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  • simian virus 40 T a
  • The simian virus 40 T antigen (Tag) expressed under the control of the rat insulin promoter (RIP) induced pancreatic beta-cell tumors producing insulin, causing progressive hypoglycemia. (nih.gov)
  • Anti-CD40 conditioning enhances the T(CD8) response to a highly tolerogenic epitope and subsequent immunotherapy of simian virus 40 T antigen-induced pancreatic tumors. (jax.org)
  • Mice
  • Subsequent adoptive transfer of virus activated spleen cells into RIP(GP x Tag2) mice further prolonged survival (168 +/- 11 d), demonstrating continued expression of the LCMV-GP tumor antigen and MHC class I. The data show that the tumor did not spontaneously induce or maintain an activated CTL response, revealing a profound lack of immunogenicity in vivo. (nih.gov)
  • EphA2 deficiency impaired tumor initiation and metastatic progression in mice overexpressing ErbB2 (also known as Neu) in the mammary epithelium (MMTV-Neu mice), but not in mice overexpressing the polyomavirus middle T antigen in mammary epithelium (MMTV-PyV-mT mice). (nih.gov)
  • Fluorescently labeled murine mammary carcinoma cells, isolated from either MMTV-PyVmT transforming growth factor-beta receptor II knockout (TβRII KO) or TβRII fl/fl control mice, were combined with mammary fibroblasts and xenografted onto the chicken embryo chorioallantoic membrane. (biomedcentral.com)
  • Polyomaviruses (PyV) were first described in 1953 in mice, but have since then been detected in different bird species, cattle, bats, rabbits, hamster, sea lion, monkeys from the Old and New World, and humans [ 1 , 2 ]. (hindawi.com)
  • Dominant-negative interference of the transforming growth factor beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice -- Gorska et al. (aacrjournals.org)
  • vitro
  • Upon in vitro restimulation with infected antigen-presenting cells, CD8(+) T cells from acutely infected susceptible neonates acquired strong MT389-specific cytotoxicity. (nih.gov)
  • Unphosphorylated T antigen is deficient in promoting DNA replication in vitro but can be activated by phosphorylation at residue threonine 124 by the cdc2 protein kinase. (cshl.edu)
  • PyV mT can readily transform cells in vitro and in vivo by stimulating key pro-tumourigenic signalling axes. (biomedcentral.com)
  • Inhibitor
  • We show that addition of the paracrine growth inhibitor transforming growth factor beta 1 (TGF-beta 1) to Mv1Lu lung epithelial cells in mid to late G1 prevents phosphorylation of RB scheduled for this cell cycle stage and arrests cells in late G1. (nih.gov)
  • Inhibition of Growth and Metastasis of Mouse Mammary Carcinoma by Selective Inhibitor of Transforming Growth Factor-{beta} Type I Receptor Kinase In vivo. (aacrjournals.org)
  • immunology
  • On episode #360 of the science show This Week in Virology , Vincent visits the University of Michigan where he and Kathy speak with Michael, Adam, and Akira about polyomaviruses, virus evolution, and virus assembly, on the occasion of naming the department of Microbiology & Immunology a Milestones in Microbiology site. (virology.ws)
  • protein
  • Polyomaviruses are a family of small, nonenveloped viruses with a circular double-stranded DNA genome of ~ 5,000 base pairs protected by an icosahedral protein structure. (hindawi.com)
  • Immunotherapy
  • In addition, the data suggest that the risk for induction of chronic autoimmune diseases is limited, which may encourage immunotherapy against antigens selectively but not exclusively expressed by the tumor. (nih.gov)
  • inhibition
  • T antigen reversed the inhibition of DNA polymerase alpha/primase activity on hRPA-coated natural ssDNA, as previously described, but was unable to reverse the inhibition on scRPA or Escherichia coli ssb-coated templates. (cshl.edu)
  • One of the targets for this inhibition is the professional antigen-presenting cell, particularly the dendritic cell. (bloodjournal.org)
  • normally
  • Preincubation of purified RP-C with T antigen and the DNA template largely eliminates the delay normally observed before the onset of rapid DNA synthesis. (duke.edu)