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  • Tumors
  • Carcinoembryonic antigen, as measured by radioimmunoassay, is present in two different human colonic tumors that have been serially transplanted and maintained in the cheek pouches of unconditioned, adult golden hamsters. (sciencemag.org)
  • However, every single peptide-based vaccine can only be used in a patient with a given single HLA type, and this strategy is not appropriate for patients with rare HLA types or with tumors without defined antigens. (uni-regensburg.de)
  • Self antigens expressed by solid tumors Do not efficiently stimulate naive or activated T cells: implications for immunotherapy. (nih.gov)
  • The simian virus 40 T antigen (Tag) expressed under the control of the rat insulin promoter (RIP) induced pancreatic beta-cell tumors producing insulin, causing progressive hypoglycemia. (nih.gov)
  • Dadachova E, Nosanchuk JD, Shi L, Schweitzer AD, Frenkel A, Nosanchuk JS, and Casadevall A. Dead cells in melanoma tumors provide abundant antigen for targeted delivery of ionizing radiation by a monoclonal antibody to melanin. (wikipedia.org)
  • The advent of monoclonal antibody technology has made it possible to raise antibodies against specific antigens presented on the surfaces of tumors. (wikipedia.org)
  • Humans
  • It interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3/CD58) in humans, or CD48 in rodents, which are expressed on the surfaces of other cells. (wikipedia.org)
  • cells
  • Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells. (nih.gov)
  • The nature and site of tumor-antigen presentation to immune T cells by bone-marrow-derived cells within the tumor microenvironment remains unresolved. (nih.gov)
  • We generated a fluorescent mouse model of spontaneous immunoevasive breast cancer and identified a subset of myeloid cells with significant similarity to dendritic cells and macrophages that constitutively ingest tumor-derived proteins and present processed tumor antigens to reactive T cells. (nih.gov)
  • The spatiotemporal dynamics revealed here implicate nonproductive interactions between T cells and antigen-presenting cells on the tumor margin. (nih.gov)
  • Expression of common acute lymphoblastic leukaemia antigen and terminal deoxynucleotidyl transferase in normal mononuclear blood cells during diffusion chamber culture. (biomedsearch.com)
  • A high percentage of cALL antigen positive cells and later on TdT containing cells appeared during culture. (biomedsearch.com)
  • Murine SC142 antibody specific for the SC142-reactive antigen has been produced by immunisation with SNU16 stomach cancer cells. (nih.gov)
  • Clinical trials using dendritic cells (DC) loaded with peptides corresponding to tumor antigens are ongoing in several institutions, and some promising results have already been published. (uni-regensburg.de)
  • Subsequent adoptive transfer of virus activated spleen cells into RIP(GP x Tag2) mice further prolonged survival (168 +/- 11 d), demonstrating continued expression of the LCMV-GP tumor antigen and MHC class I. The data show that the tumor did not spontaneously induce or maintain an activated CTL response, revealing a profound lack of immunogenicity in vivo. (nih.gov)
  • By its nature, RIT requires a tumor cell to express an antigen that is unique to the neoplasm or is not accessible in normal cells. (wikipedia.org)
  • Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. (wikipedia.org)
  • PCNA was originally identified as an antigen that is expressed in the nuclei of cells during the DNA synthesis phase of the cell cycle. (wikipedia.org)
  • Cells of the immune system, such as macrophages, mast cells, plasma cells and eosinophils are found scattered in loose connective tissue, providing the ground for starting inflammatory and immune responses upon the detection of antigens. (wikipedia.org)
  • The antigen is found bound to the membranes of all mature T-cells, and in virtually no other cell type, although it does appear to be present in small amounts in Purkinje cells. (wikipedia.org)
  • When a B cell is activated by its first encounter with an antigen that binds to its receptor (its "cognate antigen"), the cell proliferates and differentiates to generate a population of antibody-secreting plasma B cells and memory B cells. (wikipedia.org)
  • The second function is to mediate internalization for subsequent processing of the antigen and presentation of peptides to helper T cells. (wikipedia.org)
  • T cells displaying CD4 molecules (and not CD8) on their surface, therefore, are specific for antigens presented by MHC II and not by MHC class I (they are MHC class II-restricted). (wikipedia.org)
  • CD4 is a co-receptor of the T cell receptor (TCR) and assists the latter in communicating with antigen-presenting cells. (wikipedia.org)
  • Pieces of the antigen (which are now known as antigenic peptides) are loaded onto MHC II molecules, and presented on its extracellular surface to CD4+ T cells (sometimes called T helper cells). (wikipedia.org)
  • First, the B cells have to encounter a foreign antigen, and are then required to be activated by T helper cells before they differentiate to specific cells. (wikipedia.org)
  • They divide rapidly and are still capable of internalizing antigens and presenting them to T cells. (wikipedia.org)
  • Unlike their precursors, they cannot switch antibody classes, cannot act as antigen-presenting cells because they no longer display MHC-II, and do not take up antigen because they no longer display significant quantities of immunoglobulin on the cell surface. (wikipedia.org)
  • proteins
  • IKK/NF-κB Transcription Factor Pathway: CD79 and other proteins, microsignalosomes, go to activate PLC-γ after antigen recognition by the BCR and before it goes to associate into the c-SMAC. (wikipedia.org)
  • Biological
  • Lung cancers are now considered a large and extremely heterogeneous family of neoplasms that feature widely varying genetic, biological, and clinical characteristics. (wikipedia.org)
