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  • tumor
  • Introduction Adoptively transferred T cells Rabbit Polyclonal to ZADH2 can recognize tumor-associated antigens presented in association with MHC molecules on the cell surface. (researchhunt.com)
  • Until recently, however, CAR-T cells had shown little evidence of antitumor activity against solid tumors and had only brief persistence in vivo.5C7 It has been believed that engagement of the chimeric receptor by tumor antigens failed to provide the requisite costimulatory signals necessary for optimal expansion, function, and persistence because tumor cells, unlike professional antigen-presenting cells, lack costimulatory ligands and may express inhibitory ligands. (researchhunt.com)
  • Expression of Prostate-Specific Membrane Antigen in Tumor-Associated Vasculatures of Renal Neoplasms" presented on Sunday, May 21 from 1:00 p.m. to 4:00 p.m. during a Poster Session on Kidney and Ureteral Cancer: Basic Research (Abstract # 382). (salesandmarketingnetwork.com)
  • Less obviously, CD4 T cells are also implicated in defective immunity to tumors, as CD4 regulatory T cells (Tregs) limit effector responses to tumor antigens. (frontiersin.org)
  • cytokines
  • Moreover, LPS or HIV-1-activated dendritic cells (DCs) stimulated CD8(+) T cells in an IL-15-dependent but Ag-independent manner, and IL-15 expression was highly increased in DCs isolated from viremic HIV-1 patients, suggesting that CD8(+) T cells are activated by inflammatory cytokines in untreated HIV-1 patients independent of Ag specificity. (uzh.ch)
  • vaccines
  • To maintain the synergism between the kind of immunity conferred by the vaccines and the cellular location of the included antigens, new findings are gathered about the virulence factors such as toxins, adhesins, invasins (mostly enzymes), anti-apoptotic factors, anti-phagocytic factors, and many more molecules that aid in pathogenesis and invasiveness. (jyi.org)
  • Here we consider the potential, population-level effects of a particular class of emerging vaccines that use specific viral vectors to establish long-term, intermittent antigen presentation within a vaccinated host: in essence, "self-boosting" vaccines. (pnas.org)
  • Here we consider the potential impact of emerging vaccines for which attenuated viral vectors act as vehicles for the expression of recombinant, target antigens. (pnas.org)
  • Suitably chosen, these vectors could in essence provide the foundation for novel "self-boosting" vaccines, capable of recurring antigen presentation throughout a recipient's lifetime, with potentially novel, far-reaching implications for herd immunity. (pnas.org)
  • repertoire
  • 4 ) on p. 1331 of this issue identify a subset of B lymphocytes in human infants that undergoes repertoire diversification via antigen-independent V gene SHM. (rupress.org)
  • Although the size and diversity of the lymphocyte repertoire make it likely that there is an antigen, a specific lymphocyte for any given pathogen, the frequency of these cells can be extremely low and normally will not be sufficient to protect the host against a primary infection. (jyi.org)
  • expression
  • PRINCETON, N.J., May 22 (HSMN NewsFeed) -- Cytogen Corporation (Nasdaq: CYTO ) today announced the presentation of data demonstrating the expression of prostate-specific membrane antigen (PSMA) in cancer of the kidney. (salesandmarketingnetwork.com)
  • In the study, independent investigators at the Cleveland Clinic evaluated PSMA expression in normal kidneys and tissue samples from both benign and malignant renal lesions using a tissue microarray. (salesandmarketingnetwork.com)
  • Secondary
  • It is this process of clonal selection and the ultimate perpetuation of these antigen-specific memory cells that protects against a secondary infection. (jyi.org)
  • suggests
  • However, as addressed below, recent evidence suggests that B cell responses that fail to engender bona fide GC responses, such as responses to T cell-independent Ags, also generate long-lived plasma cells. (jimmunol.org)
  • cell-independent
  • This review charts plasma cell differentiation in T cell-dependent and T cell-independent Ab responses while also addressing current knowledge of the environmental cues governing life and death decisions in the plasma cell lineage. (jimmunol.org)
  • Along the way, we consider historical precedents driving the notion that plasma cells possess markedly distinct lifespans, as well as the idea that T cell-independent Ags are relatively ineffective at inducing the formation of long-lived plasma cells. (jimmunol.org)
  • ability
  • One of the most critical properties of this group of antigens is their ability to deliver prolonged and persistent signaling to the B cell. (acs.org)