tumor that begins in the cells that give rise to sperm or eggs). (wikipedia.org)
  • Teratomas belong to a class of tumors known as nonseminomatous germ cell tumor (N.S.G.C.T.). All tumors of this class are the result of abnormal development of pluripotent cells: germ cells and embryonal cells. (wikipedia.org)
  • biological
  • Among biological characteristics of tumors, Ki-67 labeling index was higher in tumors with low GnT-V expression than in those with high GnT-V expression, although this difference was not statistically significant ( P = 0.09). (aacrjournals.org)
  • cell
  • Additionally, the expression of NeuGcGM3 in nonsmall cell lung cancer as well as in Wilms tumor has been also reported [ 14 , 15 ]. (hindawi.com)
  • Several distinct types of tumors can develop in the liver because the liver is made up of various cell types. (wikipedia.org)
  • MUC16 and mesothelin interactions are thought to provide the first step in tumor cell invasion of the peritoneum. (wikipedia.org)
  • therefore
  • Therefore, the measurement of tumor M2-PK in stool samples, with follow-up by colonoscopy to clarify the tumor M2-PK positive results, may prove to be an advance in the early detection of colorectal carcinomas. (wikipedia.org)
  • survival
  • An important application of the Tumor M2-PK test in EDTA-plasma is for follow-up during tumor therapy, to monitor the success or failure of the chosen treatment, as well as predicting the chances of a "cure" and survival. (wikipedia.org)
  • targets
  • Focussing on drug discovery from key targets and placing an emphasis on the multi-disciplinary approaches necessary to challenge these issues, this book comprehensively covers the new and recent discoveries in the area of carbohydrate drug discovery. (rsc.org)
  • lectins
  • His studies showed that the monomers of legume lectins have the necessary structural features for carbohydrate recognition and that oligomerization imparts them with topology necessary for their biologic activities such as agglutination, mitogenesis etc. (wikipedia.org)
  • epitope
  • It is expressed as a carbohydrate epitope that contains a sulfoglucuronyl residue in several adhesion molecules of the nervous system. (wikipedia.org)
  • This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). (wikipedia.org)
  • patients
  • A Phase I Study of Cantuzumab Mertansine Administered as a Single Intravenous Infusion Once Weekly in Patients with Advanced Solid Tumors. (wikipedia.org)
  • ligands
  • In recent years there has been increasing evidence of the importance of carbohydrates and glycoconjugates in biomedical applications, and the use of synthetic ligands based on carbohydrates as drugs has received much attention. (rsc.org)
  • One of the reported ligands for E-selectin is the sialylated Lewis X antigen (SLex). (wikipedia.org)
  • novel
  • Once key factors or pathways are identified, we actively test novel anticancer drugs to determine their efficacy in tumor explant models. (massgeneral.org)
  • mediate
  • The structure of LAMP1 correlates with differentiation and metastatic potential of tumor cells as it is thought to help mediate cell-cell adhesion and migration. (wikipedia.org)