  • recognition
  • The variations between the two different immunological assays might be related to the increased sensitivity of ELISA over Western blotting, but other possibilities could be related to recognition of different epitopes on the same antigen in the two assays. (nih.gov)
  • distinguish
  • The great majority of T cell lymphomas and leukaemias also express CD2, making it possible to use the presence of the antigen to distinguish these conditions from B cell neoplasms. (wikipedia.org)
  • The antigen remains present in almost all T-cell lymphomas and leukaemias, and can therefore be used to distinguish them from superficially similar B-cell and myeloid neoplasms. (wikipedia.org)
  • tissues
  • SC142-reactive antigen are highly glycosylated glycoproteins expressed on tissues of gastric and colon cancers but not on normal tissues. (nih.gov)
  • prostate
  • Preferential autoimmune response in prostate cancer to cyclin B1 in a panel of tumor-associated antigens. (nih.gov)
  • Previous studies have demonstrated that sera from patients with prostate cancer (PCa) contain autoantibodies that react with tumor-associated antigens (TAAs). (nih.gov)
  • In the further analysis, 31.4% of sera from PCa patients at the early stage contained anti-cyclin B1 autoantibody, and even 29.4% of patients who had normal prostate-specific antigen (PSA) levels in their serum samples were observed anti-cyclin B1 positive. (nih.gov)
  • autoantibody
  • A neuronal lineage marker can be a neuronal antigen that is recognized by an autoantibody for example Hu, which is highly restricted to neuronal nuclei. (wikipedia.org)
  • Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin, but calreticulin is not a Ro/SS-A antigen. (wikipedia.org)
  • marker
  • Additionally, EpCAM has oncogenic potential via its capacity to upregulate c-myc, e-fabp, and cyclins A & E. Since EpCAM is expressed exclusively in epithelia and epithelial-derived neoplasms, EpCAM can be used as diagnostic marker for various cancers. (wikipedia.org)
  • latter
  • The pro-thymocytes differentiate into common thymocytes, and then into medullary thymocytes, and it is at this latter stage that CD3 antigen begins to migrate to the cell membrane. (wikipedia.org)
  • exclusively
  • In addition, the data suggest that the risk for induction of chronic autoimmune diseases is limited, which may encourage immunotherapy against antigens selectively but not exclusively expressed by the tumor. (nih.gov)
  • common
  • In 2013, two groups detected calreticulin mutations in a majority of JAK2-negative/MPL-negative patients with essential thrombocythemia and primary myelofibrosis, which makes CALR mutations the second most common in myeloproliferative neoplasms. (wikipedia.org)
  • therapy
  • The Food and Drug Administration (FDA) is announcing that it is codifying the reclassification of tumor-associated antigen immunological test systems intended as an aid in monitoring patients for disease progression or response to therapy or for the detection of recurrent or residual disease from class III (premarket approval) to class II (special controls). (biomedsearch.com)
  • various
  • Typically, markers expressed in LCLC-RP include those seen in "generic" NSCLC's, such as epithelial membrane antigen (EMA, 61%), various cytokeratins (CK's, 80%), and markers associated with the underlying "parent" pulmonary carcinoma. (wikipedia.org)
  • class
  • After the β2-microglobulin binds to the peptide-loading complex (PLC), calreticulin (along with ERp57) takes over the job of chaperoning the MHC class I protein while the tapasin links the complex to the transporter associated with antigen processing (TAP) complex. (wikipedia.org)
  • Cancer
  • A Phase I trial of 90Y-anti-carcinoembryonic antigen chimeric T84.66 radioimmunotherapy with 5-fluorouracil in patients with metastatic colorectal cancer. (wikipedia.org)
  • levels
  • However, continued exposure to antigen through those low levels of immunoglobulin is important, as it partly determines the cell's lifespan. (wikipedia.org)
  • genes
  • Other genetic abnormalities in PDGFRB lead to various forms of potentially malignant bone marrow disorders: small deletions in and chromosome translocations causing fusions between PDGFRB and anyone of at least 30 genes can cause Myeloproliferative neoplasms that commonly involve eosinophilia, eosinophil-induced organ injury, and possible progression to aggressive leukemia (see blow). (wikipedia.org)
  • Transcriptional regulators AIRE and FEZ2 are expressed by the thymic medullary epithelium, and drives the transcription of organ-specific genes such as insulin to allow maturing thymocytes to be exposed to a more complex set of self-antigens than is present in the cortex. (wikipedia.org)
  • related lymphoma
  • However, in the past a number of different terms were used for BPDCN due to their uncommon immunophenotypic, histopathological and clinical features, including blastic NK leukemia/lymphoma, histiocytic lymphoma or histiocytic associated hematologic malignancy, cutaneous a granular CD4+ CD56+ hematodermic neoplasm and NK-cell lymphoma or myelo-monocytic precursor - related lymphoma (5-12). (czytelniamedyczna.pl)
  • gene
  • IMPDH2 has been identified as an intracellular target of the natural product sanglifehrin A This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. (wikipedia.org)
  • plasma
  • Plasma cells develop from B lymphocytes which are stimulated to undergo this maturational development by T lymphocytes during the latter cells' processing of these antigens. (wikipedia.org)
  • However
  • However, one study by Mottow-Lippe, Jakobiec, and Smith suggests that the release of circulating antigens caused by local vascular permeability triggers an inflammatory cascade in the affected tissues. (wikipedia.org)
  • known
  • Pieces of the antigen (which are now known as antigenic peptides ) are loaded onto MHC II molecules, and presented on its extracellular surface to CD4+ T cells (sometimes called T helper cells ). (wikipedia.org)